Discovery of Inhibitors of 4′-Phosphopantetheine Adenylyltransferase (PPAT) To Validate PPAT as a Target for Antibacterial Therapy
DE JONGE, Boudewijn L. M, WALKUP, Grant K, JOHNSTONE, Michele, LAGANAS, Valerie, HAJEC, Laurel, GU, Rong-Fang, HAIHONG NI, CHEN, Brendan, HUTCHINGS, Kim, HOLT, Elise, MCKINNEY, David, NING GAO, LAHIRI, Sushmita D, LIVCHAK, Stephania, THRESHER, Jason, HOAN HUYNH, NECKERMANN, Georg, UTLEY, Luke, NASH, Tory J, BROCK, Jesse, SAN MARTIN, Maryann, KUTSCHKE, Amy
Published in Antimicrobial Agents and Chemotherapy (01.12.2013)
Published in Antimicrobial Agents and Chemotherapy (01.12.2013)
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Journal Article
AZD4573 Is a Highly Selective CDK9 Inhibitor That Suppresses MCL-1 and Induces Apoptosis in Hematologic Cancer Cells
Cidado, Justin, Boiko, Scott, Proia, Theresa, Ferguson, Douglas, Criscione, Steven W, San Martin, Maryann, Pop-Damkov, Petar, Su, Nancy, Roamio Franklin, Valar Nila, Sekhar Reddy Chilamakuri, Chandra, D'Santos, Clive S, Shao, Wenlin, Saeh, Jamal C, Koch, Raphael, Weinstock, David M, Zinda, Michael, Fawell, Stephen E, Drew, Lisa
Published in Clinical cancer research (15.02.2020)
Published in Clinical cancer research (15.02.2020)
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Journal Article
A pharmacokinetic–pharmacodynamic model for the MET tyrosine kinase inhibitor, savolitinib, to explore target inhibition requirements for anti‐tumour activity
Jones, Rhys D.O., Grondine, Mike, Borodovsky, Alexandra, San Martin, Maryann, DuPont, Michelle, D'Cruz, Celina, Schuller, Alwin, Henry, Ryan, Barry, Evan, Castriotta, Lillian, Anjum, Rana, Petersson, Klas, Sahota, Tarjinder, Ahmed, Ghada F.
Published in British journal of pharmacology (01.02.2021)
Published in British journal of pharmacology (01.02.2021)
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Ceftaroline efficacy against high-MIC clinical Staphylococcus aureus isolates in an in vitro hollow-fibre infection model
Singh, Renu, Almutairi, Mashal, Alm, Richard A, Lahiri, Sushmita D, San Martin, Maryann, Chen, April, Ambler, Jane E
Published in Journal of antimicrobial chemotherapy (01.10.2017)
Published in Journal of antimicrobial chemotherapy (01.10.2017)
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PARP inhibition is a modulator of anti-tumor immune response in BRCA-deficient tumors
Staniszewska, Anna D., Armenia, Joshua, King, Matthew, Michaloglou, Chrysiis, Reddy, Avinash, Singh, Maneesh, San Martin, Maryann, Prickett, Laura, Wilson, Zena, Proia, Theresa, Russell, Deanna, Thomas, Morgan, Delpuech, Oona, O'Connor, Mark J., Leo, Elisabetta, Angell, Helen, Valge-Archer, Viia
Published in Oncoimmunology (31.12.2022)
Published in Oncoimmunology (31.12.2022)
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Kupffer cells abrogate cholestatic liver injury in mice
Gehring, Stephan, Dickson, Elizabeth M, San Martin, Maryann E, van Rooijen, Nico, Papa, Elaine F, Harty, Mark W, Tracy, Jr, Thomas F, Gregory, Stephen H
Published in Gastroenterology (New York, N.Y. 1943) (01.03.2006)
Published in Gastroenterology (New York, N.Y. 1943) (01.03.2006)
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Journal Article
암 치료를 위한 조합
PROIA THERESA, DREW LISA, SAN MARTIN MARYANN, CIDADO JUSTIN, BOIKO SCOTT
Year of Publication 13.01.2021
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Year of Publication 13.01.2021
Patent
암을 치료하기 위한 BTK 억제제 및 CDK9의 억제제의 조합
PROIA THERESA, DREW LISA, SAN MARTIN MARYANN, CIDADO JUSTIN, BOIKO SCOTT
Year of Publication 27.05.2020
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Year of Publication 27.05.2020
Patent
Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies
Barlaam, Bernard, Casella, Robert, Cidado, Justin, Cook, Calum, De Savi, Chris, Dishington, Allan, Donald, Craig S, Drew, Lisa, Ferguson, Andrew D, Ferguson, Douglas, Glossop, Steve, Grebe, Tyler, Gu, Chungang, Hande, Sudhir, Hawkins, Janet, Hird, Alexander W, Holmes, Jane, Horstick, James, Jiang, Yun, Lamb, Michelle L, McGuire, Thomas M, Moore, Jane E, O’Connell, Nichole, Pike, Andy, Pike, Kurt G, Proia, Theresa, Roberts, Bryan, San Martin, Maryann, Sarkar, Ujjal, Shao, Wenlin, Stead, Darren, Sumner, Neil, Thakur, Kumar, Vasbinder, Melissa M, Varnes, Jeffrey G, Wang, Jianyan, Wang, Lei, Wu, Dedong, Wu, Liangwei, Yang, Bin, Yao, Tieguang
Published in Journal of medicinal chemistry (24.12.2020)
Published in Journal of medicinal chemistry (24.12.2020)
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Journal Article
Targeting Bfl-1 via acute CDK9 inhibition overcomes intrinsic BH3-mimetic resistance in lymphomas
Boiko, Scott, Proia, Theresa, San Martin, Maryann, Gregory, Gareth P., Wu, Michelle Min, Aryal, Neeraj, Hattersley, Maureen, Shao, Wenlin, Saeh, Jamal C., Fawell, Stephen E., Johnstone, Ricky W., Drew, Lisa, Cidado, Justin
Published in Blood (27.05.2021)
Published in Blood (27.05.2021)
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Abstract 1813: The genetic makeup of patient-derived xenografts shapes the immune landscape of humanized mice tumors
Singh, Maneesh, Bradshaw, Laura, Prickett, Laura B., Matthew, Griffin, Martin, Maryann San, Monks, Noel, Drew, Lisa, Barry, Simon T., Reimer, Corinne, Proia, Theresa
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
Abstract 1664: Inhibition of arginase in combination with radiation therapy shows increased immune-activation and anti-tumor activity in syngeneic tumor models
Schuller, Alwin, Doshi, Aatman, Cantin, Susan, Griffin, Matt, Martin, Maryann San, Proia, Theresa, Reimer, Corinne, Mlynarski, Scott, Finlay, Ray, Shao, Wenlin
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
Abstract 967: Anti-tumor and immune effects of olaparib +/- anti-PD-L1 in preclinical BRCA1mut tumor models
Staniszewska, Anna, Armenia, Joshua, King, Matthew, Michaloglou, Chrysiis, Singh, Maneesh, Martin, Maryann San, Wilson, Zena, Proia, Theresa, Delpuech, Oona, O'Connor, Mark, Leo, Elisabetta, Valge-Archer, Viia
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Diverse Drug Combinations with an Eed Inhibitor Confer Context-Specific Benefit across Multiple Tumor Types
Hsu, Jessie Hao-Ru, Borodovsky, Sasha, Wang, Yanjun, San Martin, Maryann, Shen, Minhui, Woods, Haley, Rosen, Alan, Bagal, Sharan, Rawlins, Philip, Robinson, James, Code, Erin, Prickett, Laura, Bloecher, Andrew
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article
Combination of AZD4573, a Selective CDK9 Inhibitor, with Other Cell Death Inducing Agents Can Overcome De Novo Venetoclax Resistance in Preclinical Hematologic Tumor Models
Cidado, Justin, Boiko, Scott, Proia, Theresa, Woods, Haley, Tavana, Omid, San Martin, Maryann, Tron, Adriana E., Shao, Wenlin, Drew, Lisa
Published in Blood (29.11.2018)
Published in Blood (29.11.2018)
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Journal Article
Abstract 297: AZD4573: Mechanistic PKPD model linking CDK9 inhibition to Mcl1 depletion and induction of apoptosis in preclinical AML model
Ferguson, Douglas, Proia, Theresa, Cidado, Justin, Boiko, Scott, Martin, Maryann San, Criscione, Steven, Shao, Wenlin, Drew, Lisa
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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