Strategies to sensitize cancer cells to immunotherapy
George, Andrew, Sahin, Ilyas, Carneiro, Benedito A., Dizon, Don S., Safran, Howard P., El-Deiry, Wafik S.
Published in Human vaccines & immunotherapeutics (03.08.2021)
Published in Human vaccines & immunotherapeutics (03.08.2021)
Get full text
Journal Article
Commentary: GSK-3 Inhibition as a Therapeutic Approach Against SARs CoV2: Dual Benefit of Inhibiting Viral Replication While Potentiating the Immune Response
De Souza, Andre, Tavora, Fabio A., Mahalingam, Devalingam, Munster, Pamela N., Safran, Howard P., El-Deiry, Wafik S., Carneiro, Benedito A.
Published in Frontiers in immunology (19.10.2020)
Published in Frontiers in immunology (19.10.2020)
Get full text
Journal Article
Trastuzumab with trimodality treatment for oesophageal adenocarcinoma with HER2 overexpression (NRG Oncology/RTOG 1010): a multicentre, randomised, phase 3 trial
Safran, Howard P, Winter, Kathryn, Ilson, David H, Wigle, Dennis, DiPetrillo, Thomas, Haddock, Michael G, Hong, Theodore S, Leichman, Lawrence P, Rajdev, Lakshmi, Resnick, Murray, Kachnic, Lisa A, Seaward, Samantha, Mamon, Harvey, Diaz Pardo, Dayssy Alexandra, Anderson, Carryn M, Shen, Xinglei, Sharma, Anand K, Katz, Alan W, Salo, Jonathan, Leonard, Kara L, Moughan, Jennifer, Crane, Christopher H
Published in The lancet oncology (01.02.2022)
Published in The lancet oncology (01.02.2022)
Get full text
Journal Article
Analysis of Radiation Therapy Quality Assurance in NRG Oncology RTOG 0848
Tchelebi, Leila T, Winter, Kathryn A, Abrams, Ross A, Safran, Howard P, Regine, William F, McNulty, Susan, Wu, Abraham, Du, Kevin L, Seaward, Samantha A, Bian, Shelly X, Aljumaily, Raid, Shivnani, Anand, Knoble, Jeanna L, Crocenzi, Todd S, DiPetrillo, Thomas A, Roof, Kevin S, Crane, Christopher H, Goodman, Karyn A
Published in International journal of radiation oncology, biology, physics (01.01.2024)
Published in International journal of radiation oncology, biology, physics (01.01.2024)
Get full text
Journal Article
Phase I study to assess the effect of adavosertib (AZD1775) on the pharmacokinetics of substrates of CYP1A2, CYP2C19, and CYP3A in patients with advanced solid tumors
Någård, Mats, Ah-See, Mei-Lin, Strauss, James, Wise-Draper, Trisha, Safran, Howard P., Nadeau, Laura, Edenfield, William J., Lewis, Lionel D., Ottesen, Lone H., Li, Yan, Mugundu, Ganesh M.
Published in Cancer chemotherapy and pharmacology (01.09.2023)
Published in Cancer chemotherapy and pharmacology (01.09.2023)
Get full text
Journal Article
Adavosertib (AZD1775) does not prolong the QTc interval in patients with advanced solid tumors: a phase I open-label study
Någård, Mats, Ah-See, Mei-Lin, Strauss, James, Wise-Draper, Trisha, Safran, Howard P., Nadeau, Laura, Edenfield, William J., Lewis, Lionel D., Rekić, Dinko, Dota, Corina, Ottesen, Lone H., Li, Yan, Mugundu, Ganesh M.
Published in Cancer chemotherapy and pharmacology (01.08.2023)
Published in Cancer chemotherapy and pharmacology (01.08.2023)
Get full text
Journal Article
Adjuvant FOLFOX+Nab-Paclitaxel (FOLFOX-A) for Pancreatic Cancer: A Brown University Oncology Research Group Phase II Study (BrUOG295)
Raufi, Alexander G, Breakstone, Rimini, Leonard, Kara, Charpentier, Kevin, Beard, Rachel, Renaud, Jennifer, Cavanaugh, Lindsey, Sturtevant, Ashlee, MacKinnon, Kelsey, Almhanna, Khaldoun, Olszewski, Adam, Safran, Howard P
Published in American journal of clinical oncology (01.12.2020)
Published in American journal of clinical oncology (01.12.2020)
Get more information
Journal Article
Oral administration of TRAIL-inducing small molecule ONC201/TIC10 prevents intestinal polyposis in the Apcmin/+ mouse model
Madka, Venkateshwar, De La Cruz, Arielle, Pathuri, Gopal, Panneerselvam, Janani, Zhang, Yuting, Stratton, Nicole, Hacking, Sean, Finnberg, Niklas K, Safran, Howard P, Sei, Shizuko, Glaze, Elizabeth R, Shoemaker, Robert, Fox, Jennifer T, Raufi, Alexander G, El-Deiry, Wafik S, Rao, Chinthalapally V
Published in American journal of cancer research (15.05.2022)
Get full text
Published in American journal of cancer research (15.05.2022)
Journal Article
Mechanistic insights into ADXS11-001 human papillomavirus-associated cancer immunotherapy
Miles, Brett A, Monk, Bradley J, Safran, Howard P
Published in Gynecologic oncology research and practice (02.06.2017)
Published in Gynecologic oncology research and practice (02.06.2017)
Get full text
Journal Article
Pathologic Response After Neoadjuvant Carboplatin and Weekly Paclitaxel for Early-Stage Lung Cancer: A Brown University Oncology Group Phase II Study
Ahmed, Shair, Birnbaum, Ariel E., Safran, Howard P., Dipetrillo, Thomas A., Aswad, Bassam I., Ready, Neal E., Ng, Thomas
Published in Journal of thoracic oncology (01.08.2011)
Published in Journal of thoracic oncology (01.08.2011)
Get full text
Journal Article
Abstract 4808: ONC201 decreases protein chaperone ClpX to unleash mitochondrial protease ClpP activity, intregrated stress response and tumor cell death
Zhou, Lanlan, Safran, Howard P., Glantz, Michael J., El-Deiry, Wafik S.
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Get full text
Journal Article
Abstract LB-C10: Preclinical synergistic anti-tumor effect against multiple cancer types by EZH2 inhibitor EPZ-6438 plus imipridone ONC201 to mimic H3K27M mutation observed in DIPG tumors that respond to ONC201 in the clinic
Zhang, Yiqun, Zhou, Lanlan, Zhang, Shengliang, Borsuk, Robyn, Safran, Howard P., Seyhan, Attila A., El-Deiry, Wafik S.
Published in Molecular cancer therapeutics (01.12.2019)
Published in Molecular cancer therapeutics (01.12.2019)
Get full text
Journal Article
Abstract B092: Assessment of glycogen synthase kinase-3 beta (GSK3β) genomic landscape to inform use of cancer therapeutics
Borden, Brittany A., Crawford, Lorin, Safran, Howard P., Giles, Francis J., El-Deiry, Wafik S., Carneiro, Benedito A.
Published in Molecular cancer therapeutics (01.12.2019)
Published in Molecular cancer therapeutics (01.12.2019)
Get full text
Journal Article
Abstract P021: Genomic biomarkers for response to 9-ING-41, a small molecule selective glycogen synthase kinase-3 (GSK-3) inhibitor, in pancreas cancer: Preliminary results
Borden, Brittany A., De Souza, Andre, Mahalingam, Devalingam, Powell, Steven, Munster, Pamela N., Huntington, Kelsey, Mazar, Andrew, Calvacante, Ludmila, Giles, Francis J., El-Deiry, Wafik S., Safran, Howard P., Carneiro, Benedito A.
Published in Molecular cancer therapeutics (01.12.2021)
Published in Molecular cancer therapeutics (01.12.2021)
Get full text
Journal Article
Abstract 14: TRAIL inducing small molecule ONC201 prevents intestinal tumors in FAP mouse model
Rao, Chinthalapally V., Madka, Venkateshwar, Zhang, Yuting, Pathuri, Gopal, Panneerselvam, Janani, Stratton, Nicole, Finnberg, Niklas K., Safran, Howard P., Fox, Jennifer, Sei, Shizuko, Glaze, Elizabeth R., Shoemaker, Robert, El-Deiry, Wafik S.
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Get full text
Journal Article