Discovery and Optimization of N‑Heteroaryl Indazole LRRK2 Inhibitors
Logan, Kaitlyn M., Kaplan, Will, Simov, Vladimir, Zhou, Hua, Li, Derun, Torres, Luis, Morriello, Gregori J., Acton, John J., Pio, Barbara, Chen, Yi-Heng, Keylor, Mitchell H., Johnson, Rebecca, Kattar, Solomon D., Chau, Ryan, Yan, Xin, Ardolino, Michael, Zarate, Cayetana, Otte, Karin M., Palte, Rachel L., Xiong, Tina, McMinn, Spencer E., Lin, Shishi, Neelamkavil, Santhosh F., Liu, Ping, Su, Jing, Hegde, Laxminarayan G., Woodhouse, Janice D., Moy, Lily Y., Ciaccio, Paul J., Piesvaux, Jennifer, Zebisch, Matthias, Henry, Clare, Barker, John, Wood, Harold B., Kennedy, Matthew E., DiMauro, Erin F., Fell, Matthew J., Fuller, Peter H.
Published in Journal of medicinal chemistry (26.09.2024)
Published in Journal of medicinal chemistry (26.09.2024)
Get full text
Journal Article
Discovery of MK-8282 as a Potent G‑Protein-Coupled Receptor 119 Agonist for the Treatment of Type 2 Diabetes
Neelamkavil, Santhosh F, Stamford, Andrew W, Kowalski, Timothy, Biswas, Dipshikha, Boyle, Craig, Chackalamannil, Samuel, Xia, Yan, Jayne, Charles, Neustadt, Bernard, Hao, Jinsong, Liu, Hong, Dai, Xing, Baker, Hana, Hawes, Brian, O’Neill, Kim, Tang, Huadong, Greenlee, William J
Published in ACS medicinal chemistry letters (10.05.2018)
Published in ACS medicinal chemistry letters (10.05.2018)
Get full text
Journal Article
Discovery of MK-8831, A Novel Spiro-Proline Macrocycle as a Pan-Genotypic HCV-NS3/4a Protease Inhibitor
Neelamkavil, Santhosh F, Agrawal, Sony, Bara, Thomas, Bennett, Chad, Bhat, Sathesh, Biswas, Dipshikha, Brockunier, Linda, Buist, Nicole, Burnette, Duane, Cartwright, Mark, Chackalamannil, Samuel, Chase, Robert, Chelliah, Mariappan, Chen, Austin, Clasby, Martin, Colandrea, Vincent J, Davies, Ian W, Eagen, Keith, Guo, Zhuyan, Han, Yongxin, Howe, John, Jayne, Charles, Josien, Hubert, Kargman, Stacia, Marcantonio, Karen, Miao, Shouwu, Miller, Randy, Nolting, Andrew, Pinto, Patrick, Rajagopalan, Murali, Ruck, Rebecca T, Shah, Unmesh, Soriano, Aileen, Sperbeck, Donald, Velazquez, Francisco, Wu, Jin, Xia, Yan, Venkatraman, Srikanth
Published in ACS medicinal chemistry letters (14.01.2016)
Published in ACS medicinal chemistry letters (14.01.2016)
Get full text
Journal Article
N-heteroaryl indazole derivatives as LRRK2 inhibitors, pharmaceutical compositions, and uses thereof
Liu, Ping, Ardolino, Michael J, Li, Derun, Yan, Xin, Kaplan, William P, Gunaydin, Hakan, Chen, Joanna L, Zhou, Hua, Simov, Vladimir, Morriello, Gregori J, Methot, Joey, Logan, Kaitlyn Marie, Fuller, Peter H, Acton, III, John J, Torres, Luis, Neelamkavil, Santhosh F
Year of Publication 09.07.2024
Get full text
Year of Publication 09.07.2024
Patent
FACTOR XIA INHIBITORS
HRUZA, Alan W, KEVIN, Nancy Jo, MONINGKA, Remond, NEELAMKAVIL, Santhosh, F, HUSSAIN, Zahid, EDMONDSON, Scott D, GUO, Zhuyan
Year of Publication 10.08.2022
Get full text
Year of Publication 10.08.2022
Patent
MACROCYCLIC COMPOUNDS AS FACTOR XIA INHIBITORS
XU, JIAYI, SUN, WANYING, YANG, MENG, ZHOU, WEI, EDMONDSON, SCOTT D, BARA, THOMAS, MERTZ, ERIC, NEELAMKAVIL, SANTHOSH F, ALI, AMJAD, SHEN, DONG-MING, ZHU, CHENG, LIU, WEIGUO, HARPER, BART, LIM, YEON-HEE, GAO, YING-DUO
Year of Publication 26.03.2024
Get full text
Year of Publication 26.03.2024
Patent
N-(HETEROARYL) QUINAZOLIN-2-AMINE DERIVATIVES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF
MARGREY, Kaila, A, YAN, Xin, GULATI, Anmol, NEELAMKAVIL, Santhosh, F, FULLER, Peter, H, ZARATE SAEZ, Cayetana Carmela, ARDOLINO, Michael, J, JOHNSON, Rebecca Elizabeth, KATTAR, Solomon, D, CHAU, Ryan, W, KEYLOR, Mitchell, H, YU, Elsie, C, MORRIELLO, Gregori, J
Year of Publication 22.11.2023
Get full text
Year of Publication 22.11.2023
Patent
FACTOR XIA INHIBITORS
HRUZA, Alan W, MONINGKA, Remond, HUSSAIN, Zahid, LESBURG, Charles, NEELAMKAVIL, Santhosh F, EDMONDSON, Scott D
Year of Publication 18.11.2020
Get full text
Year of Publication 18.11.2020
Patent
N-(HETEROARYL) QUINAZOLIN-2-AMINE DERIVATIVES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF
Ardolino, Michael J, Yan, Xin, Johnson, Rebecca Elizabeth, Morriello, Gregori J, Fuller, Peter H, Zarate Saez, Cayetana Carmela, Keylor, Mitchell H, Chau, Ryan W, Margrey, Kaila A, Yu, Elsie C, Gulati, Anmol, Neelamkavil, Santhosh F, Kattar, Solomon D
Year of Publication 26.01.2023
Get full text
Year of Publication 26.01.2023
Patent
INDAZOLYL-SPIRO[2.3]HEXANE-CARBONITRILE DERIVATIVES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF
PIO, Barbara, ELLIS, J. Michael, WOOD, Harold, B, NEELAMKAVIL, Santhosh, F, FULLER, Peter, H, LAPOINTE, Blair, T, CANDITO, David Annunziato, LIU, Weiguo, METHOT, Joey, L, SIMOV, Vladimir, ACTON, John, GUNAYDIN, Hakan
Year of Publication 16.11.2022
Get full text
Year of Publication 16.11.2022
Patent
N-(HETEROARYL) QUINAZOLIN-2-AMINE DERIVATIVES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF
MARGREY, Kaila, A, YAN, Xin, GULATI, Anmol, NEELAMKAVIL, Santhosh, F, FULLER, Peter, H, ZARATE SAEZ, Cayetana Carmela, ARDOLINO, Michael, J, JOHNSON, Rebecca Elizabeth, KATTAR, Solomon, D, CHAU, Ryan, W, KEYLOR, Mitchell, H, YU, Elsie, C, MORRIELLO, Gregori, J
Year of Publication 31.08.2022
Get full text
Year of Publication 31.08.2022
Patent
MACROCYCLIC PYRIDINE-N-OXIDE DERIVATIVES AS FACTOR XIA INHIBITORS
ALI, Amjad, ZHU, Cheng, NEELAMKAVIL, Santhosh, F, GAO, Ying-Duo, SUN, Wanying, BARA, Thomas, YANG, Meng, SHEN, Dong-Ming, XU, Jiayi, ZHOU, Wei, HARPER, Bart, LIM, Yeon-Hee, LIU, Weiguo, EDMONDSON, Scott, D, MERTZ, Eric
Year of Publication 20.07.2022
Get full text
Year of Publication 20.07.2022
Patent
1-PYRAZOLYL, 5-, 6- DISUBSTITUTED INDAZOLE DERIVATIVES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF
YAN, Xin, CHEN, Yi-Heng, LU, Min, PIO, Barbara, TORRES, Luis, GULATI, Anmol, NEELAMKAVIL, Santhosh, F, FULLER, Peter, H, SCIAMMETTA, Nunzio, LOGAN, Kaitlyn Marie, SIMOV, Vladimir, ACTON, John, J., III, ARDOLINO, Michael, J, JOHNSON, Rebecca Elizabeth, KATTAR, Solomon, D, ZHOU, Hua, SU, Jing, KAPLAN, William, P, LI, Derun, KEYLOR, Mitchell, H, MORRIELLO, Gregori, J
Year of Publication 31.05.2023
Get full text
Year of Publication 31.05.2023
Patent
INDAZOLYL-SPIRO[2.2]PENTANE-CARBONITRILE DERIVATIVES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF
KEYLOR, Mitchell Henry, TONG, Ling, ELLIS, J. Michael, WOOD, Harold, B, GULATI, Anmol, NEELAMKAVIL, Santhosh, F, FULLER, Peter, H, CANDITO, David Annunziato, CHAU, Ryan Wing-Kun, METHOT, Joey, L, SIMOV, Vladimir, ACTON, John, GRAHAM, Thomas, H, LAPOINTE, Blair, T, KATTAR, Solomon, LIU, Weiguo, CHEN, Joanna, L, LIU, Ping, GUNAYDIN, Hakan
Year of Publication 19.04.2023
Get full text
Year of Publication 19.04.2023
Patent
N-(heteroaryl) quinazolin-2-amine derivatives as LRRK2 inhibitors, pharmaceutical compositions, and uses thereof
YAN, Xin, KATTAR, Solomon D, CHAU, Ryan W, ARDOLINO, Michael J, GULATI, Anmol, KEYLOR, Mitchell H, MARGREY, Kaila A, ZARATE SAEZ, Cayetana Carmela, JOHNSON, Rebecca Elizabeth, YU, Elsie, MORRIELLO, Gregori J, FULLER, Peter H, NEELAMKAVIL, Santhosh F
Year of Publication 05.05.2022
Get full text
Year of Publication 05.05.2022
Patent
Indazolyl-spiro[2.3]hexane-carbonitrile derivatives as LRRK2 inhibitors, pharmaceutical compositions, and uses thereof
Fuller, Peter H, Wood, Harold B, Methot, Joey L, Ellis, J. Michael, Gunaydin, Hakan, Liu, Weiguo, Lapointe, Blair T, Pio, Barbara, Acton, John, Candito, David Annunziato, Simov, Vladimir, Neelamkavil, Santhosh F
Year of Publication 16.11.2021
Get full text
Year of Publication 16.11.2021
Patent
1-PYRAZOLYL, 5-, 6- DISUBSTITUTED INDAZOLE DERIVATIVES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF
Sciammetta, Nunzio, Su, Jing, Ardolino, Michael J, Li, Derun, Yan, Xin, Kaplan, William P, Zhou, Hua, Pio, Barbara, Chen, Yi-Heng, Simov, Vladimir, Johnson, Rebecca Elizabeth, Morriello, Gregori J, Logan, Kaitlyn Marie, Fuller, Peter H, Lu, Min, Keylor, Mitchell H, Acton, III, John J, Torres, Luis, Gulati, Anmol, Neelamkavil, Santhosh F, Kattar, Solomon D
Year of Publication 18.08.2022
Get full text
Year of Publication 18.08.2022
Patent
N-HETEROARYL INDAZOLE DERIVATIVES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF
YAN, Xin, TORRES, Luis, NEELAMKAVIL, Santhosh, F, FULLER, Peter, H, LOGAN, Kaitlyn Marie, SIMOV, Vladimir, ACTON, John, J., III, ARDOLINO, Michael, J, ZHOU, Hua, KAPLAN, William, P, METHOT, Joey, LI, Derun, CHEN, Joanna, L, LIU, Ping, MORRIELLO, Gregori, J, GUNAYDIN, Hakan
Year of Publication 15.06.2022
Get full text
Year of Publication 15.06.2022
Patent