The evolution of P2X7 antagonists with a focus on CNS indications
Rech, Jason C., Bhattacharya, Anindya, Letavic, Michael A., Savall, Brad M.
Published in Bioorganic & medicinal chemistry letters (15.08.2016)
Published in Bioorganic & medicinal chemistry letters (15.08.2016)
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Journal Article
Discovery and Characterization of AMPA Receptor Modulators Selective for TARP-γ8
Maher, Michael P, Wu, Nyantsz, Ravula, Suchitra, Ameriks, Michael K, Savall, Brad M, Liu, Changlu, Lord, Brian, Wyatt, Ryan M, Matta, Jose A, Dugovic, Christine, Yun, Sujin, Ver Donck, Luc, Steckler, Thomas, Wickenden, Alan D, Carruthers, Nicholas I, Lovenberg, Timothy W
Published in The Journal of pharmacology and experimental therapeutics (01.05.2016)
Published in The Journal of pharmacology and experimental therapeutics (01.05.2016)
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Journal Article
4‑Methyl-6,7-dihydro‑4H‑triazolo[4,5‑c]pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate
Letavic, Michael A, Savall, Brad M, Allison, Brett D, Aluisio, Leah, Andres, Jose Ignacio, De Angelis, Meri, Ao, Hong, Beauchamp, Derek A, Bonaventure, Pascal, Bryant, Stewart, Carruthers, Nicholas I, Ceusters, Marc, Coe, Kevin J, Dvorak, Curt A, Fraser, Ian C, Gelin, Christine F, Koudriakova, Tatiana, Liang, Jimmy, Lord, Brian, Lovenberg, Timothy W, Otieno, Monicah A, Schoetens, Freddy, Swanson, Devin M, Wang, Qi, Wickenden, Alan D, Bhattacharya, Anindya
Published in Journal of medicinal chemistry (08.06.2017)
Published in Journal of medicinal chemistry (08.06.2017)
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Journal Article
Identification of (R)‑(2-Chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyridin-2-yl)-4-methyl-6,7-dihydro‑1H‑imidazo[4,5‑c]pyridin-5(4H)‑yl)methanone (JNJ 54166060), a Small Molecule Antagonist of the P2X7 receptor
Swanson, Devin M, Savall, Brad M, Coe, Kevin J, Schoetens, Freddy, Koudriakova, Tatiana, Skaptason, Judith, Wall, Jessica, Rech, Jason, Deng, Xiahou, De Angelis, Meri, Everson, Anita, Lord, Brian, Wang, Qi, Ao, Hong, Scott, Brian, Sepassi, Kia, Lovenberg, Timothy W, Carruthers, Nicholas I, Bhattacharya, Anindya, Letavic, Michael A
Published in Journal of medicinal chemistry (22.09.2016)
Published in Journal of medicinal chemistry (22.09.2016)
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Journal Article
Allyl-Assisted, Cu(I)-Catalyzed Azide–Alkyne Cycloaddition/Allylation Reaction: Assembly of the [1,2,3]Triazolo-4,5,6,7-tetrahydropyridine Core Structure
Deng, Xiaohu, Liang, Jimmy, Allison, Brett B, Dvorak, Curt, McAllister, Heather, Savall, Brad M, Mani, Neelakandha S
Published in Journal of organic chemistry (06.11.2015)
Published in Journal of organic chemistry (06.11.2015)
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Journal Article
Functional Profiling of 2-Aminopyrimidine Histamine H4 Receptor Modulators
Tichenor, Mark S, Thurmond, Robin L, Venable, Jennifer D, Savall, Brad M
Published in Journal of medicinal chemistry (24.09.2015)
Published in Journal of medicinal chemistry (24.09.2015)
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Journal Article
Preclinical characterization of substituted 6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one P2X7 receptor antagonists
Ameriks, Michael K., Ao, Hong, Carruthers, Nicholas I., Lord, Brian, Ravula, Suchitra, Rech, Jason C., Savall, Brad M., Wall, Jessica L., Wang, Qi, Bhattacharya, Anindya, Letavic, Michael A.
Published in Bioorganic & medicinal chemistry letters (15.01.2016)
Published in Bioorganic & medicinal chemistry letters (15.01.2016)
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Journal Article
Synthesis, SAR, and Pharmacological Characterization of Brain Penetrant P2X7 Receptor Antagonists
Savall, Brad M., Wu, Duncan, De Angelis, Meri, Carruthers, Nicholas I., Ao, Hong, Wang, Qi, Lord, Brian, Bhattacharya, Anindya, Letavic, Michael A.
Published in ACS medicinal chemistry letters (11.06.2015)
Published in ACS medicinal chemistry letters (11.06.2015)
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Journal Article
Discovery of Imidazo[1,2‑a]pyrazines and Pyrazolo[1,5‑c]pyrimidines as TARP γ‑8 Selective AMPAR Negative Modulators
Savall, Brad M, Wu, Dongpei, Swanson, Devin M, Seierstad, Mark, Wu, Nyantsz, Vives Martinez, Jorge, García Olmos, Beatriz, Lord, Brian, Coe, Kevin, Koudriakova, Tatiana, Lovenberg, Timothy W, Carruthers, Nicholas I, Maher, Michael P, Ameriks, Michael K
Published in ACS medicinal chemistry letters (14.03.2019)
Published in ACS medicinal chemistry letters (14.03.2019)
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Journal Article
Lead Optimization of 5‑Aryl Benzimidazolone- and Oxindole-Based AMPA Receptor Modulators Selective for TARP γ‑8
Ravula, Suchitra, Savall, Brad M, Wu, Nyantsz, Lord, Brian, Coe, Kevin, Wang, Kai, Seierstad, Mark, Swanson, Devin M, Ziff, Jeannie, Nguyen, Minh, Leung, Perry, Rynberg, Ray, La, David, Pippel, Daniel J, Koudriakova, Tatiana, Lovenberg, Timothy W, Carruthers, Nicholas I, Maher, Michael P, Ameriks, Michael K
Published in ACS medicinal chemistry letters (09.08.2018)
Published in ACS medicinal chemistry letters (09.08.2018)
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Journal Article
Diaminopyrimidines, diaminopyridines and diaminopyridazines as histamine H4 receptor modulators
Savall, Brad M., Meduna, Steven P., Tays, Kevin, Cai, Hui, Thurmond, Robin L., McGovern, Patricia, Gaul, Michael, Zhao, Bao-Ping, Edwards, James P.
Published in Bioorganic & medicinal chemistry letters (15.02.2015)
Published in Bioorganic & medicinal chemistry letters (15.02.2015)
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Journal Article
Tricyclic aminopyrimidine histamine H4 receptor antagonists
SAVALL, Brad M, GOMEZ, Laurent, EDWARDS, James P, CHAVEZ, Frank, CURTIS, Michael, MEDUNA, Steven P, KEARNEY, Aaron, DUNFORD, Paul, COWDEN, Jeffery, THURMOND, Robin L, GRICE, Cheryl
Published in Bioorganic & medicinal chemistry letters (01.11.2011)
Published in Bioorganic & medicinal chemistry letters (01.11.2011)
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Journal Article
Total Synthesis of (−)-Bafilomycin A1
Scheidt, Karl A, Bannister, Thomas D, Tasaka, Akihiro, Wendt, Michael D, Savall, Brad M, Fegley, Glenn J, Roush, William R
Published in Journal of the American Chemical Society (19.06.2002)
Published in Journal of the American Chemical Society (19.06.2002)
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Journal Article
Triamino pyrimidines and pyridines as histamine H₄ receptor modulators
Meduna, Steven P, Savall, Brad M, Cai, Hui, Edwards, James P, Thurmond, Robin L, McGovern, Patricia M
Published in Bioorganic & medicinal chemistry letters (15.05.2011)
Published in Bioorganic & medicinal chemistry letters (15.05.2011)
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Journal Article
Agonist/antagonist modulation in a series of 2-aryl benzimidazole H4 receptor ligands
Savall, Brad M., Edwards, James P., Venable, Jennifer D., Buzard, Daniel J., Thurmond, Robin, Hack, Michael, McGovern, Patricia
Published in Bioorganic & medicinal chemistry letters (01.06.2010)
Published in Bioorganic & medicinal chemistry letters (01.06.2010)
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Journal Article
Total Synthesis of Formamicin
Durham, Timothy B, Blanchard, Nicolas, Savall, Brad M, Powell, Noel A, Roush, William R
Published in Journal of the American Chemical Society (04.08.2004)
Published in Journal of the American Chemical Society (04.08.2004)
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Journal Article
Discovery and SAR of 6‑Alkyl-2,4-diaminopyrimidines as Histamine H4 Receptor Antagonists
Savall, Brad M, Chavez, Frank, Tays, Kevin, Dunford, Paul J, Cowden, Jeffery M, Hack, Michael D, Wolin, Ronald L, Thurmond, Robin L, Edwards, James P
Published in Journal of medicinal chemistry (27.03.2014)
Published in Journal of medicinal chemistry (27.03.2014)
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Journal Article