Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates
Komander, David, Fairservice, Alison, Deak, Maria, Kular, Gursant S, Prescott, Alan R, Peter Downes, C, Safrany, Stephen T, Alessi, Dario R, van Aalten, Daan MF
Published in The EMBO journal (13.10.2004)
Published in The EMBO journal (13.10.2004)
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Small molecule antagonists of the σ-1 receptor cause selective release of the death program in tumor and self-reliant cells and inhibit tumor growth in vitro and in vivo
SPRUCE, Barbara A, CAMPBELL, Lorna A, MCLEAN, Doris, LESLIE, Nick R, SAFRANY, Stephen T, FERGUSON, Michelle J, PETERS, John A, PRESCOTT, Alan R, BOX, Gary, HAYES, Angela, NUTLEY, Bernard, RAYNAUD, Florence, MCTAVISH, Niall, DOWNES, C. Peter, LAMBERT, Jeremy J, THOMPSON, Alastair M, ECCLES, Suzanne, COOPER, Michelle A, APPLEYARD, M. Virginia L, O'NEILL, Mary, HOWIE, Jacqueline, SAMSON, Jayne, WATT, Stephen, MURRAY, Karen
Published in Cancer research (Chicago, Ill.) (15.07.2004)
Published in Cancer research (Chicago, Ill.) (15.07.2004)
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diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase. Overlapping substrate specificities in a MutT-type protein
Safrany, S.T, Ingram, S.W, Cartwright, J.L, Falck, J.R, McLennan, A.G, Barness, L.D, Shears, S.B
Published in The Journal of biological chemistry (30.07.1999)
Published in The Journal of biological chemistry (30.07.1999)
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Journal Article
A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase
Safrany, Stephen T., Caffrey, James J., Yang, Xiaonian, Bembenek, Michael E., Moyer, Mary B., Burkhart, William A., Shears, Stephen B.
Published in The EMBO journal (16.11.1998)
Published in The EMBO journal (16.11.1998)
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Nudix Hydrolases That Degrade Dinucleoside and Diphosphoinositol Polyphosphates Also Have 5-Phosphoribosyl 1-Pyrophosphate (PRPP) Pyrophosphatase Activity That Generates the Glycolytic Activator Ribose 1,5-Bisphosphate
Fisher, David I., Safrany, Stephen T., Strike, Peter, McLennan, Alexander G., Cartwright, Jared L.
Published in The Journal of biological chemistry (06.12.2002)
Published in The Journal of biological chemistry (06.12.2002)
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Journal Article
The g5R (D250) Gene of African Swine Fever Virus Encodes a Nudix Hydrolase That Preferentially Degrades Diphosphoinositol Polyphosphates
Cartwright, Jared L, Safrany, Stephen T, Dixon, Linda K, Darzynkiewicz, Edward, Stepinski, Janusz, Burke, Richard, McLennan, Alexander G
Published in Journal of Virology (01.02.2002)
Published in Journal of Virology (01.02.2002)
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PTEN M-CBR3, a Versatile and Selective Regulator of Inositol 1,3,4,5,6- Pentakisphosphate (Ins(1,3,4,5,6)P sub(5)): Evidence for Ins(1,3,4,5,6)P sub(5) as a proliferative signal
Orchiston, E A, Bennett, D, Leslie, N R, Clarke, R G, Winward, L, Downes, C P, Safrany, ST
Published in The Journal of biological chemistry (09.01.2004)
Published in The Journal of biological chemistry (09.01.2004)
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Journal Article
Molecular cloning and expression of a rat hepatic multiple inositol polyphosphate phosphatase
Craxton, A, Caffrey, J J, Burkhart, W, Safrany, S T, Shears, S B
Published in Biochemical journal (15.11.1997)
Published in Biochemical journal (15.11.1997)
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Journal Article
Biological variability in the structures of diphosphoinositol polyphosphates in Dictyostelium discoideum and mammalian cells
Albert, C, Safrany, S T, Bembenek, M E, Reddy, K M, Reddy, K, Falck, J, Bröcker, M, Shears, S B, Mayr, G W
Published in Biochemical journal (15.10.1997)
Published in Biochemical journal (15.10.1997)
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Journal Article
Diphosphoinositol Polyphosphates: The Final Frontier for Inositide Research?
Safrany, S. T., Caffrey, J. J., Yang, X., Shears, S. B.
Published in Biological chemistry (01.07.1999)
Published in Biological chemistry (01.07.1999)
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Journal Article
The g5R (D250) Gene of African Swine Fever Virus Encodes a Nudix Hydrolase That Preferentially Degrades Diphosphoinositol Polyphosphates
Cartwright, Jared L., Safrany, Stephen T., Dixon, Linda K., Darzynkiewicz, Edward, Stepinski, Janusz, Burke, Richard, McLennan, Alexander G.
Published in Journal of virology (01.07.2002)
Published in Journal of virology (01.07.2002)
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Journal Article
Interaction of synthetic D-6-deoxy- myo-inositol 1,4,5-trisphosphate with the Ca 2+-releasing D- myo-inositol 1,4,5-trisphosphate receptor, and the metabolic enzymes 5-phosphatase and 3-kinase
Safrany, S.T., Wojcikiewicz, R.J.H., Strupish, J., Nahorski, S.R., Dubreuil, D., Cleophax, J., Gero, S.D., Potter, B.V.L.
Published in FEBS letters (28.01.1991)
Published in FEBS letters (28.01.1991)
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