MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis
Samson, Andre L., Zhang, Ying, Geoghegan, Niall D., Gavin, Xavier J., Davies, Katherine A., Mlodzianoski, Michael J., Whitehead, Lachlan W., Frank, Daniel, Garnish, Sarah E., Fitzgibbon, Cheree, Hempel, Anne, Young, Samuel N., Jacobsen, Annette V., Cawthorne, Wayne, Petrie, Emma J., Faux, Maree C., Shield-Artin, Kristy, Lalaoui, Najoua, Hildebrand, Joanne M., Silke, John, Rogers, Kelly L., Lessene, Guillaume, Hawkins, Edwin D., Murphy, James M.
Published in Nature communications (19.06.2020)
Published in Nature communications (19.06.2020)
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VDAC2 enables BAX to mediate apoptosis and limit tumor development
Chin, Hui San, Li, Mark X., Tan, Iris K. L., Ninnis, Robert L., Reljic, Boris, Scicluna, Kristen, Dagley, Laura F., Sandow, Jarrod J., Kelly, Gemma L., Samson, Andre L., Chappaz, Stephane, Khaw, Seong L., Chang, Catherine, Morokoff, Andrew, Brinkmann, Kerstin, Webb, Andrew, Hockings, Colin, Hall, Cathrine M., Kueh, Andrew J., Ryan, Michael T., Kluck, Ruth M., Bouillet, Philippe, Herold, Marco J., Gray, Daniel H. D., Huang, David C. S., van Delft, Mark F., Dewson, Grant
Published in Nature communications (26.11.2018)
Published in Nature communications (26.11.2018)
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Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis
Garnish, Sarah E., Meng, Yanxiang, Koide, Akiko, Sandow, Jarrod J., Denbaum, Eric, Jacobsen, Annette V., Yeung, Wayland, Samson, Andre L., Horne, Christopher R., Fitzgibbon, Cheree, Young, Samuel N., Smith, Phoebe P. C., Webb, Andrew I., Petrie, Emma J., Hildebrand, Joanne M., Kannan, Natarajan, Czabotar, Peter E., Koide, Shohei, Murphy, James M.
Published in Nature communications (13.04.2021)
Published in Nature communications (13.04.2021)
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Journal Article
Endogenous fibrinolysis facilitates clot retraction in vivo
Samson, Andre L., Alwis, Imala, Maclean, Jessica A.A., Priyananda, Pramith, Hawkett, Brian, Schoenwaelder, Simone M., Jackson, Shaun P.
Published in Blood (07.12.2017)
Published in Blood (07.12.2017)
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Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis
Meng, Yanxiang, Davies, Katherine A., Fitzgibbon, Cheree, Young, Samuel N., Garnish, Sarah E., Horne, Christopher R., Luo, Cindy, Garnier, Jean-Marc, Liang, Lung-Yu, Cowan, Angus D., Samson, Andre L., Lessene, Guillaume, Sandow, Jarrod J., Czabotar, Peter E., Murphy, James M.
Published in Nature communications (22.11.2021)
Published in Nature communications (22.11.2021)
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Identification of MLKL membrane translocation as a checkpoint in necroptotic cell death using Monobodies
Petrie, Emma J., Birkinshaw, Richard W., Koide, Akiko, Denbaum, Eric, Hildebrand, Joanne M., Garnish, Sarah E., Davies, Katherine A., Sandow, Jarrod J., Samson, Andre L., Gavin, Xavier, Fitzgibbon, Cheree, Young, Samuel N., Hennessy, Patrick J., Smith, Phoebe P. C., Webb, Andrew I., Czabotar, Peter E., Koide, Shohei, Murphy, James M.
Published in Proceedings of the National Academy of Sciences - PNAS (14.04.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (14.04.2020)
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In situ visualization of endothelial cell-derived extracellular vesicle formation in steady state and malignant conditions
Atkin-Smith, Georgia K., Santavanond, Jascinta P., Light, Amanda, Rimes, Joel S., Samson, Andre L., Er, Jeremy, Liu, Joy, Johnson, Darryl N., Le Page, Mélanie, Rajasekhar, Pradeep, Yip, Raymond K. H., Geoghegan, Niall D., Rogers, Kelly L., Chang, Catherine, Bryant, Vanessa L., Margetts, Mai, Keightley, M. Cristina, Kilpatrick, Trevor J., Binder, Michele D., Tran, Sharon, Lee, Erinna F., Fairlie, Walter D., Ozkocak, Dilara C., Wei, Andrew H., Hawkins, Edwin D., Poon, Ivan K. H.
Published in Nature communications (22.10.2024)
Published in Nature communications (22.10.2024)
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MouseMove: an open source program for semi-automated analysis of movement and cognitive testing in rodents
Samson, Andre L., Ju, Lining, Ah Kim, Hyun, Zhang, Shenpeng R., Lee, Jessica A. A., Sturgeon, Sharelle A., Sobey, Christopher G., Jackson, Shaun P., Schoenwaelder, Simone M.
Published in Scientific reports (04.11.2015)
Published in Scientific reports (04.11.2015)
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Dendritic Cell-Mediated Phagocytosis but Not Immune Activation Is Enhanced by Plasmin
Borg, Rachael J, Samson, Andre L, Au, Amanda E-L, Scholzen, Anja, Fuchsberger, Martina, Kong, Ying Y, Freeman, Roxann, Mifsud, Nicole A, Plebanski, Magdalena, Medcalf, Robert L
Published in PloS one (01.07.2015)
Published in PloS one (01.07.2015)
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The tissue-type plasminogen activator― plasminogen activator inhibitor 1 complex promotes neurovascular injury in brain trauma: evidence from mice and humans
SASHINDRANATH, Maithili, SALES, Eunice, ROSENFELD, Jeffrey V, MADANI, Rime, VASSALLI, Jean-Dominique, SU, Enming J, LAWRENCE, Daniel A, MEDCALF, Robert L, DAGLAS, Maria, FREEMAN, Roxann, SAMSON, Andre L, COPS, Elisa J, BECKHAM, Simone, GALLE, Adam, MCLEAN, Catriona, MORGANTI-KOSSMANN, Cristina
Published in Brain (London, England : 1878) (01.11.2012)
Published in Brain (London, England : 1878) (01.11.2012)
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Nucleocytoplasmic Coagulation: An Injury-Induced Aggregation Event that Disulfide Crosslinks Proteins and Facilitates Their Removal by Plasmin
Samson, Andre L., Knaupp, Anja S., Sashindranath, Maithili, Borg, Rachael J., Au, Amanda E.-L., Cops, Elisa J., Saunders, Helen M., Cody, Stephen H., McLean, Catriona A., Nowell, Cameron J., Hughes, Victoria A., Bottomley, Stephen P., Medcalf, Robert L.
Published in Cell reports (Cambridge) (25.10.2012)
Published in Cell reports (Cambridge) (25.10.2012)
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A nonfibrin macromolecular cofactor for tPA-mediated plasmin generation following cellular injury
Samson, Andre L., Borg, Rachael J., Niego, Be'eri, Wong, Connie H.Y., Crack, Peter J., Yongqing, Tang, Medcalf, Robert L.
Published in Blood (27.08.2009)
Published in Blood (27.08.2009)
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Ubiquitylation of RIPK3 beyond-the-RHIM can limit RIPK3 activity and cell death
Frank, Daniel, Garnish, Sarah E., Sandow, Jarrod J., Weir, Ashley, Liu, Lin, Clayer, Elise, Meza, Lizeth, Rashidi, Maryam, Cobbold, Simon A., Scutts, Simon R., Doerflinger, Marcel, Anderton, Holly, Lawlor, Kate E., Lalaoui, Najoua, Kueh, Andrew J., Eng, Vik Ven, Ambrose, Rebecca L., Herold, Marco J., Samson, Andre L., Feltham, Rebecca, Murphy, James M., Ebert, Gregor, Pearson, Jaclyn S., Vince, James E.
Published in iScience (15.07.2022)
Published in iScience (15.07.2022)
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Physicochemical properties that control protein aggregation also determine whether a protein is retained or released from necrotic cells
Samson, Andre L., Ho, Bosco, Au, Amanda E., Schoenwaelder, Simone M., Smyth, Mark J., Bottomley, Stephen P., Kleifeld, Oded, Medcalf, Robert L.
Published in Open biology (01.11.2016)
Published in Open biology (01.11.2016)
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Journal Article
Location, location, location: A compartmentalized view of TNF-induced necroptotic signaling
Samson, André L, Garnish, Sarah E, Hildebrand, Joanne M, Murphy, James M
Published in Science signaling (02.02.2021)
Published in Science signaling (02.02.2021)
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Journal Article
The web of death: the expanding complexity of necroptotic signaling
Horne, Christopher R., Samson, André L., Murphy, James M.
Published in Trends in cell biology (01.02.2023)
Published in Trends in cell biology (01.02.2023)
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Journal Article
Ferroptosis mediates selective motor neuron death in amyotrophic lateral sclerosis
Wang, Taide, Tomas, Doris, Perera, Nirma D., Cuic, Brittany, Luikinga, Sophia, Viden, Aida, Barton, Samantha K., McLean, Catriona A., Samson, André L., Southon, Adam, Bush, Ashley I., Murphy, James M., Turner, Bradley J.
Published in Cell death and differentiation (01.06.2022)
Published in Cell death and differentiation (01.06.2022)
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