Coupling Data Mining and Laboratory Experiments to Discover Drug Interactions Causing QT Prolongation
Lorberbaum, Tal, MA, Sampson, Kevin J., PhD, Chang, Jeremy B., PhD, Iyer, Vivek, MD, MSE, Woosley, Raymond L., MD, PhD, Kass, Robert S., PhD, Tatonetti, Nicholas P., PhD
Published in Journal of the American College of Cardiology (18.10.2016)
Published in Journal of the American College of Cardiology (18.10.2016)
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Journal Article
Reengineering an Antiarrhythmic Drug Using Patient hiPSC Cardiomyocytes to Improve Therapeutic Potential and Reduce Toxicity
McKeithan, Wesley L., Feyen, Dries A.M., Bruyneel, Arne A.N., Okolotowicz, Karl J., Ryan, Daniel A., Sampson, Kevin J., Potet, Franck, Savchenko, Alex, Gómez-Galeno, Jorge, Vu, Michelle, Serrano, Ricardo, George, Alfred L., Kass, Robert S., Cashman, John R., Mercola, Mark
Published in Cell stem cell (05.11.2020)
Published in Cell stem cell (05.11.2020)
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Journal Article
KCNE1 alters the voltage sensor movements necessary to open the KCNQ1 channel gate
Osteen, Jeremiah D., Gonzalez, Carlos, Sampson, Kevin J., Iyer, Vivek, Rebolledo, Santiago, Larsson, H. Peter, Kass, Robert S., Jan, Lily Yeh
Published in Proceedings of the National Academy of Sciences - PNAS (28.12.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (28.12.2010)
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Journal Article
Pharmacological rescue of specific long QT variants of KCNQ1/KCNE1 channels
Zou, Xinle, Wu, Xiaoan, Sampson, Kevin J, Colecraft, Henry M, Larsson, H Peter, Kass, Robert S
Published in Frontiers in physiology (23.11.2022)
Published in Frontiers in physiology (23.11.2022)
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Journal Article
Potassium Channels as Therapeutic Targets in Pulmonary Arterial Hypertension
Redel-Traub, Gabriel, Sampson, Kevin J, Kass, Robert S, Bohnen, Michael S
Published in Biomolecules (Basel, Switzerland) (22.09.2022)
Published in Biomolecules (Basel, Switzerland) (22.09.2022)
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Journal Article
Two small-molecule activators share similar effector sites in the KCNQ1 channel pore but have distinct effects on voltage sensor movements
Chen, Lei, Peng, Gary, Comollo, Thomas W, Zou, Xinle, Sampson, Kevin J, Larsson, H Peter, Kass, Robert S
Published in Frontiers in physiology (25.07.2022)
Published in Frontiers in physiology (25.07.2022)
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Journal Article
Allosteric gating mechanism underlies the flexible gating of KCNQ1 potassium channels
Osteen, Jeremiah D., Barro-Soria, Rene, Robey, Seth, Sampson, Kevin J., Kass, Robert S., Larsson, H. Peter
Published in Proceedings of the National Academy of Sciences - PNAS (01.05.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (01.05.2012)
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Journal Article
Molecular basis of ranolazine block of LQT‐3 mutant sodium channels: evidence for site of action
Fredj, Sandra, Sampson, Kevin J, Liu, Huajun, Kass, Robert S
Published in British journal of pharmacology (01.05.2006)
Published in British journal of pharmacology (01.05.2006)
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Journal Article
Exploring mutation specific beta blocker pharmacology of the pathogenic late sodium channel current from patient-specific pluripotent stem cell myocytes derived from long QT syndrome mutation carriers
Comollo, Thomas W., Zou, Xinle, Zhang, Chuangeng, Kesters, Divya, Hof, Thomas, Sampson, Kevin J., Kass, Robert S.
Published in Channels (Austin, Tex.) (31.12.2022)
Published in Channels (Austin, Tex.) (31.12.2022)
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Journal Article
Cardiac Delayed Rectifier Potassium Channels in Health and Disease
Chen, Lei, Sampson, Kevin J, Kass, Robert S
Published in Cardiac electrophysiology clinics (01.06.2016)
Published in Cardiac electrophysiology clinics (01.06.2016)
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Journal Article
The Impact of Heterozygous KCNK3 Mutations Associated With Pulmonary Arterial Hypertension on Channel Function and Pharmacological Recovery
Bohnen, Michael S., Roman‐Campos, Danilo, Terrenoire, Cecile, Jnani, Jack, Sampson, Kevin J., Chung, Wendy K., Kass, Robert S.
Published in Journal of the American Heart Association (01.09.2017)
Published in Journal of the American Heart Association (01.09.2017)
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Journal Article
Biophysical properties of slow potassium channels in human embryonic stem cell derived cardiomyocytes implicate subunit stoichiometry
Wang, Kai, Terrenoire, Cecile, Sampson, Kevin J., Iyer, Vivek, Osteen, Jeremiah D., Lu, Jonathan, Keller, Gordon, Kotton, Darrell N., Kass, Robert S.
Published in The Journal of physiology (01.12.2011)
Published in The Journal of physiology (01.12.2011)
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Journal Article
cardiac IKs channel, complex indeed
Osteen, Jeremiah D, Sampson, Kevin J, Kass, Robert S
Published in Proceedings of the National Academy of Sciences - PNAS (02.11.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (02.11.2010)
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Journal Article
Characterization of KCNQ1 atrial fibrillation mutations reveals distinct dependence on KCNE1
Chan, Priscilla J, Osteen, Jeremiah D, Xiong, Dazhi, Bohnen, Michael S, Doshi, Darshan, Sampson, Kevin J, Marx, Steven O, Karlin, Arthur, Kass, Robert S
Published in The Journal of general physiology (01.02.2012)
Published in The Journal of general physiology (01.02.2012)
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Journal Article
A novel and lethal de novo LQT-3 mutation in a newborn with distinct molecular pharmacology and therapeutic response
Bankston, John R, Yue, Minerva, Chung, Wendy, Spyres, Meghan, Pass, Robert H, Silver, Eric, Sampson, Kevin J, Kass, Robert S
Published in PloS one (05.12.2007)
Published in PloS one (05.12.2007)
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