The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration
Ritschka, Birgit, Storer, Mekayla, Mas, Alba, Heinzmann, Florian, Ortells, Mari Carmen, Morton, Jennifer P, Sansom, Owen J, Zender, Lars, Keyes, William M
Published in Genes & development (15.01.2017)
Published in Genes & development (15.01.2017)
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Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties
Schwitalla, Sarah, Fingerle, Alexander A., Cammareri, Patrizia, Nebelsiek, Tim, Göktuna, Serkan I., Ziegler, Paul K., Canli, Ozge, Heijmans, Jarom, Huels, David J., Moreaux, Guenievre, Rupec, Rudolf A., Gerhard, Markus, Schmid, Roland, Barker, Nick, Clevers, Hans, Lang, Roland, Neumann, Jens, Kirchner, Thomas, Taketo, Makoto M., van den Brink, Gijs R., Sansom, Owen J., Arkan, Melek C., Greten, Florian R.
Published in Cell (17.01.2013)
Published in Cell (17.01.2013)
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Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids
Fumagalli, Arianna, Drost, Jarno, Suijkerbuijk, Saskia J. E., van Boxtel, Ruben, de Ligt, Joep, Offerhaus, G. Johan, Begthel, Harry, Beerling, Evelyne, Tan, Ee Hong, Sansom, Owen J., Cuppen, Edwin, Clevers, Hans, van Rheenen, Jacco
Published in Proceedings of the National Academy of Sciences - PNAS (21.03.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (21.03.2017)
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Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis
Jackstadt, Rene, van Hooff, Sander R., Leach, Joshua D., Cortes-Lavaud, Xabier, Lohuis, Jeroen O., Ridgway, Rachel A., Wouters, Valérie M., Roper, Jatin, Kendall, Timothy J., Roxburgh, Campbell S., Horgan, Paul G., Nixon, Colin, Nourse, Craig, Gunzer, Matthias, Clark, William, Hedley, Ann, Yilmaz, Omer H., Rashid, Mamunur, Bailey, Peter, Biankin, Andrew V., Campbell, Andrew D., Adams, David J., Barry, Simon T., Steele, Colin W., Medema, Jan Paul, Sansom, Owen J.
Published in Cancer cell (16.09.2019)
Published in Cancer cell (16.09.2019)
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MicroRNA-135b Promotes Cancer Progression by Acting as a Downstream Effector of Oncogenic Pathways in Colon Cancer
Valeri, Nicola, Braconi, Chiara, Gasparini, Pierluigi, Murgia, Claudio, Lampis, Andrea, Paulus-Hock, Viola, Hart, Jonathan R., Ueno, Lynn, Grivennikov, Sergei I., Lovat, Francesca, Paone, Alessio, Cascione, Luciano, Sumani, Khlea M., Veronese, Angelo, Fabbri, Muller, Carasi, Stefania, Alder, Hansjuerg, Lanza, Giovanni, Gafa’, Roberta, Moyer, Mary P., Ridgway, Rachel A., Cordero, Julia, Nuovo, Gerard J., Frankel, Wendy L., Rugge, Massimo, Fassan, Matteo, Groden, Joanna, Vogt, Peter K., Karin, Michael, Sansom, Owen J., Croce, Carlo M.
Published in Cancer cell (14.04.2014)
Published in Cancer cell (14.04.2014)
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Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy
Tajan, Mylène, Hennequart, Marc, Cheung, Eric C, Zani, Fabio, Hock, Andreas K, Legrave, Nathalie, Maddocks, Oliver D K, Ridgway, Rachel A, Athineos, Dimitris, Suárez-Bonnet, Alejandro, Ludwig, Robert L, Novellasdemunt, Laura, Angelis, Nikolaos, Li, Vivian S W, Vlachogiannis, Georgios, Valeri, Nicola, Mainolfi, Nello, Suri, Vipin, Friedman, Adam, Manfredi, Mark, Blyth, Karen, Sansom, Owen J, Vousden, Karen H
Published in Nature communications (14.01.2021)
Published in Nature communications (14.01.2021)
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A complex secretory program orchestrated by the inflammasome controls paracrine senescence
Acosta, Juan Carlos, Banito, Ana, Wuestefeld, Torsten, Georgilis, Athena, Janich, Peggy, Morton, Jennifer P, Athineos, Dimitris, Kang, Tae-Won, Lasitschka, Felix, Andrulis, Mindaugas, Pascual, Gloria, Morris, Kelly J, Khan, Sadaf, Jin, Hong, Dharmalingam, Gopuraja, Snijders, Ambrosius P, Carroll, Thomas, Capper, David, Pritchard, Catrin, Inman, Gareth J, Longerich, Thomas, Sansom, Owen J, Benitah, Salvador Aznar, Zender, Lars, Gil, Jesús
Published in Nature cell biology (01.08.2013)
Published in Nature cell biology (01.08.2013)
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In-situ measurement of internal gas pressure within cylindrical lithium-ion cells
Gulsoy, B., Vincent, T.A., Briggs, C., Sansom, J.E.H., Marco, J.
Published in Journal of power sources (30.06.2023)
Published in Journal of power sources (30.06.2023)
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Targeting the Metabolic Response to Statin-Mediated Oxidative Stress Produces a Synergistic Antitumor Response
McGregor, Grace H, Campbell, Andrew D, Fey, Sigrid K, Tumanov, Sergey, Sumpton, David, Blanco, Giovanny Rodriguez, Mackay, Gillian, Nixon, Colin, Vazquez, Alexei, Sansom, Owen J, Kamphorst, Jurre J
Published in Cancer research (Chicago, Ill.) (15.01.2020)
Published in Cancer research (Chicago, Ill.) (15.01.2020)
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NOTUM from Apc-mutant cells biases clonal competition to initiate cancer
Flanagan, Dustin J, Pentinmikko, Nalle, Luopajärvi, Kalle, Willis, Nicky J, Gilroy, Kathryn, Raven, Alexander P, Mcgarry, Lynn, Englund, Johanna I, Webb, Anna T, Scharaw, Sandra, Nasreddin, Nadia, Hodder, Michael C, Ridgway, Rachel A, Minnee, Emma, Sphyris, Nathalie, Gilchrist, Ella, Najumudeen, Arafath K, Romagnolo, Beatrice, Perret, Christine, Williams, Ann C, Clevers, Hans, Nummela, Pirjo, Lähde, Marianne, Alitalo, Kari, Hietakangas, Ville, Hedley, Ann, Clark, William, Nixon, Colin, Kirschner, Kristina, Jones, E Yvonne, Ristimäki, Ari, Leedham, Simon J, Fish, Paul V, Vincent, Jean-Paul, Katajisto, Pekka, Sansom, Owen J
Published in Nature (London) (17.06.2021)
Published in Nature (London) (17.06.2021)
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Cancer Cell-Autonomous TRAIL-R Signaling Promotes KRAS-Driven Cancer Progression, Invasion, and Metastasis
von Karstedt, Silvia, Conti, Annalisa, Nobis, Max, Montinaro, Antonella, Hartwig, Torsten, Lemke, Johannes, Legler, Karen, Annewanter, Franka, Campbell, Andrew D., Taraborrelli, Lucia, Grosse-Wilde, Anne, Coy, Johannes F., El-Bahrawy, Mona A., Bergmann, Frank, Koschny, Ronald, Werner, Jens, Ganten, Tom M., Schweiger, Thomas, Hoetzenecker, Konrad, Kenessey, Istvan, Hegedüs, Balazs, Bergmann, Michael, Hauser, Charlotte, Egberts, Jan-Hendrik, Becker, Thomas, Röcken, Christoph, Kalthoff, Holger, Trauzold, Anna, Anderson, Kurt I., Sansom, Owen J., Walczak, Henning
Published in Cancer cell (13.04.2015)
Published in Cancer cell (13.04.2015)
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Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease
Boulter, Luke, Govaere, Olivier, Bird, Tom G, Radulescu, Sorina, Ramachandran, Prakash, Pellicoro, Antonella, Ridgway, Rachel A, Seo, Sang Soo, Spee, Bart, Van Rooijen, Nico, Sansom, Owen J, Iredale, John P, Lowell, Sally, Roskams, Tania, Forbes, Stuart J
Published in Nature medicine (01.04.2012)
Published in Nature medicine (01.04.2012)
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Crypt stem cells as the cells-of-origin of intestinal cancer
van de Wetering, Marc, van Es, Johan H, Sansom, Owen J, Begthel, Harry, van den Born, Maaike, Barker, Nick, Danenberg, Esther, Clarke, Alan R, Clevers, Hans, Ridgway, Rachel A
Published in Nature (29.01.2009)
Published in Nature (29.01.2009)
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Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis
Jamieson, Thomas, Clarke, Mairi, Steele, Colin W, Samuel, Michael S, Neumann, Jens, Jung, Andreas, Huels, David, Olson, Michael F, Das, Sudipto, Nibbs, Robert J B, Sansom, Owen J
Published in The Journal of clinical investigation (01.09.2012)
Published in The Journal of clinical investigation (01.09.2012)
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Journal Article
CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma
Steele, Colin W., Karim, Saadia A., Leach, Joshua D.G., Bailey, Peter, Upstill-Goddard, Rosanna, Rishi, Loveena, Foth, Mona, Bryson, Sheila, McDaid, Karen, Wilson, Zena, Eberlein, Catherine, Candido, Juliana B., Clarke, Mairi, Nixon, Colin, Connelly, John, Jamieson, Nigel, Carter, C. Ross, Balkwill, Frances, Chang, David K., Evans, T.R. Jeffry, Strathdee, Douglas, Biankin, Andrew V., Nibbs, Robert J.B., Barry, Simon T., Sansom, Owen J., Morton, Jennifer P.
Published in Cancer cell (13.06.2016)
Published in Cancer cell (13.06.2016)
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Rab25 and CLIC3 Collaborate to Promote Integrin Recycling from Late Endosomes/Lysosomes and Drive Cancer Progression
Dozynkiewicz, Marta A., Jamieson, Nigel B., MacPherson, Iain, Grindlay, Joan, van den Berghe, Peter V.E., von Thun, Anne, Morton, Jennifer P., Gourley, Charlie, Timpson, Paul, Nixon, Colin, McKay, Colin J., Carter, Ross, Strachan, David, Anderson, Kurt, Sansom, Owen J., Caswell, Patrick T., Norman, Jim C.
Published in Developmental cell (17.01.2012)
Published in Developmental cell (17.01.2012)
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The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers
Muñoz, Javier, Stange, Daniel E, Schepers, Arnout G, van de Wetering, Marc, Koo, Bon-Kyoung, Itzkovitz, Shalev, Volckmann, Richard, Kung, Kevin S, Koster, Jan, Radulescu, Sorina, Myant, Kevin, Versteeg, Rogier, Sansom, Owen J, van Es, Johan H, Barker, Nick, van Oudenaarden, Alexander, Mohammed, Shabaz, Heck, Albert J R, Clevers, Hans
Published in The EMBO journal (18.07.2012)
Published in The EMBO journal (18.07.2012)
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Integrin signalling regulates YAP and TAZ to control skin homeostasis
Elbediwy, Ahmed, Vincent-Mistiaen, Zoé I, Spencer-Dene, Bradley, Stone, Richard K, Boeing, Stefan, Wculek, Stefanie K, Cordero, Julia, Tan, Ee H, Ridgway, Rachel, Brunton, Val G, Sahai, Erik, Gerhardt, Holger, Behrens, Axel, Malanchi, Ilaria, Sansom, Owen J, Thompson, Barry J
Published in Development (Cambridge) (15.05.2016)
Published in Development (Cambridge) (15.05.2016)
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