The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages
Schulthess, Julie, Pandey, Sumeet, Capitani, Melania, Rue-Albrecht, Kevin C., Arnold, Isabelle, Franchini, Fanny, Chomka, Agnieszka, Ilott, Nicholas E., Johnston, Daniel G.W., Pires, Elisabete, McCullagh, James, Sansom, Stephen N., Arancibia-Cárcamo, Carolina V., Uhlig, Holm H., Powrie, Fiona
Published in Immunity (Cambridge, Mass.) (19.02.2019)
Published in Immunity (Cambridge, Mass.) (19.02.2019)
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Distinct fibroblast subsets drive inflammation and damage in arthritis
Croft, Adam P., Campos, Joana, Jansen, Kathrin, Turner, Jason D., Marshall, Jennifer, Attar, Moustafa, Savary, Loriane, Wehmeyer, Corinna, Naylor, Amy J., Kemble, Samuel, Begum, Jenefa, Dürholz, Kerstin, Perlman, Harris, Barone, Francesca, McGettrick, Helen M., Fearon, Douglas T., Wei, Kevin, Raychaudhuri, Soumya, Korsunsky, Ilya, Brenner, Michael B., Coles, Mark, Sansom, Stephen N., Filer, Andrew, Buckley, Christopher D.
Published in Nature (London) (01.06.2019)
Published in Nature (London) (01.06.2019)
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Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis
Alivernini, Stefano, MacDonald, Lucy, Elmesmari, Aziza, Finlay, Samuel, Tolusso, Barbara, Gigante, Maria Rita, Petricca, Luca, Di Mario, Clara, Bui, Laura, Perniola, Simone, Attar, Moustafa, Gessi, Marco, Fedele, Anna Laura, Chilaka, Sabarinadh, Somma, Domenico, Sansom, Stephen N., Filer, Andrew, McSharry, Charles, Millar, Neal L., Kirschner, Kristina, Nerviani, Alessandra, Lewis, Myles J., Pitzalis, Costantino, Clark, Andrew R., Ferraccioli, Gianfranco, Udalova, Irina, Buckley, Christopher D., Gremese, Elisa, McInnes, Iain B., Otto, Thomas D., Kurowska-Stolarska, Mariola
Published in Nature medicine (01.08.2020)
Published in Nature medicine (01.08.2020)
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Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia
Sansom, Stephen N, Shikama-Dorn, Noriko, Zhanybekova, Saule, Nusspaumer, Gretel, Macaulay, Iain C, Deadman, Mary E, Heger, Andreas, Ponting, Chris P, Holländer, Georg A
Published in Genome research (01.12.2014)
Published in Genome research (01.12.2014)
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Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus
Downes, Damien J., Cross, Amy R., Hua, Peng, Roberts, Nigel, Schwessinger, Ron, Cutler, Antony J., Munis, Altar M., Brown, Jill, Mielczarek, Olga, de Andrea, Carlos E., Melero, Ignacio, Gill, Deborah R., Hyde, Stephen C., Knight, Julian C., Todd, John A., Sansom, Stephen N., Issa, Fadi, Davies, James O. J., Hughes, Jim R.
Published in Nature genetics (01.11.2021)
Published in Nature genetics (01.11.2021)
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GM-CSF drives dysregulated hematopoietic stem cell activity and pathogenic extramedullary myelopoiesis in experimental spondyloarthritis
Regan-Komito, Daniel, Swann, James W., Demetriou, Philippos, Cohen, E. Suzanne, Horwood, Nicole J., Sansom, Stephen N., Griseri, Thibault
Published in Nature communications (09.01.2020)
Published in Nature communications (09.01.2020)
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A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response
Haenseler, Walther, Sansom, Stephen N., Buchrieser, Julian, Newey, Sarah E., Moore, Craig S., Nicholls, Francesca J., Chintawar, Satyan, Schnell, Christian, Antel, Jack P., Allen, Nicholas D., Cader, M. Zameel, Wade-Martins, Richard, James, William S., Cowley, Sally A.
Published in Stem cell reports (06.06.2017)
Published in Stem cell reports (06.06.2017)
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Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex
Pereira, João D., Sansom, Stephen N., Smith, James, Dobenecker, Marc-Werner, Tarakhovsky, Alexander, Livesey, Frederick J., Crabtree, Gerald R.
Published in Proceedings of the National Academy of Sciences - PNAS (07.09.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (07.09.2010)
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Journal Article
IL-33 promotes anemia during chronic inflammation by inhibiting differentiation of erythroid progenitors
Swann, James W, Koneva, Lada A, Regan-Komito, Daniel, Sansom, Stephen N, Powrie, Fiona, Griseri, Thibault
Published in The Journal of experimental medicine (07.09.2020)
Published in The Journal of experimental medicine (07.09.2020)
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Journal Article
The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis
Sansom, Stephen N, Griffiths, Dean S, Faedo, Andrea, Kleinjan, Dirk-Jan, Ruan, Youlin, Smith, James, van Heyningen, Veronica, Rubenstein, John L, Livesey, Frederick J
Published in PLoS genetics (01.06.2009)
Published in PLoS genetics (01.06.2009)
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Interferon Regulatory Factor 5 Controls Necrotic Core Formation in Atherosclerotic Lesions by Impairing Efferocytosis
Seneviratne, Anusha N, Edsfeldt, Andreas, Cole, Jennifer E, Kassiteridi, Christina, Swart, Maarten, Park, Inhye, Green, Patricia, Khoyratty, Tariq, Saliba, David, Goddard, Michael E, Sansom, Stephen N, Goncalves, Isabel, Krams, Rob, Udalova, Irina A, Monaco, Claudia
Published in Circulation (New York, N.Y.) (19.09.2017)
Published in Circulation (New York, N.Y.) (19.09.2017)
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Journal Article
The long non-coding RNA Dali is an epigenetic regulator of neural differentiation
Chalei, Vladislava, Sansom, Stephen N, Kong, Lesheng, Lee, Sheena, Montiel, Juan F, Vance, Keith W, Ponting, Chris P
Published in eLife (21.11.2014)
Published in eLife (21.11.2014)
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IFNγ signaling in cytotoxic T cells restricts anti-tumor responses by inhibiting the maintenance and diversity of intra-tumoral stem-like T cells
Mazet, Julie M., Mahale, Jagdish N., Tong, Orion, Watson, Robert A., Lechuga‐Vieco, Ana Victoria, Pirgova, Gabriela, Lau, Vivian W. C., Attar, Moustafa, Koneva, Lada A., Sansom, Stephen N., Fairfax, Benjamin P., Gérard, Audrey
Published in Nature communications (19.01.2023)
Published in Nature communications (19.01.2023)
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Journal Article
Pax6 Exerts Regional Control of Cortical Progenitor Proliferation via Direct Repression of Cdk6 and Hypophosphorylation of pRb
Mi, Da, Carr, Catherine B., Georgala, Petrina A., Huang, Yu-Ting, Manuel, Martine N., Jeanes, Emily, Niisato, Emi, Sansom, Stephen N., Livesey, Frederick J., Theil, Thomas, Hasenpusch-Theil, Kerstin, Simpson, T. Ian, Mason, John O., Price, David J.
Published in Neuron (Cambridge, Mass.) (24.04.2013)
Published in Neuron (Cambridge, Mass.) (24.04.2013)
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Journal Article
Cellular census of human fibrosis defines functionally distinct stromal cell types and states
Layton, Thomas B., Williams, Lynn, McCann, Fiona, Zhang, Mingjun, Fritzsche, Marco, Colin-York, Huw, Cabrita, Marisa, Ng, Michael T. H., Feldmann, Marc, Sansom, Stephen N., Furniss, Dominic, Xie, Weilin, Nanchahal, Jagdeep
Published in Nature communications (02.06.2020)
Published in Nature communications (02.06.2020)
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Journal Article
Alpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis
Ryzhakov, Grigory, West, Nathaniel R., Franchini, Fanny, Clare, Simon, Ilott, Nicholas E., Sansom, Stephen N., Bullers, Samuel J., Pearson, Claire, Costain, Alice, Vaughan-Jackson, Alun, Goettel, Jeremy A., Ermann, Joerg, Horwitz, Bruce H., Buti, Ludovico, Lu, Xin, Mukhopadhyay, Subhankar, Snapper, Scott B., Powrie, Fiona
Published in Nature communications (18.09.2018)
Published in Nature communications (18.09.2018)
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Journal Article
CGAT: computational genomics analysis toolkit
Sims, David, Ilott, Nicholas E., Sansom, Stephen N., Sudbery, Ian M., Johnson, Jethro S., Fawcett, Katherine A., Berlanga-Taylor, Antonio J., Luna-Valero, Sebastian, Ponting, Chris P., Heger, Andreas
Published in Bioinformatics (01.05.2014)
Published in Bioinformatics (01.05.2014)
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Journal Article
A critical epithelial survival axis regulated by MCL-1 maintains thymic function in mice
Jain, Reema, Sheridan, Julie M., Policheni, Antonia, Heinlein, Melanie, Gandolfo, Luke C., Dewson, Grant, Smyth, Gordon K., Sansom, Stephen N., Fu, Nai Yang, Visvader, Jane E., Holländer, Georg A., Strasser, Andreas, Gray, Daniel H.D.
Published in Blood (07.12.2017)
Published in Blood (07.12.2017)
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Author Correction: Cellular census of human fibrosis defines functionally distinct stromal cell types and states
Layton, Thomas B., Williams, Lynn, McCann, Fiona, Zhang, Mingjun, Fritzsche, Marco, Colin-York, Huw, Cabrita, Marisa, Ng, Michael T. H., Feldmann, Marc, Sansom, Stephen N., Furniss, Dominic, Xie, Weilin, Nanchahal, Jagdeep
Published in Nature communications (24.06.2020)
Published in Nature communications (24.06.2020)
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