The Role of MDM2 Amplification and Overexpression in Tumorigenesis
Oliner, Jonathan D, Saiki, Anne Y, Caenepeel, Sean
Published in Cold Spring Harbor perspectives in medicine (01.06.2016)
Published in Cold Spring Harbor perspectives in medicine (01.06.2016)
Get full text
Journal Article
The MDM2 Inhibitor AMG 232 Demonstrates Robust Antitumor Efficacy and Potentiates the Activity of p53-Inducing Cytotoxic Agents
Canon, Jude, Osgood, Tao, Olson, Steven H, Saiki, Anne Y, Robertson, Rebecca, Yu, Dongyin, Eksterowicz, John, Ye, Qiuping, Jin, Lixia, Chen, Ada, Zhou, Jing, Cordover, David, Kaufman, Stephen, Kendall, Richard, Oliner, Jonathan D, Coxon, Angela, Radinsky, Robert
Published in Molecular cancer therapeutics (01.03.2015)
Published in Molecular cancer therapeutics (01.03.2015)
Get full text
Journal Article
Structure-Based Design of Novel Inhibitors of the MDM2–p53 Interaction
Rew, Yosup, Sun, Daqing, Gonzalez-Lopez De Turiso, Felix, Bartberger, Michael D, Beck, Hilary P, Canon, Jude, Chen, Ada, Chow, David, Deignan, Jeffrey, Fox, Brian M, Gustin, Darin, Huang, Xin, Jiang, Min, Jiao, Xianyun, Jin, Lixia, Kayser, Frank, Kopecky, David J, Li, Yihong, Lo, Mei-Chu, Long, Alexander M, Michelsen, Klaus, Oliner, Jonathan D, Osgood, Tao, Ragains, Mark, Saiki, Anne Y, Schneider, Steve, Toteva, Maria, Yakowec, Peter, Yan, Xuelei, Ye, Qiuping, Yu, Dongyin, Zhao, Xiaoning, Zhou, Jing, Medina, Julio C, Olson, Steven H
Published in Journal of medicinal chemistry (14.06.2012)
Published in Journal of medicinal chemistry (14.06.2012)
Get full text
Journal Article
The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity
Canon, Jude, Rex, Karen, Saiki, Anne Y, Mohr, Christopher, Cooke, Keegan, Bagal, Dhanashri, Gaida, Kevin, Holt, Tyler, Knutson, Charles G, Koppada, Neelima, Lanman, Brian A, Werner, Jonathan, Rapaport, Aaron S, San Miguel, Tisha, Ortiz, Roberto, Osgood, Tao, Sun, Ji-Rong, Zhu, Xiaochun, McCarter, John D, Volak, Laurie P, Houk, Brett E, Fakih, Marwan G, O'Neil, Bert H, Price, Timothy J, Falchook, Gerald S, Desai, Jayesh, Kuo, James, Govindan, Ramaswamy, Hong, David S, Ouyang, Wenjun, Henary, Haby, Arvedson, Tara, Cee, Victor J, Lipford, J Russell
Published in Nature (London) (01.11.2019)
Published in Nature (London) (01.11.2019)
Get full text
Journal Article
Diverse alterations associated with resistance to KRAS(G12C) inhibition
Zhao, Yulei, Murciano-Goroff, Yonina R, Xue, Jenny Y, Ang, Agnes, Lucas, Jessica, Mai, Trang T, Da Cruz Paula, Arnaud F, Saiki, Anne Y, Mohn, Deanna, Achanta, Pragathi, Sisk, Ann E, Arora, Kanika S, Roy, Rohan S, Kim, Dongsung, Li, Chuanchuan, Lim, Lee P, Li, Mark, Bahr, Amber, Loomis, Brian R, de Stanchina, Elisa, Reis-Filho, Jorge S, Weigelt, Britta, Berger, Michael, Riely, Gregory, Arbour, Kathryn C, Lipford, J Russell, Li, Bob T, Lito, Piro
Published in Nature (London) (25.11.2021)
Published in Nature (London) (25.11.2021)
Get full text
Journal Article
Identifying the determinants of response to MDM2 inhibition
Saiki, Anne Y, Caenepeel, Sean, Cosgrove, Elissa, Su, Cheng, Boedigheimer, Michael, Oliner, Jonathan D
Published in Oncotarget (10.04.2015)
Published in Oncotarget (10.04.2015)
Get full text
Journal Article
Selective and Potent Morpholinone Inhibitors of the MDM2–p53 Protein–Protein Interaction
Gonzalez, Ana Z, Eksterowicz, John, Bartberger, Michael D, Beck, Hilary P, Canon, Jude, Chen, Ada, Chow, David, Duquette, Jason, Fox, Brian M, Fu, Jiasheng, Huang, Xin, Houze, Jonathan B, Jin, Lixia, Li, Yihong, Li, Zhihong, Ling, Yun, Lo, Mei-Chu, Long, Alexander M, McGee, Lawrence R, McIntosh, Joel, McMinn, Dustin L, Oliner, Jonathan D, Osgood, Tao, Rew, Yosup, Saiki, Anne Y, Shaffer, Paul, Wortman, Sarah, Yakowec, Peter, Yan, Xuelei, Ye, Qiuping, Yu, Dongyin, Zhao, Xiaoning, Zhou, Jing, Olson, Steven H, Medina, Julio C, Sun, Daqing
Published in Journal of medicinal chemistry (27.03.2014)
Published in Journal of medicinal chemistry (27.03.2014)
Get full text
Journal Article
Abstract 3761: The MDM2 inhibitor AMG 232 causes tumor regression and potentiates the anti-tumor activity of MEK inhibition and DNA-damaging cytotoxic agents in preclinical models of acute myeloid leukemia
Canon, Jude R., Osgood, Tao, Saiki, Anne Y., Oliner, Jonathan D.
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Get full text
Journal Article
Rational Design and Binding Mode Duality of MDM2–p53 Inhibitors
Gonzalez-Lopez de Turiso, Felix, Sun, Daqing, Rew, Yosup, Bartberger, Michael D, Beck, Hilary P, Canon, Jude, Chen, Ada, Chow, David, Correll, Tiffany L, Huang, Xin, Julian, Lisa D, Kayser, Frank, Lo, Mei-Chu, Long, Alexander M, McMinn, Dustin, Oliner, Jonathan D, Osgood, Tao, Powers, Jay P, Saiki, Anne Y, Schneider, Steve, Shaffer, Paul, Xiao, Shou-Hua, Yakowec, Peter, Yan, Xuelei, Ye, Qiuping, Yu, Dongyin, Zhao, Xiaoning, Zhou, Jing, Medina, Julio C, Olson, Steven H
Published in Journal of medicinal chemistry (23.05.2013)
Published in Journal of medicinal chemistry (23.05.2013)
Get full text
Journal Article
Discovery of AM-7209, a Potent and Selective 4‑Amidobenzoic Acid Inhibitor of the MDM2–p53 Interaction
Rew, Yosup, Sun, Daqing, Yan, Xuelei, Beck, Hilary P, Canon, Jude, Chen, Ada, Duquette, Jason, Eksterowicz, John, Fox, Brian M, Fu, Jiasheng, Gonzalez, Ana Z, Houze, Jonathan, Huang, Xin, Jiang, Min, Jin, Lixia, Li, Yihong, Li, Zhihong, Ling, Yun, Lo, Mei-Chu, Long, Alexander M, McGee, Lawrence R, McIntosh, Joel, Oliner, Jonathan D, Osgood, Tao, Saiki, Anne Y, Shaffer, Paul, Wang, Yu Chung, Wortman, Sarah, Yakowec, Peter, Ye, Qiuping, Yu, Dongyin, Zhao, Xiaoning, Zhou, Jing, Medina, Julio C, Olson, Steven H
Published in Journal of medicinal chemistry (26.12.2014)
Published in Journal of medicinal chemistry (26.12.2014)
Get full text
Journal Article
Novel Inhibitors of the MDM2-p53 Interaction Featuring Hydrogen Bond Acceptors as Carboxylic Acid Isosteres
Gonzalez, Ana Z, Li, Zhihong, Beck, Hilary P, Canon, Jude, Chen, Ada, Chow, David, Duquette, Jason, Eksterowicz, John, Fox, Brian M, Fu, Jiasheng, Huang, Xin, Houze, Jonathan, Jin, Lixia, Li, Yihong, Ling, Yun, Lo, Mei-Chu, Long, Alexander M, McGee, Lawrence R, McIntosh, Joel, Oliner, Jonathan D, Osgood, Tao, Rew, Yosup, Saiki, Anne Y, Shaffer, Paul, Wortman, Sarah, Yakowec, Peter, Yan, Xuelei, Ye, Qiuping, Yu, Dongyin, Zhao, Xiaoning, Zhou, Jing, Olson, Steven H, Sun, Daqing, Medina, Julio C
Published in Journal of medicinal chemistry (10.04.2014)
Published in Journal of medicinal chemistry (10.04.2014)
Get full text
Journal Article
MDM2 antagonists synergize broadly and robustly with compounds targeting fundamental oncogenic signaling pathways
Saiki, Anne Y, Caenepeel, Sean, Yu, Dongyin, Lofgren, Julie A, Osgood, Tao, Robertson, Rebecca, Canon, Jude, Su, Cheng, Jones, Adrie, Zhao, Xiaoning, Deshpande, Chetan, Payton, Marc, Ledell, Jebediah, Hughes, Paul E, Oliner, Jonathan D
Published in Oncotarget (30.04.2014)
Published in Oncotarget (30.04.2014)
Get full text
Journal Article
Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors
Lanman, Brian A, Allen, Jennifer R, Allen, John G, Amegadzie, Albert K, Ashton, Kate S, Booker, Shon K, Chen, Jian Jeffrey, Chen, Ning, Frohn, Michael J, Goodman, Guy, Kopecky, David J, Liu, Longbin, Lopez, Patricia, Low, Jonathan D, Ma, Vu, Minatti, Ana E, Nguyen, Thomas T, Nishimura, Nobuko, Pickrell, Alexander J, Reed, Anthony B, Shin, Youngsook, Siegmund, Aaron C, Tamayo, Nuria A, Tegley, Christopher M, Walton, Mary C, Wang, Hui-Ling, Wurz, Ryan P, Xue, May, Yang, Kevin C, Achanta, Pragathi, Bartberger, Michael D, Canon, Jude, Hollis, L. Steven, McCarter, John D, Mohr, Christopher, Rex, Karen, Saiki, Anne Y, San Miguel, Tisha, Volak, Laurie P, Wang, Kevin H, Whittington, Douglas A, Zech, Stephan G, Lipford, J. Russell, Cee, Victor J
Published in Journal of medicinal chemistry (09.01.2020)
Published in Journal of medicinal chemistry (09.01.2020)
Get full text
Journal Article
Discovery of a Covalent Inhibitor of KRAS G12C (AMG 510) for the Treatment of Solid Tumors
Lanman, Brian A, Allen, Jennifer R, Allen, John G, Amegadzie, Albert K, Ashton, Kate S, Booker, Shon K, Chen, Jian Jeffrey, Chen, Ning, Frohn, Michael J, Goodman, Guy, Kopecky, David J, Liu, Longbin, Lopez, Patricia, Low, Jonathan D, Ma, Vu, Minatti, Ana E, Nguyen, Thomas T, Nishimura, Nobuko, Pickrell, Alexander J, Reed, Anthony B, Shin, Youngsook, Siegmund, Aaron C, Tamayo, Nuria A, Tegley, Christopher M, Walton, Mary C, Wang, Hui-Ling, Wurz, Ryan P, Xue, May, Yang, Kevin C, Achanta, Pragathi, Bartberger, Michael D, Canon, Jude, Hollis, L Steven, McCarter, John D, Mohr, Christopher, Rex, Karen, Saiki, Anne Y, San Miguel, Tisha, Volak, Laurie P, Wang, Kevin H, Whittington, Douglas A, Zech, Stephan G, Lipford, J Russell, Cee, Victor J
Published in Journal of medicinal chemistry (09.01.2020)
Published in Journal of medicinal chemistry (09.01.2020)
Get full text
Journal Article
Improvement of the synthesis and pharmacokinetic properties of chromenotriazolopyrimidine MDM2-p53 protein-protein inhibitors
Beck, Hilary P., DeGraffenreid, Michael, Fox, Brian, Allen, John G., Rew, Yosup, Schneider, Stephen, Saiki, Anne Y., Yu, Dongyin, Oliner, Jonathan D., Salyers, Kevin, Ye, Qiuping, Olson, Steven
Published in Bioorganic & medicinal chemistry letters (01.05.2011)
Published in Bioorganic & medicinal chemistry letters (01.05.2011)
Get full text
Journal Article
Discovery of N -(1-Acryloylazetidin-3-yl)-2-(1 H -indol-1-yl)acetamides as Covalent Inhibitors of KRAS G12C
Shin, Youngsook, Jeong, Joon Won, Wurz, Ryan P, Achanta, Pragathi, Arvedson, Tara, Bartberger, Michael D, Campuzano, Iain D G, Fucini, Ray, Hansen, Stig K, Ingersoll, John, Iwig, Jeffrey S, Lipford, J Russell, Ma, Vu, Kopecky, David J, McCarter, John, San Miguel, Tisha, Mohr, Christopher, Sabet, Sudi, Saiki, Anne Y, Sawayama, Andrew, Sethofer, Steven, Tegley, Christopher M, Volak, Laurie P, Yang, Kevin, Lanman, Brian A, Erlanson, Daniel A, Cee, Victor J
Published in ACS medicinal chemistry letters (12.09.2019)
Published in ACS medicinal chemistry letters (12.09.2019)
Get full text
Journal Article
Discovery of N‑(1-Acryloylazetidin-3-yl)-2-(1H‑indol-1-yl)acetamides as Covalent Inhibitors of KRASG12C
Shin, Youngsook, Jeong, Joon Won, Wurz, Ryan P, Achanta, Pragathi, Arvedson, Tara, Bartberger, Michael D, Campuzano, Iain D. G, Fucini, Ray, Hansen, Stig K, Ingersoll, John, Iwig, Jeffrey S, Lipford, J. Russell, Ma, Vu, Kopecky, David J, McCarter, John, San Miguel, Tisha, Mohr, Christopher, Sabet, Sudi, Saiki, Anne Y, Sawayama, Andrew, Sethofer, Steven, Tegley, Christopher M, Volak, Laurie P, Yang, Kevin, Lanman, Brian A, Erlanson, Daniel A, Cee, Victor J
Published in ACS medicinal chemistry letters (12.09.2019)
Published in ACS medicinal chemistry letters (12.09.2019)
Get full text
Journal Article
Discovery of Potent and Simplified Piperidinone-Based Inhibitors of the MDM2–p53 Interaction
Yu, Ming, Wang, Yingcai, Zhu, Jiang, Bartberger, Michael D, Canon, Jude, Chen, Ada, Chow, David, Eksterowicz, John, Fox, Brian, Fu, Jiasheng, Gribble, Michael, Huang, Xin, Li, Zhihong, Liu, Jiwen (Jim), Lo, Mei-chu, McMinn, Dustin, Oliner, Jonathan D, Osgood, Tao, Rew, Yosup, Saiki, Anne Y, Shaffer, Paul, Yan, Xuelei, Ye, Qiuping, Yu, Dongyin, Zhao, Xiaoning, Zhou, Jing, Olson, Steven H, Medina, Julio C, Sun, Daqing
Published in ACS medicinal chemistry letters (14.08.2014)
Published in ACS medicinal chemistry letters (14.08.2014)
Get full text
Journal Article