A First-in-Class Inhibitor of ISWI-Mediated (ATP-Dependent) Transcription Repression Releases Terminal-Differentiation in AML Cells While Sparing Normal Hematopoiesis
Kishtagari, Ashwin, Ng, Kwok Peng, Jarman, Charlotte, Tiwari, Anand D., Phillips, James G, Schuerger, Caroline, Jha, Babal K., Saunthararajah, Yogenthiran
Published in Blood (29.11.2018)
Published in Blood (29.11.2018)
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Journal Article
Effect of the Oral LSD1 Inhibitor Ory-1001 on F-Retics in Baboons ( Papio anubis )
Ibanez, Vinzon, Vaitkus, Kestis, Molokie, Robert, Saunthararajah, Yogenthiran, Lavelle, Donald
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
FLT3-ITD Degrades CEBPA Via the Ubiquitin-Proteosome Pathway
Gu, Xiaorong, Zahran, Zeinab Albadry M., Sakre, Nneha, Schuerger, Caroline, Saunthararajah, Yogenthiran
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
Prolonged Combinatorial Pharmacological Therapy Targeting the Epigenome Increases Fetal Hemoglobin to Clinically Relevant Levels in Normal, Nonanemic Baboons
Ibanez, Vinzon, Vaitkus, Kestis, Molokie, Robert E., Ramasamy, Jagadeesh, Saunthararajah, Yogenthiran, Lavelle, Donald
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
Iron Catalyzed Hydrogen Sulfide and Its Prevalence during Oxidative Events in Sickle Cell Disease
Yang, Jie, Bithi, Nazmin, Link, Christopher, Saunthararajah, Yogenthiran, Hine, Christopher
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Journal Article
Nicotinamide Improves Anemia and Decreases Reactive Oxygen Species in Sickle Cell Disease Mice
Ramasamy, Jagadeesh, Ibanez, Vinzon, Yalagala, Vijaya Lakshmi, Saunthararajah, Yogenthiran, Molokie, Robert E., Rivers, Angela, Lavelle, Donald
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article
Effect of Nicotinamide, 1-Methylnicotinamide, and N’-Methylnicotinamide on Erythroid Colony Formation and γ-Globin Expression in Cultured Baboon CD34+ Cells
Lavelle, Donald, Ibanez, Vinzon, Vaitkus, Kestis, Saunthararajah, Yogenthiran, Molokie, Robert E.
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
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Journal Article
Combinatorial Administration of Pharmacological Inhibitors Targeting DNMT1 and KDM1A Produces Synergistic and Additive Increases in F Retiulocytes and γ-Globin Expression in Normal Baboons
Ibanez, Vinzon, Vaitkus, Kestis, Molokie, Robert E., Saunthararajah, Yogenthiran, Lavelle, Donald
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
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Journal Article
A Novel Approach to Induce ATRA Mediated Differentiation in NPM1 Mutant Acute Myeloid Leukemia
Hasipek, Metis, Guan, Yihong, Grabowski, Dale, Gu, Xiaorong, Maciejewski, Jaroslaw P., Saunthararajah, Yogenthiran, Carraway, Hetty E., Jha, Babal K.
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article
Fatty Acid Binding Protein FABP5 Inhibition Activates Retinoic Acid Signaling and Induces Differentiation in Acute Myeloid Leukemia
Singh, Divya Jyoti, Hasipek, Metis, Jiang, Dongxu, Vail, Daniel, Zhang, Yahan, Durkin, Jill, Kawashima, Naomi, Schlanger, Simon, Gu, Xiaorong, Maciejewski, Jaroslaw P., Saunthararajah, Yogenthiran, Carraway, Hetty E., Jha, Babal Kant
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
Translating an HPFH-Mechanism into Oral Small Molecule Therapy for Beta-Hemoglobinopathies: Clinical Proof-of-Principle
Molokie, Robert, Saraf, Santosh L., Krauz, Lani, Pacini, Michael, Chan, David, Aziz-Bradley, Alana, Gansari, Rebeca, Hassan, Taif, Woost, Philip, Jacobberger, James, Gordeuk, Victor R., Lavelle, Donald E., DeSimone, Joseph, Saunthararajah, Yogenthiran
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
Role of Oligoadenylate Synthetases in Myeloid Neoplasia
Hasipek, Metis, Guan, Yihong, Grabowski, Dale, Gu, Xiaorong, Saunthararajah, Yogenthiran, Silverman, Robert, Stark, George R, Maciejewski, Jaroslaw, Jha, Babal K.
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
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Journal Article
Low-Dose Weekly Decitabine and Venetoclax in TP53-Mutated Myeloid Malignancies
Shapiro, Lauren C, Mantzaris, Ioannis, Shastri, Aditi, Sica, R. Alejandro, Bachier-Rodriguez, Lizamarie, Kornblum, Noah, Gritsman, Kira, Feldman, Eric J., Verma, Amit, Braunschweig, Ira, Saunthararajah, Yogenthiran, Goldfinger, Mendel
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article
A Non-Cytotoxic Regimen Using a Weekly Low Dose Decitabine and Venetoclax for MDS and AML in a Real World Cohort
Levitz, David, Fedorov, Kateryna, Pradhan, Kith, Shapiro, Lauren C, Shastri, Aditi, Gritsman, Kira, Shah, Nishi, Kornblum, Noah, Sica, R. Alejandro, Braunschweig, Ira, Konopleva, Marina, Feldman, Eric J., Verma, Amit, Mantzaris, Ioannis, Saunthararajah, Yogenthiran, Goldfinger, Mendel
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
Pyrimethamine, a STAT3 Inhibitor, Synergizes with Venetoclax and Shows Efficacy in Hypomethylating Agent Resistant MDS and AML
Rivera, Bianca L, Chakraborty, Samarpana, Shi, Yang, Zhang, Hui, Choudhary, Gaurav S, Gordon, Shanisha, Pradhan, Kith, Fu, Bowen, Tosic, Isidora, Zhao, Rongbao, Goldfinger, Mendel, Mantzaris, Ioannis, Carbajal, Milagros, Ramachandra, Nandini, Konopleva, Marina, Frank, David, Saunthararajah, Yogenthiran, Verma, Amit, Shastri, Aditi
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
Venetoclax Inhibition of Pyrimidine Synthesis Guides Methods for Integration with Decitabine or 5-Azacytidine That Are Non-Myelosuppressive
Gu, Xiaorong, Tohme, Rita, Goldfinger, Mendel, Tomlinson, Benjamin K., Sakre, Nneha, Hanmer, Shannon, Jha, Babal K., Maciejewski, Jaroslaw P., Verma, Amit, Saunthararajah, Yogenthiran
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
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Journal Article
Epigenetic Enzyme Mutations in Myeloid Malignancies Are Selected By Chromatin-Remodeling Requirements That Vary By Lineage- and Maturation-Stage
Kongkiatkamon, Sunisa, Gu, Xiaorong, Ng, Kwok Peng, Pagliuca, Simona, Adema, Vera, Walter, Wencke, Nagata, Yasunobu, Kerr, Cassandra M, Meggendorfer, Manja, Awada, Hassan, Hutter, Stephan, Gurnari, Carmelo, Haferlach, Claudia, Jha, Babal K., Visconte, Valeria, Haferlach, Torsten, Maciejewski, Jaroslaw P., Saunthararajah, Yogenthiran
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article
The Drive to Acquire Biallelic Hits Inversely Correlates with the Functional Impact of the Primary TP53 Lesion: The Complexity of TP53 Role Assessment
Bahaj, Waled, Gurnari, Carmelo, Kewan, Tariq, Balasubramanian, Suresh Kumar, Pagliuca, Simona, Saunthararajah, Yogenthiran, Terkawi, Laila, Zawit, Misam, Awada, Hassan, Jha, Babal K., Visconte, Valeria, Hamilton, Betty K., Carraway, Hetty E., Maciejewski, Jaroslaw P.
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article