PD-1- CD45RA+ effector-memory CD8 T cells and CXCL10+ macrophages are associated with response to atezolizumab plus bevacizumab in advanced hepatocellular carcinoma
Cappuyns, Sarah, Philips, Gino, Vandecaveye, Vincent, Boeckx, Bram, Schepers, Rogier, Van Brussel, Thomas, Arijs, Ingrid, Mechels, Aurelie, Bassez, Ayse, Lodi, Francesca, Jaekers, Joris, Topal, Halit, Topal, Baki, Bricard, Orian, Qian, Junbin, Van Cutsem, Eric, Verslype, Chris, Lambrechts, Diether, Dekervel, Jeroen
Published in Nature communications (29.11.2023)
Published in Nature communications (29.11.2023)
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Journal Article
Oncogenic role of PMEPA1 and its association with immune exhaustion and TGF-β activation in HCC
Piqué-Gili, Marta, Andreu-Oller, Carmen, Mesropian, Agavni, Esteban-Fabró, Roger, Bárcena-Varela, Marina, Ruiz de Galarreta, Marina, Montironi, Carla, Martinez-Quetglas, Iris, Cappuyns, Sarah, Peix, Judit, Keraite, Ieva, Gris-Oliver, Albert, Fernández-Martínez, Elisa, Mauro, Ezequiel, Torres-Martin, Miguel, Abril-Fornaguera, Jordi, Lindblad, Katherine E., Lambrechts, Diether, Dekervel, Jeroen, Thung, Swan N., Sia, Daniela, Lujambio, Amaia, Pinyol, Roser, Llovet, Josep M.
Published in JHEP reports (01.11.2024)
Published in JHEP reports (01.11.2024)
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Journal Article
Pre-treatment cross-talk between the tumoural and peripheral immune system predicts response to checkpoint inhibition in advanced HCC: a single-cell study
Cappuyns, Sarah, Philips, Gino, Vandecaveye, Vincent, Verslype, Chris, Van Cutsem, Eric, Lambrechts, Diether, Dekervel, Jeroen
Published in Journal of hepatology (01.07.2022)
Published in Journal of hepatology (01.07.2022)
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Journal Article
DNA methylation-driven EMT is a common mechanism of resistance to various therapeutic agents in cancer
Galle, Eva, Thienpont, Bernard, Cappuyns, Sarah, Venken, Tom, Busschaert, Pieter, Van Haele, Matthias, Van Cutsem, Eric, Roskams, Tania, van Pelt, Jos, Verslype, Chris, Dekervel, Jeroen, Lambrechts, Diether
Published in Clinical epigenetics (14.02.2020)
Published in Clinical epigenetics (14.02.2020)
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Journal Article
PD1-negative CD45RA effector-memory CD8 T-cells are essential for response to checkpoint inhibition in advanced hepatocellular carcinoma
Cappuyns, Sarah, Philips, Gino, Vandecaveye, Vincent, Boeckx, Bram, Schepers, Rogier, Van Brussel, Thomas, Arijs, Ingrid, Mechels, Aurelie, Bassez, Ayse, Lodi, Francesca, Jaekers, Joris, Topal, Halit, Topal, Baki, Bricard, Orian, Qian, Junbin, Van Cutsem, Eric, Verslype, Chris, Lambrechts, Diether, Dekervel, Jeroen
Published in Journal of hepatology (01.06.2023)
Published in Journal of hepatology (01.06.2023)
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Journal Article
TOP-066 - PD1-negative CD45RA effector-memory CD8 T-cells are essential for response to checkpoint inhibition in advanced hepatocellular carcinoma
Cappuyns, Sarah, Philips, Gino, Vandecaveye, Vincent, Boeckx, Bram, Schepers, Rogier, Van Brussel, Thomas, Arijs, Ingrid, Mechels, Aurelie, Bassez, Ayse, Lodi, Francesca, Jaekers, Joris, Topal, Halit, Topal, Baki, Bricard, Orian, Qian, Junbin, Van Cutsem, Eric, Verslype, Chris, Lambrechts, Diether, Dekervel, Jeroen
Published in Journal of hepatology (01.06.2023)
Published in Journal of hepatology (01.06.2023)
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Journal Article
Predicting response to atezolizumab plus bevacizumab in advanced hepatocellular carcinoma using single-cell RNA-sequencing-derived gene signatures
Cappuyns, Sarah, Piqué-Gili, Marta, Esteban-Fabró, Roger, Philips, Gino, Pinyol, Roser, Vandecaveye, Vincent, Abril-Fornaguera, Jordi, Haber, Philipp, Verslype, Chris, Van Cutsem, Eric, Lambrechts, Diether, Villanueva, Augusto, Dekervel, Jeroen, Llovet, Josep
Published in Journal of hepatology (01.06.2023)
Published in Journal of hepatology (01.06.2023)
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Journal Article
OS-059-YI - Predicting response to atezolizumab plus bevacizumab in advanced hepatocellular carcinoma using single-cell RNA-sequencing-derived gene signatures
Cappuyns, Sarah, Piqué-Gili, Marta, Esteban-Fabró, Roger, Philips, Gino, Pinyol, Roser, Vandecaveye, Vincent, Abril-Fornaguera, Jordi, Haber, Philipp, Verslype, Chris, Van Cutsem, Eric, Lambrechts, Diether, Villanueva, Augusto, Dekervel, Jeroen, Llovet, Josep
Published in Journal of hepatology (01.06.2023)
Published in Journal of hepatology (01.06.2023)
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Journal Article
Applications of single-cell multi-omics in liver cancerKey points
Frederik Peeters, Sarah Cappuyns, Marta Piqué-Gili, Gino Phillips, Chris Verslype, Diether Lambrechts, Jeroen Dekervel
Published in JHEP reports (01.07.2024)
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Published in JHEP reports (01.07.2024)
Journal Article
Applications of single-cell multi-omics in liver cancer
Peeters, Frederik, Cappuyns, Sarah, Piqué-Gili, Marta, Phillips, Gino, Verslype, Chris, Lambrechts, Diether, Dekervel, Jeroen
Published in JHEP reports (01.07.2024)
Published in JHEP reports (01.07.2024)
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Journal Article
TOP-507-YI Single-cell RNA sequencing-derived gene signatures reveal distinct response mechanisms to atezolizumab + bevacizumab in advanced hepatocellular carcinoma
Cappuyns, Sarah, Piqué-Gili, Marta, Esteban-Fabró, Roger, Philips, Gino, Pinyol, Roser, Gris-Oliver, Albert, Vandecaveye, Vincent, Abril-Fornaguera, Jordi, Montironi, Carla, Bassaganyas, Laia, Peix, Judit, Zeitlhoefler, Marcus, Mesropian, Agavni, Huguet-Pradell, Júlia, Haber, Philipp, Mohr, Raphael, Meyer, Tim, Reeves, Helen Louise, Edeline, Julien, Finkelmeier, Fabian, Trojan, Jörg, Galle, Peter R., Foerster, Friedrich, Minguez, Beatriz, Montal, Robert, Heikenwälder, Mathias, Verslype, Chris, Van Cutsem, Eric, Lambrechts, Diether, Villanueva, Augusto, Dekervel, Jeroen, Llovet, Josep
Published in Journal of hepatology (01.06.2024)
Published in Journal of hepatology (01.06.2024)
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Journal Article
Abstract PO002: Pretreatment immune cell composition and checkpoint ligand expression define the response to immunotherapy in advanced HCC: a study using single-cell sequencing
Cappuyns, Sarah, Philips, Gino, Vandecaveye, Vincent, Verslype, Chris, Van Cutsem, Eric, Lambrechts, Diether, Derkervel, Jeroen
Published in Clinical cancer research (01.09.2022)
Published in Clinical cancer research (01.09.2022)
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Journal Article
Abstract PR03: Pretreatment immune cell composition and checkpoint ligand expression define the response to immunotherapy in advanced HCC: a study using single-cell sequencing
Cappuyns, Sarah, Philips, Gino, Vandecaveye, Vincent, Verslype, Chris, Van Cutsem, Eric, Lambrechts, Diether, Derkervel, Jeroen
Published in Clinical cancer research (01.09.2022)
Published in Clinical cancer research (01.09.2022)
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Journal Article
Impact of underlying liver disease on unresectable hepatocellular carcinoma treated with immune checkpoint inhibitors
Wu, Y. Linda, Cappuyns, Sarah, Loh, Amanda, Sun, Sean, Lewis, Sara, Sung, Max W., Schwartz, Myron, Llovet, Josep M., Cohen, Deirdre J.
Published in BJC reports (29.01.2024)
Published in BJC reports (29.01.2024)
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Journal Article
Clinical factors associated with early disease progression after radioembolization for hepatocellular carcinoma and feasibility of post‐progression systemic therapy
Van Laeken, Charlotte, Taelman, Thibault, Cappuyns, Sarah, Maleux, Geert, Vandecaveye, Vincent, Verslype, Chris, Deroose, Christophe, Dekervel, Jeroen
Published in Liver cancer international (01.09.2022)
Published in Liver cancer international (01.09.2022)
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Journal Article