ABCC Multidrug Transporters in Childhood Neuroblastoma: Clinical and Biological Effects Independent of Cytotoxic Drug Efflux
Henderson, Michelle J., Haber, Michelle, Porro, Antonio, Munoz, Marcia A., Iraci, Nunzio, Xue, Chengyuan, Murray, Jayne, Flemming, Claudia L., Smith, Janice, Fletcher, Jamie I., Gherardi, Samuele, Kwek, Chin-Kiat, Russell, Amanda J., Valli, Emanuele, London, Wendy B., Buxton, Allen B., Ashton, Lesley J., Sartorelli, Alan C., Cohn, Susan L., Schwab, Manfred, Marshall, Glenn M., Perini, Giovanni, Norris, Murray D.
Published in JNCI : Journal of the National Cancer Institute (17.08.2011)
Published in JNCI : Journal of the National Cancer Institute (17.08.2011)
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Triapine disrupts CtIP-mediated homologous recombination repair and sensitizes ovarian cancer cells to PARP and topoisomerase inhibitors
Lin, Z Ping, Ratner, Elena S, Whicker, Margaret E, Lee, Yashang, Sartorelli, Alan C
Published in Molecular cancer research (01.03.2014)
Published in Molecular cancer research (01.03.2014)
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MK-2206 sensitizes BRCA-deficient epithelial ovarian adenocarcinoma to cisplatin and olaparib
Whicker, Margaret E, Lin, Z Ping, Hanna, Ruth, Sartorelli, Alan C, Ratner, Elena S
Published in BMC cancer (27.07.2016)
Published in BMC cancer (27.07.2016)
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4-Nitrobenzyloxycarbonyl Derivatives of O 6-Benzylguanine as Hypoxia-Activated Prodrug Inhibitors of O 6-Alkylguanine-DNA Alkyltransferase (AGT), Which Produces Resistance to Agents Targeting the O-6 Position of DNA Guanine
Zhu, Rui, Liu, Mao-Chin, Luo, Mei-Zhen, Penketh, Philip G, Baumann, Raymond P, Shyam, Krishnamurthy, Sartorelli, Alan C
Published in Journal of medicinal chemistry (10.11.2011)
Published in Journal of medicinal chemistry (10.11.2011)
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Triapine potentiates platinum-based combination therapy by disruption of homologous recombination repair
Ratner, Elena S, Zhu, Yong-Lian, Penketh, Philip G, Berenblum, Julie, Whicker, Margaret E, Huang, Pamela H, Lee, Yashang, Ishiguro, Kimiko, Zhu, Rui, Sartorelli, Alan C, Lin, Z Ping
Published in British journal of cancer (29.03.2016)
Published in British journal of cancer (29.03.2016)
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Small-Molecule Multidrug Resistance―Associated Protein 1 Inhibitor Reversan Increases the Therapeutic Index of Chemotherapy in Mouse Models of Neuroblastoma
BURKHART, Catherine A, WATT, Fujiko, KOMAROV, Pavel G, GUROVA, Katerina V, SARTORELLI, Alan C, MARSHALL, Glenn M, NORRIS, Murray D, GUDKOV, Andrei V, HABER, Michelle, MURRAY, Jayne, PAJIC, Marina, PROKVOLIT, Anatoly, CHENGYUAN XUE, FLEMMING, Claudia, SMITH, Janice, PURMAL, Andrei, ISACHENKO, Nadezhda
Published in Cancer research (Chicago, Ill.) (15.08.2009)
Published in Cancer research (Chicago, Ill.) (15.08.2009)
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Hypoxia-Selective O 6‑Alkylguanine-DNA Alkyltransferase Inhibitors: Design, Synthesis, and Evaluation of 6‑(Benzyloxy)-2-(aryldiazenyl)‑9H‑purines as Prodrugs of O 6‑Benzylguanine
Zhu, Rui, Baumann, Raymond P, Penketh, Philip G, Shyam, Krishnamurthy, Sartorelli, Alan C
Published in Journal of medicinal chemistry (14.02.2013)
Published in Journal of medicinal chemistry (14.02.2013)
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Distinct mechanisms of cell-kill by triapine and its terminally dimethylated derivative Dp44mT due to a loss or gain of activity of their copper(II) complexes
Ishiguro, Kimiko, Lin, Z. Ping, Penketh, Philip G., Shyam, Krishnamurthy, Zhu, Rui, Baumann, Raymond P., Zhu, Yong-Lian, Sartorelli, Alan C., Rutherford, Thomas J., Ratner, Elena S.
Published in Biochemical pharmacology (01.10.2014)
Published in Biochemical pharmacology (01.10.2014)
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4-nitrobenzyloxycarbonyl derivatives of O(6)-benzylguanine as hypoxia-activated prodrug inhibitors of O(6)-alkylguanine-DNA alkyltransferase (AGT), which produces resistance to agents targeting the O-6 position of DNA guanine
Zhu, Rui, Liu, Mao-Chin, Luo, Mei-Zhen, Penketh, Philip G, Baumann, Raymond P, Shyam, Krishnamurthy, Sartorelli, Alan C
Published in Journal of medicinal chemistry (10.11.2011)
Published in Journal of medicinal chemistry (10.11.2011)
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Antitumor Sulfonylhydrazines: Design, Structure–Activity Relationships, Resistance Mechanisms, and Strategies for Improving Therapeutic Utility
Shyam, Krishnamurthy, Penketh, Philip G, Baumann, Raymond P, Finch, Rick A, Zhu, Rui, Zhu, Yong-Lian, Sartorelli, Alan C
Published in Journal of medicinal chemistry (14.05.2015)
Published in Journal of medicinal chemistry (14.05.2015)
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Disruption of cAMP and Prostaglandin E2 Transport by Multidrug Resistance Protein 4 Deficiency Alters cAMP-Mediated Signaling and Nociceptive Response
Lin, Z Ping, Zhu, Yong-Lian, Johnson, Dennis R, Rice, Kevin P, Nottoli, Timothy, Hains, Bryan C, McGrath, James, Waxman, Stephen G, Sartorelli, Alan C
Published in Molecular pharmacology (01.01.2008)
Published in Molecular pharmacology (01.01.2008)
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Development of an O(6)-alkylguanine-DNA alkyltransferase assay based on covalent transfer of the benzyl moiety from [benzene-3H]O(6)-benzylguanine to the protein
Ishiguro, Kimiko, Shyam, Krishnamurthy, Penketh, Philip G, Sartorelli, Alan C
Published in Analytical biochemistry (01.12.2008)
Published in Analytical biochemistry (01.12.2008)
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KS900: A hypoxia-directed, reductively activated methylating antitumor prodrug that selectively ablates O 6-alkylguanine-DNA alkyltransferase in neoplastic cells
Baumann, Raymond P., Ishiguro, Kimiko, Penketh, Philip G., Shyam, Krishnamurthy, Zhu, Rui, Sartorelli, Alan C.
Published in Biochemical pharmacology (15.05.2011)
Published in Biochemical pharmacology (15.05.2011)
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KS900: A hypoxia-directed, reductively activated methylating antitumor prodrug that selectively ablates O(6)-alkylguanine-DNA alkyltransferase in neoplastic cells
Baumann, Raymond P, Ishiguro, Kimiko, Penketh, Philip G, Shyam, Krishnamurthy, Zhu, Rui, Sartorelli, Alan C
Published in Biochemical pharmacology (15.05.2011)
Published in Biochemical pharmacology (15.05.2011)
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Influence of Phosphate and Phosphoesters on the Decomposition Pathway of 1,2-Bis(methylsulfonyl)-1-(2-chloroethyhydrazine (90CE), the Active Anticancer Moiety Generated by Laromustine, KS119, and KS119W
Penketh, Philip G, Shyam, Krishnamurthy, Zhu, Rui, Baumann, Raymond P, Ishiguro, Kimiko, Sartorelli, Alan C
Published in Chemical research in toxicology (19.05.2014)
Published in Chemical research in toxicology (19.05.2014)
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Quantitative relationship between guanine O(6)-alkyl lesions produced by Onrigin™ and tumor resistance by O(6)-alkylguanine-DNA alkyltransferase
Ishiguro, Kimiko, Zhu, Yong-Lian, Shyam, Krishnamurthy, Penketh, Philip G, Baumann, Raymond P, Sartorelli, Alan C
Published in Biochemical pharmacology (01.11.2010)
Published in Biochemical pharmacology (01.11.2010)
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