Structural basis for enzymatic photocatalysis in chlorophyll biosynthesis
Zhang, Shaowei, Heyes, Derren J., Feng, Lingling, Sun, Wenli, Johannissen, Linus O., Liu, Huanting, Levy, Colin W., Li, Xuemei, Yang, Ji, Yu, Xiaolan, Lin, Min, Hardman, Samantha J. O., Hoeven, Robin, Sakuma, Michiyo, Hay, Sam, Leys, David, Rao, Zihe, Zhou, Aiwu, Cheng, Qi, Scrutton, Nigel S.
Published in Nature (London) (01.10.2019)
Published in Nature (London) (01.10.2019)
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Photocobilins integrate B12 and bilin photochemistry for enzyme control
Zhang, Shaowei, Jeffreys, Laura N., Poddar, Harshwardhan, Yu, Yuqi, Liu, Chuanyang, Patel, Kaylee, Johannissen, Linus O., Zhu, Lingyun, Cliff, Matthew J., Yan, Cunyu, Schirò, Giorgio, Weik, Martin, Sakuma, Michiyo, Levy, Colin W., Leys, David, Heyes, Derren J., Scrutton, Nigel S.
Published in Nature communications (28.03.2024)
Published in Nature communications (28.03.2024)
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Redox driven B12-ligand switch drives CarH photoresponse
Poddar, Harshwardhan, Rios-Santacruz, Ronald, Heyes, Derren J., Shanmugam, Muralidharan, Brookfield, Adam, Johannissen, Linus O., Levy, Colin W., Jeffreys, Laura N., Zhang, Shaowei, Sakuma, Michiyo, Colletier, Jacques-Philippe, Hay, Sam, Schirò, Giorgio, Weik, Martin, Scrutton, Nigel S., Leys, David
Published in Nature communications (21.08.2023)
Published in Nature communications (21.08.2023)
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A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites
Zhang, Shaowei, Sakuma, Michiyo, Deora, Girdhar S., Levy, Colin W., Klausing, Alex, Breda, Carlo, Read, Kevin D., Edlin, Chris D., Ross, Benjamin P., Wright Muelas, Marina, Day, Philip J., O’Hagan, Stephen, Kell, Douglas B., Schwarcz, Robert, Leys, David, Heyes, Derren J., Giorgini, Flaviano, Scrutton, Nigel S.
Published in Communications biology (24.07.2019)
Published in Communications biology (24.07.2019)
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Photochemical Mechanism of an Atypical Algal Phytochrome
Choudry, Uzma, Heyes, Derren J., Hardman, Samantha J. O., Sakuma, Michiyo, Sazanovich, Igor V., Woodhouse, Joyce, De La Mora, Eugenio, Pedersen, Martin N., Wulff, Michael, Weik, Martin, Schirò, Giorgio, Scrutton, Nigel S.
Published in Chembiochem : a European journal of chemical biology (18.05.2018)
Published in Chembiochem : a European journal of chemical biology (18.05.2018)
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Ultrafast red light activation of Synechocystis phytochrome Cph1 triggers major structural change to form the Pfr signalling-competent state
Heyes, Derren J, Khara, Basile, Sakuma, Michiyo, Hardman, Samantha J O, O'Cualain, Ronan, Rigby, Stephen E J, Scrutton, Nigel S
Published in PloS one (26.12.2012)
Published in PloS one (26.12.2012)
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Human cryptochrome-1 confers light independent biological activity in transgenic Drosophila correlated with flavin radical stability
Vieira, Jacqueline, Jones, Alex R, Danon, Antoine, Sakuma, Michiyo, Hoang, Nathalie, Robles, David, Tait, Shirley, Heyes, Derren J, Picot, Marie, Yoshii, Taishi, Helfrich-Förster, Charlotte, Soubigou, Guillaume, Coppee, Jean-Yves, Klarsfeld, André, Rouyer, Francois, Scrutton, Nigel S, Ahmad, Margaret
Published in PloS one (12.03.2012)
Published in PloS one (12.03.2012)
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Conformational Events during Ternary Enzyme−Substrate Complex Formation Are Rate Limiting in the Catalytic Cycle of the Light-Driven Enzyme Protochlorophyllide Oxidoreductase
Heyes, Derren J, Menon, Binuraj R. K, Sakuma, Michiyo, Scrutton, Nigel S
Published in Biochemistry (Easton) (14.10.2008)
Published in Biochemistry (Easton) (14.10.2008)
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Journal Article
Photochemical Mechanism of Light-Driven Fatty Acid Photodecarboxylase
Heyes, Derren J, Lakavath, Balaji, Hardman, Samantha J. O, Sakuma, Michiyo, Hedison, Tobias M, Scrutton, Nigel S
Published in ACS catalysis (19.06.2020)
Published in ACS catalysis (19.06.2020)
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Mechanistic implications of the ternary complex structural models for the photoenzyme protochlorophyllide oxidoreductase
Taylor, Aoife, Zhang, Shaowei, Johannissen, Linus O., Sakuma, Michiyo, Phillips, Robert S., Green, Anthony P., Hay, Sam, Heyes, Derren J., Scrutton, Nigel S.
Published in The FEBS journal (01.04.2024)
Published in The FEBS journal (01.04.2024)
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Asymmetric Reduction of Activated Alkenes by Pentaerythritol Tetranitrate Reductase: Specificity and Control of Stereochemical Outcome by Reaction Optimisation
Fryszkowska, Anna, Toogood, Helen, Sakuma, Michiyo, Gardiner, John M., Stephens, Gill M., Scrutton, Nigel S.
Published in Advanced synthesis & catalysis (01.11.2009)
Published in Advanced synthesis & catalysis (01.11.2009)
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Journal Article
Photocobilins integrate B 12 and bilin photochemistry for enzyme control
Zhang, Shaowei, Jeffreys, Laura N, Poddar, Harshwardhan, Yu, Yuqi, Liu, Chuanyang, Patel, Kaylee, Johannissen, Linus O, Zhu, Lingyun, Cliff, Matthew J, Yan, Cunyu, Schirò, Giorgio, Weik, Martin, Sakuma, Michiyo, Levy, Colin W, Leys, David, Heyes, Derren J, Scrutton, Nigel S
Published in Nature communications (28.03.2024)
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Published in Nature communications (28.03.2024)
Journal Article
A Site-Saturated Mutagenesis Study of Pentaerythritol Tetranitrate Reductase Reveals that Residues 181 and 184 Influence Ligand Binding, Stereochemistry and Reactivity
Toogood, Helen S., Fryszkowska, Anna, Hulley, Martyn, Sakuma, Michiyo, Mansell, David, Stephens, Gill M., Gardiner, John M., Scrutton, Nigel S.
Published in Chembiochem : a European journal of chemical biology (21.03.2011)
Published in Chembiochem : a European journal of chemical biology (21.03.2011)
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Journal Article
Front Cover: Photochemical Mechanism of an Atypical Algal Phytochrome (ChemBioChem 10/2018)
Choudry, Uzma, Heyes, Derren J., Hardman, Samantha J. O., Sakuma, Michiyo, Sazanovich, Igor V., Woodhouse, Joyce, De La Mora, Eugenio, Pedersen, Martin N., Wulff, Michael, Weik, Martin, Schirò, Giorgio, Scrutton, Nigel S.
Published in Chembiochem : a European journal of chemical biology (18.05.2018)
Published in Chembiochem : a European journal of chemical biology (18.05.2018)
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