Safety, efficacy, and immunogenicity of VGX-3100, a therapeutic synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical intraepithelial neoplasia 2/3: a randomised, double-blind, placebo-controlled phase 2b trial
Trimble, Cornelia L, Prof, Morrow, Matthew P, PhD, Kraynyak, Kimberly A, PhD, Shen, Xuefei, PhD, Dallas, Michael, PhD, Yan, Jian, PhD, Edwards, Lance, MD, Parker, R Lamar, MD, Denny, Lynette, MD, Giffear, Mary, BS, Brown, Ami Shah, PhD, Marcozzi-Pierce, Kathleen, MA, Shah, Divya, MS, Slager, Anna M, MS, Sylvester, Albert J, MS, Khan, Amir, PhD, Broderick, Kate E, PhD, Juba, Robert J, MSCEP, Herring, Timothy A, MPH, Boyer, Jean, PhD, Lee, Jessica, MPH, Sardesai, Niranjan Y, PhD, Weiner, David B, Prof, Bagarazzi, Mark L, MD
Published in The Lancet (British edition) (21.11.2015)
Published in The Lancet (British edition) (21.11.2015)
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A synthetic consensus anti-spike protein DNA vaccine induces protective immunity against Middle East respiratory syndrome coronavirus in nonhuman primates
Muthumani, Karuppiah, Falzarano, Darryl, Reuschel, Emma L, Tingey, Colleen, Flingai, Seleeke, Villarreal, Daniel O, Wise, Megan, Patel, Ami, Izmirly, Abdullah, Aljuaid, Abdulelah, Seliga, Alecia M, Soule, Geoff, Morrow, Matthew, Kraynyak, Kimberly A, Khan, Amir S, Scott, Dana P, Feldmann, Friederike, LaCasse, Rachel, Meade-White, Kimberly, Okumura, Atsushi, Ugen, Kenneth E, Sardesai, Niranjan Y, Kim, J Joseph, Kobinger, Gary, Feldmann, Heinz, Weiner, David B
Published in Science translational medicine (19.08.2015)
Published in Science translational medicine (19.08.2015)
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Immunotherapy against HPV16/18 generates potent TH1 and cytotoxic cellular immune responses
Bagarazzi, Mark L, Yan, Jian, Morrow, Matthew P, Shen, Xuefei, Parker, R Lamar, Lee, Jessica C, Giffear, Mary, Pankhong, Panyupa, Khan, Amir S, Broderick, Kate E, Knott, Christine, Lin, Feng, Boyer, Jean D, Draghia-Akli, Ruxandra, White, C Jo, Kim, J Joseph, Weiner, David B, Sardesai, Niranjan Y
Published in Science translational medicine (10.10.2012)
Published in Science translational medicine (10.10.2012)
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A human immune data-informed vaccine concept elicits strong and broad T-cell specificities associated with HIV-1 control in mice and macaques
Mothe, Beatriz, Hu, Xintao, Llano, Anuska, Rosati, Margherita, Olvera, Alex, Kulkarni, Viraj, Valentin, Antonio, Alicea, Candido, Pilkington, Guy R, Sardesai, Niranjan Y, Rocafort, Muntsa, Crespo, Manel, Carrillo, Jorge, Marco, Andrés, Mullins, James I, Dorrell, Lucy, Hanke, Tomáš, Clotet, Bonaventura, Pavlakis, George N, Felber, Barbara K, Brander, Christian
Published in Journal of translational medicine (15.02.2015)
Published in Journal of translational medicine (15.02.2015)
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Intradermal SynCon® Ebola GP DNA Vaccine Is Temperature Stable and Safely Demonstrates Cellular and Humoral Immunogenicity Advantages in Healthy Volunteers
Tebas, Pablo, Kraynyak, Kimberly A, Patel, Ami, Maslow, Joel N, Morrow, Matthew P, Sylvester, Albert J, Knoblock, Dawson, Gillespie, Elisabeth, Amante, Dinah, Racine, Trina, McMullan, Trevor, Jeong, Moonsup, Roberts, Christine C, Park, Young K, Boyer, Jean, Broderick, Kate E, Kobinger, Gary P, Bagarazzi, Mark, Weiner, David B, Sardesai, Niranjan Y, White, Scott M
Published in The Journal of infectious diseases (02.07.2019)
Published in The Journal of infectious diseases (02.07.2019)
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A Synthetic DNA, Multi-Neoantigen Vaccine Drives Predominately MHC Class I CD8 + T-cell Responses, Impacting Tumor Challenge
Duperret, Elizabeth K, Perales-Puchalt, Alfredo, Stoltz, Regina, G H, Hiranjith, Mandloi, Nitin, Barlow, James, Chaudhuri, Amitabha, Sardesai, Niranjan Y, Weiner, David B
Published in Cancer immunology research (01.02.2019)
Published in Cancer immunology research (01.02.2019)
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Personalized neoantigen vaccine and pembrolizumab in advanced hepatocellular carcinoma: a phase 1/2 trial
Yarchoan, Mark, Gane, Edward J., Marron, Thomas U., Perales-Linares, Renzo, Yan, Jian, Cooch, Neil, Shu, Daniel H., Fertig, Elana J., Kagohara, Luciane T., Bartha, Gabor, Northcott, Josette, Lyle, John, Rochestie, Sarah, Peters, Joann, Connor, Jason T., Jaffee, Elizabeth M., Csiki, Ildiko, Weiner, David B., Perales-Puchalt, Alfredo, Sardesai, Niranjan Y.
Published in Nature medicine (01.04.2024)
Published in Nature medicine (01.04.2024)
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DNA vaccination protects mice against Zika virus-induced damage to the testes
Griffin, Bryan D., Muthumani, Kar, Warner, Bryce M., Majer, Anna, Hagan, Mable, Audet, Jonathan, Stein, Derek R., Ranadheera, Charlene, Racine, Trina, De La Vega, Marc-Antoine, Piret, Jocelyne, Kucas, Stephanie, Tran, Kaylie N., Frost, Kathy L., De Graff, Christine, Soule, Geoff, Scharikow, Leanne, Scott, Jennifer, McTavish, Gordon, Smid, Valerie, Park, Young K., Maslow, Joel N., Sardesai, Niranjan Y., Kim, J. Joseph, Yao, Xiao-jian, Bello, Alexander, Lindsay, Robbin, Boivin, Guy, Booth, Stephanie A., Kobasa, Darwyn, Embury-Hyatt, Carissa, Safronetz, David, Weiner, David B., Kobinger, Gary P.
Published in Nature communications (07.06.2017)
Published in Nature communications (07.06.2017)
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Rapid and Long-Term Immunity Elicited by DNA-Encoded Antibody Prophylaxis and DNA Vaccination Against Chikungunya Virus
Muthumani, Karuppiah, Block, Peter, Flingai, Seleeke, Muruganantham, Nagarajan, Chaaithanya, Itta Krishna, Tingey, Colleen, Wise, Megan, Reuschel, Emma L., Chung, Christopher, Muthumani, Abirami, Sarangan, Gopalsamy, Srikanth, Padma, Khan, Amir S., Vijayachari, Paluru, Sardesai, Niranjan Y., Kim, J. Joseph, Ugen, Kenneth E., Weiner, David B.
Published in The Journal of Infectious Diseases (01.08.2016)
Published in The Journal of Infectious Diseases (01.08.2016)
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A DNA vaccine against chikungunya virus is protective in mice and induces neutralizing antibodies in mice and nonhuman primates
Mallilankaraman, Karthik, Shedlock, Devon J, Bao, Huihui, Kawalekar, Omkar U, Fagone, Paolo, Ramanathan, Aarthi A, Ferraro, Bernadette, Stabenow, Jennifer, Vijayachari, Paluru, Sundaram, Senthil G, Muruganandam, Nagarajan, Sarangan, Gopalsamy, Srikanth, Padma, Khan, Amir S, Lewis, Mark G, Kim, J Joseph, Sardesai, Niranjan Y, Muthumani, Karuppiah, Weiner, David B
Published in PLoS neglected tropical diseases (11.01.2011)
Published in PLoS neglected tropical diseases (11.01.2011)
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Protection against dengue disease by synthetic nucleic acid antibody prophylaxis/immunotherapy
Flingai, Seleeke, Plummer, Emily M., Patel, Ami, Shresta, Sujan, Mendoza, Janess M., Broderick, Kate E., Sardesai, Niranjan Y., Muthumani, Kar, Weiner, David B.
Published in Scientific reports (29.07.2015)
Published in Scientific reports (29.07.2015)
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Altered response hierarchy and increased T-cell breadth upon HIV-1 conserved element DNA vaccination in macaques
Kulkarni, Viraj, Valentin, Antonio, Rosati, Margherita, Alicea, Candido, Singh, Ashish K, Jalah, Rashmi, Broderick, Kate E, Sardesai, Niranjan Y, Le Gall, Sylvie, Mothe, Beatriz, Brander, Christian, Rolland, Morgane, Mullins, James I, Pavlakis, George N, Felber, Barbara K
Published in PloS one (23.01.2014)
Published in PloS one (23.01.2014)
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Heterosubtypic protection against pathogenic human and avian influenza viruses via in vivo electroporation of synthetic consensus DNA antigens
Laddy, Dominick J, Yan, Jian, Kutzler, Michele, Kobasa, Darwyn, Kobinger, Gary P, Khan, Amir S, Greenhouse, Jack, Sardesai, Niranjan Y, Draghia-Akli, Ruxandra, Weiner, David B
Published in PloS one (25.06.2008)
Published in PloS one (25.06.2008)
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Safety and Comparative Immunogenicity of an HIV-1 DNA Vaccine in Combination with Plasmid Interleukin 12 and Impact of Intramuscular Electroporation for Delivery
Kalams, Spyros A., Parker, Scott D., Elizaga, Marnie, Metch, Barbara, Edupuganti, Srilatha, Hural, John, De Rosa, Stephen, Carter, Donald K., Rybczyk, Kyle, Frank, Ian, Fuchs, Jonathan, Koblin, Beryl, Kim, Denny H., Joseph, Patrice, Keefer, Michael C., Baden, Lindsey R., Eldridge, John, Boyer, Jean, Sherwat, Adam, Cardinali, Massimo, Allen, Mary, Pensiero, Michael, Butler, Chris, Khan, Amir S., Yan, Jian, Sardesai, Niranjan Y., Kublin, James G., Weiner, David B.
Published in The Journal of infectious diseases (01.09.2013)
Published in The Journal of infectious diseases (01.09.2013)
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An engineered bispecific DNA-encoded IgG antibody protects against Pseudomonas aeruginosa in a pneumonia challenge model
Patel, Ami, DiGiandomenico, Antonio, Keller, Ashley E., Smith, Trevor R. F., Park, Daniel H., Ramos, Stephanie, Schultheis, Katherine, Elliott, Sarah T. C., Mendoza, Janess, Broderick, Kate E., Wise, Megan C., Yan, Jian, Jiang, Jingjing, Flingai, Seleeke, Khan, Amir S., Muthumani, Kar, Humeau, Laurent, Cheng, Lily I., Wachter-Rosati, Leslie, Stover, C. Kendall, Sardesai, Niranjan Y., Weiner, David B.
Published in Nature communications (21.09.2017)
Published in Nature communications (21.09.2017)
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Activated CD4⁺CCR5⁺ T cells in the rectum predict increased SIV acquisition in SIVGag/Tat-vaccinated rhesus macaques
Carnathan, Diane G., Wetzel, Katherine S., Yu, Joana, Lee, S. Thera, Johnson, Brent A., Paiardini, Mirko, Yan, Jian, Morrow, Matthew P., Sardesai, Niranjan Y., Weiner, David B., Ertl, Hildegund C. J., Silvestri, Guido
Published in Proceedings of the National Academy of Sciences - PNAS (13.01.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (13.01.2015)
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DNA and protein co-immunization improves the magnitude and longevity of humoral immune responses in macaques
Jalah, Rashmi, Kulkarni, Viraj, Patel, Vainav, Rosati, Margherita, Alicea, Candido, Bear, Jenifer, Yu, Lei, Guan, Yongjun, Shen, Xiaoying, Tomaras, Georgia D, LaBranche, Celia, Montefiori, David C, Prattipati, Rajasekhar, Pinter, Abraham, Bess, Jr, Julian, Lifson, Jeffrey D, Reed, Steven G, Sardesai, Niranjan Y, Venzon, David J, Valentin, Antonio, Pavlakis, George N, Felber, Barbara K
Published in PloS one (13.03.2014)
Published in PloS one (13.03.2014)
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Clinical and Immunologic Biomarkers for Histologic Regression of High-Grade Cervical Dysplasia and Clearance of HPV16 and HPV18 after Immunotherapy
Morrow, Matthew P, Kraynyak, Kimberly A, Sylvester, Albert J, Dallas, Michael, Knoblock, Dawson, Boyer, Jean D, Yan, Jian, Vang, Russell, Khan, Amir S, Humeau, Laurent, Sardesai, Niranjan Y, Kim, J Joseph, Plotkin, Stanley, Weiner, David B, Trimble, Cornelia L, Bagarazzi, Mark L
Published in Clinical cancer research (15.01.2018)
Published in Clinical cancer research (15.01.2018)
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