Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy
Dragovich, Peter S, Pillow, Thomas H, Blake, Robert A, Sadowsky, Jack D, Adaligil, Emel, Adhikari, Pragya, Chen, Jinhua, Corr, Nicholas, dela Cruz-Chuh, Josefa, Del Rosario, Geoffrey, Fullerton, Aaron, Hartman, Steven J, Jiang, Fan, Kaufman, Susan, Kleinheinz, Tracy, Kozak, Katherine R, Liu, Liling, Lu, Ying, Mulvihill, Melinda M, Murray, Jeremy M, O’Donohue, Aimee, Rowntree, Rebecca K, Sawyer, William S, Staben, Leanna R, Wai, John, Wang, Jian, Wei, BinQing, Wei, Wentao, Xu, Zijin, Yao, Hui, Yu, Shang-Fan, Zhang, Donglu, Zhang, Hongyan, Zhang, Shenhua, Zhao, Yongxin, Zhou, Hao, Zhu, Xiaoyu
Published in Journal of medicinal chemistry (11.03.2021)
Published in Journal of medicinal chemistry (11.03.2021)
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Journal Article
Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 1: Exploration of Antibody Linker, Payload Loading, and Payload Molecular Properties
Dragovich, Peter S, Pillow, Thomas H, Blake, Robert A, Sadowsky, Jack D, Adaligil, Emel, Adhikari, Pragya, Bhakta, Sunil, Blaquiere, Nicole, Chen, Jinhua, dela Cruz-Chuh, Josefa, Gascoigne, Karen E, Hartman, Steven J, He, Mingtao, Kaufman, Susan, Kleinheinz, Tracy, Kozak, Katherine R, Liu, Liang, Liu, Liling, Liu, Qi, Lu, Ying, Meng, Fanwei, Mulvihill, Melinda M, O’Donohue, Aimee, Rowntree, Rebecca K, Staben, Leanna R, Staben, Steven T, Wai, John, Wang, Jian, Wei, BinQing, Wilson, Catherine, Xin, Jianfeng, Xu, Zijin, Yao, Hui, Zhang, Donglu, Zhang, Hongyan, Zhou, Hao, Zhu, Xiaoyu
Published in Journal of medicinal chemistry (11.03.2021)
Published in Journal of medicinal chemistry (11.03.2021)
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Journal Article
A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1
Rettenmaier, T. Justin, Sadowsky, Jack D., Thomsen, Nathan D., Chen, Steven C., Doak, Allison K., Arkin, Michelle R., Wells, James A.
Published in Proceedings of the National Academy of Sciences - PNAS (30.12.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (30.12.2014)
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Journal Article
Turning a protein kinase on or off from a single allosteric site via disulfide trapping
Sadowsky, Jack D, Burlingame, Mark A, Wolan, Dennis W, McClendon, Christopher L, Jacobson, Matthew P, Wells, James A
Published in Proceedings of the National Academy of Sciences - PNAS (12.04.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (12.04.2011)
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Journal Article
High-Resolution Structural Characterization of a Helical α/β-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-xL
Lee, Erinna F, Sadowsky, Jack D, Smith, Brian J, Czabotar, Peter E, Peterson-Kaufman, Kimberly J, Colman, Peter M, Gellman, Samuel H, Fairlie, W. Douglas
Published in Angewandte Chemie (International ed.) (01.01.2009)
Published in Angewandte Chemie (International ed.) (01.01.2009)
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Journal Article
Chimeric (α/β + α)-Peptide Ligands for the BH3-Recognition Cleft of Bcl-xL: Critical Role of the Molecular Scaffold in Protein Surface Recognition
Sadowsky, Jack D, Schmitt, Margaret A, Lee, Hee-Seung, Umezawa, Naoki, Wang, Shaomeng, Tomita, York, Gellman, Samuel H
Published in Journal of the American Chemical Society (31.08.2005)
Published in Journal of the American Chemical Society (31.08.2005)
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Journal Article
Ring-Closing Metathesis of Olefinic Peptides: Design, Synthesis, and Structural Characterization of Macrocyclic Helical Peptides
Blackwell, Helen E, Sadowsky, Jack D, Howard, Rebecca J, Sampson, Joshua N, Chao, Jeffery A, Steinmetz, Wayne E, O'Leary, Daniel J, Grubbs, Robert H
Published in Journal of organic chemistry (10.08.2001)
Published in Journal of organic chemistry (10.08.2001)
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Journal Article
Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity
Pillow, Thomas H., Adhikari, Pragya, Blake, Robert A., Chen, Jinhua, Del Rosario, Geoffrey, Deshmukh, Gauri, Figueroa, Isabel, Gascoigne, Karen E., Kamath, Amrita V., Kaufman, Susan, Kleinheinz, Tracy, Kozak, Katherine R., Latifi, Brandon, Leipold, Douglas D., Sing Li, Chun, Li, Ruina, Mulvihill, Melinda M., O'Donohue, Aimee, Rowntree, Rebecca K., Sadowsky, Jack D., Wai, John, Wang, Xinxin, Wu, Cong, Xu, Zijin, Yao, Hui, Yu, Shang‐Fan, Zhang, Donglu, Zang, Richard, Zhang, Hongyan, Zhou, Hao, Zhu, Xiaoyu, Dragovich, Peter S.
Published in ChemMedChem (07.01.2020)
Published in ChemMedChem (07.01.2020)
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Journal Article
Decoupling stability and release in disulfide bonds with antibody-small molecule conjugates
Pillow, Thomas H., Sadowsky, Jack D., Zhang, Donglu, Yu, Shang-Fan, Del Rosario, Geoffrey, Xu, Keyang, He, Jintang, Bhakta, Sunil, Ohri, Rachana, Kozak, Katherine R., Ha, Edward, Junutula, Jagath R., Flygare, John A.
Published in Chemical science (Cambridge) (01.01.2017)
Published in Chemical science (Cambridge) (01.01.2017)
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Journal Article
On Demand Bioorthogonal Switching of an Antibody-Conjugated SPECT Probe to a Cytotoxic Payload: from Imaging to Therapy
Adhikari, Pragya, Li, Guangmin, Go, MaryAnn, Mandikian, Danielle, Rafidi, Hanine, Ng, Carl, Anifa, Sagana, Johnson, Kevin, Bao, Linda, Hernandez Barry, Hilda, Rowntree, Rebecca, Agard, Nicholas, Wu, Cong, Chou, Kang-Jye, Zhang, Donglu, Kozak, Katherine R., Pillow, Thomas H., Lewis, Gail D., Yu, Shang-Fan, Boswell, C. Andrew, Sadowsky, Jack D.
Published in Journal of the American Chemical Society (17.07.2024)
Published in Journal of the American Chemical Society (17.07.2024)
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Journal Article
Catalytic Cleavage of Disulfide Bonds in Small Molecules and Linkers of Antibody-Drug Conjugates
Zhang, Donglu, Fourie-O'Donohue, Aimee, Dragovich, Peter S, Pillow, Thomas H, Sadowsky, Jack D, Kozak, Katherine R, Cass, Robert T, Liu, Liling, Deng, Yuzhong, Liu, Yichin, Hop, Cornelis E C A, Khojasteh, S Cyrus
Published in Drug metabolism and disposition (01.10.2019)
Published in Drug metabolism and disposition (01.10.2019)
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Journal Article
Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues
Zhang, Donglu, Dragovich, Peter S, Yu, Shang-Fan, Ma, Yong, Pillow, Thomas H, Sadowsky, Jack D, Su, Dian, Wang, Wei, Polson, Andrew, Khojasteh, S Cyrus, Hop, Cornelis E C A
Published in Drug metabolism and disposition (01.10.2019)
Published in Drug metabolism and disposition (01.10.2019)
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Journal Article
An Anti-CD22- seco -CBI-Dimer Antibody-Drug Conjugate (ADC) for the Treatment of Non-Hodgkin Lymphoma That Provides a Longer Duration of Response than Auristatin-Based ADCs in Preclinical Models
Yu, Shang-Fan, Lee, Donna W, Zheng, Bing, Del Rosario, Geoffrey, Leipold, Douglas, Booler, Helen, Zhong, Fiona, Carrasco-Triguero, Montserrat, Hong, Kyu, Yan, Peter, Rowntree, Rebecca K, Schutten, Melissa M, Pillow, Thomas, Sadowsky, Jack D, Dragovich, Peter S, Polson, Andrew G
Published in Molecular cancer therapeutics (01.02.2021)
Published in Molecular cancer therapeutics (01.02.2021)
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Journal Article
Intratumoral Payload Concentration Correlates with the Activity of Antibody-Drug Conjugates
Zhang, Donglu, Yu, Shang-Fan, Khojasteh, S Cyrus, Ma, Yong, Pillow, Thomas H, Sadowsky, Jack D, Su, Dian, Kozak, Katherine R, Xu, Keyang, Polson, Andrew G, Dragovich, Peter S, Hop, Cornelis E C A
Published in Molecular cancer therapeutics (01.03.2018)
Published in Molecular cancer therapeutics (01.03.2018)
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Journal Article
Development of Efficient Chemistry to Generate Site-Specific Disulfide-Linked Protein– and Peptide–Payload Conjugates: Application to THIOMAB Antibody–Drug Conjugates
Sadowsky, Jack D, Pillow, Thomas H, Chen, Jinhua, Fan, Fang, He, Changrong, Wang, Yanli, Yan, Gang, Yao, Hui, Xu, Zijin, Martin, Shanique, Zhang, Donglu, Chu, Phillip, dela Cruz-Chuh, Josefa, O’Donohue, Aimee, Li, Guangmin, Del Rosario, Geoffrey, He, Jintang, Liu, Luna, Ng, Carl, Su, Dian, Lewis Phillips, Gail D, Kozak, Katherine R, Yu, Shang-Fan, Xu, Keyang, Leipold, Douglas, Wai, John
Published in Bioconjugate chemistry (16.08.2017)
Published in Bioconjugate chemistry (16.08.2017)
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Journal Article
High‐Resolution Structural Characterization of a Helical α/β‐Peptide Foldamer Bound to the Anti‐Apoptotic Protein Bcl‐x L
Lee, Erinna F., Sadowsky, Jack D., Smith, Brian J., Czabotar, Peter E., Peterson‐Kaufman, Kimberly J., Colman, Peter M., Gellman, Samuel H., Fairlie, W. Douglas
Published in Angewandte Chemie International Edition (02.06.2009)
Published in Angewandte Chemie International Edition (02.06.2009)
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Journal Article
Effect of Modulating FcRn Binding on Direct and Pretargeted Tumor Uptake of Full-length Antibodies
Nazarova, Lidia, Rafidi, Hanine, Mandikian, Danielle, Ferl, Gregory Z, Koerber, James T, Davies, Christopher W, Ulufatu, Sheila, Ho, Jason, Lau, Jeffrey, Yu, Shang-Fan, Ernst, James, Sadowsky, Jack D, Boswell, C Andrew
Published in Molecular cancer therapeutics (01.04.2020)
Published in Molecular cancer therapeutics (01.04.2020)
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Journal Article
Ordering a Dynamic Protein Via a Small-Molecule Stabilizer
Wang, Ningkun, Majmudar, Chinmay Y, Pomerantz, William C, Gagnon, Jessica K, Sadowsky, Jack D, Meagher, Jennifer L, Johnson, Taylor K, Stuckey, Jeanne A, Brooks, Charles L, Wells, James A, Mapp, Anna K
Published in Journal of the American Chemical Society (06.03.2013)
Published in Journal of the American Chemical Society (06.03.2013)
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Journal Article
Immolation of p‑Aminobenzyl Ether Linker and Payload Potency and Stability Determine the Cell-Killing Activity of Antibody–Drug Conjugates with Phenol-Containing Payloads
Zhang, Donglu, Le, Hoa, Cruz-Chuh, Josefa dela, Bobba, Sudheer, Guo, Jun, Staben, Leanna, Zhang, Chenghong, Ma, Yong, Kozak, Katherine R, Lewis Phillips, Gail D, Vollmar, Breanna S, Sadowsky, Jack D, Vandlen, Richard, Wei, BinQing, Su, Dian, Fan, Peter, Dragovich, Peter S, Khojasteh, S. Cyrus, Hop, Cornelis E. C. A, Pillow, Thomas H
Published in Bioconjugate chemistry (21.02.2018)
Published in Bioconjugate chemistry (21.02.2018)
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Journal Article
(alpha/beta+alpha)-Peptide antagonists of BH3 Domain/Bcl-x(L) recognition: Toward general strategies for foldamer-based inhibition of protein-protein interactions
Sadowsky, Jack D., Douglas Fairlie, W., Hadley, Erik B., Lee, Hee-Seung, Umezawa, Naoki, Nikolovska-Coleska, Zaneta, Wang, Shaomeng, Huang, David C. S., Tomita, York, Gellman, Samuel H.
Published in Journal of the American Chemical Society (10.01.2007)
Published in Journal of the American Chemical Society (10.01.2007)
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Journal Article