Syntaxin-6 delays prion protein fibril formation and prolongs the presence of toxic aggregation intermediates
Sangar, Daljit, Hill, Elizabeth, Jack, Kezia, Batchelor, Mark, Mistry, Beenaben, Ribes, Juan M, Jackson, Graham S, Mead, Simon, Bieschke, Jan
Published in eLife (07.08.2024)
Published in eLife (07.08.2024)
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Journal Article
Structural effects of the highly protective V127 polymorphism on human prion protein
Hosszu, Laszlo L. P., Conners, Rebecca, Sangar, Daljit, Batchelor, Mark, Sawyer, Elizabeth B., Fisher, Stuart, Cliff, Matthew J., Hounslow, Andrea M., McAuley, Katherine, Leo Brady, R., Jackson, Graham S., Bieschke, Jan, Waltho, Jonathan P., Collinge, John
Published in Communications biology (29.07.2020)
Published in Communications biology (29.07.2020)
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Journal Article
Direct Observation of Competing Prion Protein Fibril Populations with Distinct Structures and Kinetics
Sun, Yuanzi, Jack, Kezia, Ercolani, Tiziana, Sangar, Daljit, Hosszu, Laszlo, Collinge, John, Bieschke, Jan
Published in ACS nano (11.04.2023)
Published in ACS nano (11.04.2023)
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Journal Article
Loss of Residues 119–136, Including the First β-strand of Human Prion Protein, Generates an Aggregation-competent Partially “Open” Form
Hosszu, Laszlo L.P., Sangar, Daljit, Batchelor, Mark, Risse, Emmanuel, Hounslow, Andrea M., Collinge, John, Waltho, Jonathan P., Bieschke, Jan
Published in Journal of molecular biology (01.08.2023)
Published in Journal of molecular biology (01.08.2023)
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Journal Article
Loss of the first β-strand of human prion protein generates an aggregation-competent partially "open" form
Hosszu, Laszlo L P, Sangar, Daljit, Batchelor, Mark, Risse, Emmanuel, Hounslow, Andrea M, Waltho, Jonathan P, Collinge, John, Bieschke, Jan
Published in bioRxiv (21.09.2022)
Published in bioRxiv (21.09.2022)
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