Pharmacological inhibition of TAK1, with the selective inhibitor takinib, alleviates clinical manifestation of arthritis in CIA mice
Scarneo, Scott A, Eibschutz, Liesl S, Bendele, Phillip J, Yang, Kelly W, Totzke, Juliane, Hughes, Philip, Fox, David A, Haystead, Timothy A J
Published in Arthritis research & therapy (17.12.2019)
Published in Arthritis research & therapy (17.12.2019)
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Journal Article
TAK1: a potent tumour necrosis factor inhibitor for the treatment of inflammatory diseases
Totzke, Juliane, Scarneo, Scott A., Yang, Kelly W., Haystead, Timothy A. J.
Published in Open biology (01.09.2020)
Published in Open biology (01.09.2020)
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Journal Article
Genetic and pharmacological validation of TAK1 inhibition in macrophages as a therapeutic strategy to effectively inhibit TNF secretion
Scarneo, Scott A, Mansourati, Antoine, Eibschutz, Liesl S, Totzke, Juliane, Roques, Jose R, Loiselle, David, Carlson, David, Hughes, Philip, Haystead, Timothy A J
Published in Scientific reports (19.11.2018)
Published in Scientific reports (19.11.2018)
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Journal Article
Expression of membrane Hsp90 is a molecular signature of T cell activation
Scarneo, Scott A, Smith, Aaron P, Favret, Jacob, O'Connell, Robert, Pickeral, Joy, Yang, Kelly W, Ferrari, Guido, Loiselle, David R, Hughes, Philip F, Kulkarni, Manjusha M, Gargesha, Madhusudhana, Scott, Bryan, Roy, Debashish, Haynes, Barton F, Kwiek, Jesse J, Haystead, Timothy A J
Published in Scientific reports (27.10.2022)
Published in Scientific reports (27.10.2022)
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Journal Article
Expression of ectopic heat shock protein 90 in male and female primary afferent nociceptors regulates inflammatory pain
Wang, Yaomin, Scarneo, Scott A, Kim, Shin Hyung, Zhang, Xin, Chen, Jiegen, Yang, Kelly W, Hughes, Philip, Haystead, Timothy, Nackley, Andrea G
Published in Pain (Amsterdam) (01.06.2022)
Published in Pain (Amsterdam) (01.06.2022)
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Journal Article
A highly selective inhibitor of interleukin-1 receptor–associated kinases 1/4 (IRAK-1/4) delineates the distinct signaling roles of IRAK-1/4 and the TAK1 kinase
Scarneo, Scott A., Hughes, Philip F., Yang, Kelly W., Carlson, David A., Gurbani, Deepak, Westover, Kenneth D., Haystead, Timothy A.J.
Published in The Journal of biological chemistry (07.02.2020)
Published in The Journal of biological chemistry (07.02.2020)
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Journal Article
TAK1 regulates the tumor microenvironment through inflammatory, angiogenetic and apoptotic signaling cascades
Scarneo, Scott A., Yang, Kelly W., Roques, Jose R., Dai, Alanna, Eibschutz, Liesl S., Hughes, Philip, Haystead, Timothy A.J.
Published in Oncotarget (26.05.2020)
Published in Oncotarget (26.05.2020)
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Journal Article
A highly selective inhibitor of interleukin-1 receptor-associated kinases 1/4 (IRAK-1/4) delineates the distinct signaling roles of IRAK-1/4 and the TAK1 kinase
Scarneo, Scott A, Hughes, Philip F, Yang, Kelly W, Carlson, David A, Gurbani, Deepak, Westover, Kenneth D, Haystead, Timothy A J
Published in The Journal of biological chemistry (07.02.2020)
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Published in The Journal of biological chemistry (07.02.2020)
Journal Article