The atypical ‘hippocampal’ glutamate receptor coupled to phospholipase D that controls stretch‐sensitivity in primary mechanosensory nerve endings is homomeric purely metabotropic GluK2
Thompson, Karen J., Watson, Sonia, Zanato, Chiara, Dall'Angelo, Sergio, De Nooij, Joriene C., Pace‐Bonello, Bethany, Shenton, Fiona C., Sanger, Helen E., Heinz, Beverly A., Broad, Lisa M., Grosjean, Noelle, McQuillian, Jessica R., Dubini, Marina, Pyner, Susan, Greig, Iain, Zanda, Matteo, Bleakman, David, Banks, Robert W., Bewick, Guy S.
Published in Experimental physiology (01.01.2024)
Published in Experimental physiology (01.01.2024)
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Journal Article
M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss
Bradley, Sophie J, Bourgognon, Julie-Myrtille, Sanger, Helen E, Verity, Nicholas, Mogg, Adrian J, White, David J, Butcher, Adrian J, Moreno, Julie A, Molloy, Colin, Macedo-Hatch, Timothy, Edwards, Jennifer M, Wess, Jurgen, Pawlak, Robert, Read, David J, Sexton, Patrick M, Broad, Lisa M, Steinert, Joern R, Mallucci, Giovanna R, Christopoulos, Arthur, Felder, Christian C, Tobin, Andrew B
Published in The Journal of clinical investigation (01.02.2017)
Published in The Journal of clinical investigation (01.02.2017)
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Journal Article
Activation of Muscarinic M1 Acetylcholine Receptors Induces Long-Term Potentiation in the Hippocampus
Dennis, Siobhan H, Pasqui, Francesca, Colvin, Ellen M, Sanger, Helen, Mogg, Adrian J, Felder, Christian C, Broad, Lisa M, Fitzjohn, Steve M, Isaac, John T R, Mellor, Jack R
Published in Cerebral cortex (New York, N.Y. 1991) (01.01.2016)
Published in Cerebral cortex (New York, N.Y. 1991) (01.01.2016)
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Recovery, rehabilitation and follow-up services following critical illness: an updated UK national cross-sectional survey and progress report
Connolly, Bronwen, Milton-Cole, Rhian, Adams, Claire, Battle, Ceri, McPeake, Joanne, Quasim, Tara, Silversides, Jon, Slack, Andrew, Waldmann, Carl, Wilson, Elizabeth, Meyer, Joel, Waldmann, Carl, Meyer, Joel, Slack, Andrew, Barton, Greg, Bastin, Anthony, Bear, Danielle, Bench, Suzanne, Davies, Martin, Ferguson, Andrew, Firshmann, Penny, Gager, Melanie, Highfield, Julie, Linford, Sarah, McPeake, Joanne, Merriweather, Judith, Parry-Jones, Jack, Phillips, Margaret, Quasim, Tara, Sanger, Helen, Sturmey, Gordon, Wade, Dorothy, Wilson, Elizabeth
Published in BMJ open (04.10.2021)
Published in BMJ open (04.10.2021)
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Journal Article
Bitopic Binding Mode of an M1 Muscarinic Acetylcholine Receptor Agonist Associated with Adverse Clinical Trial Outcomes
Bradley, Sophie J, Molloy, Colin, Bundgaard, Christoffer, Mogg, Adrian J, Thompson, Karen J, Dwomoh, Louis, Sanger, Helen E, Crabtree, Michael D, Brooke, Simon M, Sexton, Patrick M, Felder, Christian C, Christopoulos, Arthur, Broad, Lisa M, Tobin, Andrew B, Langmead, Christopher J
Published in Molecular pharmacology (01.06.2018)
Published in Molecular pharmacology (01.06.2018)
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Journal Article
Bitopic Binding Mode of an M 1 Muscarinic Acetylcholine Receptor Agonist Associated with Adverse Clinical Trial Outcomes
Bradley, Sophie J, Molloy, Colin, Bundgaard, Christoffer, Mogg, Adrian J, Thompson, Karen J, Dwomoh, Louis, Sanger, Helen E, Crabtree, Michael D, Brooke, Simon M, Sexton, Patrick M, Felder, Christian C, Christopoulos, Arthur, Broad, Lisa M, Tobin, Andrew B, Langmead, Christopher J
Published in Molecular pharmacology (01.06.2018)
Published in Molecular pharmacology (01.06.2018)
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Journal Article
Identification and pharmacological profile of SPP1, a potent, functionally selective and brain penetrant agonist at muscarinic M1 receptors
Broad, Lisa M, Sanger, Helen E, Mogg, Adrian J, Colvin, Ellen M, Zwart, Ruud, Evans, David A, Pasqui, Francesca, Sher, Emanuele, Wishart, Graham N, Barth, Vanessa N, Felder, Christian C, Goldsmith, Paul J
Published in British journal of pharmacology (01.01.2019)
Published in British journal of pharmacology (01.01.2019)
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Journal Article
In Vitro Pharmacological Characterization and In Vivo Validation of LSN3172176 a Novel M1 Selective Muscarinic Receptor Agonist Tracer Molecule for Positron Emission Tomography
Mogg, Adrian J, Eessalu, Thomas, Johnson, Megan, Wright, Rebecca, Sanger, Helen E, Xiao, Hongling, Crabtree, Michael G, Smith, Alex, Colvin, Ellen M, Schober, Douglas, Gehlert, Donald, Jesudason, Cynthia, Goldsmith, Paul J, Johnson, Michael P, Felder, Christian C, Barth, Vanessa N, Broad, Lisa M
Published in The Journal of pharmacology and experimental therapeutics (01.06.2018)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2018)
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Journal Article
In vitro pharmacological and rat pharmacokinetic characterization of LY3020371, a potent and selective mGlu2/3 receptor antagonist
Witkin, Jeffrey M., Ornstein, Paul L., Mitch, Charles H., Li, Renhua, Smith, Stephon C., Heinz, Beverly A., Wang, Xu-Shan, Xiang, Chuanxi, Carter, Joan H., Anderson, Wesley H., Li, Xia, Broad, Lisa M., Pasqui, Francesca, Fitzjohn, Stephen M., Sanger, Helen E., Smith, Jodi L., Catlow, John, Swanson, Steven, Monn, James A.
Published in Neuropharmacology (15.03.2017)
Published in Neuropharmacology (15.03.2017)
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Journal Article
In vitro pharmacological and rat pharmacokinetic characterization of LY3020371, a potent and selective mGlu 2/3 receptor antagonist
Witkin, Jeffrey M, Ornstein, Paul L, Mitch, Charles H, Li, Renhua, Smith, Stephon C, Heinz, Beverly A, Wang, Xu-Shan, Xiang, Chuanxi, Carter, Joan H, Anderson, Wesley H, Li, Xia, Broad, Lisa M, Pasqui, Francesca, Fitzjohn, Stephen M, Sanger, Helen E, Smith, Jodi L, Catlow, John, Swanson, Steven, Monn, James A
Published in Neuropharmacology (01.03.2017)
Published in Neuropharmacology (01.03.2017)
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Journal Article
Dyspnoea in intensive care unit: a truly multi-professional problem
Sanger, Helen, Swingwood, Ema, Smith, Lucy, Highfield, Julie
Published in Intensive care medicine (01.07.2024)
Published in Intensive care medicine (01.07.2024)
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Journal Article
Metabotropic Glutamate Receptors Modulate Exocytotic Tau Release and Propagation
Mazzo, Francesca, Butnaru, Ioana, Grubisha, Olivera, Ficulle, Elena, Sanger, Helen, Fitzgerald, Griffin, Pan, Feng, Pasqui, Francesca, Murray, Tracey, Monn, James, Li, Xia, Hutton, Michael, Bose, Suchira, Schiavo, Giampietro, Sher, Emanuele
Published in The Journal of pharmacology and experimental therapeutics (01.11.2022)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2022)
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Phosphodiesterase-1b (Pde1b) knockout mice are resistant to forced swim and tail suspension induced immobility and show upregulation of Pde10a
Hufgard, Jillian R., Williams, Michael T., Skelton, Matthew R., Grubisha, Olivera, Ferreira, Filipa M., Sanger, Helen, Wright, Mary E., Reed-Kessler, Tracy M., Rasmussen, Kurt, Duman, Ronald S., Vorhees, Charles V.
Published in Psychopharmacology (01.06.2017)
Published in Psychopharmacology (01.06.2017)
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Journal Article
Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1 S ,2 S ,5 R ,6 S -2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a Potent, Selective Metabotropic Glutamate Receptor Agonist and Determination of Agonist-Bound Human mGlu2 and mGlu3 Amino Terminal Domain Structures
Monn, James A., Prieto, Lourdes, Taboada, Lorena, Pedregal, Concepcion, Hao, Junliang, Reinhard, Matt R., Henry, Steven S., Goldsmith, Paul J., Beadle, Christopher D., Walton, Lesley, Man, Teresa, Rudyk, Helene, Clark, Barry, Tupper, David, Baker, S. Richard, Lamas, Carlos, Montero, Carlos, Marcos, Alicia, Blanco, Jaime, Bures, Mark, Clawson, David K., Atwell, Shane, Lu, Frances, Wang, Jing, Russell, Marijane, Heinz, Beverly A., Wang, Xushan, Carter, Joan H., Xiang, Chuanxi, Catlow, John T., Swanson, Steven, Sanger, Helen, Broad, Lisa M., Johnson, Michael P., Knopp, Kelly L., Simmons, Rosa M. A., Johnson, Bryan G., Shaw, David B., McKinzie, David L.
Published in Journal of medicinal chemistry (26.02.2015)
Published in Journal of medicinal chemistry (26.02.2015)
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Journal Article
Identification and pharmacological profile of SPP1, a potent, functionally selective and brain penetrant agonist at muscarinic M 1 receptors
Broad, Lisa M, Sanger, Helen E, Mogg, Adrian J, Colvin, Ellen M, Zwart, Ruud, Evans, David A, Pasqui, Francesca, Sher, Emanuele, Wishart, Graham N, Barth, Vanessa N, Felder, Christian C, Goldsmith, Paul J
Published in British journal of pharmacology (01.01.2019)
Published in British journal of pharmacology (01.01.2019)
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Journal Article
Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1S,2S,5R,6S‑2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a Potent, Selective Metabotropic Glutamate Receptor Agonist and Determination of Agonist-Bound Human mGlu2 and mGlu3 Amino Terminal Domain Structures
Monn, James A, Prieto, Lourdes, Taboada, Lorena, Pedregal, Concepcion, Hao, Junliang, Reinhard, Matt R, Henry, Steven S, Goldsmith, Paul J, Beadle, Christopher D, Walton, Lesley, Man, Teresa, Rudyk, Helene, Clark, Barry, Tupper, David, Baker, S. Richard, Lamas, Carlos, Montero, Carlos, Marcos, Alicia, Blanco, Jaime, Bures, Mark, Clawson, David K, Atwell, Shane, Lu, Frances, Wang, Jing, Russell, Marijane, Heinz, Beverly A, Wang, Xushan, Carter, Joan H, Xiang, Chuanxi, Catlow, John T, Swanson, Steven, Sanger, Helen, Broad, Lisa M, Johnson, Michael P, Knopp, Kelly L, Simmons, Rosa M. A, Johnson, Bryan G, Shaw, David B, McKinzie, David L
Published in Journal of medicinal chemistry (26.02.2015)
Published in Journal of medicinal chemistry (26.02.2015)
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Journal Article
Pharmacological profiling of the TRPV3 channel in recombinant and native assays
Grubisha, Olivera, Mogg, Adrian J, Sorge, Jessica L, Ball, Laura‐Jayne, Sanger, Helen, Ruble, Cara L A, Folly, Elizabeth A, Ursu, Daniel, Broad, Lisa M
Published in British journal of pharmacology (01.05.2014)
Published in British journal of pharmacology (01.05.2014)
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Journal Article
Pharmacological profiling of native group II metabotropic glutamate receptors in primary cortical neuronal cultures using a FLIPR
Sanger, Helen, Hanna, Lydia, Colvin, Ellen M., Grubisha, Olivera, Ursu, Daniel, Heinz, Beverly A., Findlay, Jeremy D., Vivier, Richard G., Sher, Emanuele, Lodge, David, Monn, James A., Broad, Lisa M.
Published in Neuropharmacology (01.03.2013)
Published in Neuropharmacology (01.03.2013)
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