SARS-CoV-2 variants with mutations at the S1/S2 cleavage site are generated in vitro during propagation in TMPRSS2-deficient cells
Sasaki, Michihito, Uemura, Kentaro, Sato, Akihiko, Toba, Shinsuke, Sanaki, Takao, Maenaka, Katsumi, Hall, William W, Orba, Yasuko, Sawa, Hirofumi
Published in PLoS pathogens (21.01.2021)
Published in PLoS pathogens (21.01.2021)
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MRC5 cells engineered to express ACE2 serve as a model system for the discovery of antivirals targeting SARS-CoV-2
Uemura, Kentaro, Sasaki, Michihito, Sanaki, Takao, Toba, Shinsuke, Takahashi, Yoshimasa, Orba, Yasuko, Hall, William W., Maenaka, Katsumi, Sawa, Hirofumi, Sato, Akihiko
Published in Scientific reports (08.03.2021)
Published in Scientific reports (08.03.2021)
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TMPRSS11D and TMPRSS13 Activate the SARS-CoV-2 Spike Protein
Kishimoto, Mai, Uemura, Kentaro, Sanaki, Takao, Sato, Akihiko, Hall, William W, Kariwa, Hiroaki, Orba, Yasuko, Sawa, Hirofumi, Sasaki, Michihito
Published in Viruses (01.03.2021)
Published in Viruses (01.03.2021)
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Efficacy of ensitrelvir against SARS-CoV-2 in a delayed-treatment mouse model
Nobori, Haruaki, Fukao, Keita, Kuroda, Takayuki, Anan, Naomi, Tashima, Ryoichi, Nakashima, Masaaki, Noda, Sayuri, Tajiri, Minako, Torii, Mikinori, Toba, Shinsuke, Uemura, Kentaro, Sanaki, Takao, Shishido, Takao, Tachibana, Yuki, Kato, Teruhisa
Published in Journal of antimicrobial chemotherapy (28.10.2022)
Published in Journal of antimicrobial chemotherapy (28.10.2022)
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Contribution of synovial macrophages to rat advanced osteoarthritis pain resistant to cyclooxygenase inhibitors
Sakurai, Yusuke, Fujita, Masahide, Kawasaki, Shiori, Sanaki, Takao, Yoshioka, Takeshi, Higashino, Kenichi, Tofukuji, Soichi, Yoneda, Sosuke, Takahashi, Tatsuya, Koda, Ken, Asaki, Toshiyuki, Hasegawa, Minoru, Morioka, Yasuhide
Published in Pain (Amsterdam) (01.04.2019)
Published in Pain (Amsterdam) (01.04.2019)
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SARS-CoV-2 Bearing a Mutation at the S1/S2 Cleavage Site Exhibits Attenuated Virulence and Confers Protective Immunity
Sasaki, Michihito, Toba, Shinsuke, Itakura, Yukari, Chambaro, Herman M, Kishimoto, Mai, Tabata, Koshiro, Intaruck, Kittiya, Uemura, Kentaro, Sanaki, Takao, Sato, Akihiko, Hall, William W, Orba, Yasuko, Sawa, Hirofumi
Published in mBio (31.08.2021)
Published in mBio (31.08.2021)
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Inhibition of dengue virus infection by 1-stearoyl-2-arachidonoyl-phosphatidylinositol in vitro
Sanaki, Takao, Wakabayashi, Masato, Yoshioka, Takeshi, Yoshida, Ryu, Shishido, Takao, Hall, William W, Sawa, Hirofumi, Sato, Akihiko
Published in The FASEB journal (01.12.2019)
Published in The FASEB journal (01.12.2019)
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Possible roles of long-chain sphingomyelines and sphingomyelin synthase 2 in mouse macrophage inflammatory response
Sakamoto, Hideaki, Yoshida, Tetsuya, Sanaki, Takao, Shigaki, Shuhei, Morita, Hirotoshi, Oyama, Miki, Mitsui, Masaru, Tanaka, Yoshikazu, Nakano, Toru, Mitsutake, Susumu, Igarashi, Yasuyuki, Takemoto, Hiroshi
Published in Biochemical and biophysical research communications (08.01.2017)
Published in Biochemical and biophysical research communications (08.01.2017)
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Characterization of the In Vitro and In Vivo Efficacy of Baloxavir Marboxil against H5 Highly Pathogenic Avian Influenza Virus Infection
Taniguchi, Keiichi, Ando, Yoshinori, Kobayashi, Masanori, Toba, Shinsuke, Nobori, Haruaki, Sanaki, Takao, Noshi, Takeshi, Kawai, Makoto, Yoshida, Ryu, Sato, Akihiko, Shishido, Takao, Naito, Akira, Matsuno, Keita, Okamatsu, Masatoshi, Sakoda, Yoshihiro, Kida, Hiroshi
Published in Viruses (01.01.2022)
Published in Viruses (01.01.2022)
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A hybrid strategy using global analysis of oxidized fatty acids and bioconversion by Bacillus circulans
Sanaki, Takao, Inaba, Yoko, Fujiwara, Takuji, Yoshioka, Takeshi, Matsushima, Keisuke, Minagawa, Kazuyuki, Higashino, Kenichi, Nakano, Toru, Numata, Yoshito
Published in Rapid communications in mass spectrometry (30.03.2016)
Published in Rapid communications in mass spectrometry (30.03.2016)
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5-Hydroxymethyltubercidin exhibits potent antiviral activity against flaviviruses and coronaviruses, including SARS-CoV-2
Uemura, Kentaro, Nobori, Haruaki, Sato, Akihiko, Sanaki, Takao, Toba, Shinsuke, Sasaki, Michihito, Murai, Akiho, Saito-Tarashima, Noriko, Minakawa, Noriaki, Orba, Yasuko, Kariwa, Hiroaki, Hall, William W., Sawa, Hirofumi, Matsuda, Akira, Maenaka, Katsumi
Published in iScience (22.10.2021)
Published in iScience (22.10.2021)
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Direct Involvement of Arachidonic Acid in the Development of Ear Edema via TRPV3
Sanaki, Takao, Kasai-Yamamoto, Erika, Yoshioka, Takeshi, Sakai, Shota, Yuyama, Kohei, Fujiwara, Takuji, Numata, Yoshito, Igarashi, Yasuyuki
Published in Journal of Oleo Science (01.06.2017)
Published in Journal of Oleo Science (01.06.2017)
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Efficacy and Safety of Ensitrelvir in Patients With Mild-to-Moderate Coronavirus Disease 2019: The Phase 2b Part of a Randomized, Placebo-Controlled, Phase 2/3 Study
Mukae, Hiroshi, Yotsuyanagi, Hiroshi, Ohmagari, Norio, Doi, Yohei, Sakaguchi, Hiroki, Sonoyama, Takuhiro, Ichihashi, Genki, Sanaki, Takao, Baba, Keiko, Tsuge, Yuko, Uehara, Takeki
Published in Clinical infectious diseases (17.04.2023)
Published in Clinical infectious diseases (17.04.2023)
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A Randomized Phase 2/3 Study of Ensitrelvir, a Novel Oral SARS-CoV-2 3C-Like Protease Inhibitor, in Japanese Patients with Mild-to-Moderate COVID-19 or Asymptomatic SARS-CoV-2 Infection: Results of the Phase 2a Part
Mukae, Hiroshi, Yotsuyanagi, Hiroshi, Ohmagari, Norio, Doi, Yohei, Imamura, Takumi, Sonoyama, Takuhiro, Fukuhara, Takahiro, Ichihashi, Genki, Sanaki, Takao, Baba, Keiko, Takeda, Yosuke, Tsuge, Yuko, Uehara, Takeki
Published in Antimicrobial agents and chemotherapy (18.10.2022)
Published in Antimicrobial agents and chemotherapy (18.10.2022)
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Discovery of S‑217622, a Noncovalent Oral SARS-CoV‑2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19
Unoh, Yuto, Uehara, Shota, Nakahara, Kenji, Nobori, Haruaki, Yamatsu, Yukiko, Yamamoto, Shiho, Maruyama, Yuki, Taoda, Yoshiyuki, Kasamatsu, Koji, Suto, Takahiro, Kouki, Kensuke, Nakahashi, Atsufumi, Kawashima, Sho, Sanaki, Takao, Toba, Shinsuke, Uemura, Kentaro, Mizutare, Tohru, Ando, Shigeru, Sasaki, Michihito, Orba, Yasuko, Sawa, Hirofumi, Sato, Akihiko, Sato, Takafumi, Kato, Teruhisa, Tachibana, Yuki
Published in Journal of medicinal chemistry (12.05.2022)
Published in Journal of medicinal chemistry (12.05.2022)
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Journal Article
Discovery of S-217622, a Noncovalent Oral SARS-CoV-2 3CLProtease Inhibitor Clinical Candidate for Treating COVID-19
Unoh, Yuto, Uehara, Shota, Nakahara, Kenji, Nobori, Haruaki, Yamatsu, Yukiko, Yamamoto, Shiho, Maruyama, Yuki, Taoda, Yoshiyuki, Kasamatsu, Koji, Suto, Takahiro, Kouki, Kensuke, Nakahashi, Atsufumi, Kawashima, Sho, Sanaki, Takao, Toba, Shinsuke, Uemura, Kentaro, Mizutare, Tohru, Ando, Shigeru, Sasaki, Michihito, Orba, Yasuko, Sawa, Hirofumi, Sato, Akihiko, Sato, Takafumi, Kato, Teruhisa, Tachibana, Yuki
Published in Journal of medicinal chemistry (12.05.2022)
Published in Journal of medicinal chemistry (12.05.2022)
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A phase 2/3 study of S-217622 in participants with SARS-CoV-2 infection (Phase 3 part)
Yotsuyanagi, Hiroshi, Ohmagari, Norio, Doi, Yohei, Imamura, Takumi, Sonoyama, Takuhiro, Ichihashi, Genki, Sanaki, Takao, Tsuge, Yuko, Uehara, Takeki, Mukae, Hiroshi
Published in Medicine (Baltimore) (22.02.2023)
Published in Medicine (Baltimore) (22.02.2023)
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Acsl1 is essential for skin barrier function through the activation of linoleic acid and biosynthesis of ω-O-acylceramide in mice
Kato, Ayumi, Ito, Mana, Sanaki, Takao, Okuda, Tomohiko, Tsuchiya, Noriko, Yoshimoto, Ryo, Yukioka, Hideo
Published in Biochimica et biophysica acta. Molecular and cell biology of lipids (01.02.2022)
Published in Biochimica et biophysica acta. Molecular and cell biology of lipids (01.02.2022)
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