Mechanistic Investigation of Bone Marrow Suppression Associated with Palbociclib and its Differentiation from Cytotoxic Chemotherapies
Hu, Wenyue, Sung, Tae, Jessen, Bart A, Thibault, Stephane, Finkelstein, Martin B, Khan, Nasir K, Sacaan, Aida I
Published in Clinical cancer research (15.04.2016)
Published in Clinical cancer research (15.04.2016)
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Pharmaceutical industry perspective on combination toxicity studies: Results from an intra-industry survey conducted by IQ DruSafe Leadership Group
Birkebak, Joanne, Buckley, Lorrene A., Dambach, Donna, Musvasva, Eunice, Price, Karen, Ralston, Sherry, Sacaan, Aida
Published in Regulatory toxicology and pharmacology (01.03.2019)
Published in Regulatory toxicology and pharmacology (01.03.2019)
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CDK4/6 Inhibition on Glucose and Pancreatic Beta Cell Homeostasis in Young and Aged Rats
Sacaan, Aida I, Thibault, Stephane, Hong, Miyoun, Kondegowda, Nagesha G, Nichols, Tim, Li, Rosemary, Rosselot, Carolina, Evering, Winston, Fenutria, Rafael, Vitsky, Allison, Brown, Thomas, Finkelstein, Martin, Garcia-Ocaña, Adolfo, Khan, Nasir, Stewart, Andrew F, Vasavada, Rupangi C
Published in Molecular cancer research (01.11.2017)
Published in Molecular cancer research (01.11.2017)
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Characterization of Novel Selective H1-Antihistamines for Clinical Evaluation in the Treatment of Insomnia
Moree, Wilna J, Li, Bin-Feng, Jovic, Florence, Coon, Timothy, Yu, Jinghua, Gross, Raymond S, Tucci, Fabio, Marinkovic, Dragan, Zamani-Kord, Said, Malany, Siobhan, Bradbury, Margaret J, Hernandez, Lisa M, O’Brien, Zhihong, Wen, Jianyun, Wang, Hua, Hoare, Samuel R. J, Petroski, Robert E, Sacaan, Aida, Madan, Ajay, Crowe, Paul D, Beaton, Graham
Published in Journal of medicinal chemistry (10.09.2009)
Published in Journal of medicinal chemistry (10.09.2009)
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SIB-1757 and SIB-1893: Selective, Noncompetitive Antagonists of Metabotropic Glutamate Receptor Type 5
Varney, M A, Cosford, N D, Jachec, C, Rao, S P, Sacaan, A, Lin, F F, Bleicher, L, Santori, E M, Flor, P J, Allgeier, H, Gasparini, F, Kuhn, R, Hess, S D, Veliçelebi, G, Johnson, E C
Published in The Journal of pharmacology and experimental therapeutics (01.07.1999)
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Published in The Journal of pharmacology and experimental therapeutics (01.07.1999)
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Pharmacological characterization of dopamine, norepinephrine and serotonin release in the rat prefrontal cortex by neuronal nicotinic acetylcholine receptor agonists
Rao, Tadimeti S., Correa, Lucia D., Adams, Pamala, Santori, Emily M., Sacaan, Aida I.
Published in Brain research (14.11.2003)
Published in Brain research (14.11.2003)
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Novel benzothiophene H1-antihistamines for the treatment of insomnia
MOREE, Wilna J, JOVIC, Florence, HERNANDEZ, Lisa M, O'BRIEN, Zhihong, JIANYUN WEN, HUA WANG, HOARE, Samuel R. J, PETROSKI, Robert E, SACAAN, Aida, MADAN, Ajay, CROWE, Paul D, BEATON, Graham, COON, Timothy, JINGHUA YU, LI, Bin-Feng, TUCCI, Fabio C, MARINKOVIC, Dragan, GROSS, Raymond S, MALANY, Siobhan, BRADBURY, Margaret J
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
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Journal Article
2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist
Gasparini, Fabrizio, Lingenhöhl, Kurt, Stoehr, Natacha, Flor, Peter J, Heinrich, Micheline, Vranesic, Ivo, Biollaz, Michel, Allgeier, Hans, Heckendorn, Roland, Urwyler, Stephan, Varney, Mark A, Johnson, Edwin C, Hess, Stephen D, Rao, Sara P, Sacaan, Aida I, Santori, Emily M, Veliçelebi, Gönul, Kuhn, Rainer
Published in Neuropharmacology (01.10.1999)
Published in Neuropharmacology (01.10.1999)
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An Approach to Early-Phase Salt Selection: Application to NBI-75043
Gross, Timothy D, Schaab, Kevin, Ouellette, Michael, Zook, Scott, Reddy, Jayachandra P, Shurtleff, Arthur, Sacaan, Aida I, Alebic-Kolbah, Tanja, Bozigian, Haig
Published in Organic process research & development (01.05.2007)
Published in Organic process research & development (01.05.2007)
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Pharmacological characterization of (S)-(2)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine HCl (SIB-1508Y, Altinicline), a novel nicotinic acetylcholine receptor agonist
Rao, Tadimeti S, Adams, Pamala B, Correa, Lucia D, Santori, Emily M, Sacaan, Aida I, Reid, Richard T, Cosford, Nicholas D.P
Published in Brain research (09.10.2008)
Published in Brain research (09.10.2008)
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Gemtuzumab Ozogamicin Treatment Results in Decreased Proliferation and Differentiation of Human Megakaryocytes but Does Not Inhibit Mature Platelet Function
Vitsky, Allison, Sacaan, Aida, Hu, Wenyue, Finkelstein, Martin, Reagan, William
Published in Toxicologic pathology (01.10.2022)
Published in Toxicologic pathology (01.10.2022)
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In vitro pharmacological characterization of (±)-4-[2-(1-methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride (SIB-1553A), a nicotinic acetylcholine receptor ligand
Rao, Tadimeti S., Adams, Pamala B., Correa, Lucia D., Santori, Emily M., Sacaan, Aida I., Reid, Richard T., Suto, Carla M., Michel Vernier, Jean
Published in Brain research (15.08.2003)
Published in Brain research (15.08.2003)
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(S)-(−)-5-Ethynyl-3-(1-methyl-2-pyrroli- dinyl)pyridine Maleate (SIB-1508Y): A Novel Anti-Parkinsonian Agent with Selectivity for Neuronal Nicotinic Acetylcholine Receptors
Cosford, Nicholas D. P, Bleicher, Leo, Herbaut, Audrey, McCallum, J. Stuart, Vernier, Jean-Michel, Dawson, Heather, Whitten, Jeffrey P, Adams, Pamala, Chavez-Noriega, Laura, Correa, Lucia D, Crona, James H, Mahaffy, Lorrence S, Menzaghi, Frederique, Rao, Tadimeti S, Reid, Richard, Sacaan, Aida I, Santori, Emily, Stauderman, Kenneth A, Whelan, Kevin, Lloyd, G. Kenneth, McDonald, Ian A
Published in Journal of medicinal chemistry (16.08.1996)
Published in Journal of medicinal chemistry (16.08.1996)
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In vivo pharmacological characterization of (±)-4-[2-(1-methyl-2-pyrrolidinyl)ethyl]thiophenol hydrochloride (SIB-1553A), a novel cholinergic ligand: microdialysis studies
Rao, Tadimeti S, Reid, Richard T, Correa, Lucia D, Santori, Emily M, Gardner, Michael F, Sacaan, Aida I, Lorrain, Daniel, Vernier, Jean-Michel
Published in Brain research (03.10.2003)
Published in Brain research (03.10.2003)
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Journal Article
Pharmacological characterization of SIB-1663, a conformationally rigid analog of nicotine
Rao, Tadimeti S, Sacaan, Aida I, Menzaghi, Frederique M, Reid, Richard T, Adams, Pamala B, Correa, Lucia D, Whelan, Kevin T, Vernier, Jean-Michel
Published in Brain research (02.04.2004)
Published in Brain research (02.04.2004)
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Intestinal Toxicity in Rats Following Administration of CDK4/6 Inhibitors Is Independent of Primary Pharmacology
Thibault, Stephane, Hu, Wenyue, Hirakawa, Brad, Kalabat, Dalia, Franks, Tania, Sung, Tae, Khoh-Reiter, Su, Lu, Shuyan, Finkelstein, Martin, Jessen, Bart, Sacaan, Aida
Published in Molecular cancer therapeutics (01.02.2019)
Published in Molecular cancer therapeutics (01.02.2019)
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Journal Article
4-[[2-(1-Methyl-2-pyrrolidinyl)ethyl]thio]- phenol Hydrochloride (SIB-1553A): A Novel Cognitive Enhancer with Selectivity for Neuronal Nicotinic Acetylcholine Receptors
Vernier, Jean-Michel, El-Abdellaoui, Hassan, Holsenback, Heather, Cosford, Nicholas D. P, Bleicher, Leo, Barker, Geoffrey, Bontempi, Bruno, Chavez-Noriega, Laura, Menzaghi, Frederique, Rao, Tadimeti S, Reid, Richard, Sacaan, Aida I, Suto, Carla, Washburn, Mark, Lloyd, G. Kenneth, McDonald, Ian A
Published in Journal of medicinal chemistry (20.05.1999)
Published in Journal of medicinal chemistry (20.05.1999)
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