X-ray crystal structures of native HIV-1 capsid protein reveal conformational variability
Gres, Anna T., Kirby, Karen A., KewalRamani, Vineet N., Tanner, John J., Pornillos, Owen, Sarafianos, Stefan G.
Published in Science (American Association for the Advancement of Science) (03.07.2015)
Published in Science (American Association for the Advancement of Science) (03.07.2015)
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HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains
Francis, Ashwanth C., Marin, Mariana, Singh, Parmit K., Achuthan, Vasudevan, Prellberg, Mathew J., Palermino-Rowland, Kristina, Lan, Shuiyun, Tedbury, Philip R., Sarafianos, Stefan G., Engelman, Alan N., Melikyan, Gregory B.
Published in Nature communications (14.07.2020)
Published in Nature communications (14.07.2020)
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The HIV-1 capsid core is an opportunistic nuclear import receptor
Xue, Guangai, Yu, Hyun Jae, Buffone, Cindy, Huang, Szu-Wei, Lee, KyeongEun, Goh, Shih Lin, Gres, Anna T., Guney, Mehmet Hakan, Sarafianos, Stefan G., Luban, Jeremy, Diaz-Griffero, Felipe, KewalRamani, Vineet N.
Published in Nature communications (24.06.2023)
Published in Nature communications (24.06.2023)
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Selection and identification of an RNA aptamer that specifically binds the HIV-1 capsid lattice and inhibits viral replication
Gruenke, Paige R, Aneja, Rachna, Welbourn, Sarah, Ukah, Obiaara B, Sarafianos, Stefan G, Burke, Donald H, Lange, Margaret J
Published in Nucleic acids research (22.02.2022)
Published in Nucleic acids research (22.02.2022)
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Rotten to the core: antivirals targeting the HIV-1 capsid core
McFadden, William M, Snyder, Alexa A, Kirby, Karen A, Tedbury, Philip R, Raj, Monika, Wang, Zhengqiang, Sarafianos, Stefan G
Published in Retrovirology (22.12.2021)
Published in Retrovirology (22.12.2021)
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Structural basis of HIV inhibition by translocation-defective RT inhibitor 4′-ethynyl-2-fluoro-2′-deoxyadenosine (EFdA)
Li Salie, Zhe, Kirby, Karen A., Michailidis, Eleftherios, Marchand, Bruno, Singh, Kamalendra, Rohan, Lisa C., Kodama, Eiichi N., Mitsuya, Hiroaki, Parniak, Michael A., Sarafianos, Stefan G.
Published in Proceedings of the National Academy of Sciences - PNAS (16.08.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (16.08.2016)
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Structure and Function of HIV-1 Reverse Transcriptase: Molecular Mechanisms of Polymerization and Inhibition
Sarafianos, Stefan G., Marchand, Bruno, Das, Kalyan, Himmel, Daniel M., Parniak, Michael A., Hughes, Stephen H., Arnold, Eddy
Published in Journal of molecular biology (23.01.2009)
Published in Journal of molecular biology (23.01.2009)
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Design, Synthesis, and Biological Evaluations of Hydroxypyridonecarboxylic Acids as Inhibitors of HIV Reverse Transcriptase Associated RNase H
Kankanala, Jayakanth, Kirby, Karen A., Liu, Feng, Miller, Lena, Nagy, Eva, Wilson, Daniel J., Parniak, Michael A., Sarafianos, Stefan G., Wang, Zhengqiang
Published in Journal of medicinal chemistry (26.05.2016)
Published in Journal of medicinal chemistry (26.05.2016)
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Baicalein and Baicalin Inhibit SARS-CoV-2 RNA-Dependent-RNA Polymerase
Zandi, Keivan, Musall, Katie, Oo, Adrian, Cao, Dongdong, Liang, Bo, Hassandarvish, Pouya, Lan, Shuiyun, Slack, Ryan L, Kirby, Karen A, Bassit, Leda, Amblard, Franck, Kim, Baek, AbuBakar, Sazaly, Sarafianos, Stefan G, Schinazi, Raymond F
Published in Microorganisms (Basel) (22.04.2021)
Published in Microorganisms (Basel) (22.04.2021)
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The hepatitis B virus ribonuclease H is sensitive to inhibitors of the human immunodeficiency virus ribonuclease H and integrase enzymes
Tavis, John E, Cheng, Xiaohong, Hu, Yuan, Totten, Michael, Cao, Feng, Michailidis, Eleftherios, Aurora, Rajeev, Meyers, Marvin J, Jacobsen, E Jon, Parniak, Michael A, Sarafianos, Stefan G
Published in PLoS pathogens (01.01.2013)
Published in PLoS pathogens (01.01.2013)
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Specific mutations in the HIV-1 G-tract of the 3′-polypurine tract cause resistance to integrase strand transfer inhibitors
Hachiya, Atsuko, Kubota, Mai, Shigemi, Urara, Ode, Hirotaka, Yokomaku, Yoshiyuki, Kirby, Karen A, Sarafianos, Stefan G, Iwatani, Yasumasa
Published in Journal of antimicrobial chemotherapy (23.02.2022)
Published in Journal of antimicrobial chemotherapy (23.02.2022)
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HIV-1 usurps mixed-charge domain-dependent CPSF6 phase separation for higher-order capsid binding, nuclear entry and viral DNA integration
Jang, Sooin, Bedwell, Gregory J, Singh, Satya P, Yu, Hyun Jae, Arnarson, Bjarki, Singh, Parmit K, Radhakrishnan, Rajalingam, Douglas, AidanDarian W, Ingram, Zachary M, Freniere, Christian, Akkermans, Onno, Sarafianos, Stefan G, Ambrose, Zandrea, Xiong, Yong, Anekal, Praju V, Montero Llopis, Paula, KewalRamani, Vineet N, Francis, Ashwanth C, Engelman, Alan N
Published in Nucleic acids research (14.10.2024)
Published in Nucleic acids research (14.10.2024)
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Mechanism of nucleic acid unwinding by SARS-CoV helicase
Adedeji, Adeyemi O, Marchand, Bruno, Te Velthuis, Aartjan J W, Snijder, Eric J, Weiss, Susan, Eoff, Robert L, Singh, Kamalendra, Sarafianos, Stefan G
Published in PloS one (15.05.2012)
Published in PloS one (15.05.2012)
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Multiplex single-cell visualization of nucleic acids and protein during HIV infection
Puray-Chavez, Maritza, Tedbury, Philip R., Huber, Andrew D., Ukah, Obiaara B., Yapo, Vincent, Liu, Dandan, Ji, Juan, Wolf, Jennifer J., Engelman, Alan N., Sarafianos, Stefan G.
Published in Nature communications (01.12.2017)
Published in Nature communications (01.12.2017)
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Journal Article
Long-Acting Anti-HIV Drugs Targeting HIV-1 Reverse Transcriptase and Integrase
Singh, Kamal, Sarafianos, Stefan G, Sönnerborg, Anders
Published in Pharmaceuticals (Basel, Switzerland) (20.04.2019)
Published in Pharmaceuticals (Basel, Switzerland) (20.04.2019)
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Journal Article
Multidisciplinary studies with mutated HIV-1 capsid proteins reveal structural mechanisms of lattice stabilization
Gres, Anna T., Kirby, Karen A., McFadden, William M., Du, Haijuan, Liu, Dandan, Xu, Chaoyi, Bryer, Alexander J., Perilla, Juan R., Shi, Jiong, Aiken, Christopher, Fu, Xiaofeng, Zhang, Peijun, Francis, Ashwanth C., Melikyan, Gregory B., Sarafianos, Stefan G.
Published in Nature communications (12.09.2023)
Published in Nature communications (12.09.2023)
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Effect of P-body component Mov10 on HCV virus production and infectivity
Liu, Dandan, Ndongwe, Tanyaradzwa P, Puray-Chavez, Maritza, Casey, Mary C, Izumi, Taisuke, Pathak, Vinay K, Tedbury, Philip R, Sarafianos, Stefan G
Published in The FASEB journal (01.07.2020)
Published in The FASEB journal (01.07.2020)
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