SIRT3 Deacetylates and Activates OPA1 To Regulate Mitochondrial Dynamics during Stress
Samant, Sadhana A., Zhang, Hannah J., Hong, Zhigang, Pillai, Vinodkumar B., Sundaresan, Nagalingam R., Wolfgeher, Donald, Archer, Stephen L., Chan, David C., Gupta, Mahesh P.
Published in Molecular and Cellular Biology (01.03.2014)
Published in Molecular and Cellular Biology (01.03.2014)
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Journal Article
The nuclear and mitochondrial sirtuins, Sirt6 and Sirt3, regulate each other's activity and protect the heart from developing obesity-mediated diabetic cardiomyopathy
Kanwal, Abhinav, Pillai, Vinodkumar B, Samant, Sadhana, Gupta, Madhu, Gupta, Mahesh P
Published in The FASEB journal (01.10.2019)
Published in The FASEB journal (01.10.2019)
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Journal Article
Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3
Pillai, Vinodkumar B., Samant, Sadhana, Sundaresan, Nagalingam R., Raghuraman, Hariharasundaram, Kim, Gene, Bonner, Michael Y., Arbiser, Jack L., Walker, Douglas I., Jones, Dean P., Gius, David, Gupta, Mahesh P.
Published in Nature communications (14.04.2015)
Published in Nature communications (14.04.2015)
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Journal Article
SIRT3 Is a Stress-Responsive Deacetylase in Cardiomyocytes That Protects Cells from Stress-Mediated Cell Death by Deacetylation of Ku70
Sundaresan, Nagalingam R., Samant, Sadhana A., Pillai, Vinodkumar B., Rajamohan, Senthilkumar B., Gupta, Mahesh P.
Published in Molecular and Cellular Biology (01.10.2008)
Published in Molecular and Cellular Biology (01.10.2008)
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Journal Article
The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun
Sundaresan, Nagalingam R, Vasudevan, Prabhakaran, Zhong, Lei, Kim, Gene, Samant, Sadhana, Parekh, Vishwas, Pillai, Vinodkumar B, Ravindra, P V, Gupta, Madhu, Jeevanandam, Valluvan, Cunningham, John M, Deng, Chu-Xia, Lombard, David B, Mostoslavsky, Raul, Gupta, Mahesh P
Published in Nature medicine (01.11.2012)
Published in Nature medicine (01.11.2012)
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Journal Article
Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice
Pillai, Vinodkumar B, Kanwal, Abhinav, Fang, Yong Hu, Sharp, Willard W, Samant, Sadhana, Arbiser, Jack, Gupta, Mahesh P
Published in Oncotarget (23.05.2017)
Published in Oncotarget (23.05.2017)
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Journal Article
Sirt3 protects mitochondrial DNA damage and blocks the development of doxorubicin-induced cardiomyopathy in mice
Pillai, Vinodkumar B, Bindu, Samik, Sharp, Will, Fang, Yong Hu, Kim, Gene, Gupta, Madhu, Samant, Sadhana, Gupta, Mahesh P
Published in American journal of physiology. Heart and circulatory physiology (15.04.2016)
Published in American journal of physiology. Heart and circulatory physiology (15.04.2016)
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Journal Article
The histone deacetylase SIRT6 blocks myostatin expression and development of muscle atrophy
Samant, Sadhana A., Kanwal, Abhinav, Pillai, Vinodkumar B., Bao, Riyue, Gupta, Mahesh P.
Published in Scientific reports (19.09.2017)
Published in Scientific reports (19.09.2017)
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Journal Article
The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy
Sundaresan, Nagalingam R, Pillai, Vinodkumar B, Wolfgeher, Don, Samant, Sadhana, Vasudevan, Prabhakaran, Parekh, Vishwas, Raghuraman, Hariharasundaram, Cunningham, John M, Gupta, Madhu, Gupta, Mahesh P
Published in Science signaling (19.07.2011)
Published in Science signaling (19.07.2011)
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Journal Article
SIRT3 blocks myofibroblast differentiation and pulmonary fibrosis by preventing mitochondrial DNA damage
Bindu, Samik, Pillai, Vinodkumar B, Kanwal, Abhinav, Samant, Sadhana, Mutlu, Gökhan M, Verdin, Eric, Dulin, Nickolai, Gupta, Mahesh P
Published in American journal of physiology. Lung cellular and molecular physiology (01.01.2017)
Published in American journal of physiology. Lung cellular and molecular physiology (01.01.2017)
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Journal Article
Exogenous NAD Blocks Cardiac Hypertrophic Response via Activation of the SIRT3-LKB1-AMP-activated Kinase Pathway
Pillai, Vinodkumar B., Sundaresan, Nagalingam R., Kim, Gene, Gupta, Madhu, Rajamohan, Senthilkumar B., Pillai, Jyothish B., Samant, Sadhana, Ravindra, P.V., Isbatan, Ayman, Gupta, Mahesh P.
Published in The Journal of biological chemistry (29.01.2010)
Published in The Journal of biological chemistry (29.01.2010)
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Journal Article
Histone Deacetylase 3 (HDAC3)-dependent Reversible Lysine Acetylation of Cardiac Myosin Heavy Chain Isoforms Modulates Their Enzymatic and Motor Activity
Samant, Sadhana A., Pillai, Vinodkumar B., Sundaresan, Nagalingam R., Shroff, Sanjeev G., Gupta, Mahesh P.
Published in The Journal of biological chemistry (19.06.2015)
Published in The Journal of biological chemistry (19.06.2015)
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Journal Article
Cellular mechanisms promoting cachexia and how they are opposed by sirtuins
Samant, Sadhana A, Pillai, Vinodkumar B, Gupta, Mahesh P
Published in Canadian journal of physiology and pharmacology (01.04.2019)
Published in Canadian journal of physiology and pharmacology (01.04.2019)
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Journal Article
Nampt secreted from cardiomyocytes promotes development of cardiac hypertrophy and adverse ventricular remodeling
Pillai, Vinodkumar B, Sundaresan, Nagalingam R, Kim, Gene, Samant, Sadhana, Moreno-Vinasco, Liliana, Garcia, Joe G N, Gupta, Mahesh P
Published in American journal of physiology. Heart and circulatory physiology (01.02.2013)
Published in American journal of physiology. Heart and circulatory physiology (01.02.2013)
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Journal Article
Acetylation of a Conserved Lysine Residue in the ATP Binding Pocket of p38 Augments Its Kinase Activity during Hypertrophy of Cardiomyocytes
Pillai, Vinodkumar B., Sundaresan, Nagalingam R., Samant, Sadhana A., Wolfgeher, Don, Trivedi, Chinmay M., Gupta, Mahesh P.
Published in Molecular and Cellular Biology (01.06.2011)
Published in Molecular and Cellular Biology (01.06.2011)
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Journal Article
SIRT1 Promotes Cell Survival under Stress by Deacetylation-Dependent Deactivation of Poly(ADP-Ribose) Polymerase 1
Rajamohan, Senthilkumar B., Pillai, Vinodkumar B., Gupta, Madhu, Sundaresan, Nagalingam R., Birukov, Konstantin G., Samant, Sadhana, Hottiger, Michael O., Gupta, Mahesh P.
Published in Molecular and Cellular Biology (01.08.2009)
Published in Molecular and Cellular Biology (01.08.2009)
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Journal Article
HDAC3-dependent Reversible Lysine Acetylation of Cardiac Myosin Heavy Chain Isoforms Modulates Their Enzymatic and Motor Activity
Samant, Sadhana A., Courson, David S., Sundaresan, Nagalingam R., Pillai, Vinodkumar B., Tan, Minjia, Zhao, Yingming, Shroff, Sanjeev G., Rock, Ronald S., Gupta, Mahesh P.
Published in The Journal of biological chemistry (18.02.2011)
Published in The Journal of biological chemistry (18.02.2011)
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