Discovery of the pan-genotypic hepatitis C virus NS3/4A protease inhibitor voxilaprevir (GS-9857): A component of Vosevi
Taylor, James G., Zipfel, Sheila, Ramey, Kyla, Vivian, Randy, Schrier, Adam, Karki, Kapil K., Katana, Ashley, Kato, Darryl, Kobayashi, Tetsuya, Martinez, Ruben, Sangi, Michael, Siegel, Dustin, Tran, Chinh V., Yang, Zheng-Yu, Zablocki, Jeff, Yang, Cheng Y., Wang, Yujin, Wang, Kelly, Chan, Katie, Barauskas, Ona, Cheng, Guofeng, Jin, Debi, Schultz, Brian E., Appleby, Todd, Villaseñor, Armando G., Link, John O.
Published in Bioorganic & medicinal chemistry letters (15.08.2019)
Published in Bioorganic & medicinal chemistry letters (15.08.2019)
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Discovery of an Oral Respiratory Syncytial Virus (RSV) Fusion Inhibitor (GS-5806) and Clinical Proof of Concept in a Human RSV Challenge Study
Mackman, Richard L, Sangi, Michael, Sperandio, David, Parrish, Jay P, Eisenberg, Eugene, Perron, Michel, Hui, Hon, Zhang, Lijun, Siegel, Dustin, Yang, Hai, Saunders, Oliver, Boojamra, Constantine, Lee, Gary, Samuel, Dharmaraj, Babaoglu, Kerim, Carey, Anne, Gilbert, Brian E, Piedra, Pedro A, Strickley, Robert, Iwata, Quynh, Hayes, Jaclyn, Stray, Kirsten, Kinkade, April, Theodore, Dorothy, Jordan, Robert, Desai, Manoj, Cihlar, Tomas
Published in Journal of medicinal chemistry (26.02.2015)
Published in Journal of medicinal chemistry (26.02.2015)
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Discovery of N‑[4-[6-tert-Butyl-5-methoxy-8-(6-methoxy-2-oxo‑1H‑pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide (RG7109), a Potent Inhibitor of the Hepatitis C Virus NS5B Polymerase
Talamas, Francisco X., Abbot, Sarah C., Anand, Shalini, Brameld, Ken A., Carter, David S., Chen, Jun, Davis, Dana, de Vicente, Javier, Fung, Amy D., Gong, Leyi, Harris, Seth F., Inbar, Petra, Labadie, Sharada S., Lee, Eun K., Lemoine, Remy, Le Pogam, Sophie, Leveque, Vincent, Li, Jim, McIntosh, Joel, Nájera, Isabel, Park, Jaehyeon, Railkar, Aruna, Rajyaguru, Sonal, Sangi, Michael, Schoenfeld, Ryan C., Staben, Leanna R., Tan, Yunchou, Taygerly, Joshua P., Villaseñor, Armando G., Weller, Paul E.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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GS-5806 Inhibits a Broad Range of Respiratory Syncytial Virus Clinical Isolates by Blocking the Virus-Cell Fusion Process
Perron, Michel, Stray, Kirsten, Kinkade, April, Theodore, Dorothy, Lee, Gary, Eisenberg, Eugene, Sangi, Michael, Gilbert, Brian E, Jordan, Robert, Piedra, Pedro A, Toms, Geoffery L, Mackman, Richard, Cihlar, Tomas
Published in Antimicrobial agents and chemotherapy (01.03.2016)
Published in Antimicrobial agents and chemotherapy (01.03.2016)
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Journal Article
Discovery of a Potent and Orally Bioavailable Cyclophilin Inhibitor Derived from the Sanglifehrin Macrocycle
Mackman, Richard L, Steadman, Victoria A, Dean, David K, Jansa, Petr, Poullennec, Karine G, Appleby, Todd, Austin, Carol, Blakemore, Caroline A, Cai, Ruby, Cannizzaro, Carina, Chin, Gregory, Chiva, Jean-Yves C, Dunbar, Neil A, Fliri, Hans, Highton, Adrian J, Hui, Hon, Ji, Mingzhe, Jin, Haolun, Karki, Kapil, Keats, Andrew J, Lazarides, Linos, Lee, Yu-Jen, Liclican, Albert, Mish, Michael, Murray, Bernard, Pettit, Simon B, Pyun, Peter, Sangi, Michael, Santos, Rex, Sanvoisin, Jonathan, Schmitz, Uli, Schrier, Adam, Siegel, Dustin, Sperandio, David, Stepan, George, Tian, Yang, Watt, Gregory M, Yang, Hai, Schultz, Brian E
Published in Journal of medicinal chemistry (08.11.2018)
Published in Journal of medicinal chemistry (08.11.2018)
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술피닐아미노벤즈아미드 및 술포닐아미노벤즈아미드 유도체
SANGI MICHAEL, SPERANDIO DAVID, FARAND JULIE, KAPLAN JOSHUA A, NOTTE GREGORY, OLEN CASEY LOCKWOOD
Year of Publication 28.01.2021
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Year of Publication 28.01.2021
Patent
Discovery of a Novel Series of Potent Non-Nucleoside Inhibitors of Hepatitis C Virus NS5B
Schoenfeld, Ryan C, Bourdet, David L, Brameld, Ken A, Chin, Elbert, de Vicente, Javier, Fung, Amy, Harris, Seth F, Lee, Eun K, Le Pogam, Sophie, Leveque, Vincent, Li, Jim, Lui, Alfred S.-T, Najera, Isabel, Rajyaguru, Sonal, Sangi, Michael, Steiner, Sandra, Talamas, Francisco X, Taygerly, Joshua P, Zhao, Junping
Published in Journal of medicinal chemistry (24.10.2013)
Published in Journal of medicinal chemistry (24.10.2013)
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COMPOUNDS AND METHODS FOR ANTIVIRAL TREATMENT
HUI HON CHUNG, SIEGEL DUSTIN, MACKMAN RICHARD L, PARRISH JAY P, SPERANDIO DAVID, YANG HAI, SANGI MICHAEL
Year of Publication 29.04.2020
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Year of Publication 29.04.2020
Patent
INHIBITORS OF HEPATITIS C VIRUS
ZABLOCKI JEFF, LINK JOHN O, TREJO MARTIN TERESA ALEJANDRA, COTTELL JEROMY J, VIVIAN RANDALL W, ZIPFEL SHEILA, CANALES EDA, TAYLOR JAMES G, KOBAYASHI TETSUYA, KATO DARRYL, KATANA ASHLEY ANNE, PYUN HYUNG JUNG, SCHRIER ADAM JAMES, SIEGEL DUSTIN, YANG ZHENG YU, MARTINEZ RUBEN, BJORNSON KYLA, SANGI MICHAEL, TRAN CHINH VIET, KARKI KAPIL KUMAR, PHILLIPS BARTON W
Year of Publication 04.11.2019
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Year of Publication 04.11.2019
Patent
COMPOUNDS AND METHODS FOR ANTIVIRAL TREATMENT
HUI HON CHUNG, SIEGEL DUSTIN, MACKMAN RICHARD L, PARRISH JAY P, SPERANDIO DAVID, YANG HAI, SANGI MICHAEL
Year of Publication 23.12.2014
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Year of Publication 23.12.2014
Patent
SYNTHESIS OF A MACROCYCLIC HCV NS3 INHIBITING TRIPEPTIDE
WALTMAN ANDREW W, COLBY DENISE A, CHAN JOHANN, KEATON KATIE ANN, SENG PAMELA, SHAPIRO NATHAN, REYNOLDS TROY, TAYLOR JAMES G, KONDAPALLY SUDHA, CAGULADA AMY, LEVINS CHRIS, CHAN LINA, PCION DOMINIKA, KATO DARRYL, ROSS BRUCE, YU LAWRENCE, SIEGEL DUSTIN, TRIPP JONATHAN, MARTINEZ RUBEN, TANG DONALD, LITTKE ADAM, SANGI MICHAEL, KARKI KAPIL KUMAR, SCHRIER ADAM J
Year of Publication 26.08.2016
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Year of Publication 26.08.2016
Patent
PYRAZOLO[1,5-A]PYRIMIDINES AS ANTIVIRAL AGENTS
HUI HON CHUNG, BOOJAMRA CONSTANTINE G, EISENBERG EUGENE J, SIEGEL DUSTIN, SAUNDERS OLIVER L, MACKMAN RICHARD L, PARRISH JAY P, SANGI MICHAEL, SPERANDIO DAVID, YANG HAI, BABAOGLU KERIM
Year of Publication 14.03.2014
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Year of Publication 14.03.2014
Patent
INHIBITORS OF HEPATITIS C VIRUS
ZABLOCKI JEFF, LINK JOHN O, TREJO MARTIN TERESA ALEJANDRA, COTTELL JEROMY J, VIVIAN RANDALL W, ZIPFEL SHEILA, CANALES EDA, TAYLOR JAMES G, KOBAYASHI TETSUYA, KATO DARRYL, KATANA ASHLEY ANNE, PYUN HYUNG JUNG, SCHRIER ADAM JAMES, SIEGEL DUSTIN, YANG ZHENG YU, MARTINEZ RUBEN, BJORNSON KYLA, SANGI MICHAEL, TRAN CHINH VIET, KARKI KAPIL KUMAR, PHILLIPS BARTON W
Year of Publication 14.04.2016
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Year of Publication 14.04.2016
Patent
SYK INHIBITORS
ZABLOCKI JEFF, WATKINS WILLIAM J, LEE SEUNG H, ZHAO ZHONGDONG, KROPF JEFFREY, STEVENS KIRK L, FARAND JULIE, LAZERWITH SCOTT E, SCHMITT AARON C, CURRIE KEVIN S, KATANA ASHLEY A, KATO DARRYL, PYUN HYUNG JUNG, GUERRERO JUAN A, XIONG JINMING, BLOMGREN PETER, SCHRIER ADAM J, LO JENNIFER, CHANDRASEKHAR JAYARAMAN, MITCHELL SCOTT A, LINK JOHN O, MAI NICHOLAS, ZIPFEL SHEILA, VENKATARAMANI CHANDRASEKAR, XU JIANJUN, YANG ZHENG YU, LI JIAYAO, DU ZHIMIN, SANGI MICHAEL, NOTTE GREGORY
Year of Publication 05.04.2016
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Year of Publication 05.04.2016
Patent
Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives
Sangi, Michael, Sperandio, David, Notte, Gregory, Farand, Julie, Kaplan, Joshua A, Olen, Casey Lockwood
Year of Publication 01.08.2024
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Year of Publication 01.08.2024
Patent
Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives
Sangi, Michael, Sperandio, David, Notte, Gregory, Farand, Julie, Kaplan, Joshua A, Olen, Casey Lockwood
Year of Publication 30.07.2024
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Year of Publication 30.07.2024
Patent
SULFONYLAMINOBENZAMIDE DERIVATIVES
FARAND, Julie, KAPLAN, Joshua A, SPERANDIO, David, OLEN, Casey Lockwood, SANGI, Michael, NOTTE, Gregory
Year of Publication 28.04.2024
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Year of Publication 28.04.2024
Patent
SULFONYLAMINOBENZAMIDE DERIVATIVES
SPERANDIO David, KAPLAN Joshua A, SANGI Michael, NOTTE Gregory, OLEN Casey Lockwood, FARAND Julie
Year of Publication 29.02.2024
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Year of Publication 29.02.2024
Patent