Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer
Drost, Jarno, van Boxtel, Ruben, Blokzijl, Francis, Mizutani, Tomohiro, Sasaki, Nobuo, Sasselli, Valentina, de Ligt, Joep, Behjati, Sam, Grolleman, Judith E., van Wezel, Tom, Nik-Zainal, Serena, Kuiper, Roland P., Cuppen, Edwin, Clevers, Hans
Published in Science (American Association for the Advancement of Science) (13.10.2017)
Published in Science (American Association for the Advancement of Science) (13.10.2017)
Get full text
Journal Article
Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients
Schwank, Gerald, Koo, Bon-Kyoung, Sasselli, Valentina, Dekkers, Johanna F., Heo, Inha, Demircan, Turan, Sasaki, Nobuo, Boymans, Sander, Cuppen, Edwin, van der Ent, Cornelis K., Nieuwenhuis, Edward E.S., Beekman, Jeffrey M., Clevers, Hans
Published in Cell stem cell (05.12.2013)
Published in Cell stem cell (05.12.2013)
Get full text
Journal Article
Ascl2 Acts as an R-spondin/Wnt-Responsive Switch to Control Stemness in Intestinal Crypts
Schuijers, Jurian, Junker, Jan Philipp, Mokry, Michal, Hatzis, Pantelis, Koo, Bon-Kyoung, Sasselli, Valentina, van der Flier, Laurens G., Cuppen, Edwin, van Oudenaarden, Alexander, Clevers, Hans
Published in Cell stem cell (05.02.2015)
Published in Cell stem cell (05.02.2015)
Get full text
Journal Article
Retroviral gene expression control in primary organoid cultures
Koo, Bon-Kyoung, Sasselli, Valentina, Clevers, Hans
Published in Current protocols in stem cell biology (01.11.2013)
Published in Current protocols in stem cell biology (01.11.2013)
Get more information
Journal Article
Developmental Biology Outstanding Paper Award
Published in Developmental biology
(01.06.2016)
Get full text
Journal Article
The enteric nervous system
Sasselli, Valentina, Pachnis, Vassilis, Burns, Alan J.
Published in Developmental biology (01.06.2012)
Published in Developmental biology (01.06.2012)
Get full text
Journal Article
Measuring mutation accumulation in single human adult stem cells by whole-genome sequencing of organoid cultures
Jager, Myrthe, Blokzijl, Francis, Sasselli, Valentina, Boymans, Sander, Janssen, Roel, Besselink, Nicolle, Clevers, Hans, van Boxtel, Ruben, Cuppen, Edwin
Published in Nature protocols (01.01.2018)
Published in Nature protocols (01.01.2018)
Get full text
Journal Article
Tissue-specific mutation accumulation in human adult stem cells during life
Blokzijl, Francis, de Ligt, Joep, Jager, Myrthe, Sasselli, Valentina, Roerink, Sophie, Sasaki, Nobuo, Huch, Meritxell, Boymans, Sander, Kuijk, Ewart, Prins, Pjotr, Nijman, Isaac J., Martincorena, Inigo, Mokry, Michal, Wiegerinck, Caroline L., Middendorp, Sabine, Sato, Toshiro, Schwank, Gerald, Nieuwenhuis, Edward E. S., Verstegen, Monique M. A., van der Laan, Luc J. W., de Jonge, Jeroen, IJzermans, Jan N. M., Vries, Robert G., van de Wetering, Marc, Stratton, Michael R., Clevers, Hans, Cuppen, Edwin, van Boxtel, Ruben
Published in Nature (London) (13.10.2016)
Published in Nature (London) (13.10.2016)
Get full text
Journal Article