Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton
Dos D. Sarbassov, Ali, Siraj M, Kim, Do-Hyung, Guertin, David A, Latek, Robert R, Erdjument-Bromage, Hediye, Tempst, Paul, Sabatini, David M
Published in Current biology (27.07.2004)
Published in Current biology (27.07.2004)
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Journal Article
FoxO Transcription Factors Promote AKT Ser473 Phosphorylation and Renal Tumor Growth in Response to Pharmacologic Inhibition of the PI3K-AKT Pathway
AIFU LIN, PIAO, Hai-Long, LI ZHUANG, SARBASSOV, Dos D, LI MA, BOYI GAN
Published in Cancer research (Chicago, Ill.) (15.03.2014)
Published in Cancer research (Chicago, Ill.) (15.03.2014)
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Journal Article
Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB
Sarbassov, Dos D., Ali, Siraj M., Sengupta, Shomit, Sheen, Joon-Ho, Hsu, Peggy P., Bagley, Alex F., Markhard, Andrew L., Sabatini, David M.
Published in Molecular cell (21.04.2006)
Published in Molecular cell (21.04.2006)
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Journal Article
Growing roles for the mTOR pathway
Sarbassov, Dos D, Ali, Siraj M, Sabatini, David M
Published in Current opinion in cell biology (01.12.2005)
Published in Current opinion in cell biology (01.12.2005)
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Journal Article
ATF4 induction through an atypical integrated stress response to ONC201 triggers p53-independent apoptosis in hematological malignancies
Ishizawa, Jo, Kojima, Kensuke, Chachad, Dhruv, Ruvolo, Peter, Ruvolo, Vivian, Jacamo, Rodrigo O, Borthakur, Gautam, Mu, Hong, Zeng, Zhihong, Tabe, Yoko, Allen, Joshua E, Wang, Zhiqiang, Ma, Wencai, Lee, Hans C, Orlowski, Robert, Sarbassov, Dos D, Lorenzi, Philip L, Huang, Xuelin, Neelapu, Sattva S, McDonnell, Timothy, Miranda, Roberto N, Wang, Michael, Kantarjian, Hagop, Konopleva, Marina, Davis, R Eric, Andreeff, Michael
Published in Science signaling (16.02.2016)
Published in Science signaling (16.02.2016)
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Skp2-Mediated RagA Ubiquitination Elicits a Negative Feedback to Prevent Amino-Acid-Dependent mTORC1 Hyperactivation by Recruiting GATOR1
Jin, Guoxiang, Lee, Szu-Wei, Zhang, Xian, Cai, Zhen, Gao, Yuan, Chou, Ping-Chieh, Rezaeian, Abdol Hossein, Han, Fei, Wang, Chi-Yun, Yao, Juo-Chin, Gong, Zhaohui, Chan, Chia-Hsin, Huang, Chih-Yang, Tsai, Fuu-Jen, Tsai, Chang-Hai, Tu, Shih-Hsin, Wu, Chih-Hsiung, Sarbassov, Dos D., Ho, Yuan-Soon, Lin, Hui-Kuan
Published in Molecular cell (18.06.2015)
Published in Molecular cell (18.06.2015)
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Journal Article
Two distinct mTORC2-dependent pathways converge on Rac1 to drive breast cancer metastasis
Morrison Joly, Meghan, Williams, Michelle M, Hicks, Donna J, Jones, Bayley, Sanchez, Violeta, Young, Christian D, Sarbassov, Dos D, Muller, William J, Brantley-Sieders, Dana, Cook, Rebecca S
Published in Breast cancer research : BCR (30.06.2017)
Published in Breast cancer research : BCR (30.06.2017)
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Journal Article
The Vitamin C Enantiomers Possess a Comparable Potency in the Induction of Oxidative Stress in Cancer Cells but Differ in Their Toxicity
Begimbetova, Dinara, Burska, Agata N, Baltabekova, Aidana, Kussainova, Assiya, Kukanova, Assiya, Fazyl, Fatima, Ibragimova, Milana, Manekenova, Kenzhekyz, Makishev, Abay, Bersimbaev, Rakhmetkazhi I, Sarbassov, Dos D
Published in International journal of molecular sciences (22.02.2024)
Published in International journal of molecular sciences (22.02.2024)
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Journal Article
Rictor regulates cell migration by suppressing RhoGDI2
Agarwal, N K, Chen, C-H, Cho, H, Boulbès, D R, Spooner, E, Sarbassov, D D
Published in Oncogene (16.05.2013)
Published in Oncogene (16.05.2013)
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Journal Article
mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery
Kim, Do-Hyung, Sarbassov, Dos D., Ali, Siraj M., King, Jessie E., Latek, Robert R., Erdjument-Bromage, Hediye, Tempst, Paul, Sabatini, David M.
Published in Cell (26.07.2002)
Published in Cell (26.07.2002)
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Journal Article
Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML
Zeng, Zhihong, Sarbassov, Dos D., Samudio, Ismael J., Yee, Karen W.L., Munsell, Mark F., Ellen Jackson, C., Giles, Francis J., Sabatini, David M., Andreeff, Michael, Konopleva, Marina
Published in Blood (15.04.2007)
Published in Blood (15.04.2007)
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Formation of mammalian preribosomes proceeds from intermediate to composed state during ribosome maturation
Abetov, Danysh A., Kiyan, Vladimir S., Zhylkibayev, Assylbek A., Sarbassova, Dilara A., Alybayev, Sanzhar D., Spooner, Eric, Song, Min Sup, Bersimbaev, Rakhmetkazhy I., Sarbassov, Dos D.
Published in The Journal of biological chemistry (12.07.2019)
Published in The Journal of biological chemistry (12.07.2019)
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Journal Article
GβL, a Positive Regulator of the Rapamycin-Sensitive Pathway Required for the Nutrient-Sensitive Interaction between Raptor and mTOR
Kim, Do-Hyung, Sarbassov, Dos D, Ali, Siraj M, Latek, Robert R, Guntur, Kalyani V.P, Erdjument-Bromage, Hediye, Tempst, Paul, Sabatini, David M
Published in Molecular cell (01.04.2003)
Published in Molecular cell (01.04.2003)
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Enhancing an Oxidative "Trojan Horse" Action of Vitamin C with Arsenic Trioxide for Effective Suppression of KRAS-Mutant Cancers: A Promising Path at the Bedside
Burska, Agata N, Ilyassova, Bayansulu, Dildabek, Aruzhan, Khamijan, Medina, Begimbetova, Dinara, Molnár, Ferdinand, Sarbassov, Dos D
Published in Cells (Basel, Switzerland) (01.11.2022)
Published in Cells (Basel, Switzerland) (01.11.2022)
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Journal Article
Peptidyl-prolyl cis/trans isomerase Pin1 is critical for the regulation of PKB/Akt stability and activation phosphorylation
Liao, Y, Wei, Y, Zhou, X, Yang, J -Y, Dai, C, Chen, Y -J, Agarwal, N K, Sarbassov, D, Shi, D, Yu, D, Hung, M -C
Published in Oncogene (02.07.2009)
Published in Oncogene (02.07.2009)
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Journal Article
Autoregulation of the Mechanistic Target of Rapamycin (mTOR) Complex 2 Integrity Is Controlled by an ATP-dependent Mechanism
Chen, Chien-Hung, Kiyan, Vladimir, Zhylkibayev, Assylbek A., Kazyken, Dubek, Bulgakova, Olga, Page, Kent E., Bersimbaev, Rakhmet I., Spooner, Eric, Sarbassov, Dos D.
Published in The Journal of biological chemistry (20.09.2013)
Published in The Journal of biological chemistry (20.09.2013)
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High-throughput profiling of signaling networks identifies mechanism-based combination therapy to eliminate microenvironmental resistance in acute myeloid leukemia
Zeng, Zhihong, Liu, Wenbin, Tsao, Twee, Qiu, YiHua, Zhao, Yang, Samudio, Ismael, Sarbassov, Dos D, Kornblau, Steven M, Baggerly, Keith A, Kantarjian, Hagop M, Konopleva, Marina, Andreeff, Michael
Published in Haematologica (Roma) (01.09.2017)
Published in Haematologica (Roma) (01.09.2017)
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Journal Article
Integrity of mTORC2 is dependent on the rictor Gly-934 site
Aimbetov, R, Chen, C-H, Bulgakova, O, Abetov, D, Bissenbaev, A K, Bersimbaev, R I, Sarbassov, D D
Published in Oncogene (19.04.2012)
Published in Oncogene (19.04.2012)
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