Molecular characterization of mutant TP53 acute myeloid leukemia and high-risk myelodysplastic syndrome
Grob, Tim, Al Hinai, Adil S.A., Sanders, Mathijs A., Kavelaars, François G., Rijken, Melissa, Gradowska, Patrycja L., Biemond, Bart J., Breems, Dimitri A., Maertens, Johan, van Marwijk Kooy, Marinus, Pabst, Thomas, de Weerdt, Okke, Ossenkoppele, Gert J., van de Loosdrecht, Arjan A., Huls, Gerwin A., Cornelissen, Jan J., Beverloo, H. Berna, Löwenberg, Bob, Jongen-Lavrencic, Mojca, Valk, Peter J.M.
Published in Blood (14.04.2022)
Published in Blood (14.04.2022)
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Journal Article
The landscape of somatic mutation in normal colorectal epithelial cells
Lee-Six, Henry, Olafsson, Sigurgeir, Ellis, Peter, Osborne, Robert J., Sanders, Mathijs A., Moore, Luiza, Georgakopoulos, Nikitas, Torrente, Franco, Noorani, Ayesha, Goddard, Martin, Robinson, Philip, Coorens, Tim H. H., O’Neill, Laura, Alder, Christopher, Wang, Jingwei, Fitzgerald, Rebecca C., Zilbauer, Matthias, Coleman, Nicholas, Saeb-Parsy, Kourosh, Martincorena, Inigo, Campbell, Peter J., Stratton, Michael R.
Published in Nature (London) (01.10.2019)
Published in Nature (London) (01.10.2019)
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Journal Article
Somatic mutations and clonal dynamics in healthy and cirrhotic human liver
Brunner, Simon F., Roberts, Nicola D., Wylie, Luke A., Moore, Luiza, Aitken, Sarah J., Davies, Susan E., Sanders, Mathijs A., Ellis, Pete, Alder, Chris, Hooks, Yvette, Abascal, Federico, Stratton, Michael R., Martincorena, Inigo, Hoare, Matthew, Campbell, Peter J.
Published in Nature (London) (01.10.2019)
Published in Nature (London) (01.10.2019)
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Journal Article
The mutational landscape of normal human endometrial epithelium
Moore, Luiza, Leongamornlert, Daniel, Coorens, Tim H. H., Sanders, Mathijs A., Ellis, Peter, Dentro, Stefan C., Dawson, Kevin J., Butler, Tim, Rahbari, Raheleh, Mitchell, Thomas J., Maura, Francesco, Nangalia, Jyoti, Tarpey, Patrick S., Brunner, Simon F., Lee-Six, Henry, Hooks, Yvette, Moody, Sarah, Mahbubani, Krishnaa T., Jimenez-Linan, Mercedes, Brosens, Jan J., Iacobuzio-Donahue, Christine A., Martincorena, Inigo, Saeb-Parsy, Kourosh, Campbell, Peter J., Stratton, Michael R.
Published in Nature (London) (30.04.2020)
Published in Nature (London) (30.04.2020)
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Journal Article
MLL-AF9 Expression in Hematopoietic Stem Cells Drives a Highly Invasive AML Expressing EMT-Related Genes Linked to Poor Outcome
Stavropoulou, Vaia, Kaspar, Susanne, Brault, Laurent, Sanders, Mathijs A., Juge, Sabine, Morettini, Stefano, Tzankov, Alexandar, Iacovino, Michelina, Lau, I-Jun, Milne, Thomas A., Royo, Hélène, Kyba, Michael, Valk, Peter J.M., Peters, Antoine H.F.M., Schwaller, Juerg
Published in Cancer cell (11.07.2016)
Published in Cancer cell (11.07.2016)
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Journal Article
Mesenchymal Inflammation Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Disease Evolution in Human Pre-leukemia
Zambetti, Noemi A., Ping, Zhen, Chen, Si, Kenswil, Keane J.G., Mylona, Maria A., Sanders, Mathijs A., Hoogenboezem, Remco M., Bindels, Eric M.J., Adisty, Maria N., Van Strien, Paulina M.H., van der Leije, Cindy S., Westers, Theresia M., Cremers, Eline M.P., Milanese, Chiara, Mastroberardino, Pier G., van Leeuwen, Johannes P.T.M., van der Eerden, Bram C.J., Touw, Ivo P., Kuijpers, Taco W., Kanaar, Roland, van de Loosdrecht, Arjan A., Vogl, Thomas, Raaijmakers, Marc H.G.P.
Published in Cell stem cell (03.11.2016)
Published in Cell stem cell (03.11.2016)
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Journal Article
A single oncogenic enhancer rearrangement causes concomitant EVI1 and GATA2 deregulation in leukemia
Gröschel, Stefan, Sanders, Mathijs A, Hoogenboezem, Remco, de Wit, Elzo, Bouwman, Britta A M, Erpelinck, Claudia, van der Velden, Vincent H J, Havermans, Marije, Avellino, Roberto, van Lom, Kirsten, Rombouts, Elwin J, van Duin, Mark, Döhner, Konstanze, Beverloo, H Berna, Bradner, James E, Döhner, Hartmut, Löwenberg, Bob, Valk, Peter J M, Bindels, Eric M J, de Laat, Wouter, Delwel, Ruud
Published in Cell (10.04.2014)
Published in Cell (10.04.2014)
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Journal Article
Somatic Evolution in Non-neoplastic IBD-Affected Colon
Olafsson, Sigurgeir, McIntyre, Rebecca E., Coorens, Tim, Butler, Timothy, Jung, Hyunchul, Robinson, Philip S., Lee-Six, Henry, Sanders, Mathijs A., Arestang, Kenneth, Dawson, Claire, Tripathi, Monika, Strongili, Konstantina, Hooks, Yvette, Stratton, Michael R., Parkes, Miles, Martincorena, Inigo, Raine, Tim, Campbell, Peter J., Anderson, Carl A.
Published in Cell (06.08.2020)
Published in Cell (06.08.2020)
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Journal Article
Convergent somatic mutations in metabolism genes in chronic liver disease
Ng, Stanley W. K., Rouhani, Foad J., Brunner, Simon F., Brzozowska, Natalia, Aitken, Sarah J., Yang, Ming, Abascal, Federico, Moore, Luiza, Nikitopoulou, Efterpi, Chappell, Lia, Leongamornlert, Daniel, Ivovic, Aleksandra, Robinson, Philip, Butler, Timothy, Sanders, Mathijs A., Williams, Nicholas, Coorens, Tim H. H., Teague, Jon, Raine, Keiran, Butler, Adam P., Hooks, Yvette, Wilson, Beverley, Birtchnell, Natalie, Naylor, Huw, Davies, Susan E., Stratton, Michael R., Martincorena, Iñigo, Rahbari, Raheleh, Frezza, Christian, Hoare, Matthew, Campbell, Peter J.
Published in Nature (London) (21.10.2021)
Published in Nature (London) (21.10.2021)
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Journal Article
Integrative genomic and transcriptomic analysis of leiomyosarcoma
Chudasama, Priya, Mughal, Sadaf S., Sanders, Mathijs A., Hübschmann, Daniel, Chung, Inn, Deeg, Katharina I., Wong, Siao-Han, Rabe, Sophie, Hlevnjak, Mario, Zapatka, Marc, Ernst, Aurélie, Kleinheinz, Kortine, Schlesner, Matthias, Sieverling, Lina, Klink, Barbara, Schröck, Evelin, Hoogenboezem, Remco M., Kasper, Bernd, Heilig, Christoph E., Egerer, Gerlinde, Wolf, Stephan, von Kalle, Christof, Eils, Roland, Stenzinger, Albrecht, Weichert, Wilko, Glimm, Hanno, Gröschel, Stefan, Kopp, Hans-Georg, Omlor, Georg, Lehner, Burkhard, Bauer, Sebastian, Schimmack, Simon, Ulrich, Alexis, Mechtersheimer, Gunhild, Rippe, Karsten, Brors, Benedikt, Hutter, Barbara, Renner, Marcus, Hohenberger, Peter, Scholl, Claudia, Fröhling, Stefan
Published in Nature communications (10.01.2018)
Published in Nature communications (10.01.2018)
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Journal Article
Increased somatic mutation burdens in normal human cells due to defective DNA polymerases
Robinson, Philip S., Coorens, Tim H. H., Palles, Claire, Mitchell, Emily, Abascal, Federico, Olafsson, Sigurgeir, Lee, Bernard C. H., Lawson, Andrew R. J., Lee-Six, Henry, Moore, Luiza, Sanders, Mathijs A., Hewinson, James, Martin, Lynn, Pinna, Claudia M. A., Galavotti, Sara, Rahbari, Raheleh, Campbell, Peter J., Martincorena, Iñigo, Tomlinson, Ian, Stratton, Michael R.
Published in Nature genetics (01.10.2021)
Published in Nature genetics (01.10.2021)
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Journal Article
Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia
Li, Sheng, Garrett-Bakelman, Francine E, Chung, Stephen S, Sanders, Mathijs A, Hricik, Todd, Rapaport, Franck, Patel, Jay, Dillon, Richard, Vijay, Priyanka, Brown, Anna L, Perl, Alexander E, Cannon, Joy, Bullinger, Lars, Luger, Selina, Becker, Michael, Lewis, Ian D, To, Luen Bik, Delwel, Ruud, Löwenberg, Bob, Döhner, Hartmut, Döhner, Konstanze, Guzman, Monica L, Hassane, Duane C, Roboz, Gail J, Grimwade, David, Valk, Peter J M, D'Andrea, Richard J, Carroll, Martin, Park, Christopher Y, Neuberg, Donna, Levine, Ross, Melnick, Ari M, Mason, Christopher E
Published in Nature medicine (01.07.2016)
Published in Nature medicine (01.07.2016)
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Journal Article
Prognostic Value of FLT3 -Internal Tandem Duplication Residual Disease in Acute Myeloid Leukemia
Grob, Tim, Sanders, Mathijs A, Vonk, Christian M, Kavelaars, Franҫois G, Rijken, Melissa, Hanekamp, Diana W, Gradowska, Patrycja L, Cloos, Jacqueline, Fløisand, Yngvar, van Marwijk Kooy, Marinus, Manz, Markus G, Ossenkoppele, Gert J, Tick, Lidwine W, Havelange, Violaine, Löwenberg, Bob, Jongen-Lavrencic, Mojca, Valk, Peter J M
Published in Journal of clinical oncology (01.02.2023)
Published in Journal of clinical oncology (01.02.2023)
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Journal Article
Widespread chromatin context-dependencies of DNA double-strand break repair proteins
Vergara, Xabier, Manjón, Anna G., de Haas, Marcel, Morris, Ben, Schep, Ruben, Leemans, Christ, Friskes, Anoek, Beijersbergen, Roderick L., Sanders, Mathijs A., Medema, René H., van Steensel, Bas
Published in Nature communications (22.06.2024)
Published in Nature communications (22.06.2024)
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Journal Article
Inherited MUTYH mutations cause elevated somatic mutation rates and distinctive mutational signatures in normal human cells
Robinson, Philip S., Thomas, Laura E., Abascal, Federico, Jung, Hyunchul, Harvey, Luke M. R., West, Hannah D., Olafsson, Sigurgeir, Lee, Bernard C. H., Coorens, Tim H. H., Lee-Six, Henry, Butlin, Laura, Lander, Nicola, Truscott, Rebekah, Sanders, Mathijs A., Lensing, Stefanie V., Buczacki, Simon J. A., ten Hoopen, Rogier, Coleman, Nicholas, Brunton-Sim, Roxanne, Rushbrook, Simon, Saeb-Parsy, Kourosh, Lalloo, Fiona, Campbell, Peter J., Martincorena, Iñigo, Sampson, Julian R., Stratton, Michael R.
Published in Nature communications (08.07.2022)
Published in Nature communications (08.07.2022)
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Journal Article
Mutational landscape of normal epithelial cells in Lynch Syndrome patients
Lee, Bernard C. H., Robinson, Philip S., Coorens, Tim H. H., Yan, Helen H. N., Olafsson, Sigurgeir, Lee-Six, Henry, Sanders, Mathijs A., Siu, Hoi Cheong, Hewinson, James, Yue, Sarah S. K., Tsui, Wai Yin, Chan, Annie S. Y., Chan, Anthony K. W., Ho, Siu Lun, Campbell, Peter J., Martincorena, Inigo, Buczacki, Simon J. A., Yuen, Siu Tsan, Leung, Suet Yi, Stratton, Michael R.
Published in Nature communications (17.05.2022)
Published in Nature communications (17.05.2022)
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Journal Article
Autophagy inhibition as a potential future targeted therapy for ETV6-RUNX1-driven B-cell precursor acute lymphoblastic leukemia
Polak, Roel, Bierings, Marc B, van der Leije, Cindy S, Sanders, Mathijs A, Roovers, Onno, Marchante, João R M, Boer, Judith M, Cornelissen, Jan J, Pieters, Rob, den Boer, Monique L, Buitenhuis, Miranda
Published in Haematologica (Roma) (01.04.2019)
Published in Haematologica (Roma) (01.04.2019)
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Journal Article
Sequential gain of mutations in severe congenital neutropenia progressing to acute myeloid leukemia
Beekman, Renée, Valkhof, Marijke G., Sanders, Mathijs A., van Strien, Paulette M.H., Haanstra, Jurgen R., Broeders, Lianne, Geertsma-Kleinekoort, Wendy M., Veerman, Anjo J.P., Valk, Peter J.M., Verhaak, Roel G., Löwenberg, Bob, Touw, Ivo P.
Published in Blood (31.05.2012)
Published in Blood (31.05.2012)
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Journal Article
An autonomous CEBPA enhancer specific for myeloid-lineage priming and neutrophilic differentiation
Avellino, Roberto, Havermans, Marije, Erpelinck, Claudia, Sanders, Mathijs A., Hoogenboezem, Remco, van de Werken, Harmen J.G., Rombouts, Elwin, van Lom, Kirsten, van Strien, Paulina M.H., Gebhard, Claudia, Rehli, Michael, Pimanda, John, Beck, Dominik, Erkeland, Stefan, Kuiken, Thijs, de Looper, Hans, Gröschel, Stefan, Touw, Ivo, Bindels, Eric, Delwel, Ruud
Published in Blood (16.06.2016)
Published in Blood (16.06.2016)
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Journal Article