Potential disease-modifying therapies for Huntington's disease: lessons learned and future opportunities
Tabrizi, Sarah J, Estevez-Fraga, Carlos, van Roon-Mom, Willeke M C, Flower, Michael D, Scahill, Rachael I, Wild, Edward J, Muñoz-Sanjuan, Ignacio, Sampaio, Cristina, Rosser, Anne E, Leavitt, Blair R
Published in Lancet neurology (01.07.2022)
Published in Lancet neurology (01.07.2022)
Get full text
Journal Article
Diffusion MRI marks progressive alterations in fiber integrity in the zQ175DN mouse model of Huntington's disease
Vidas-Guscic, Nicholas, van Rijswijk, Joëlle, Van Audekerke, Johan, Jeurissen, Ben, Nnah, Israel, Tang, Haiying, Muñoz-Sanjuan, Ignacio, Pustina, Dorian, Cachope, Roger, Van der Linden, Annemie, Bertoglio, Daniele, Verhoye, Marleen
Published in Neurobiology of disease (01.04.2024)
Published in Neurobiology of disease (01.04.2024)
Get full text
Journal Article
Longitudinal alterations in brain perfusion and vascular reactivity in the zQ175DN mouse model of Huntington's disease
Vasilkovska, Tamara, Salajeghe, Somaie, Vanreusel, Verdi, Van Audekerke, Johan, Verschuuren, Marlies, Hirschler, Lydiane, Warnking, Jan, Pintelon, Isabel, Pustina, Dorian, Cachope, Roger, Mrzljak, Ladislav, Muñoz-Sanjuan, Ignacio, Barbier, Emmanuel L, De Vos, Winnok H, Van der Linden, Annemie, Verhoye, Marleen
Published in Journal of biomedical science (16.04.2024)
Published in Journal of biomedical science (16.04.2024)
Get full text
Journal Article
Identification and Optimization of RNA-Splicing Modulators as Huntingtin Protein-Lowering Agents for the Treatment of Huntington’s Disease
Liu, Longbin, Malagu, Karine, Haughan, Alan F., Khetarpal, Vinod, Stott, Andrew J., Esmieu, William, Vater, Huw D., Webster, Stephen J., Van de Poël, Amanda J., Clissold, Cole, Cosgrove, Brett, Sutton, Benjamin, Spencer, Jonathan A., Breccia, Perla, Gancia, Emanuela, Bonomo, Silvia, Ladduwahetty, Tammy, Lazari, Ovadia, Patel, Hiral, Atton, Helen C., Clifton, Steve, Mota, Daniel M., Magnani, Dario, O’Neill, Amy, Stebbeds, Marta, Macabuag, Natsuko, Todd, Daniel, Herva, Maria E., Mitchell, Philip, Visser, Mijke, Compte Sancerni, Sara, Grand Moursel, Laure, da Silva, Marta, Kritikou, Eva, Heikkinen, Taneli T., Bolkvadze, Tamuna, Fodale, Valentina, Spadafora, Debora, Daldin, Manuel, Bresciani, Alberto, Mangette, John E., Doherty, Elizabeth M., Lee, Matthew R., Herbst, Todd, Monteagudo, Edith, Macdonald, Douglas, Plotnikov, Nikolay V., Chambers, Mark, McAllister, George, Muňoz-Sanjuan, Ignacio, Dominguez, Celia
Published in Journal of medicinal chemistry (28.09.2023)
Published in Journal of medicinal chemistry (28.09.2023)
Get full text
Journal Article
Structure-Based Exploration of Selectivity for ATM Inhibitors in Huntington’s Disease
Van de Poël, Amanda, Toledo-Sherman, Leticia, Breccia, Perla, Cachope, Roger, Bate, Jennifer R, Angulo-Herrera, Ivan, Wishart, Grant, Matthews, Kim L, Martin, Sarah L, Peacock, Marcus, Barnard, Amy, Cox, Helen C, Jones, Graham, McAllister, George, Vater, Huw, Esmieu, William, Clissold, Cole, Lamers, Marieke, Leonard, Philip, Jarvis, Rebecca E, Blackaby, Wesley, Eznarriaga, Maria, Lazari, Ovadia, Yates, Dawn, Rose, Mark, Jang, Sung-Wook, Muñoz-Sanjuan, Ignacio, Dominguez, Celia
Published in Journal of medicinal chemistry (22.04.2021)
Published in Journal of medicinal chemistry (22.04.2021)
Get full text
Journal Article
Modelling the Human Blood–Brain Barrier in Huntington Disease
Vignone, Domenico, Gonzalez Paz, Odalys, Fini, Ivan, Cellucci, Antonella, Auciello, Giulio, Battista, Maria Rosaria, Gloaguen, Isabelle, Fortuni, Silvia, Cariulo, Cristina, Khetarpal, Vinod, Dominguez, Celia, Muñoz-Sanjuán, Ignacio, Di Marco, Annalise
Published in International journal of molecular sciences (15.07.2022)
Published in International journal of molecular sciences (15.07.2022)
Get full text
Journal Article
Optimization of Potent and Selective Ataxia Telangiectasia-Mutated Inhibitors Suitable for a Proof-of-Concept Study in Huntington’s Disease Models
Toledo-Sherman, Leticia, Breccia, Perla, Cachope, Roger, Bate, Jennifer R, Angulo-Herrera, Ivan, Wishart, Grant, Matthews, Kim L, Martin, Sarah L, Cox, Helen C, McAllister, George, Penrose, Stephen D, Vater, Huw, Esmieu, William, Van de Poël, Amanda, Van de Bospoort, Rhea, Strijbosch, Annelieke, Lamers, Marieke, Leonard, Philip, Jarvis, Rebecca E, Blackaby, Wesley, Barnes, Karen, Eznarriaga, Maria, Dowler, Simon, Smith, Graham D, Fischer, David F, Lazari, Ovadia, Yates, Dawn, Rose, Mark, Jang, Sung-Wook, Muñoz-Sanjuan, Ignacio, Dominguez, Celia
Published in Journal of medicinal chemistry (28.03.2019)
Published in Journal of medicinal chemistry (28.03.2019)
Get full text
Journal Article
Global Rhes knockout in the Q175 Huntington's disease mouse model
Heikkinen, Taneli, Bragge, Timo, Kuosmanen, Juha, Parkkari, Teija, Gustafsson, Sanna, Kwan, Mei, Beltran, Jose, Ghavami, Afshin, Subramaniam, Srinivasa, Shahani, Neelam, Ramírez-Jarquín, Uri Nimrod, Park, Larry, Muñoz-Sanjuán, Ignacio, Marchionini, Deanna M
Published in PloS one (14.10.2021)
Published in PloS one (14.10.2021)
Get full text
Journal Article
Combined Peptide and Small-Molecule Approach toward Nonacidic THIQ Inhibitors of the KEAP1/NRF2 Interaction
Ontoria, Jesus M, Biancofiore, Ilaria, Fezzardi, Paola, Ferrigno, Federica, Torrente, Esther, Colarusso, Stefania, Bianchi, Elisabetta, Andreini, Matteo, Patsilinakos, Alexandros, Kempf, Georg, Augustin, Martin, Steinbacher, Stefan, Summa, Vincenzo, Pacifici, Robert, Muñoz-Sanjuan, Ignacio, Park, Larry, Bresciani, Alberto, Dominguez, Celia, Sherman, Leticia Toledo, Harper, Steven
Published in ACS medicinal chemistry letters (14.05.2020)
Published in ACS medicinal chemistry letters (14.05.2020)
Get full text
Journal Article
Design and Evaluation of [18F]CHDI-650 as a Positron Emission Tomography Ligand to Image Mutant Huntingtin Aggregates
Liu, Longbin, Johnson, Peter D., Prime, Michael E., Khetarpal, Vinod, Brown, Christopher J., Anzillotti, Luca, Bertoglio, Daniele, Chen, Xuemei, Coe, Samuel, Davis, Randall, Dickie, Anthony P., Esposito, Simone, Gadouleau, Elise, Giles, Paul R., Greenaway, Catherine, Haber, James, Halldin, Christer, Haller, Scott, Hayes, Sarah, Herbst, Todd, Herrmann, Frank, Heßmann, Manuela, Hsai, Ming Min, Khani, Yaser, Kotey, Adrian, Lembo, Angelo, Mangette, John E., Marriner, Gwendolyn A., Marston, Richard W., Mills, Matthew R., Monteagudo, Edith, Forsberg-Morén, Anton, Nag, Sangram, Orsatti, Laura, Sandiego, Christine, Schaertl, Sabine, Sproston, Joanne, Staelens, Steven, Tookey, Jack, Turner, Penelope A., Vecchi, Andrea, Veneziano, Maria, Muñoz-Sanjuan, Ignacio, Bard, Jonathan, Dominguez, Celia
Published in Journal of medicinal chemistry (12.01.2023)
Published in Journal of medicinal chemistry (12.01.2023)
Get full text
Journal Article
Lead Optimization toward Proof-of-Concept Tools for Huntington’s Disease within a 4‑(1H‑Pyrazol-4-yl)pyrimidine Class of Pan-JNK Inhibitors
Wityak, John, McGee, Kevin F, Conlon, Michael P, Song, Ren Hua, Duffy, Bryan C, Clayton, Brent, Lynch, Michael, Wang, Gwen, Freeman, Emily, Haber, James, Kitchen, Douglas B, Manning, David D, Ismail, Jiffry, Khmelnitsky, Yuri, Michels, Peter, Webster, Jeff, Irigoyen, Macarena, Luche, Michele, Hultman, Monica, Bai, Mei, Kuok, IokTeng D, Newell, Ryan, Lamers, Marieke, Leonard, Philip, Yates, Dawn, Matthews, Kim, Ongeri, Lynette, Clifton, Steve, Mead, Tania, Deupree, Susan, Wheelan, Pat, Lyons, Kathy, Wilson, Claire, Kiselyov, Alex, Toledo-Sherman, Leticia, Beconi, Maria, Muñoz-Sanjuan, Ignacio, Bard, Jonathan, Dominguez, Celia
Published in Journal of medicinal chemistry (09.04.2015)
Published in Journal of medicinal chemistry (09.04.2015)
Get full text
Journal Article
Molecular signature of human embryonic stem cells and its comparison with the mouse
Sato, Noboru, Sanjuan, Ignacio Munoz, Heke, Michael, Uchida, Makiko, Naef, Felix, Brivanlou, Ali H.
Published in Developmental biology (15.08.2003)
Published in Developmental biology (15.08.2003)
Get full text
Journal Article
Establishment of an in Vitro Human Blood-Brain Barrier Model Derived from Induced Pluripotent Stem Cells and Comparison to a Porcine Cell-Based System
Di Marco, Annalise, Vignone, Domenico, Gonzalez Paz, Odalys, Fini, Ivan, Battista, Maria Rosaria, Cellucci, Antonella, Bracacel, Elena, Auciello, Giulio, Veneziano, Maria, Khetarpal, Vinod, Rose, Mark, Rosa, Alessandro, Gloaguen, Isabelle, Monteagudo, Edith, Herbst, Todd, Dominguez, Celia, Muñoz-Sanjuán, Ignacio
Published in Cells (Basel, Switzerland) (16.04.2020)
Published in Cells (Basel, Switzerland) (16.04.2020)
Get full text
Journal Article
Discovery and Structure–Activity Relationship of Potent and Selective Covalent Inhibitors of Transglutaminase 2 for Huntington’s Disease
Prime, Michael E, Andersen, Ole A, Barker, John J, Brooks, Mark A, Cheng, Robert K. Y, Toogood-Johnson, Ian, Courtney, Stephen M, Brookfield, Frederick A, Yarnold, Christopher J, Marston, Richard W, Johnson, Peter D, Johnsen, Siw F, Palfrey, Jordan J, Vaidya, Darshan, Erfan, Sayeh, Ichihara, Osamu, Felicetti, Brunella, Palan, Shilpa, Pedret-Dunn, Anna, Schaertl, Sabine, Sternberger, Ina, Ebneth, Andreas, Scheel, Andreas, Winkler, Dirk, Toledo-Sherman, Leticia, Beconi, Maria, Macdonald, Douglas, Muñoz-Sanjuan, Ignacio, Dominguez, Celia, Wityak, John
Published in Journal of medicinal chemistry (09.02.2012)
Published in Journal of medicinal chemistry (09.02.2012)
Get full text
Journal Article
Operando Scanning Electrochemical Probe Microscopy during Electrocatalysis
Santana Santos, Carla, Jaato, Bright Nsolebna, Sanjuán, Ignacio, Schuhmann, Wolfgang, Andronescu, Corina
Published in Chemical reviews (26.04.2023)
Published in Chemical reviews (26.04.2023)
Get full text
Journal Article
Human glia can both induce and rescue aspects of disease phenotype in Huntington disease
Benraiss, Abdellatif, Wang, Su, Herrlinger, Stephanie, Li, Xiaojie, Chandler-Militello, Devin, Mauceri, Joseph, Burm, Hayley B., Toner, Michael, Osipovitch, Mikhail, Jim Xu, Qiwu, Ding, Fengfei, Wang, Fushun, Kang, Ning, Kang, Jian, Curtin, Paul C., Brunner, Daniela, Windrem, Martha S., Munoz-Sanjuan, Ignacio, Nedergaard, Maiken, Goldman, Steven A.
Published in Nature communications (07.06.2016)
Published in Nature communications (07.06.2016)
Get full text
Journal Article
Characterization of neurophysiological and behavioral changes, MRI brain volumetry and 1H MRS in zQ175 knock-in mouse model of Huntington's disease
Heikkinen, Taneli, Lehtimäki, Kimmo, Vartiainen, Nina, Puoliväli, Jukka, Hendricks, Susan J, Glaser, Jack R, Bradaia, Amyaouch, Wadel, Kristian, Touller, Chrystelle, Kontkanen, Outi, Yrjänheikki, Juha M, Buisson, Bruno, Howland, David, Beaumont, Vahri, Munoz-Sanjuan, Ignacio, Park, Larry C
Published in PloS one (20.12.2012)
Published in PloS one (20.12.2012)
Get full text
Journal Article
Rapid and robust patterns of spontaneous locomotor deficits in mouse models of Huntington's disease
Heikkinen, Taneli, Bragge, Timo, Bhattarai, Niina, Parkkari, Teija, Puoliväli, Jukka, Kontkanen, Outi, Sweeney, Patrick, Park, Larry C, Munoz-Sanjuan, Ignacio
Published in PloS one (28.12.2020)
Published in PloS one (28.12.2020)
Get full text
Journal Article