Discovery of ABBV/GLPG-3221, a Potent Corrector of CFTR for the Treatment of Cystic Fibrosis
Scanio, Marc J. C, Searle, Xenia B, Liu, Bo, Koenig, John R, Altenbach, Robert, Gfesser, Gregory A, Bogdan, Andrew, Greszler, Stephen, Zhao, Gang, Singh, Ashvani, Fan, Yihong, Swensen, Andrew M, Vortherms, Timothy, Manelli, Arlene, Balut, Corina, Jia, Ying, Gao, Wenqing, Yong, Hong, Schrimpf, Michael, Tse, Chris, Kym, Philip, Wang, Xueqing
Published in ACS medicinal chemistry letters (14.11.2019)
Published in ACS medicinal chemistry letters (14.11.2019)
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Journal Article
Transition Metal-Catalyzed Hetero-[5 + 2] Cycloadditions of Cyclopropyl Imines and Alkynes: Dihydroazepines from Simple, Readily Available Starting Materials
Wender, Paul A, Pedersen, Torben M, Scanio, Marc J. C
Published in Journal of the American Chemical Society (25.12.2002)
Published in Journal of the American Chemical Society (25.12.2002)
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Journal Article
Discovery and Biological Evaluation of 5-Aryl-2-furfuramides, Potent and Selective Blockers of the Nav1.8 Sodium Channel with Efficacy in Models of Neuropathic and Inflammatory Pain
Kort, Michael E, Drizin, Irene, Gregg, Robert J, Scanio, Marc J. C, Shi, Lei, Gross, Michael F, Atkinson, Robert N, Johnson, Matthew S, Pacofsky, Gregory J, Thomas, James B, Carroll, William A, Krambis, Michael J, Liu, Dong, Shieh, Char-Chang, Zhang, XuFeng, Hernandez, Gricelda, Mikusa, Joseph P, Zhong, Chengmin, Joshi, Shailen, Honore, Prisca, Roeloffs, Rosemarie, Marsh, Kennan C, Murray, Bernard P, Liu, Jinrong, Werness, Stephen, Faltynek, Connie R, Krafte, Douglas S, Jarvis, Michael F, Chapman, Mark L, Marron, Brian E
Published in Journal of medicinal chemistry (14.02.2008)
Published in Journal of medicinal chemistry (14.02.2008)
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Journal Article
Structure–Activity Studies of Diazabicyclo[3.3.0]octane-Substituted Pyrazines and Pyridines as Potent α4β2 Nicotinic Acetylcholine Receptor Ligands
Scanio, Marc J. C, Shi, Lei, Bunnelle, William H, Anderson, David J, Helfrich, Rosalind J, Malysz, John, Thorin-Hagene, Kirsten K, Van Handel, Ceclia E, Marsh, Kennan C, Lee, Chih-Hung, Gopalakrishnan, Murali
Published in Journal of medicinal chemistry (10.11.2011)
Published in Journal of medicinal chemistry (10.11.2011)
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Journal Article
Toward the ideal synthesis. New transition metal-catalyzed reactions inspired by novel medicinal leads
Wender, Paul A., Bi, F. Christopher, Gamber, Gabriel G., Gosselin, Francis, Hubbard, Robert D., Scanio, Marc J. C., Sun, Robert, Williams, Travis J., Zhang, Lei
Published in Pure and applied chemistry (01.01.2002)
Published in Pure and applied chemistry (01.01.2002)
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Journal Article
Discovery and SAR of 4-aminopyrrolidine-2-carboxylic acid correctors of CFTR for the treatment of cystic fibrosis
Scanio, Marc J.C., Searle, Xenia B., Liu, Bo, Koenig, John R., Altenbach, Robert J., Gfesser, Gregory A., Bogdan, Andrew, Greszler, Stephen, Zhao, Gang, Singh, Ashvani, Fan, Yihong, Swensen, Andrew M., Vortherms, Timothy, Manelli, Arlene, Balut, Corina, Gao, Wenqing, Yong, Hong, Schrimpf, Michael, Tse, Chris, Kym, Philip, Wang, Xueqing
Published in Bioorganic & medicinal chemistry letters (15.09.2022)
Published in Bioorganic & medicinal chemistry letters (15.09.2022)
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Journal Article
Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Na(v)1.8 sodium channel with efficacy in a model of neuropathic pain
Scanio, Marc J C, Shi, Lei, Drizin, Irene, Gregg, Robert J, Atkinson, Robert N, Thomas, James B, Johnson, Matthew S, Chapman, Mark L, Liu, Dong, Krambis, Michael J, Liu, Yi, Shieh, Char-Chang, Zhang, Xufeng, Simler, Gricelda H, Joshi, Shailen, Honore, Prisca, Marsh, Kennan C, Knox, Alison, Werness, Stephen, Antonio, Brett, Krafte, Douglas S, Jarvis, Michael F, Faltynek, Connie R, Marron, Brian E, Kort, Michael E
Published in Bioorganic & medicinal chemistry (15.11.2010)
Published in Bioorganic & medicinal chemistry (15.11.2010)
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Journal Article
Subtype-selective Na(v)1.8 sodium channel blockers: identification of potent, orally active nicotinamide derivatives
Kort, Michael E, Atkinson, Robert N, Thomas, James B, Drizin, Irene, Johnson, Matthew S, Secrest, Matthew A, Gregg, Robert J, Scanio, Marc J C, Shi, Lei, Hakeem, Ahmed H, Matulenko, Mark A, Chapman, Mark L, Krambis, Michael J, Liu, Dong, Shieh, Char-Chang, Zhang, XuFeng, Simler, Gricelda, Mikusa, Joseph P, Zhong, Chengmin, Joshi, Shailen, Honore, Prisca, Roeloffs, Rosemarie, Werness, Stephen, Antonio, Brett, Marsh, Kennan C, Faltynek, Connie R, Krafte, Douglas S, Jarvis, Michael F, Marron, Brian E
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
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Journal Article
Octahydropyrrolo[3,4-c]pyrrole: A Diamine Scaffold for Construction of Either α4β2 or α7-Selective Nicotinic Acetylcholine Receptor (nAChR) Ligands. Substitutions that Switch Subtype Selectivity
Bunnelle, William H, Tietje, Karin R, Frost, Jennifer M, Peters, Dan, Ji, Jianguo, Li, Tao, Scanio, Marc J. C, Shi, Lei, Anderson, David J, Dyhring, Tino, Grønlien, Jens H, Ween, Hilde, Thorin-Hagene, Kirsten, Meyer, Michael D
Published in Journal of medicinal chemistry (23.07.2009)
Published in Journal of medicinal chemistry (23.07.2009)
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Journal Article
Voltage-gated sodium channel blockers for the treatment of chronic pain
Matulenko, Mark A, Scanio, Marc J C, Kort, Michael E
Published in Current topics in medicinal chemistry (01.03.2009)
Published in Current topics in medicinal chemistry (01.03.2009)
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Journal Article
A Selective Nav1.8 Sodium Channel Blocker, A-803467 [5-(4-Chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], Attenuates Spinal Neuronal Activity in Neuropathic Rats
McGaraughty, Steve, Chu, Katharine L, Scanio, Marc J C, Kort, Michael E, Faltynek, Connie R, Jarvis, Michael F
Published in The Journal of pharmacology and experimental therapeutics (01.03.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2008)
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Journal Article
Serial [5+2]/[4+2] Cycloadditions: Facile, Preparative, Multi-Component Syntheses of Polycyclic Compounds from Simple, Readily Available Starting Materials
Wender, Paul A., Gamber, Gabriel G., Scanio, Marc J. C.
Published in Angewandte Chemie (International ed.) (15.10.2001)
Published in Angewandte Chemie (International ed.) (15.10.2001)
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Journal Article
치환된 삼환식 화합물 및 사용 방법
MALAGU KARINE FABIENNE, KOENIG JOHN R, GRESZLER STEPHEN N, PATEL SACHIN V, KYM PHILIP R, ALTENBACH ROBERT J, LIU BO, SEARLE XENIA B, WANG XUEQING, GFESSER GREGORY A, YEUNG MING C, COWART MARLON D, SCANIO MARC J, VOIGHT ERIC, BOGDAN ANDREW, ESMIEU WILLIAM RAMESH
Year of Publication 21.03.2018
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Year of Publication 21.03.2018
Patent
6-- 6---2- 6-HETEROARYLOXY- AND 6-ARYLOXY-QUINOLINE-2-CARBOXAMIDES AND USES THEREOF
PATEL MEENA V, PELTIER HILLARY, KOENIG JOHN R, WAKEFIELD BRIAN D, JINKERSON TAMMIE K, KORT MICHAEL E, DEGOEY DAVID A, LIU BO, MATULENKO MARK A, COWART MARLON D, SCANIO MARC J, NELSON DEREK W, BOGDAN ANDREW
Year of Publication 11.10.2016
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Year of Publication 11.10.2016
Patent
Discovery of (R)-(3-fluoropyrrolidin-1-yl)(6-((5-(trifluoromethyl) pyridin-2-yl)oxy)quinolin-2-yl)methanone (ABBV-318) and analogs as small molecule Na(v)1.7/Nav1.8 blockers for the treatment of pain
Patel, Meena, Peltier, Hillary M., Matulenko, Mark A., Koenig, John R., Scanio, Marc J. C., Gum, Rebecca J., El-Kouhen, Odile F., Fricano, Meagan M., Lundgaard, Greta L., Neelands, Torben, Zhang, Xu-Feng, Zhan, Cenchen, Pai, Madhavi, Ghoreishi-Haack, Nayereh, Hudzik, Thomas, Gintant, Gary, Martin, Ruth, McGaraughty, Steve, Xu, Jun, Bow, Daniel, Kalvass, John C., Kym, Philip R., DeGoey, David A., Kort, Michael E.
Published in Bioorganic & medicinal chemistry (01.06.2022)
Published in Bioorganic & medicinal chemistry (01.06.2022)
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Journal Article
A Selective Na v 1.8 Sodium Channel Blocker, A-803467 [5-(4-Chlorophenyl- N -(3,5-dimethoxyphenyl)furan-2-carboxamide], Attenuates Spinal Neuronal Activity in Neuropathic Rats
McGaraughty, Steve, Chu, Katharine L., Scanio, Marc J. C., Kort, Michael E., Faltynek, Connie R., Jarvis, Michael F.
Published in The Journal of pharmacology and experimental therapeutics (01.03.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2008)
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Journal Article
Serial [5+2]/[4+2] Cycloadditions: Facile, Preparative, Multi-Component Syntheses of Polycyclic Compounds from Simple, Readily Available Starting Materials This research was supported by grant CHE-9800445 from the National Science Foundation. The Stanford Graduate Fellowship (M.J.C.S. and G.G.G.) is gratefully acknowledged
Wender, Paul A., Gamber, Gabriel G., Scanio, Marc J. C.
Published in Angewandte Chemie International Edition (15.10.2001)
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Published in Angewandte Chemie International Edition (15.10.2001)
Journal Article
Discovery and biological evaluation of 5-aryl-2-furfuramides, potent and selective blockers of the Na(v)1.8 sodium channel with efficacy in models of neuropathic and inflammatory pain
Kort, Michael E., Drizin, Irene, Gregg, Robert J., Scanio, Marc J. C., Shi, Lei, Gross, Michael F., Atkinson, Robert N., Johnson, Matthew S., Pacofsky, Gregory J., Thomas, James B., Carroll, William A., Krambis, Michael J., Liu, Dong, Shieh, Char-Chang, Zhang, XuFeng, Hernandez, Gricelda, Mikusa, Joseph P., Zhong, Chengmin, Joshi, Shailen, Honore, Prisca, Roeloffs, Rosemarie, Marsh, Kennan C., Murray, Bernard P., Liu, Jinrong, Werness, Stephen, Faltynek, Connie R., Krafte, Douglas S., Jarvis, Michael F., Chapman, Mark L., Marron, Brian E.
Published in Journal of medicinal chemistry (14.02.2008)
Published in Journal of medicinal chemistry (14.02.2008)
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Journal Article
Discovery of (R)-(3-fluoropyrrolidin-1-yl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)quinolin-2-yl)methanone (ABBV-318) and analogs as small molecule Na v 1.7/ Nav1.8 blockers for the treatment of pain
Patel, Meena V, Peltier, Hillary M, Matulenko, Mark A, Koenig, John R, C Scanio, Marc J, Gum, Rebecca J, El-Kouhen, Odile F, Fricano, Meagan M, Lundgaard, Greta L, Neelands, Torben, Zhang, Xu-Feng, Zhan, Cenchen, Pai, Madhavi, Ghoreishi-Haack, Nayereh, Hudzik, Thomas, Gintant, Gary, Martin, Ruth, McGaraughty, Steve, Xu, Jun, Bow, Daniel, Kalvass, John C, Kym, Philip R, DeGoey, David A, Kort, Michael E
Published in Bioorganic & medicinal chemistry (01.06.2022)
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Published in Bioorganic & medicinal chemistry (01.06.2022)
Journal Article