The cryo-EM structure of the bd oxidase from M. tuberculosis reveals a unique structural framework and enables rational drug design to combat TB
Safarian, Schara, Opel-Reading, Helen K., Wu, Di, Mehdipour, Ahmad R., Hards, Kiel, Harold, Liam K., Radloff, Melanie, Stewart, Ian, Welsch, Sonja, Hummer, Gerhard, Cook, Gregory M., Krause, Kurt L., Michel, Hartmut
Published in Nature communications (02.09.2021)
Published in Nature communications (02.09.2021)
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Journal Article
Structure of a bd oxidase indicates similar mechanisms for membrane-integrated oxygen reductases
Safarian, Schara, Rajendran, Chitra, Müller, Hannelore, Preu, Julia, Langer, Julian D., Ovchinnikov, Sergey, Hirose, Taichiro, Kusumoto, Tomoichirou, Sakamoto, Junshi, Michel, Hartmut
Published in Science (American Association for the Advancement of Science) (29.04.2016)
Published in Science (American Association for the Advancement of Science) (29.04.2016)
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Journal Article
Structural basis for amino acid exchange by a human heteromeric amino acid transporter
Wu, Di, Grund, Tamara N., Welsch, Sonja, Mills, Deryck J., Michel, Max, Safarian, Schara, Michel, Hartmut
Published in Proceedings of the National Academy of Sciences - PNAS (01.09.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (01.09.2020)
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Journal Article
Short-chain aurachin D derivatives are selective inhibitors of E. coli cytochrome bd-I and bd-II oxidases
Radloff, Melanie, Elamri, Isam, Grund, Tamara N., Witte, Luca F., Hohmann, Katharina F., Nakagaki, Sayaka, Goojani, Hojjat G., Nasiri, Hamid, Hideto Miyoshi, Bald, Dirk, Xie, Hao, Sakamoto, Junshi, Schwalbe, Harald, Safarian, Schara
Published in Scientific reports (13.12.2021)
Published in Scientific reports (13.12.2021)
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Journal Article
Inward-facing conformation of a multidrug resistance MATE family transporter
Zakrzewska, Sandra, Mehdipour, Ahmad Reza, Malviya, Viveka Nand, Nonaka, Tsuyoshi, Koepke, Juergen, Muenke, Cornelia, Hausner, Winfried, Hummer, Gerhard, Safarian, Schara, Miche, Hartmut
Published in Proceedings of the National Academy of Sciences - PNAS (18.06.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (18.06.2019)
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Journal Article
The cryoEM structure of cytochrome bd from C. glutamicum provides novel insights into structural properties of actinobacterial terminal oxidases
Grund, Tamara N, Kabashima, Yoshiki, Kusumoto, Tomoichirou, Wu, Di, Welsch, Sonja, Sakamoto, Junshi, Michel, Hartmut, Safarian, Schara
Published in Frontiers in chemistry (04.01.2023)
Published in Frontiers in chemistry (04.01.2023)
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Journal Article
High resolution cryoEM structures of terminal oxidases
Michel, Hartmut, Hatlem, Daniel, Wu, Di, Safarian, Schara
Published in Biochimica et biophysica acta. Bioenergetics (01.09.2024)
Published in Biochimica et biophysica acta. Bioenergetics (01.09.2024)
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Journal Article
Structure of a bd oxidase indicates similar mechanisms for membraneintegrated oxygen reductases
Safarian, Schara, Rajendran, Chitra, Müller, Hannelore, Preu, Julia, Langer, Julian D., Ovchinnikov, Sergey, Hirose, Taichiro, Kusumoto, Tomoichirou, Sakamoto, Junshi, Michel, Hartmut
Published in Science (American Association for the Advancement of Science) (29.04.2016)
Published in Science (American Association for the Advancement of Science) (29.04.2016)
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Journal Article
The Two TpsB-Like Proteins in Anabaena sp. Strain PCC 7120 Are Involved in Secretion of Selected Substrates
Ngo, Giang, Girbas, Melis, Schätzle, Hannah, Hammer, Andreas, Safarian, Schara, Hübinger, Maximilian, Schleiff, Enrico
Published in Journal of bacteriology (25.01.2021)
Published in Journal of bacteriology (25.01.2021)
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Journal Article
The structure of the Aquifex aeolicus MATE family multidrug resistance transporter and sequence comparisons suggest the existence of a new subfamily
Zhao, Jiangfeng, Xie, Hao, Mehdipour, Ahmad Reza, Safarian, Schara, Ermler, Ulrich, Münke, Cornelia, Thielmann, Yvonne, Hummer, Gerhard, Ebersberger, Ingo, Wang, Jingkang, Michel, Hartmut
Published in Proceedings of the National Academy of Sciences - PNAS (16.11.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (16.11.2021)
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Journal Article
Dissecting the conformational complexity and mechanism of a bacterial heme transporter
Wu, Di, Mehdipour, Ahmad R., Finke, Franziska, Goojani, Hojjat G., Groh, Roan R., Grund, Tamara N., Reichhart, Thomas M.B., Zimmermann, Rita, Welsch, Sonja, Bald, Dirk, Shepherd, Mark, Hummer, Gerhard, Safarian, Schara
Published in Biochimica et biophysica acta. Bioenergetics (01.09.2024)
Published in Biochimica et biophysica acta. Bioenergetics (01.09.2024)
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Journal Article
Mechanistic and structural diversity between cytochrome bd isoforms of Escherichia coli
Grund, Tamara N., Radloff, Melanie, Wu, Di, Goojani, Hojjat G., Witte, Luca F., Jösting, Wiebke, Buschmann, Sabine, Müller, Hannelore, Elamri, Isam, Welsch, Sonja, Schwalbe, Harald, Michel, Hartmut, Bald, Dirk, Safarian, Schara
Published in Proceedings of the National Academy of Sciences - PNAS (14.12.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (14.12.2021)
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Journal Article
Molecular mechanism of choline and ethanolamine transport in humans
Ri, Keiken, Weng, Tsai-Hsuan, Claveras Cabezudo, Ainara, Jösting, Wiebke, Zhang, Yu, Bazzone, Andre, Leong, Nancy C. P., Welsch, Sonja, Doty, Raymond T., Gursu, Gonca, Lim, Tiffany Jia Ying, Schmidt, Sarah Luise, Abkowitz, Janis L., Hummer, Gerhard, Wu, Di, Nguyen, Long N., Safarian, Schara
Published in Nature (London) (22.05.2024)
Published in Nature (London) (22.05.2024)
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Journal Article
Electrocatalytic evidence of the diversity of the oxygen reaction in the bacterial bd oxidase from different organisms
Nikolaev, Anton, Safarian, Schara, Thesseling, Alexander, Wohlwend, Daniel, Friedrich, Thorsten, Michel, Hartmut, Kusumoto, Tomoichirou, Sakamoto, Junshi, Melin, Frederic, Hellwig, Petra
Published in Biochimica et biophysica acta. Bioenergetics (01.08.2021)
Published in Biochimica et biophysica acta. Bioenergetics (01.08.2021)
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Journal Article
Dissecting the conformational complexity and mechanism of a bacterial heme transporter
Wu, Di, Mehdipour, Ahmad R., Finke, Franziska, Goojani, Hojjat G., Groh, Roan R., Grund, Tamara N., Reichhart, Thomas M. B., Zimmermann, Rita, Welsch, Sonja, Bald, Dirk, Shepherd, Mark, Hummer, Gerhard, Safarian, Schara
Published in Nature chemical biology (01.08.2023)
Published in Nature chemical biology (01.08.2023)
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Journal Article
Synthesis and Biological Screening of New Lawson Derivatives as Selective Substrate-Based Inhibitors of Cytochrome bo(3) Ubiquinol Oxidase from Escherichia coli
Elamri, Isam, Radloff, Melanie, Hohmann, Katharina F., Nimbarte, Vijaykumar D., Nasiri, Hamid R., Bolte, Michael, Safarian, Schara, Michel, Hartmut, Schwalbe, Harald
Published in ChemMedChem (20.07.2020)
Published in ChemMedChem (20.07.2020)
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Journal Article
Front Cover: Synthesis and Biological Screening of New Lawson Derivatives as Selective Substrate‐Based Inhibitors of Cytochrome bo 3 Ubiquinol Oxidase from Escherichia coli (ChemMedChem 14/2020)
Elamri, Isam, Radloff, Melanie, Hohmann, Katharina F., Nimbarte, Vijaykumar D., Nasiri, Hamid R., Bolte, Michael, Safarian, Schara, Michel, Hartmut, Schwalbe, Harald
Published in ChemMedChem (20.07.2020)
Published in ChemMedChem (20.07.2020)
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Journal Article
Front Cover: Synthesis and Biological Screening of New Lawson Derivatives as Selective Substrate‐Based Inhibitors of Cytochrome bo3 Ubiquinol Oxidase from Escherichia coli (ChemMedChem 14/2020)
Elamri, Isam, Radloff, Melanie, Hohmann, Katharina F., Nimbarte, Vijaykumar D., Nasiri, Hamid R., Bolte, Michael, Safarian, Schara, Michel, Hartmut, Schwalbe, Harald
Published in ChemMedChem (20.07.2020)
Published in ChemMedChem (20.07.2020)
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