Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation Approaches: A Systematic Review of Published Models, Applications, and Model Verification
Sager, Jennifer E, Yu, Jingjing, Ragueneau-Majlessi, Isabelle, Isoherranen, Nina
Published in Drug metabolism and disposition (01.11.2015)
Published in Drug metabolism and disposition (01.11.2015)
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Journal Article
Population pharmacokinetics and exposure‐response analysis of a single dose of sotrovimab in the early treatment of patients with mild to moderate COVID‐19
Sager, Jennifer E., El‐Zailik, Asma, Passarell, Julie, Roepcke, Stefan, Li, Xiaobin, Aldinger, Melissa, Nader, Ahmed, Skingsley, Andrew, Alexander, Elizabeth L., Yeh, Wendy W., Mogalian, Erik, Garner, Chad, Peppercorn, Amanda, Shapiro, Adrienne E., Reyes, Maribel
Published in CPT: pharmacometrics and systems pharmacology (01.06.2023)
Published in CPT: pharmacometrics and systems pharmacology (01.06.2023)
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Journal Article
Effect of Sotrovimab on Hospitalization or Death Among High-risk Patients With Mild to Moderate COVID-19: A Randomized Clinical Trial
Gupta, Anil, Gonzalez-Rojas, Yaneicy, Juarez, Erick, Crespo Casal, Manuel, Moya, Jaynier, Rodrigues Falci, Diego, Sarkis, Elias, Solis, Joel, Zheng, Hanzhe, Scott, Nicola, Cathcart, Andrea L, Parra, Sergio, Sager, Jennifer E, Austin, Daren, Peppercorn, Amanda, Alexander, Elizabeth, Yeh, Wendy W, Brinson, Cynthia, Aldinger, Melissa, Shapiro, Adrienne E
Published in JAMA : the journal of the American Medical Association (05.04.2022)
Published in JAMA : the journal of the American Medical Association (05.04.2022)
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A phase 1 study in healthy volunteers to investigate the safety, tolerability, and pharmacokinetics of VIR-2482: a monoclonal antibody for the prevention of severe influenza A illness
Plotnik, David, Sager, Jennifer E, Aryal, Madhukar, Fanget, Marie C, Peter, Alessia, Schmid, Michael A, Cebrik, Deborah, Mogalian, Erik, Boundy, Keith, Yeh, Wendy W, Griffin, Paul, Reyes, Maribel
Published in Antimicrobial agents and chemotherapy (03.04.2024)
Published in Antimicrobial agents and chemotherapy (03.04.2024)
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Journal Article
Interaction and Transport of Methamphetamine and its Primary Metabolites by Organic Cation and Multidrug and Toxin Extrusion Transporters
Wagner, David J, Sager, Jennifer E, Duan, Haichuan, Isoherranen, Nina, Wang, Joanne
Published in Drug metabolism and disposition (01.07.2017)
Published in Drug metabolism and disposition (01.07.2017)
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Journal Article
Corrigendum to “In vitro to in vivo extrapolation of the complex drug-drug interaction of bupropion and its metabolites with CYP2D6; simultaneous reversible inhibition and CYP2D6 downregulation” [Biochem. Pharmacol. 123(2017)85–96]
Sager, Jennifer E., Tripathy, Sasmita, Price, Lauren S.L., Nath, Abhinav, Chang, Justine, Stephenson-Famy, Alyssa, Isoherranen, Nina
Published in Biochemical pharmacology (01.01.2021)
Published in Biochemical pharmacology (01.01.2021)
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Pharmacokinetics, Safety, and Tolerability of Anti-SARS-CoV-2 Monoclonal Antibody, Sotrovimab, Delivered Intravenously or Intramuscularly in Japanese and Caucasian Healthy Volunteers
Nader, Ahmed, Alexander, Elizabeth, Brintziki, Dimitra, Haggag, Amina Z., Harrison, Stephen A., Hawes, Ian A., Hezareh, Marjan, Lippa, Andrew M., Okamasa, Arisa, Okour, Malek, Okuda, Nobuhiko, Sager, Jennifer E., Segal, Scott, Shida, Yuri, Skingsley, Andrew, Williams, Robert, Yoon, Esther Y., Austin, Daren
Published in Clinical pharmacokinetics (01.01.2024)
Published in Clinical pharmacokinetics (01.01.2024)
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Quantitative Prediction of CYP3A4 Induction: Impact of Measured, Free, and Intracellular Perpetrator Concentrations from Human Hepatocyte Induction Studies on Drug-Drug Interaction Predictions
Sun, Yongkai, Chothe, Paresh P, Sager, Jennifer E, Tsao, Hong, Moore, Amanda, Laitinen, Leena, Hariparsad, Niresh
Published in Drug metabolism and disposition (01.06.2017)
Published in Drug metabolism and disposition (01.06.2017)
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Journal Article
In vitro to in vivo extrapolation of the complex drug-drug interaction of bupropion and its metabolites with CYP2D6; simultaneous reversible inhibition and CYP2D6 downregulation
Sager, Jennifer E., Tripathy, Sasmita, Price, Lauren S.L., Nath, Abhinav, Chang, Justine, Stephenson-Famy, Alyssa, Isoherranen, Nina
Published in Biochemical pharmacology (01.01.2017)
Published in Biochemical pharmacology (01.01.2017)
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Journal Article
Safety, Virology, Pharmacokinetics, and Clinical Experience of High-Dose Intravenous Sotrovimab for the Treatment of Mild to Moderate COVID-19: An Open-Label Clinical Trial
Moya, Jaynier, Temech, Marisol, Parra, Sergio, Juarez, Erick, Hernandez-Loy, Reinaldo, Gutierrez, Juan C Moises, Diaz, Jorge, Hussain, Rubaba, Segal, Scott, Xu, Claire, Skingsley, Andrew, Schnell, Gretja, El-Zailik, Asma, Sager, Jennifer E, Aldinger, Melissa, Alexander, Elizabeth L, Acloque, Gerard
Published in Open forum infectious diseases (01.07.2023)
Published in Open forum infectious diseases (01.07.2023)
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Journal Article
Complex methamphetamine inhibition kinetics of organic cation transporter 2 (OCT2)
Wagner, David J., Sager, Jennifer E., Isoherranen, Nina, Wang, Joanne
Published in Drug metabolism and pharmacokinetics (01.01.2018)
Published in Drug metabolism and pharmacokinetics (01.01.2018)
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Journal Article
Intramuscular vs Intravenous SARS-CoV-2 Neutralizing Antibody Sotrovimab for Treatment of COVID-19 (COMET-TAIL): A Randomized Noninferiority Clinical Trial
Shapiro, Adrienne E, Sarkis, Elias, Acloque, Jude, Free, Almena, Gonzalez-Rojas, Yaneicy, Hussain, Rubaba, Juarez, Erick, Moya, Jaynier, Parikh, Naval, Inman, David, Cebrik, Deborah, Nader, Ahmed, Noormohamed, Nadia, Wang, Qianwen, Skingsley, Andrew, Austin, Daren, Peppercorn, Amanda, Agostini, Maria L, Parra, Sergio, Chow, Sophia, Mogalian, Erik, Pang, Phillip S, Hong, David K, Sager, Jennifer E, Yeh, Wendy W, Alexander, Elizabeth L, Gaffney, Leah A, Kohli, Anita
Published in Open forum infectious diseases (01.08.2023)
Published in Open forum infectious diseases (01.08.2023)
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Journal Article
Fluoxetine- and norfluoxetine-mediated complex drug-drug interactions: in vitro to in vivo correlation of effects on CYP2D6, CYP2C19, and CYP3A4
Sager, J E, Lutz, J D, Foti, R S, Davis, C, Kunze, K L, Isoherranen, N
Published in Clinical pharmacology and therapeutics (01.06.2014)
Published in Clinical pharmacology and therapeutics (01.06.2014)
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