To Target or Not to Target Schistosoma mansoni Cyclic Nucleotide Phosphodiesterase 4A?
Zheng, Yang, Schroeder, Susanne, Kanev, Georgi K, Botros, Sanaa S, William, Samia, Sabra, Abdel-Nasser A, Maes, Louis, Caljon, Guy, Gil, Carmen, Martinez, Ana, Salado, Irene G, Augustyns, Koen, Edink, Ewald, Sijm, Maarten, de Heuvel, Erik, de Esch, Iwan J P, van der Meer, Tiffany, Siderius, Marco, Sterk, Geert Jan, Brown, David, Leurs, Rob
Published in International journal of molecular sciences (06.04.2023)
Published in International journal of molecular sciences (06.04.2023)
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Journal Article
Deciphering the enzymatic target of a new family of antischistosomal agents bearing a quinazoline scaffold using complementary computational tools
Sebastian-Perez, Victor, García-Rubia, Alfonso, Seif el-Din, Sayed H., Sabra, Abdel-Nasser A., El-Lakkany, Naglaa M., William, Samia, Blundell, Tom L., Maes, Louis, Martinez, Ana, Campillo, Nuria E., Botros, Sanaa S., Gil, Carmen
Published in Journal of enzyme inhibition and medicinal chemistry (01.01.2020)
Published in Journal of enzyme inhibition and medicinal chemistry (01.01.2020)
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Hepatoprotective and Antioxidant Effect of Bauhinia hookeri Extract against Carbon Tetrachloride-Induced Hepatotoxicity in Mice and Characterization of Its Bioactive Compounds by HPLC-PDA-ESI-MS/MS
Martiskainen, Olli, Sabra, Abdel-Nasser A., al-Sayed, Eman, Abdel-Daim, Mohamed M., El-Lakkany, Naglaa M., Hammam, Olfat A., Seif el-Din, Sayed H.
Published in BioMed research international (01.01.2014)
Published in BioMed research international (01.01.2014)
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Journal Article
Co-administration of metformin and N-acetylcysteine with dietary control improves the biochemical and histological manifestations in rats with non-alcoholic fatty liver
El-Lakkany, Naglaa, Seif el-Din, Sayed, Sabra, Abdel-Nasser, Hammam, Olfat, Ebeid, Fatma
Published in Research in pharmaceutical sciences (01.01.2016)
Published in Research in pharmaceutical sciences (01.01.2016)
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Journal Article
Hepatoprotective and antioxidant activity of Melaleuca styphelioides on carbon tetrachloride-induced hepatotoxicity in mice
Al-Sayed, Eman, El-Lakkany, Naglaa M., Seif el-Din, Sayed H., Sabra, Abdel-Nasser A., Hammam, Olfat A.
Published in Pharmaceutical biology (01.12.2014)
Published in Pharmaceutical biology (01.12.2014)
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Journal Article
Screening of a PDE-focused library identifies imidazoles with in vitro and in vivo antischistosomal activity
Botros, Sanaa S., William, Samia, Sabra, Abdel-Nasser A., El-Lakkany, Naglaa M., Seif el-Din, Sayed H., García-Rubia, Alfonso, Sebastián-Pérez, Victor, Blaazer, Antoni R., de Heuvel, Erik, Sijm, Maarten, Zheng, Yang, Salado, Irene G., Munday, Jane C., Maes, Louis, de Esch, Iwan J.P., Sterk, Geert J., Augustyns, Koen, Leurs, Rob, Gil, Carmen, De Koning, Harry P.
Published in International journal for parasitology -- drugs and drug resistance (01.04.2019)
Published in International journal for parasitology -- drugs and drug resistance (01.04.2019)
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Journal Article
Pharmacodynamics of mefloquine and praziquantel combination therapy in mice harbouring juvenile and adult Schistosoma mansoni
el-Lakkany, Naglaa Mohamed, el-Din, Sayed Hassan Seif, Sabra, Abdel-Nasser Abdel-Aal, Hammam, Olfat Ali
Published in Memórias do Instituto Oswaldo Cruz (01.11.2011)
Published in Memórias do Instituto Oswaldo Cruz (01.11.2011)
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Journal Article
Effect of Ketoconazole, a Cytochrome P450 Inhibitor, on the Efficacy of Quinine and Halofantrine against Schistosoma mansoni in Mice
Seif el-Din, S.H., Theodor Bilharz Research Institute, Warak El-Hadar, Giza, Egypt, Sabra, A.A., Theodor Bilharz Research Institute, Warak El-Hadar, Giza, Egypt, Hammam, O.A., Theodor Bilharz Research Institute, Warak El-Hadar, Giza, Egypt, El-Lakkany, N.M., Theodor Bilharz Research Institute, Warak El-Hadar, Giza, Egypt
Published in Korean journal of parasitology (01.04.2013)
Published in Korean journal of parasitology (01.04.2013)
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Journal Article
Itraconazole, a cytochrome P450 inhibitor, enhanced the efficacy of praziquantel against Schistosoma mansoni infection and alleviated liver injury in mice
Sabra, Abdel-Nasser A., Salem, Maha B., William, Samia, Hammam, Olfat A., El-Lakkany, Naglaa M.
Published in Experimental parasitology (01.08.2022)
Published in Experimental parasitology (01.08.2022)
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Journal Article
The phosphodiesterase-4 inhibitor roflumilast impacts Schistosoma mansoni ovipositing in vitro but displays only modest antischistosomal activity in vivo
Botros, Sanaa S., El-Lakkany, Naglaa M., Seif el-Din, Sayed H., William, Samia, Sabra, Abdel-Nasser, Hammam, Olfat A., de Koning, Harry P.
Published in Experimental parasitology (01.01.2020)
Published in Experimental parasitology (01.01.2020)
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Journal Article
Cloning and functional complementation of ten Schistosoma mansoni phosphodiesterases expressed in the mammalian host stages
Munday, Jane C, Kunz, Stefan, Kalejaiye, Titilola D, Siderius, Marco, Schroeder, Susanne, Paape, Daniel, Alghamdi, Ali H, Abbasi, Zainab, Huang, Sheng Xiang, Donachie, Anne-Marie, William, Samia, Sabra, Abdel Nasser, Sterk, Geert Jan, Botros, Sanaa S, Brown, David G, Hoffman, Charles S, Leurs, Rob, de Koning, Harry P
Published in PLoS neglected tropical diseases (01.07.2020)
Published in PLoS neglected tropical diseases (01.07.2020)
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Journal Article
Pharmacological and antioxidant actions of garlic and.or onion in non-alcoholic fatty liver disease (NAFLD) in rats
El-Din, Sayed H Seif, Sabra, Abdel-Nasser A, Hammam, Olfat A, Ebeid, Fatma A, El-Lakkany, Naglaa M
Published in Journal of the Egyptian Society of Parasitology (01.08.2014)
Published in Journal of the Egyptian Society of Parasitology (01.08.2014)
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Journal Article
Protective effect of Pelargonium graveolens against carbon tetrachloride-induced hepatotoxicity in mice and characterization of its bioactive constituents by HPLC–PDA–ESI–MS/MS analysis
Al-Sayed, Eman, Martiskainen, Olli, Seif el-Din, Sayed H., Sabra, Abdel-Nasser A., Hammam, Olfat A., El-Lakkany, Naglaa M.
Published in Medicinal chemistry research (01.04.2015)
Published in Medicinal chemistry research (01.04.2015)
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Journal Article
Comparative efficacy and bioavailability of different praziquantel brands
Botros, Sanaa, El-Lakkany, Naglaa, Seif el-Din, Sayed H., Sabra, Abdel-Nasser, Ibrahim, Magda
Published in Experimental parasitology (01.02.2011)
Published in Experimental parasitology (01.02.2011)
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Journal Article
Determination of ED50 values for praziquantel in praziquantel-resistant and -susceptible Schistosoma mansoni isolates
CIOLIA, Donato, BOTROS, Sanaa S, ALBIN, Jan, ENGELS, Dirk, DOENHOFF, Michael J, WHEATCROFT-FRANCKLOW, Katherine, MBAYE, Amadou, SOUTHGATE, Vaughan, TCHUENTE, Louis-Albert Tchuem, PICA-MATTOCCIA, Livia, TROIANI, Anna Rita, EL-DIN, Sayed H, SABRA, Abdel-Nasser A
Published in International journal for parasitology (01.07.2004)
Published in International journal for parasitology (01.07.2004)
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Journal Article
DRUG-METABOLIZING ENZYMES AND PRAZIQUANTEL BIOAVAILABILITY IN MICE HARBORING SCHISTOSOMA MANSONI ISOLATES OF DIFFERENT DRUG SUSCEPTIBILITIES
Botros, Sanaa S, Seif el-Din, Sayed H, El-Lakkany, Naglaa M, Sabra, Abdel Nasser A, Ebeid, Fatma A
Published in The Journal of parasitology (01.12.2006)
Published in The Journal of parasitology (01.12.2006)
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Journal Article
Effect of Ketoconazole, a Cytochrome P450 Inhibitor, on the Efficacy of Quinine and Halofantrine against Schistosoma mansoni in Mice
Seif el-Din, Sayed Hassan, Abdel-Aal Sabra, Abdel-Nasser, Hammam, Olfat Ali, El-Lakkany, Naglaa Mohamed
Published in Korean journal of parasitology (2013)
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Published in Korean journal of parasitology (2013)
Journal Article
To Target or Not to Target ISchistosoma mansoni/I Cyclic Nucleotide Phosphodiesterase 4A?
Zheng, Yang, Schroeder, Susanne, Kanev, Georgi K, Botros, Sanaa S, William, Samia, Sabra, Abdel-Nasser A, Maes, Louis, Caljon, Guy, Gil, Carmen, Ma, Salado, Irene G, Augustyns, Koen, Edink, Ewald, Sijm, Maarten, de Heuvel, Erik, de Esch, Iwan J. P, van der Meer, Tiffany, Siderius, Marco, Sterk, Geert Jan, Brown, David, Leurs, Rob
Published in International journal of molecular sciences (01.04.2023)
Published in International journal of molecular sciences (01.04.2023)
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Journal Article