Postnatal disruption of the disintegrin/metalloproteinase ADAM10 in brain causes epileptic seizures, learning deficits, altered spine morphology, and defective synaptic functions
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Published in The Journal of neuroscience (07.08.2013)
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Serum Starvation Induces BACE1 Processing and Secretion
Stavropoulou, A V, Mavrofrydi, O, Saftig, P, Efthimiopoulos, S
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Published in Current Alzheimer research (01.01.2017)
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ADAM10 regulates FasL cell surface expression and modulates FasL-induced cytotoxicity and activation-induced cell death
Schulte, M, Reiss, K, Lettau, M, Maretzky, T, Ludwig, A, Hartmann, D, de Strooper, B, Janssen, O, Saftig, P
Published in Cell death and differentiation (01.05.2007)
Published in Cell death and differentiation (01.05.2007)
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Cathepsin F mutations cause Type B Kufs disease, an adult-onset neuronal ceroid lipofuscinosis
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Published in Human molecular genetics (01.04.2013)
Published in Human molecular genetics (01.04.2013)
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Disruption of the Cathepsin K gene reduces atherosclerosis progression and induces plaque fibrosis but accelerates macrophage foam cell formation
LUTGENS, E, LUTGENS, S. P. M, FISHER, A, LONG, C. J, SAFTIG, P, BLACK, D, DAEMEN, M. J. A. P, CLEUTJENS, K. B. J. M, FABER, B. C. G, HEENEMAN, S, GIJBELS, M. M. J, DE WINTHER, M. P. J, FREDERIK, P, VAN DER MADE, I, DAUGHERTY, A, SIJBERS, A. M
Published in Circulation (New York, N.Y.) (03.01.2006)
Published in Circulation (New York, N.Y.) (03.01.2006)
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Tubular proteinuria in mice and humans lacking the intrinsic lysosomal protein SCARB2/Limp-2
Desmond, M J, Lee, D, Fraser, S A, Katerelos, M, Gleich, K, Martinello, P, Li, Y Q, Thomas, M C, Michelucci, R, Cole, A J, Saftig, P, Schwake, M, Stapleton, D, Berkovic, S F, Power, D A
Published in American journal of physiology. Renal physiology (01.06.2011)
Published in American journal of physiology. Renal physiology (01.06.2011)
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Bone density, strength, and formation in adult cathepsin K (−/−) mice
Pennypacker, B, Shea, M, Liu, Q, Masarachia, P, Saftig, P, Rodan, S, Rodan, G, Kimmel, D
Published in Bone (New York, N.Y.) (01.02.2009)
Published in Bone (New York, N.Y.) (01.02.2009)
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ADAM10 regulates FasL cell surface expression and modulates FasL-induced cytotoxicity and activation-induced cell death
Schulte, M, Reiss, K, Lettau, M, Maretzky, T, Ludwig, A, Hartmann, D, de Strooper, B, Janssen, O, Saftig, P
Published in Cell death and differentiation (09.02.2007)
Published in Cell death and differentiation (09.02.2007)
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Enzyme replacement therapy for alpha-mannosidosis: 12 months follow-up of a single centre, randomised, multiple dose study
Borgwardt, L., Dali, C. I., Fogh, J., Månsson, J. E., Olsen, K. J., Beck, H. C., Nielsen, K. G., Nielsen, L. H., Olsen, S. O. E., Riise Stensland, H. M. F., Nilssen, O., Wibrand, F., Thuesen, A. M., Pearl, T., Haugsted, U., Saftig, P., Blanz, J., Jones, S. A., Tylki-Szymanska, A., Guffon-Fouiloux, N., Beck, M., Lund, A. M.
Published in Journal of inherited metabolic disease (01.11.2013)
Published in Journal of inherited metabolic disease (01.11.2013)
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Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells
Saftig, P., Hetman, M., Schmahl, W., Weber, K., Heine, L., Mossmann, H., Köster, A., Hess, B., Evers, M., Figura, K.
Published in The EMBO journal (01.08.1995)
Published in The EMBO journal (01.08.1995)
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Cathepsin L is involved in cathepsin D processing and regulation of apoptosis in A549 human lung epithelial cells
Wille, A., Gerber, A., Heimburg, A., Reisenauer, A., Peters, C., Saftig, P., Reinheckel, T., Welte, T., Bühling, F.
Published in Biological chemistry (01.07.2004)
Published in Biological chemistry (01.07.2004)
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Calvarial osteoclasts express a higher level of tartrate-resistant acid phosphatase than long bone osteoclasts and activation does not depend on cathepsin K or L activity
Perez-Amodio, S, Jansen, D C, Schoenmaker, T, Vogels, I M C, Reinheckel, T, Hayman, A R, Cox, T M, Saftig, P, Beertsen, W, Everts, V
Published in Calcified tissue international (01.10.2006)
Published in Calcified tissue international (01.10.2006)
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Cathepsin D is up‐regulated in inflammatory bowel disease macrophages
HAUSMANN, M., OBERMEIER, F., SCHREITER, K., SPOTTL, T., FALK, W., SCHÖLMERICH, J., HERFARTH, H., SAFTIG, P., ROGLER, G.
Published in Clinical and experimental immunology (01.04.2004)
Published in Clinical and experimental immunology (01.04.2004)
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LIMP-2/LGP85 deficiency causes ureteric pelvic junction obstruction, deafness and peripheral neuropathy in mice
Gamp, Alexander-Christian, Tanaka, Yoshitaka, Lüllmann-Rauch, Renate, Wittke, Dorothee, D'Hooge, Rudi, De Deyn, Peter P., Moser, Tobias, Maier, Hannes, Hartmann, Dieter, Reiss, Karina, Illert, Anna-Lena, von Figura, Kurt, Saftig, Paul
Published in Human molecular genetics (15.03.2003)
Published in Human molecular genetics (15.03.2003)
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Reduced Sperm Count and Normal Fertility in Male Mice with Targeted Disruption of the ADP-Ribosylation Factor-Like 4 (Arl4) Gene
Schürmann, A., Koling, S., Jacobs, S., Saftig, P., Krauβ, S., Wennemuth, G., Kluge, R., Joost, H.-G.
Published in Molecular and Cellular Biology (01.04.2002)
Published in Molecular and Cellular Biology (01.04.2002)
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Overlapping functions of lysosomal acid phosphatase (LAP) and tartrate-resistant acid phosphatase (Acp5) revealed by doubly deficient mice
Suter, A, Everts, V, Boyde, A, Jones, S J, Lüllmann-Rauch, R, Hartmann, D, Hayman, A R, Cox, T M, Evans, M J, Meister, T, von Figura, K, Saftig, P
Published in Development (Cambridge) (01.12.2001)
Published in Development (Cambridge) (01.12.2001)
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