An immortalized adult human erythroid line facilitates sustainable and scalable generation of functional red cells
Trakarnsanga, Kongtana, Griffiths, Rebecca E, Wilson, Marieangela C, Blair, Allison, Satchwell, Timothy J, Meinders, Marjolein, Cogan, Nicola, Kupzig, Sabine, Kurita, Ryo, Nakamura, Yukio, Toye, Ashley M, Anstee, David J, Frayne, Jan
Published in Nature communications (14.03.2017)
Published in Nature communications (14.03.2017)
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An engineered baculoviral protein and DNA co-delivery system for CRISPR-based mammalian genome editing
Capin, Julien, Harrison, Alexandra, Raele, Renata A, Yadav, Sathish K N, Baiwir, Dominique, Mazzucchelli, Gabriel, Quinton, Loic, Satchwell, Timothy J, Toye, Ashley M, Schaffitzel, Christiane, Berger, Imre, Aulicino, Francesco
Published in Nucleic acids research (12.04.2024)
Published in Nucleic acids research (12.04.2024)
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Membrane-Wrapping Contributions to Malaria Parasite Invasion of the Human Erythrocyte
Dasgupta, Sabyasachi, Auth, Thorsten, Gov, Nir S., Satchwell, Timothy J., Hanssen, Eric, Zuccala, Elizabeth S., Riglar, David T., Toye, Ashley M., Betz, Timo, Baum, Jake, Gompper, Gerhard
Published in Biophysical journal (01.07.2014)
Published in Biophysical journal (01.07.2014)
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Journal Article
Basigin mediation of Plasmodium falciparum red blood cell invasion does not require its transmembrane domain or interaction with monocarboxylate transporter 1
King, Nadine R, Martins Freire, Catarina, Touhami, Jawida, Sitbon, Marc, Toye, Ashley M, Satchwell, Timothy J
Published in PLoS pathogens (01.02.2024)
Published in PLoS pathogens (01.02.2024)
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Journal Article
PIEZO1 gain-of-function mutations delay reticulocyte maturation in hereditary xerocytosis
Moura, Pedro L, Hawley, Bethan R, Dobbe, Johannes G G, Streekstra, Geert J, Rab, Minke A E, Bianchi, Paola, van Wijk, Richard, Toye, Ashley M, Satchwell, Timothy J
Published in Haematologica (Roma) (01.06.2020)
Published in Haematologica (Roma) (01.06.2020)
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Genetic manipulation of cell line derived reticulocytes enables dissection of host malaria invasion requirements
Satchwell, Timothy J, Wright, Katherine E, Haydn-Smith, Katy L, Sánchez-Román Terán, Fernando, Moura, Pedro L, Hawksworth, Joseph, Frayne, Jan, Toye, Ashley M, Baum, Jake
Published in Nature communications (23.08.2019)
Published in Nature communications (23.08.2019)
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Enhancement of red blood cell transfusion compatibility using CRISPR‐mediated erythroblast gene editing
Hawksworth, Joseph, Satchwell, Timothy J, Meinders, Marjolein, Daniels, Deborah E, Regan, Fiona, Thornton, Nicole M, Wilson, Marieangela C, Dobbe, Johannes GG, Streekstra, Geert J, Trakarnsanga, Kongtana, Heesom, Kate J, Anstee, David J, Frayne, Jan, Toye, Ashley M
Published in EMBO molecular medicine (01.06.2018)
Published in EMBO molecular medicine (01.06.2018)
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Non-muscle Myosin II drives vesicle loss during human reticulocyte maturation
Moura, Pedro L, Hawley, Bethan R, Mankelow, Tosti J, Griffiths, Rebecca E, Dobbe, Johannes G G, Streekstra, Geert J, Anstee, David J, Satchwell, Timothy J, Toye, Ashley M
Published in Haematologica (Roma) (01.12.2018)
Published in Haematologica (Roma) (01.12.2018)
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Quantitative phospho-proteomics reveals the Plasmodium merozoite triggers pre-invasion host kinase modification of the red cell cytoskeleton
Zuccala, Elizabeth S, Satchwell, Timothy J, Angrisano, Fiona, Tan, Yan Hong, Wilson, Marieangela C, Heesom, Kate J, Baum, Jake
Published in Scientific reports (02.02.2016)
Published in Scientific reports (02.02.2016)
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The majority of the in vitro erythroid expansion potential resides in CD34− cells, outweighing the contribution of CD34+ cells and significantly increasing the erythroblast yield from peripheral blood samples
VAN DEN AKKER, Emile, SATCHWELL, Timothy J, PELLEGRIN, Stephanie, DANIELS, Geoff, TOYE, Ashley M
Published in Haematologica (Roma) (01.09.2010)
Published in Haematologica (Roma) (01.09.2010)
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Protein distribution during human erythroblast enucleation in vitro
Bell, Amanda J, Satchwell, Timothy J, Heesom, Kate J, Hawley, Bethan R, Kupzig, Sabine, Hazell, Matthew, Mushens, Rosey, Herman, Andrew, Toye, Ashley M
Published in PloS one (02.04.2013)
Published in PloS one (02.04.2013)
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Severe Ankyrin-R deficiency results in impaired surface retention and lysosomal degradation of RhAG in human erythroblasts
Satchwell, Timothy J, Bell, Amanda J, Hawley, Bethan R, Pellegrin, Stephanie, Mordue, Kathryn E, van Deursen, Cees Th B M, Braak, Nicole Heitink-Ter, Huls, Gerwin, Leers, Mathie P G, Overwater, Eline, Tamminga, Rienk Y J, van der Zwaag, Bert, Fermo, Elisa, Bianchi, Paola, van Wijk, Richard, Toye, Ashley M
Published in Haematologica (Roma) (01.09.2016)
Published in Haematologica (Roma) (01.09.2016)
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Journal Article
Characteristic phenotypes associated with congenital dyserythropoietic anemia (type II) manifest at different stages of erythropoiesis
Satchwell, Timothy J, Pellegrin, Stephanie, Bianchi, Paola, Hawley, Bethan R, Gampel, Alexandra, Mordue, Kathryn E, Budnik, Annika, Fermo, Elisa, Barcellini, Wilma, Stephens, David J, van den Akker, Emile, Toye, Ashley M
Published in Haematologica (Roma) (01.11.2013)
Published in Haematologica (Roma) (01.11.2013)
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Journal Article
Reticulocyte and red blood cell deformation triggers specific phosphorylation events
Moura, Pedro L., Lizarralde Iragorri, Maria A., Français, Olivier, Le Pioufle, Bruno, Dobbe, Johannes G.G., Streekstra, Geert J., El Nemer, Wassim, Toye, Ashley M., Satchwell, Timothy J.
Published in Blood advances (10.09.2019)
Published in Blood advances (10.09.2019)
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Journal Article
Investigating the key membrane protein changes during in vitro erythropoiesis of protein 4.2 (−) cells (mutations Chartres 1 and 2)
VAN DEN AKKER, Emile, SATCHWELL, Timothy J, PELLEGRIN, Stephanie, FLATT, Joanna F, MAIGRE, Michel, DANIELS, Geoff, DELAUNAY, Jean, BRUCE, Lesley J, TOYE, Ashley M
Published in Haematologica (Roma) (01.08.2010)
Published in Haematologica (Roma) (01.08.2010)
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