Microglial activation in regions related to cognitive function predicts disease onset in Huntington's disease: A multimodal imaging study
Politis, Marios, Pavese, Nicola, Tai, Yen F., Kiferle, Lorenzo, Mason, Sarah L, Brooks, David J., Tabrizi, Sarah J., Barker, Roger A., Piccini, Paola
Published in Human brain mapping (01.02.2011)
Published in Human brain mapping (01.02.2011)
Get full text
Journal Article
PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons
Wood-Kaczmar, Alison, Gandhi, Sonia, Yao, Zhi, Abramov, Andrey Y, Abramov, Andrey S Y, Miljan, Erik A, Keen, Gregory, Stanyer, Lee, Hargreaves, Iain, Klupsch, Kristina, Deas, Emma, Downward, Julian, Mansfield, Louise, Jat, Parmjit, Taylor, Joanne, Heales, Simon, Duchen, Michael R, Latchman, David, Tabrizi, Sarah J, Wood, Nicholas W
Published in PloS one (18.06.2008)
Published in PloS one (18.06.2008)
Get full text
Journal Article
Human Huntington's disease pluripotent stem cell-derived microglia develop normally but are abnormally hyper-reactive and release elevated levels of reactive oxygen species
O'Regan, Grace C, Farag, Sahar H, Casey, Caroline S, Wood-Kaczmar, Alison, Pocock, Jennifer M, Tabrizi, Sarah J, Andre, Ralph
Published in Journal of neuroinflammation (19.04.2021)
Published in Journal of neuroinflammation (19.04.2021)
Get full text
Journal Article
Forecasting individual progression trajectories in Huntington disease enables more powered clinical trials
Koval, Igor, Dighiero-Brecht, Thomas, Tobin, Allan J, Tabrizi, Sarah J, Scahill, Rachael I, Tezenas du Montcel, Sophie, Durrleman, Stanley, Durr, Alexandra
Published in Scientific reports (07.11.2022)
Published in Scientific reports (07.11.2022)
Get full text
Journal Article
Measuring compensation in neurodegeneration using MRI
Gregory, Sarah, Long, Jeffrey D, Tabrizi, Sarah J, Rees, Geraint
Published in Current opinion in neurology (01.08.2017)
Published in Current opinion in neurology (01.08.2017)
Get more information
Journal Article
A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease
Björkqvist, Maria, Wild, Edward J, Thiele, Jenny, Silvestroni, Aurelio, Andre, Ralph, Lahiri, Nayana, Raibon, Elsa, Lee, Richard V, Benn, Caroline L, Soulet, Denis, Magnusson, Anna, Woodman, Ben, Landles, Christian, Pouladi, Mahmoud A, Hayden, Michael R, Khalili-Shirazi, Azadeh, Lowdell, Mark W, Brundin, Patrik, Bates, Gillian P, Leavitt, Blair R, Möller, Thomas, Tabrizi, Sarah J
Published in The Journal of experimental medicine (04.08.2008)
Published in The Journal of experimental medicine (04.08.2008)
Get full text
Journal Article
FAN1 controls mismatch repair complex assembly via MLH1 retention to stabilize CAG repeat expansion in Huntington’s disease
Goold, Robert, Hamilton, Joseph, Menneteau, Thomas, Flower, Michael, Bunting, Emma L., Aldous, Sarah G., Porro, Antonio, Vicente, José R., Allen, Nicholas D., Wilkinson, Hilary, Bates, Gillian P., Sartori, Alessandro A., Thalassinos, Konstantinos, Balmus, Gabriel, Tabrizi, Sarah J.
Published in Cell reports (Cambridge) (31.08.2021)
Published in Cell reports (Cambridge) (31.08.2021)
Get full text
Journal Article
Operationalizing compensation over time in neurodegenerative disease
Gregory, Sarah, Long, Jeffrey D, Klöppel, Stefan, Razi, Adeel, Scheller, Elisa, Minkova, Lora, Papoutsi, Marina, Mills, James A, Durr, Alexandra, Leavitt, Blair R, Roos, Raymund A C, Stout, Julie C, Scahill, Rachael I, Langbehn, Douglas R, Tabrizi, Sarah J, Rees, Geraint
Published in Brain (London, England : 1878) (01.04.2017)
Published in Brain (London, England : 1878) (01.04.2017)
Get full text
Journal Article
Brain Regions Showing White Matter Loss in Huntington’s Disease Are Enriched for Synaptic and Metabolic Genes
McColgan, Peter, Gregory, Sarah, Seunarine, Kiran K., Razi, Adeel, Papoutsi, Marina, Johnson, Eileanoir, Durr, Alexandra, Roos, Raymund A.C., Leavitt, Blair R., Holmans, Peter, Scahill, Rachael I., Clark, Chris A., Rees, Geraint, Tabrizi, Sarah J., Coleman, A., Decolongon, J., Fan, M., Petkau, T., Jauffret, C., Justo, D., Lehericy, S., Nigaud, K., Valabrègue, R., Schoonderbeek, A., ‘t Hart, E.P., Moss, D. J. Hensman, Ghosh, R., Crawford, H., Papoutsi, M., Berna, C., Mahaleskshmi, D., Reilmann, R., Weber, N., Labuschagne, I., Stout, J., Landwehrmeyer, B., Orth, M., Mayer, I., Johnson, H., Crawfurd, D.
Published in Biological psychiatry (1969) (01.03.2018)
Published in Biological psychiatry (1969) (01.03.2018)
Get full text
Journal Article
Lumbar puncture safety and tolerability in premanifest and manifest Huntington's disease: a multi-analysis cross-sectional study
Hassan, Yara Refaat, Brogueira Rodrigues, Filipe, Zeun, Paul, Byrne, Lauren M, Estevez-Fraga, Carlos, Tortelli, Rosanna, Scahill, Rachael I, Wild, Edward J, Tabrizi, Sarah J
Published in Scientific reports (01.11.2022)
Published in Scientific reports (01.11.2022)
Get full text
Journal Article
A genetic association study of glutamine-encoding DNA sequence structures, somatic CAG expansion, and DNA repair gene variants, with Huntington disease clinical outcomes
Ciosi, Marc, Maxwell, Alastair, Cumming, Sarah A., Hensman Moss, Davina J., Alshammari, Asma M., Flower, Michael D., Durr, Alexandra, Leavitt, Blair R., Roos, Raymund A.C., Holmans, Peter, Jones, Lesley, Langbehn, Douglas R., Kwak, Seung, Tabrizi, Sarah J., Monckton, Darren G.
Published in EBioMedicine (01.10.2019)
Published in EBioMedicine (01.10.2019)
Get full text
Journal Article
Huntington's Disease: Clinical Presentation and Treatment
Get full text
Book Chapter
Journal Article
Mutant huntingtin causes defective actin remodeling during stress: defining a new role for transglutaminase 2 in neurodegenerative disease
MUNSIE, Lise, CARON, Nicholas, SINGH ATWAL, Randy, MARSDEN, Ian, WILD, Edward J, BAMBURG, James R, TABRIZI, Sarah J, TRUANT, Ray
Published in Human molecular genetics (15.05.2011)
Published in Human molecular genetics (15.05.2011)
Get full text
Journal Article
Loss of extra-striatal phosphodiesterase 10A expression in early premanifest Huntington's disease gene carriers
Wilson, Heather, Niccolini, Flavia, Haider, Salman, Marques, Tiago Reis, Pagano, Gennaro, Coello, Christopher, Natesan, Sridhar, Kapur, Shitij, Rabiner, Eugenii A, Gunn, Roger N, Tabrizi, Sarah J, Politis, Marios
Published in Journal of the neurological sciences (15.09.2016)
Published in Journal of the neurological sciences (15.09.2016)
Get full text
Journal Article
A Computational Cognitive Biomarker for Early-Stage Huntington's Disease
Wiecki, Thomas V, Antoniades, Chrystalina A, Stevenson, Alexander, Kennard, Christopher, Borowsky, Beth, Owen, Gail, Leavitt, Blair, Roos, Raymund, Durr, Alexandra, Tabrizi, Sarah J, Frank, Michael J
Published in PloS one (12.02.2016)
Published in PloS one (12.02.2016)
Get full text
Journal Article
Brain-derived neurotrophic factor in patients with Huntington's disease
Zuccato, Chiara, Marullo, Manuela, Vitali, Barbara, Tarditi, Alessia, Mariotti, Caterina, Valenza, Marta, Lahiri, Nayana, Wild, Edward J, Sassone, Jenny, Ciammola, Andrea, Bachoud-Lèvi, Anne Catherine, Tabrizi, Sarah J, Di Donato, Stefano, Cattaneo, Elena
Published in PloS one (12.08.2011)
Published in PloS one (12.08.2011)
Get full text
Journal Article
Cerebellar abnormalities in Huntington's disease: A role in motor and psychiatric impairment?
Rees, Elin M., Farmer, Ruth, Cole, James H., Haider, Salman, Durr, Alexandra, Landwehrmeyer, Bernhard, Scahill, Rachael I., Tabrizi, Sarah J., Hobbs, Nicola Z.
Published in Movement disorders (01.11.2014)
Published in Movement disorders (01.11.2014)
Get full text
Journal Article