The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations
Nag, Suman, Trivedi, Darshan V, Sarkar, Saswata S, Adhikari, Arjun S, Sunitha, Margaret S, Sutton, Shirley, Ruppel, Kathleen M, Spudich, James A
Published in Nature structural & molecular biology (01.06.2017)
Published in Nature structural & molecular biology (01.06.2017)
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Journal Article
β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity
Adhikari, Arjun S., Trivedi, Darshan V., Sarkar, Saswata S., Song, Dan, Kooiker, Kristina B., Bernstein, Daniel, Spudich, James A., Ruppel, Kathleen M.
Published in Nature communications (18.06.2019)
Published in Nature communications (18.06.2019)
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Journal Article
Deciphering the super relaxed state of human β-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers
Anderson, Robert L., Trivedi, Darshan V., Sarkar, Saswata S., Henze, Marcus, Ma, Weikang, Gong, Henry, Rogers, Christopher S., Gorham, Joshua M., Wong, Fiona L., Morck, Makenna M., Seidman, Jonathan G., Ruppel, Kathleen M., Irving, Thomas C., Cooke, Roger, Green, Eric M., Spudich, James A.
Published in Proceedings of the National Academy of Sciences - PNAS (28.08.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (28.08.2018)
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Journal Article
Early-Onset Hypertrophic Cardiomyopathy Mutations Significantly Increase the Velocity, Force, and Actin-Activated ATPase Activity of Human β-Cardiac Myosin
Adhikari, Arjun S., Kooiker, Kristina B., Sarkar, Saswata S., Liu, Chao, Bernstein, Daniel, Spudich, James A., Ruppel, Kathleen M.
Published in Cell reports (Cambridge) (13.12.2016)
Published in Cell reports (Cambridge) (13.12.2016)
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Journal Article
Effects of hypertrophic and dilated cardiomyopathy mutations on power output by human β-cardiac myosin
Spudich, James A, Aksel, Tural, Bartholomew, Sadie R, Nag, Suman, Kawana, Masataka, Yu, Elizabeth Choe, Sarkar, Saswata S, Sung, Jongmin, Sommese, Ruth F, Sutton, Shirley, Cho, Carol, Adhikari, Arjun S, Taylor, Rebecca, Liu, Chao, Trivedi, Darshan, Ruppel, Kathleen M
Published in Journal of experimental biology (01.01.2016)
Published in Journal of experimental biology (01.01.2016)
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Journal Article
The hypertrophic cardiomyopathy mutations R403Q and R663H increase the number of myosin heads available to interact with actin
Sarkar, Saswata S, Trivedi, Darshan V, Morck, Makenna M, Adhikari, Arjun S, Pasha, Shaik N, Ruppel, Kathleen M, Spudich, James A
Published in Science advances (01.04.2020)
Published in Science advances (01.04.2020)
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Journal Article
Uncovering the Molecular and Structural Basis of Hypertrophic Cardiomyopathy-Causing Mutations in Myosin and Myosin Binding Protein-C
Nandwani, Neha, Trivedi, Darshan V., Sarkar, Saswata S., Morck, Makenna, Ruppel, Kathleen, Spudich, James A.
Published in Biophysical journal (07.02.2020)
Published in Biophysical journal (07.02.2020)
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Journal Article
Hypertrophic Cardiomyopathy Mutations Disrupt Human Beta Cardiac Myosin Intramolecular Interactions Leading to Increased Myosin Activity
Adhikari, Arjun S., Trivedi, Darshan V., Sarkar, Saswata S., Ruppel, Kathleen M., James, Spudich A.
Published in Biophysical journal (02.02.2018)
Published in Biophysical journal (02.02.2018)
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Journal Article
Impact of Hypertrophic Cardiomyopathy Mutations and the Role of Myosin Binding Protein-C on the Sequestered State of Myosin
Trivedi, Darshan V., Sarkar, Saswata S., Morck, Makenna M., Adhikari, Arjun A., Ruppel, Kathleen M., Spudich, James A.
Published in Biophysical journal (02.02.2018)
Published in Biophysical journal (02.02.2018)
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Journal Article
On the Functional Assessment of Hypertrophic Cardiomyopathy-Causing Mutations in Human β-Cardiac Myosin and the Role of Myosin Binding Protein-C
Trivedi, Darshan V., Sarkar, Saswata S., Adhikari, Arjun S., Morck, Makenna M., Kooiker, Kristina B., Bernstein, Daniel, Ruppel, Kathleen M., Spudich, James A.
Published in Biophysical journal (15.02.2019)
Published in Biophysical journal (15.02.2019)
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Journal Article
Uncovering the Molecular Interactions that Maintain the Sequestered State of Myosin and their Implication in Hypertrophic Cardiomyopathy
Trivedi, Darshan V., Nag, Suman, Sarkar, Saswata S., Adhikari, Arjun S., Sutton, Shirley, Ruppel, Kathleen M., Spudich, James A.
Published in Biophysical journal (03.02.2017)
Published in Biophysical journal (03.02.2017)
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Journal Article
Deciphering the super relaxed state of human β-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers
Anderson, Robert L., Trivedi, Darshan V., Sarkar, Saswata S., Henze, Marcus, Ma, Weikang, Gong, Henry, Rogers, Christopher S., Gorham, Joshua M., Wong, Fiona L., Morck, Makenna M., Seidman, Jonathan G., Ruppel, Kathleen M., Irving, Thomas C., Cooke, Roger, Green, Eric M., Spudich, James A.
Published in Proceedings of the National Academy of Sciences - PNAS (13.08.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (13.08.2018)
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Journal Article
Hypertrophic cardiomyopathy mutations at the folded-back sequestered β-cardiac myosin S1-S2 and S1-S1 interfaces release sequestered heads and increase myosin enzymatic activity
Adhikari, Arjun S, Trivedi, Darshan V, Sarkar, Saswata S, Song, Dan, Kooiker, Kristina B, Bernstein, Daniel, Spudich, James A, Ruppel, Kathleen M
Published in bioRxiv (31.01.2019)
Published in bioRxiv (31.01.2019)
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