Cryo-EM structures of tau filaments from Alzheimer’s disease with PET ligand APN-1607
Shi, Yang, Murzin, Alexey G., Falcon, Benjamin, Epstein, Alexander, Machin, Jonathan, Tempest, Paul, Newell, Kathy L., Vidal, Ruben, Garringer, Holly J., Sahara, Naruhiko, Higuchi, Makoto, Ghetti, Bernardino, Jang, Ming-Kuei, Scheres, Sjors H. W., Goedert, Michel
Published in Acta neuropathologica (01.05.2021)
Published in Acta neuropathologica (01.05.2021)
Get full text
Journal Article
Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer's disease
Sobue, Akira, Komine, Okiru, Hara, Yuichiro, Endo, Fumito, Mizoguchi, Hiroyuki, Watanabe, Seiji, Murayama, Shigeo, Saito, Takashi, Saido, Takaomi C, Sahara, Naruhiko, Higuchi, Makoto, Ogi, Tomoo, Yamanaka, Koji
Published in Acta neuropathologica communications (05.01.2021)
Published in Acta neuropathologica communications (05.01.2021)
Get full text
Journal Article
Tau binding protein CAPON induces tau aggregation and neurodegeneration
Hashimoto, Shoko, Matsuba, Yukio, Kamano, Naoko, Mihira, Naomi, Sahara, Naruhiko, Takano, Jiro, Muramatsu, Shin-ichi, Saido, Takaomi C., Saito, Takashi
Published in Nature communications (03.06.2019)
Published in Nature communications (03.06.2019)
Get full text
Journal Article
Detection of Alzheimer’s disease-related neuroinflammation by a PET ligand selective for glial versus vascular translocator protein
Ji, Bin, Ono, Maiko, Yamasaki, Tomoteru, Fujinaga, Masayuki, Zhang, Ming-Rong, Seki, Chie, Aoki, Ichio, Kito, Seiji, Sawada, Makoto, Suhara, Tetsuya, Sahara, Naruhiko, Higuchi, Makoto
Published in Journal of cerebral blood flow and metabolism (01.08.2021)
Published in Journal of cerebral blood flow and metabolism (01.08.2021)
Get full text
Journal Article
Propagation of Tau Pathology in a Model of Early Alzheimer's Disease
de Calignon, Alix, Polydoro, Manuela, Suárez-Calvet, Marc, William, Christopher, Adamowicz, David H., Kopeikina, Kathy J., Pitstick, Rose, Sahara, Naruhiko, Ashe, Karen H., Carlson, George A., Spires-Jones, Tara L., Hyman, Bradley T.
Published in Neuron (Cambridge, Mass.) (23.02.2012)
Published in Neuron (Cambridge, Mass.) (23.02.2012)
Get full text
Journal Article
MRS-measured glutamate versus GABA reflects excitatory versus inhibitory neural activities in awake mice
Takado, Yuhei, Takuwa, Hiroyuki, Sampei, Kazuaki, Urushihata, Takuya, Takahashi, Manami, Shimojo, Masafumi, Uchida, Shoko, Nitta, Nobuhiro, Shibata, Sayaka, Nagashima, Keisuke, Ochi, Yoshihiro, Ono, Maiko, Maeda, Jun, Tomita, Yutaka, Sahara, Naruhiko, Near, Jamie, Aoki, Ichio, Shibata, Kazuhisa, Higuchi, Makoto
Published in Journal of cerebral blood flow and metabolism (01.01.2022)
Published in Journal of cerebral blood flow and metabolism (01.01.2022)
Get full text
Journal Article
Imaging of Tau Pathology in a Tauopathy Mouse Model and in Alzheimer Patients Compared to Normal Controls
Maruyama, Masahiro, Shimada, Hitoshi, Suhara, Tetsuya, Shinotoh, Hitoshi, Ji, Bin, Maeda, Jun, Zhang, Ming-Rong, Trojanowski, John Q., Lee, Virginia M.-Y., Ono, Maiko, Masamoto, Kazuto, Takano, Harumasa, Sahara, Naruhiko, Iwata, Nobuhisa, Okamura, Nobuyuki, Furumoto, Shozo, Kudo, Yukitsuka, Chang, Qing, Saido, Takaomi C., Takashima, Akihiko, Lewis, Jada, Jang, Ming-Kuei, Aoki, Ichio, Ito, Hiroshi, Higuchi, Makoto
Published in Neuron (Cambridge, Mass.) (18.09.2013)
Published in Neuron (Cambridge, Mass.) (18.09.2013)
Get full text
Journal Article
Selective Disruption of Inhibitory Synapses Leading to Neuronal Hyperexcitability at an Early Stage of Tau Pathogenesis in a Mouse Model
Shimojo, Masafumi, Takuwa, Hiroyuki, Takado, Yuhei, Tokunaga, Masaki, Tsukamoto, Satoshi, Minatohara, Keiichiro, Ono, Maiko, Seki, Chie, Maeda, Jun, Urushihata, Takuya, Minamihisamatsu, Takeharu, Aoki, Ichio, Kawamura, Kazunori, Zhang, Ming-Rong, Suhara, Tetsuya, Sahara, Naruhiko, Higuchi, Makoto
Published in The Journal of neuroscience (22.04.2020)
Published in The Journal of neuroscience (22.04.2020)
Get full text
Journal Article
Distinct binding of PET ligands PBB3 and AV-1451 to tau fibril strains in neurodegenerative tauopathies
Ono, Maiko, Sahara, Naruhiko, Kumata, Katsushi, Ji, Bin, Ni, Ruiqing, Koga, Shunsuke, Dickson, Dennis W, Trojanowski, John Q, Lee, Virginia M-Y, Yoshida, Mari, Hozumi, Isao, Yoshiyama, Yasumasa, van Swieten, John C, Nordberg, Agneta, Suhara, Tetsuya, Zhang, Ming-Rong, Higuchi, Makoto
Published in Brain (London, England : 1878) (01.03.2017)
Published in Brain (London, England : 1878) (01.03.2017)
Get full text
Journal Article
Central role for p62/SQSTM1 in the elimination of toxic tau species in a mouse model of tauopathy
Ono, Maiko, Komatsu, Masaaki, Ji, Bin, Takado, Yuhei, Shimojo, Masafumi, Minamihisamatsu, Takeharu, Warabi, Eiji, Yanagawa, Toru, Matsumoto, Gen, Aoki, Ichio, Kanaan, Nicholas M., Suhara, Tetsuya, Sahara, Naruhiko, Higuchi, Makoto
Published in Aging cell (01.07.2022)
Published in Aging cell (01.07.2022)
Get full text
Journal Article
PET-detectable tau pathology correlates with long-term neuropsychiatric outcomes in patients with traumatic brain injury
Takahata, Keisuke, Kimura, Yasuyuki, Sahara, Naruhiko, Koga, Shunsuke, Shimada, Hitoshi, Ichise, Masanori, Saito, Fumie, Moriguchi, Sho, Kitamura, Soichiro, Kubota, Manabu, Umeda, Satoshi, Niwa, Fumitoshi, Mizushima, Jin, Morimoto, Yoko, Funayama, Michitaka, Tabuchi, Hajime, Bieniek, Kevin F, Kawamura, Kazunori, Zhang, Ming-Rong, Dickson, Dennis W, Mimura, Masaru, Kato, Motoichiro, Suhara, Tetsuya, Higuchi, Makoto
Published in Brain (London, England : 1878) (01.10.2019)
Published in Brain (London, England : 1878) (01.10.2019)
Get full text
Journal Article
A genetically targeted reporter for PET imaging of deep neuronal circuits in mammalian brains
Shimojo, Masafumi, Ono, Maiko, Takuwa, Hiroyuki, Mimura, Koki, Nagai, Yuji, Fujinaga, Masayuki, Kikuchi, Tatsuya, Okada, Maki, Seki, Chie, Tokunaga, Masaki, Maeda, Jun, Takado, Yuhei, Takahashi, Manami, Minamihisamatsu, Takeharu, Zhang, Ming‐Rong, Tomita, Yutaka, Suzuki, Norihiro, Maximov, Anton, Suhara, Tetsuya, Minamimoto, Takafumi, Sahara, Naruhiko, Higuchi, Makoto
Published in The EMBO journal (15.11.2021)
Published in The EMBO journal (15.11.2021)
Get full text
Journal Article