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Published in Clinical pharmacology and therapeutics (01.01.2019)
Published in Clinical pharmacology and therapeutics (01.01.2019)
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Degorce, Sébastien L., Aagaard, Anna, Anjum, Rana, Cumming, Iain A., Diène, Coura R., Fallan, Charlene, Johnson, Tony, Leuchowius, Karl-Johan, Orton, Alexandra L., Pearson, Stuart, Robb, Graeme R., Rosen, Alan, Scarfe, Graeme B., Scott, James S., Smith, James M., Steward, Oliver R., Terstiege, Ina, Tucker, Michael J., Turner, Paul, Wilkinson, Stephen D., Wrigley, Gail L., Xue, Yafeng
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Published in Bioorganic & medicinal chemistry (01.12.2020)
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Published in Clinical therapeutics (01.09.2016)
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Published in Drug design, development and therapy (01.01.2016)
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High-Performance Liquid Chromatography Linked to Inductively Coupled Plasma Mass Spectrometry and Orthogonal Acceleration Time-of-Flight Mass Spectrometry for the Simultaneous Detection and Identification of Metabolites of 2-Bromo-4- trifluoromethyl-[13C]-acetanilide in Rat Urine
Nicholson, Jeremy K, Lindon, John C, Scarfe, Graeme B, Wilson, Ian D, Abou-Shakra, Fadi, Sage, Ashley B, Castro-Perez, Jose
Published in Analytical chemistry (Washington) (01.04.2001)
Published in Analytical chemistry (Washington) (01.04.2001)
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THE OLIVACINE DERIVATIVE S 16020 (9-HYDROXY-5,6-DIMETHYL-N-[2-(DIMETHYLAMINO)ETHYL)-6H-PYRIDO(4,3-B)-CARBAZOLE-1-CARBOXAMIDE) INDUCES CYP1A AND ITS OWN METABOLISM IN HUMAN HEPATOCYTES IN PRIMARY CULTURE
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Published in Drug metabolism and disposition (01.01.2004)
Published in Drug metabolism and disposition (01.01.2004)
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Ren, Song, Vishwanathan, Karthick, Cantarini, Mireille, Frewer, Paul, Hara, Indira, Scarfe, Graeme, Burke, Wendy, Schalkwijk, Stein, Li, Yan, Han, David, Goldwater, Ronald
Published in British journal of clinical pharmacology (01.02.2022)
Published in British journal of clinical pharmacology (01.02.2022)
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Considerations for Human ADME Strategy and Design Paradigm Shift(s) – An Industry White Paper
Young, Graeme C., Spracklin, Douglas K., James, Alexander D., Hvenegaard, Mette G., Scarfe, Graeme, Wagner, David S., Georgi, Katrin, Schieferstein, Hanno, Bjornsdottir, Inga, Groen, Bianca, Romeo, Andrea A., Cassidy, Kenneth C., Da‐violante, Georges, Bister, Bojan, Blech, Stefan, Lyer, Ramaswamy, Schulz, Simone I., Cuyckens, Filip, Moliner, Patricia
Published in Clinical pharmacology and therapeutics (01.04.2023)
Published in Clinical pharmacology and therapeutics (01.04.2023)
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Directly coupled CZE-NMR and CEC-NMR spectroscopy for metabolite analysis : paracetamol metabolites in human urine
SCHEWITZ, J, GFRÖRER, P, LINDON, J. C, PUSECKER, K, TSENG, L.-H, ALBERT, K, BAYER, E, WILSON, I. D, BAILEY, N. J, SCARFE, G. B, NICHOLSON, J. K
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Published in Analyst (London) (1998)
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Jones, Barry C, Markandu, Roshini, Gu, Chungang, Scarfe, Graeme
Published in Drug metabolism and disposition (01.11.2017)
Published in Drug metabolism and disposition (01.11.2017)
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Non‐Labeled, Stable Labeled, or Radiolabelled Approaches for Provision of Intravenous Pharmacokinetics in Humans: A Discussion Piece
Young, Graeme C., Spracklin, Douglas K., James, Alexander D., Hvenegaard, Mette G., Pedersen, Mette L., Wagner, David S., Georgi, Katrin, Schieferstein, Hanno, Bjornsdottir, Inga, Romeo, Andrea A., Cassidy, Kenneth C., Da‐violante, Georges, Blech, Stefan, Schulz, Simone I., Cuyckens, Filip, Nguyen, Mai Anh, Scarfe, Graeme
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A PKPD Case Study: Achieving Clinically Relevant Exposures of AZD5991 in Oncology Mouse Models
White, Michael J., Cheatham, Letitia, Wen, Shenghua, Scarfe, Graeme, Cidado, Justin, Reimer, Corinne, Hariparsad, Niresh, Jones, Rhys D. O., Drew, Lisa, McGinnity, Dermot F., Vasalou, Christina
Published in The AAPS journal (28.06.2023)
Published in The AAPS journal (28.06.2023)
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Phase I study of orally administered 14Carbon-isotope labelled-vistusertib (AZD2014), a dual TORC1/2 kinase inhibitor, to assess the absorption, metabolism, excretion, and pharmacokinetics in patients with advanced solid malignancies
MacDonald, Alexander, Scarfe, Graeme, Magirr, Dominic, Sarvotham, Tinnu, Charlton, Julie, Brugger, Wolfram, Dean, Emma
Published in Cancer chemotherapy and pharmacology (01.04.2019)
Published in Cancer chemotherapy and pharmacology (01.04.2019)
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Discovery and characterisation of quinazolines and 8-Azaquinazolines as NLRP3 agonists with oral bioavailability in mice
O'Donovan, Daniel H., Baker, David, Ciotta, Giovanni, Degorce, Sebastien L., Demanze, Sylvain, Dockerill, Milly, Escudero-Ibarz, Leire, Ireland, Lucy, Mao, Yumeng, Packer, Martin J., Robinson, James, Scarfe, Graeme, Tang, Haoran, Valge-Archer, Viia
Published in Bioorganic & medicinal chemistry letters (15.11.2023)
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Recommendations on the Use of Multiple Labels in Human Mass Balance Studies
Cuyckens, Filip, Hvenegaard, Mette G, Cassidy, Kenneth C, Spracklin, Douglas K, James, Alexander D, Pedersen, Mette L, Scarfe, Graeme, Wagner, David S, Georgi, Katrin, Schulz, Simone I, Schieferstein, Hanno, Bjornsdottir, Inga, Romeo, Andrea A, Da Violante, Georges, Blech, Stefan, Moliner, Patricia, Young, Graeme C
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Published in Drug metabolism and disposition (01.03.2024)
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A Phase 1 Study to Evaluate Absolute Bioavailability and Absorption, Distribution, Metabolism, and Excretion of Savolitinib in Healthy Male Volunteers
Miah, Kowser, Vishwanathan, Karthick, Scarfe, Graeme, Li, Yan, Hara, Indira, Cantarini, Mireille, Argue, John, Menakuru, Somasekhar R.
Published in Clinical pharmacology in drug development (01.04.2023)
Published in Clinical pharmacology in drug development (01.04.2023)
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Phase I study of orally administered 14 Carbon-isotope labelled-vistusertib (AZD2014), a dual TORC1/2 kinase inhibitor, to assess the absorption, metabolism, excretion, and pharmacokinetics in patients with advanced solid malignancies
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Published in Cancer chemotherapy and pharmacology (01.04.2019)
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Virtual Chromatographic Resolution Enhancement in Cryoflow LC−NMR Experiments via Statistical Total Correlation Spectroscopy
Cloarec, Olivier, Campbell, Alison, Tseng, Li-hong, Braumann, Ulrich, Spraul, Manfred, Scarfe, Graeme, Weaver, Richard, Nicholson, Jeremy K
Published in Analytical chemistry (Washington) (01.05.2007)
Published in Analytical chemistry (Washington) (01.05.2007)
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Investigation of the Quantitative Metabolic Fate and Urinary Excretion of 3-Methyl-4-Trifluoromethylaniline and 3-Methyl-4-Trifluoromethylacetanilide in the Rat
SCARFE, G. B, LINDON, J. C, NICHOLSON, J. K, WRIGHT, B, CLAYTON, E, WILSON, I. D
Published in Drug metabolism and disposition (01.10.1999)
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Published in Drug metabolism and disposition (01.10.1999)
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