Synthesis, biological evaluation, and pharmacokinetic study of prolyl-1-piperazinylacetic acid and prolyl-4-piperidinylacetic acid derivatives as VLA-4 antagonists
Chiba, Jun, Takayama, Gensuke, Takashi, Tohru, Yokoyama, Mika, Nakayama, Atsushi, Baldwin, John J., McDonald, Edward, Moriarty, Kevin J., Sarko, Christopher R., Saionz, Kurt W., Swanson, Robert, Hussain, Zahid, Wong, Angela, Machinaga, Nobuo
Published in Bioorganic & medicinal chemistry (15.04.2006)
Published in Bioorganic & medicinal chemistry (15.04.2006)
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Development and Applications of a Practical Continuous Flow Microwave Cell
Wilson, Noel S., Sarko, Christopher R., Roth, Gregory P.
Published in Organic process research & development (01.05.2004)
Published in Organic process research & development (01.05.2004)
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Hit-to-lead studies on benzimidazole inhibitors of ITK: Discovery of a novel class of kinase inhibitors
Snow, Roger J., Abeywardane, Asitha, Campbell, Scot, Lord, John, Kashem, Mohammed A., Khine, Hnin Hnin, King, Josephine, Kowalski, Jennifer A., Pullen, Steven S., Roma, Teresa, Roth, Gregory P., Sarko, Christopher R., Wilson, Noel S., Winters, Michael P., Wolak, John P., Cywin, Charles L.
Published in Bioorganic & medicinal chemistry letters (01.07.2007)
Published in Bioorganic & medicinal chemistry letters (01.07.2007)
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BCl3- and TiCl4-Mediated Reductions of β-Hydroxy Ketones
Sarko, Christopher R, Collibee, Scott E, Knorr, Allison L, DiMare, Marcello
Published in Journal of organic chemistry (09.02.1996)
Published in Journal of organic chemistry (09.02.1996)
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Chelation-controlled protocol for the diastereoselective reduction of ketones
Sarko, Christopher R, Guch, Ian C, DiMare, Marcello
Published in Journal of organic chemistry (01.02.1994)
Published in Journal of organic chemistry (01.02.1994)
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Identified a morpholinyl-4-piperidinylacetic acid derivative as a potent oral active VLA-4 antagonist
Chiba, Jun, Machinaga, Nobuo, Takashi, Tohru, Ejima, Akio, Takayama, Gensuke, Yokoyama, Mika, Nakayama, Atsushi, Baldwin, John J., McDonald, Edward, Saionz, Kurt W., Swanson, Robert, Hussain, Zahid, Wong, Angela
Published in Bioorganic & medicinal chemistry letters (03.01.2005)
Published in Bioorganic & medicinal chemistry letters (03.01.2005)
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Corrigendum to “Identified a morpholinyl-4-piperidinylacetic acid derivatives as a potent oral active VLA-4 antagonist”: [Bioorg. Med. Chem. Lett. 15 (1) (2005) 41]
Chiba, Jun, Machinaga, Nobuo, Takashi, Tohru, Ejima, Akio, Takayama, Gensuke, Yokoyama, Mika, Nakayama, Atsushi, Baldwin, John J., McDonald, Edward, Moriarty, Kevin J., Sarko, Christopher R., Saionz, Kurt W., Swanson, Robert, Hussain, Zahid, Wong, Angela
Published in Bioorganic & medicinal chemistry letters (01.02.2005)
Published in Bioorganic & medicinal chemistry letters (01.02.2005)
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Efficient stereoselective synthesis of the epoxyacid fragment of the azinomycins
Coleman, Robert S., Sarko, Christopher R., Gittinger, Jens P.
Published in Tetrahedron letters (01.08.1997)
Published in Tetrahedron letters (01.08.1997)
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Journal Article
BCl 3 - and TiCl 4 -Mediated Reductions of β-Hydroxy Ketones
Sarko, Christopher R., Collibee, Scott E., Knorr, Allison L., DiMare, Marcello
Published in Journal of organic chemistry (01.01.1996)
Published in Journal of organic chemistry (01.01.1996)
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Journal Article
VLA-4 inhibitor compounds
MCDONALD EDWARD, MACHINAGA NOBUO, IIMURA SHIN, YONEDA YOSHIYUKI, SARKO CHRISTOPHER R, NAKAYAMA ATSUSHI, BALDWIN JOHN J, MORIARTY KEVIN J, CHIBA JUN
Year of Publication 08.03.2007
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Year of Publication 08.03.2007
Patent
BENZIMIDAZOLES USEFUL AS PROTEIN KINASE INHIBITORS
CHARLES L. CYWIN, JINBO LEE, NOEL S. WILSON, ROGER JOHN SNOW, GREGORY P. ROUTH, STEVEN S. PULLEN, CHRISTOPHER R. SARKO
Year of Publication 30.04.2005
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Year of Publication 30.04.2005
Patent