Single-copy expression of an amyotrophic lateral sclerosis-linked TDP-43 mutation (M337V) in BAC transgenic mice leads to altered stress granule dynamics and progressive motor dysfunction
Gordon, David, Dafinca, Ruxandra, Scaber, Jakub, Alegre-Abarrategui, Javier, Farrimond, Lucy, Scott, Connor, Biggs, Daniel, Kent, Louisa, Oliver, Peter L., Davies, Benjamin, Ansorge, Olaf, Wade-Martins, Richard, Talbot, Kevin
Published in Neurobiology of disease (01.01.2019)
Published in Neurobiology of disease (01.01.2019)
Get full text
Journal Article
C9orf72 and RAB7L1 regulate vesicle trafficking in amyotrophic lateral sclerosis and frontotemporal dementia
Aoki, Yoshitsugu, Manzano, Raquel, Lee, Yi, Dafinca, Ruxandra, Aoki, Misako, Douglas, Andrew G L, Varela, Miguel A, Sathyaprakash, Chaitra, Scaber, Jakub, Barbagallo, Paola, Vader, Pieter, Mäger, Imre, Ezzat, Kariem, Turner, Martin R, Ito, Naoki, Gasco, Samanta, Ohbayashi, Norihiko, El Andaloussi, Samir, Takeda, Shin'ichi, Fukuda, Mitsunori, Talbot, Kevin, Wood, Matthew J A
Published in Brain (London, England : 1878) (01.04.2017)
Published in Brain (London, England : 1878) (01.04.2017)
Get full text
Journal Article
C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9
Vahsen, Björn F., Nalluru, Sumedha, Morgan, Georgia R., Farrimond, Lucy, Carroll, Emily, Xu, Yinyan, Cramb, Kaitlyn M. L., Amein, Benazir, Scaber, Jakub, Katsikoudi, Antigoni, Candalija, Ana, Carcolé, Mireia, Dafinca, Ruxandra, Isaacs, Adrian M., Wade-Martins, Richard, Gray, Elizabeth, Turner, Martin R., Cowley, Sally A., Talbot, Kevin
Published in Nature communications (22.09.2023)
Published in Nature communications (22.09.2023)
Get full text
Journal Article
Embryonic progenitor pools generate diversity in fine-scale excitatory cortical subnetworks
Ellender, Tommas J., Avery, Sophie V., Mahfooz, Kashif, Scaber, Jakub, von Klemperer, Alexander, Nixon, Sophie L., Buchan, Matthew J., van Rheede, Joram J., Gatti, Aleksandra, Waites, Cameron, Pavlou, Hania J., Sims, David, Newey, Sarah E., Akerman, Colin J.
Published in Nature communications (19.11.2019)
Published in Nature communications (19.11.2019)
Get full text
Journal Article
Human iPSC co-culture model to investigate the interaction between microglia and motor neurons
Vahsen, Björn F., Gray, Elizabeth, Candalija, Ana, Cramb, Kaitlyn M. L., Scaber, Jakub, Dafinca, Ruxandra, Katsikoudi, Antigoni, Xu, Yinyan, Farrimond, Lucy, Wade-Martins, Richard, James, William S., Turner, Martin R., Cowley, Sally A., Talbot, Kevin
Published in Scientific reports (23.07.2022)
Published in Scientific reports (23.07.2022)
Get full text
Journal Article
Multicentre appraisal of amyotrophic lateral sclerosis biofluid biomarkers shows primacy of blood neurofilament light chain
Thompson, Alexander G., Gray, Elizabeth, Verber, Nick, Bobeva, Yoana, Lombardi, Vittoria, Shepheard, Stephanie R., Yildiz, Ozlem, Feneberg, Emily, Farrimond, Lucy, Dharmadasa, Thanuja, Gray, Pamela, Edmond, Evan C., Scaber, Jakub, Gagliardi, Delia, Kirby, Janine, Jenkins, Thomas M., Fratta, Pietro, McDermott, Christopher J., Manohar, Sanjay G., Talbot, Kevin, Malaspina, Andrea, Shaw, Pamela J., Turner, Martin R.
Published in Brain communications (04.01.2022)
Published in Brain communications (04.01.2022)
Get full text
Journal Article
TDP-43 expression in mouse models of amyotrophic lateral sclerosis and spinal muscular atrophy
Turner, Bradley J, Bäumer, Dirk, Parkinson, Nicholas J, Scaber, Jakub, Ansorge, Olaf, Talbot, Kevin
Published in BMC neuroscience (28.10.2008)
Published in BMC neuroscience (28.10.2008)
Get full text
Journal Article
CGAT-core: a python framework for building scalable, reproducible computational biology workflows [version 2; peer review: 1 approved, 1 approved with reservations]
Cribbs, Adam P, Luna-Valero, Sebastian, George, Charlotte, Sudbery, Ian M, Berlanga-Taylor, Antonio J, Sansom, Stephen N, Smith, Tom, Ilott, Nicholas E, Johnson, Jethro, Scaber, Jakub, Brown, Katherine, Sims, David, Heger, Andreas
Published in F1000 research (2019)
Published in F1000 research (2019)
Get full text
Journal Article
Human stem cell models of neurodegeneration: From basic science of amyotrophic lateral sclerosis to clinical translation
Giacomelli, Elisa, Vahsen, Björn F., Calder, Elizabeth L., Xu, Yinyan, Scaber, Jakub, Gray, Elizabeth, Dafinca, Ruxandra, Talbot, Kevin, Studer, Lorenz
Published in Cell stem cell (06.01.2022)
Published in Cell stem cell (06.01.2022)
Get full text
Journal Article
Impairment of Mitochondrial Calcium Buffering Links Mutations in C9ORF72 and TARDBP in iPS-Derived Motor Neurons from Patients with ALS/FTD
Dafinca, Ruxandra, Barbagallo, Paola, Farrimond, Lucy, Candalija, Ana, Scaber, Jakub, Ababneh, Nida'a A., Sathyaprakash, Chaitra, Vowles, Jane, Cowley, Sally A., Talbot, Kevin
Published in Stem cell reports (12.05.2020)
Published in Stem cell reports (12.05.2020)
Get full text
Journal Article
C9orf72 Hexanucleotide Expansions Are Associated with Altered Endoplasmic Reticulum Calcium Homeostasis and Stress Granule Formation in Induced Pluripotent Stem Cell‐Derived Neurons from Patients with Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
Dafinca, Ruxandra, Scaber, Jakub, Ababneh, Nida'a, Lalic, Tatjana, Weir, Gregory, Christian, Helen, Vowles, Jane, Douglas, Andrew G.L., Fletcher‐Jones, Alexandra, Browne, Cathy, Nakanishi, Mahito, Turner, Martin R., Wade‐Martins, Richard, Cowley, Sally A., Talbot, Kevin
Published in Stem cells (Dayton, Ohio) (01.08.2016)
Published in Stem cells (Dayton, Ohio) (01.08.2016)
Get full text
Journal Article
Correction of amyotrophic lateral sclerosis related phenotypes in induced pluripotent stem cell-derived motor neurons carrying a hexanucleotide expansion mutation in C9orf72 by CRISPR/Cas9 genome editing using homology-directed repair
Ababneh, Nidaa A, Scaber, Jakub, Flynn, Rowan, Douglas, Andrew, Barbagallo, Paola, Candalija, Ana, Turner, Martin R, Sims, David, Dafinca, Ruxandra, Cowley, Sally A, Talbot, Kevin
Published in Human molecular genetics (03.08.2020)
Published in Human molecular genetics (03.08.2020)
Get full text
Journal Article
Amyotrophic lateral sclerosis: the complex path to precision medicine
Talbot, Kevin, Feneberg, Emily, Scaber, Jakub, Thompson, Alexander G., Turner, Martin R.
Published in Journal of neurology (01.10.2018)
Published in Journal of neurology (01.10.2018)
Get full text
Journal Article
Genetic testing in motor neurone disease
Dharmadasa, Thanuja, Scaber, Jakub, Edmond, Evan, Marsden, Rachael, Thompson, Alexander, Talbot, Kevin, Turner, Martin R
Published in Practical neurology (01.04.2022)
Published in Practical neurology (01.04.2022)
Get full text
Journal Article
Advantages of routine next‐generation sequencing over standard genetic testing in the amyotrophic lateral sclerosis clinic
Scaber, Jakub, Thompson, Alexander G., Farrimond, Lucy, Feneberg, Emily, Proudfoot, Malcolm, Ossher, Lynn, Turner, Martin R., Talbot, Kevin
Published in European journal of neurology (01.08.2023)
Published in European journal of neurology (01.08.2023)
Get full text
Journal Article
Pattern of spread and prognosis in lower limb-onset ALS
Turner, Martin R., Brockington, Alice, Scaber, Jakub, Hollinger, Hannah, Marsden, Rachael, Shaw, Pamela J., Talbot, Kevin
Published in Amyotrophic lateral sclerosis (01.08.2010)
Published in Amyotrophic lateral sclerosis (01.08.2010)
Get full text
Journal Article