Moving CTLA-4 from the trash to recycling
Sansom, David M
Published in Science (American Association for the Advancement of Science) (24.07.2015)
Published in Science (American Association for the Advancement of Science) (24.07.2015)
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Journal Article
Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4
Qureshi, Omar S., Zheng, Yong, Nakamura, Kyoko, Attridge, Kesley, Manzotti, Claire, Schmidt, Emily M., Baker, Jennifer, Jeffery, Louisa E., Kaur, Satdip, Briggs, Zoe, Hou, Tie Z., Futter, Clare E., Anderson, Graham, Walker, Lucy S.K., Sansom, David M.
Published in Science (American Association for the Advancement of Science) (29.04.2011)
Published in Science (American Association for the Advancement of Science) (29.04.2011)
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Journal Article
Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation
Kennedy, Alan, Waters, Erin, Rowshanravan, Behzad, Hinze, Claudia, Williams, Cayman, Janman, Daniel, Fox, Thomas A., Booth, Claire, Pesenacker, Anne M., Halliday, Neil, Soskic, Blagoje, Kaur, Satdip, Qureshi, Omar S., Morris, Emma C., Ikemizu, Shinji, Paluch, Christopher, Huo, Jiandong, Davis, Simon J., Boucrot, Emmanuel, Walker, Lucy S. K., Sansom, David M.
Published in Nature immunology (01.09.2022)
Published in Nature immunology (01.09.2022)
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Journal Article
Thymus transplantation for complete DiGeorge syndrome: European experience
Davies, E. Graham, FRCPCH, Cheung, Melissa, BSc, Gilmour, Kimberly, PhD, Maimaris, Jesmeen, MRCPCH, Curry, Joe, FRCS, Furmanski, Anna, PhD, Sebire, Neil, FRCPATH, Halliday, Neil, MB, BSc, Mengrelis, Konstantinos, PhD, Adams, Stuart, PhD, Bernatoniene, Jolanta, MD, Bremner, Ronald, FRCPCH, Browning, Michael, FRCPATH, Devlin, Blythe, PhD, Erichsen, Hans Christian, MD, Gaspar, H. Bobby, PhD, Hutchison, Lizzie, RCN, Ip, Winnie, PhD, Ifversen, Marianne, MD, Leahy, T. Ronan, PhD, McCarthy, Elizabeth, PhD, Moshous, Despina, PhD, Neuling, Kim, FRCPCH, Pac, Malgorzata, MD, Papadopol, Alina, MD, Parsley, Kathryn L., PhD, Poliani, Luigi, PhD, Ricciardelli, Ida, PhD, Sansom, David M., PhD, Voor, Tiia, MD, Worth, Austen, PhD, Crompton, Tessa, PhD, Markert, M. Louise, PhD, Thrasher, Adrian J., PhD
Published in Journal of allergy and clinical immunology (01.12.2017)
Published in Journal of allergy and clinical immunology (01.12.2017)
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Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4–insufficient subjects
Schwab, Charlotte, Gabrysch, Annemarie, Olbrich, Peter, Patiño, Virginia, Warnatz, Klaus, Wolff, Daniel, Hoshino, Akihiro, Kobayashi, Masao, Imai, Kohsuke, Takagi, Masatoshi, Dybedal, Ingunn, Haddock, Jamanda A., Sansom, David M., Lucena, Jose M., Seidl, Maximilian, Schmitt-Graeff, Annette, Reiser, Veronika, Emmerich, Florian, Frede, Natalie, Bulashevska, Alla, Salzer, Ulrich, Schubert, Desirée, Hayakawa, Seiichi, Okada, Satoshi, Kanariou, Maria, Kucuk, Zeynep Yesim, Chapdelaine, Hugo, Petruzelkova, Lenka, Sumnik, Zdenek, Sediva, Anna, Slatter, Mary, Arkwright, Peter D., Cant, Andrew, Lorenz, Hanns-Martin, Giese, Thomas, Lougaris, Vassilios, Plebani, Alessandro, Price, Christina, Sullivan, Kathleen E., Moutschen, Michel, Litzman, Jiri, Freiberger, Tomas, van de Veerdonk, Frank L., Recher, Mike, Albert, Michael H., Hauck, Fabian, Seneviratne, Suranjith, Pachlopnik Schmid, Jana, Kolios, Antonios, Unglik, Gary, Klemann, Christian, Speckmann, Carsten, Ehl, Stephan, Leichtner, Alan, Blumberg, Richard, Franke, Andre, Snapper, Scott, Zeissig, Sebastian, Cunningham-Rundles, Charlotte, Giulino-Roth, Lisa, Elemento, Olivier, Dückers, Gregor, Niehues, Tim, Fronkova, Eva, Kanderová, Veronika, Platt, Craig D., Chou, Janet, Chatila, Talal A., Geha, Raif, McDermott, Elizabeth, Bunn, Su, Kurzai, Monika, Schulz, Ansgar, Alsina, Laia, Casals, Ferran, Deyà-Martinez, Angela, Hambleton, Sophie, Kanegane, Hirokazu, Taskén, Kjetil, Neth, Olaf, Grimbacher, Bodo
Published in Journal of allergy and clinical immunology (01.12.2018)
Published in Journal of allergy and clinical immunology (01.12.2018)
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Web Resource
CTLA-4 controls follicular helper T-cell differentiation by regulating the strength of CD28 engagement
Wang, Chun Jing, Heuts, Frank, Ovcinnikovs, Vitalijs, Wardzinski, Lukasz, Bowers, Chantelle, Schmidt, Emily M., Kogimtzis, Alexandros, Kenefeck, Rupert, Sansom, David M., Walker, Lucy S. K.
Published in Proceedings of the National Academy of Sciences - PNAS (13.01.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (13.01.2015)
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Journal Article
The CTLA‐4 immune checkpoint protein regulates PD‐L1:PD‐1 interaction via transendocytosis of its ligand CD80
Kennedy, Alan, Robinson, Maximillian A, Hinze, Claudia, Waters, Erin, Williams, Cayman, Halliday, Neil, Dovedi, Simon, Sansom, David M
Published in The EMBO journal (01.03.2023)
Published in The EMBO journal (01.03.2023)
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Journal Article
Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations
Schubert, Desirée, Bode, Claudia, Kenefeck, Rupert, Hou, Tie Zheng, Wing, James B, Kennedy, Alan, Bulashevska, Alla, Petersen, Britt-Sabina, Schäffer, Alejandro A, Grüning, Björn A, Unger, Susanne, Frede, Natalie, Baumann, Ulrich, Witte, Torsten, Schmidt, Reinhold E, Dueckers, Gregor, Niehues, Tim, Seneviratne, Suranjith, Kanariou, Maria, Speckmann, Carsten, Ehl, Stephan, Rensing-Ehl, Anne, Warnatz, Klaus, Rakhmanov, Mirzokhid, Thimme, Robert, Hasselblatt, Peter, Emmerich, Florian, Cathomen, Toni, Backofen, Rolf, Fisch, Paul, Seidl, Maximilian, May, Annette, Schmitt-Graeff, Annette, Ikemizu, Shinji, Salzer, Ulrich, Franke, Andre, Sakaguchi, Shimon, Walker, Lucy S K, Sansom, David M, Grimbacher, Bodo
Published in Nature medicine (01.12.2014)
Published in Nature medicine (01.12.2014)
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Journal Article
Characterization of CTLA4 Trafficking and Implications for Its Function
Khailaie, Sahamoddin, Rowshanravan, Behzad, Robert, Philippe A., Waters, Erin, Halliday, Neil, Badillo Herrera, Jesus David, Walker, Lucy S.K., Sansom, David M., Meyer-Hermann, Michael
Published in Biophysical journal (02.10.2018)
Published in Biophysical journal (02.10.2018)
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Journal Article
Availability of 25-Hydroxyvitamin D3 to APCs Controls the Balance between Regulatory and Inflammatory T Cell Responses
Jeffery, Louisa E., Wood, Alice M., Qureshi, Omar S., Hou, Tie Zheng, Gardner, David, Briggs, Zoe, Kaur, Satdip, Raza, Karim, Sansom, David M.
Published in The Journal of immunology (1950) (01.12.2012)
Published in The Journal of immunology (1950) (01.12.2012)
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Journal Article
Vitamin D Antagonises the Suppressive Effect of Inflammatory Cytokines on CTLA-4 Expression and Regulatory Function
Jeffery, Louisa E, Qureshi, Omar S, Gardner, David, Hou, Tie Z, Briggs, Zoe, Soskic, Blagoje, Baker, Jennifer, Raza, Karim, Sansom, David M
Published in PloS one (02.07.2015)
Published in PloS one (02.07.2015)
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Journal Article
1,25-Dihydroxyvitamin D3 and IL-2 Combine to Inhibit T Cell Production of Inflammatory Cytokines and Promote Development of Regulatory T Cells Expressing CTLA-4 and FoxP3
Jeffery, Louisa E, Burke, Fiona, Mura, Manuela, Zheng, Yong, Qureshi, Omar S, Hewison, Martin, Walker, Lucy S. K, Lammas, David A, Raza, Karim, Sansom, David M
Published in The Journal of immunology (1950) (01.11.2009)
Published in The Journal of immunology (1950) (01.11.2009)
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Journal Article
Identifying functional defects in patients with immune dysregulation due to LRBA and CTLA-4 mutations
Hou, Tie Zheng, Verma, Nisha, Wanders, Jennifer, Kennedy, Alan, Soskic, Blagoje, Janman, Daniel, Halliday, Neil, Rowshanravan, Behzad, Worth, Austen, Qasim, Waseem, Baxendale, Helen, Stauss, Hans, Seneviratne, Suranjith, Neth, Olaf, Olbrich, Peter, Hambleton, Sophie, Arkwright, Peter D., Burns, Siobhan O., Walker, Lucy S.K., Sansom, David M.
Published in Blood (16.03.2017)
Published in Blood (16.03.2017)
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Journal Article
CD86 Is a Selective CD28 Ligand Supporting FoxP3+ Regulatory T Cell Homeostasis in the Presence of High Levels of CTLA-4
Halliday, Neil, Williams, Cayman, Kennedy, Alan, Waters, Erin, Pesenacker, Anne M, Soskic, Blagoje, Hinze, Claudia, Hou, Tie Zheng, Rowshanravan, Behzad, Janman, Daniel, Walker, Lucy S K, Sansom, David M
Published in Frontiers in immunology (08.12.2020)
Published in Frontiers in immunology (08.12.2020)
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Journal Article
Follicular helper T cell signature in type 1 diabetes
Kenefeck, Rupert, Wang, Chun Jing, Kapadi, Tauseef, Wardzinski, Lukasz, Attridge, Kesley, Clough, Louise E, Heuts, Frank, Kogimtzis, Alexandros, Patel, Sapna, Rosenthal, Miranda, Ono, Masahiro, Sansom, David M, Narendran, Parth, Walker, Lucy S K
Published in The Journal of clinical investigation (01.01.2015)
Published in The Journal of clinical investigation (01.01.2015)
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Journal Article
Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS)
Dancer, Rachel C A, Parekh, Dhruv, Lax, Sian, D'Souza, Vijay, Zheng, Shengxing, Bassford, Chris R, Park, Daniel, Bartis, D G, Mahida, Rahul, Turner, Alice M, Sapey, Elizabeth, Wei, Wenbin, Naidu, Babu, Stewart, Paul M, Fraser, William D, Christopher, Kenneth B, Cooper, Mark S, Gao, Fang, Sansom, David M, Martineau, Adrian R, Perkins, Gavin D, Thickett, David R
Published in Thorax (01.07.2015)
Published in Thorax (01.07.2015)
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