DDR1 role in fibrosis and its pharmacological targeting
Moll, Solange, Desmoulière, Alexis, Moeller, Marcus J., Pache, Jean-Claude, Badi, Laura, Arcadu, Filippo, Richter, Hans, Satz, Alexander, Uhles, Sabine, Cavalli, Andrea, Drawnel, Faye, Scapozza, Leonardo, Prunotto, Marco
Published in Biochimica et biophysica acta. Molecular cell research (01.11.2019)
Published in Biochimica et biophysica acta. Molecular cell research (01.11.2019)
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Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans
Finan, Brian, Ma, Tao, Ottaway, Nickki, Müller, Timo D, Habegger, Kirk M, Heppner, Kristy M, Kirchner, Henriette, Holland, Jenna, Hembree, Jazzminn, Raver, Christine, Lockie, Sarah H, Smiley, David L, Gelfanov, Vasily, Yang, Bin, Hofmann, Susanna, Bruemmer, Dennis, Drucker, Daniel J, Pfluger, Paul T, Perez-Tilve, Diego, Gidda, Jaswant, Vignati, Louis, Zhang, Lianshan, Hauptman, Jonathan B, Lau, Michele, Brecheisen, Mathieu, Uhles, Sabine, Riboulet, William, Hainaut, Emmanuelle, Sebokova, Elena, Conde-Knape, Karin, Konkar, Anish, DiMarchi, Richard D, Tschöp, Matthias H
Published in Science translational medicine (30.10.2013)
Published in Science translational medicine (30.10.2013)
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DNA-Encoded Library-Derived DDR1 Inhibitor Prevents Fibrosis and Renal Function Loss in a Genetic Mouse Model of Alport Syndrome
Richter, Hans, Satz, Alexander L, Bedoucha, Marc, Buettelmann, Bernd, Petersen, Ann C, Harmeier, Anja, Hermosilla, Ricardo, Hochstrasser, Remo, Burger, Dominique, Gsell, Bernard, Gasser, Rodolfo, Huber, Sylwia, Hug, Melanie N, Kocer, Buelent, Kuhn, Bernd, Ritter, Martin, Rudolph, Markus G, Weibel, Franziska, Molina-David, Judith, Kim, Jin-Ju, Santos, Javier Varona, Stihle, Martine, Georges, Guy J, Bonfil, R. Daniel, Fridman, Rafael, Uhles, Sabine, Moll, Solange, Faul, Christian, Fornoni, Alessia, Prunotto, Marco
Published in ACS chemical biology (18.01.2019)
Published in ACS chemical biology (18.01.2019)
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Journal Article
Inducers of the endothelial cell barrier identified through chemogenomic screening in genome-edited hPSC-endothelial cells
Roudnicky, Filip, Kim, Bo Kyoung, Pandya, Nikhil J., Lan, Yanjun, Sach-Peltason, Lisa, Ragelle, Heloise, Strassburger, Pamela, Gruener, Sabine, Lazendic, Mirjana, Uhles, Sabine, Revelant, Franco, Eidam, Oliv, Sturm, Gregor, Kueppers, Verena, Christensen, Klaus, Goldstein, Leonard D., Tzouros, Manuel, Banfai, Balazs, Modrusan, Zora, Graf, Martin, Patsch, Christoph, Burcin, Mark, Meyer, Claas A., Westenskow, Peter D., Cowan, Chad A.
Published in Proceedings of the National Academy of Sciences - PNAS (18.08.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (18.08.2020)
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Journal Article
Delineating effects of angiopoietin-2 inhibition on vascular permeability and inflammation in models of retinal neovascularization and ischemia/reperfusion
Canonica, Jérémie, Foxton, Richard, Garrido, Marina Garcia, Lin, Cheng-Mao, Uhles, Sabine, Shanmugam, Sumathi, Antonetti, David A, Abcouwer, Steven F, Westenskow, Peter D
Published in Frontiers in cellular neuroscience (12.06.2023)
Published in Frontiers in cellular neuroscience (12.06.2023)
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RG7774 (Vicasinabin), an orally bioavailable cannabinoid receptor 2 (CB2R) agonist, decreases retinal vascular permeability, leukocyte adhesion, and ocular inflammation in animal models
Grether, Uwe, Foxton, Richard H, Gruener, Sabine, Korn, Claudia, Kimbara, Atsushi, Osterwald, Anja, Zirwes, Elisabeth, Uhles, Sabine, Thoele, Janina, Colé, Nadine, Rogers-Evans, Mark, Röver, Stephan, Nettekoven, Matthias, Martin, Rainer E, Adam, Jean-Michel, Fingerle, Jürgen, Bissantz, Caterina, Guba, Wolfgang, Alker, André, Szczesniak, Anna M, Porter, Ross F, Toguri, Tom J, Revelant, Franco, Poirier, Agnès, Perret, Camille, Winther, Lotte, Caruso, Antonello, Fezza, Filomena, Maccarrone, Mauro, Kelly, Melanie E M, Fauser, Sascha, Ullmer, Christoph
Published in Frontiers in pharmacology (12.07.2024)
Published in Frontiers in pharmacology (12.07.2024)
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Journal Article
Incretin-like effects of small molecule trace amine-associated receptor 1 agonists
Raab, Susanne, Wang, Haiyan, Uhles, Sabine, Cole, Nadine, Alvarez-Sanchez, Ruben, Künnecke, Basil, Ullmer, Christoph, Matile, Hugues, Bedoucha, Marc, Norcross, Roger D, Ottaway-Parker, Nickki, Perez-Tilve, Diego, Conde Knape, Karin, Tschöp, Matthias H, Hoener, Marius C, Sewing, Sabine
Published in Molecular metabolism (Germany) (01.01.2016)
Published in Molecular metabolism (Germany) (01.01.2016)
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Selective pharmacological inhibition of DDR1 prevents experimentally-induced glomerulonephritis in prevention and therapeutic regime
Moll, Solange, Yasui, Yukari, Abed, Ahmed, Murata, Takeshi, Shimada, Hideaki, Maeda, Akira, Fukushima, Naoshi, Kanamori, Masakazu, Uhles, Sabine, Badi, Laura, Cagarelli, Thomas, Formentini, Ivan, Drawnel, Faye, Georges, Guy, Bergauer, Tobias, Gasser, Rodolfo, Bonfil, R Daniel, Fridman, Rafael, Richter, Hans, Funk, Juergen, Moeller, Marcus J, Chatziantoniou, Christos, Prunotto, Marco
Published in Journal of translational medicine (01.06.2018)
Published in Journal of translational medicine (01.06.2018)
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Journal Article
Apolipoprotein CIII Promotes Ca2+-Dependent β Cell Death in Type 1 Diabetes
Juntti-Berggren, Lisa, Refai, Essam, Appelskog, Ioulia, Andersson, Mats, Imreh, Gabriela, Dekki, Nancy, Uhles, Sabine, Yu, Lina, Griffiths, William J., Zaitsev, Sergei, Leibiger, Ingo, Yang, Shao-Nian, Olivecronal, Gunilla, Jörnvall, Hans, Berggren, Per-Olof, Spiegelman, Bruce M.
Published in Proceedings of the National Academy of Sciences - PNAS (06.07.2004)
Published in Proceedings of the National Academy of Sciences - PNAS (06.07.2004)
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Journal Article
A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents
Finan, Brian, Yang, Bin, Ottaway, Nickki, Smiley, David L, Ma, Tao, Clemmensen, Christoffer, Chabenne, Joe, Zhang, Lianshan, Habegger, Kirk M, Fischer, Katrin, Campbell, Jonathan E, Sandoval, Darleen, Seeley, Randy J, Bleicher, Konrad, Uhles, Sabine, Riboulet, William, Funk, Jürgen, Hertel, Cornelia, Belli, Sara, Sebokova, Elena, Conde-Knape, Karin, Konkar, Anish, Drucker, Daniel J, Gelfanov, Vasily, Pfluger, Paul T, Müller, Timo D, Perez-Tilve, Diego, DiMarchi, Richard D, Tschöp, Matthias H
Published in Nature medicine (01.01.2015)
Published in Nature medicine (01.01.2015)
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Journal Article
New data in a mouse model of spontaneous choroidal neovascularisation support the role of angiopoietin‐2 inhibition in driving sustained vascular stabilisation and reduced fibrosis progression
Canonica, Jérémie, Uhles, Sabine, Foxton, Richard, Revelant, Franco, Cole, Nadine, Westenkow, Peter, Scheidl, Stefan, Ullmer, Christoph
Published in Acta ophthalmologica (Oxford, England) (01.01.2021)
Published in Acta ophthalmologica (Oxford, England) (01.01.2021)
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Journal Article
Removal of Ca2+ Channel β3 Subunit Enhances Ca2+ Oscillation Frequency and Insulin Exocytosis
Berggren, Per-Olof, Yang, Shao-Nian, Murakami, Manabu, Efanov, Alexander M., Uhles, Sabine, Köhler, Martin, Moede, Tilo, Fernström, Andreas, Appelskog, Ioulia B., Aspinwall, Craig A., Zaitsev, Sergei V., Larsson, Olof, de Vargas, Lina Moitoso, Fecher-Trost, Claudia, Weißgerber, Petra, Ludwig, Andreas, Leibiger, Barbara, Juntti-Berggren, Lisa, Barker, Christopher J., Gromada, Jesper, Freichel, Marc, Leibiger, Ingo B., Flockerzi, Veit
Published in Cell (01.10.2004)
Published in Cell (01.10.2004)
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Dual angiopoietin‐2/VEGF‐A neutralisation prevents vascular leakage, cell death and subretinal macrophage infiltration in mouse models of retinal ischaemia/reperfusion injury and spontaneous CNV
Canonica, Jérémie, Shanmugam, Sumathi, Lin, Cheng‐mao, Antonetti, David, Foxton, Richard, Uhles, Sabine, Westenkow, Peter, Abcouwer, Steve, Garcia Garrido, Marina
Published in Acta ophthalmologica (Oxford, England) (01.01.2022)
Published in Acta ophthalmologica (Oxford, England) (01.01.2022)
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Journal Article
Insulin-feedback via PI3K-C2α activated PKBα/Akt1 is required for glucose-stimulated insulin secretion
Leibiger, Barbara, Moede, Tilo, Uhles, Sabine, Barker, Christopher J, Creveaux, Marion, Domin, Jan, Berggren, Per-Olof, Leibiger, Ingo B
Published in The FASEB journal (01.06.2010)
Published in The FASEB journal (01.06.2010)
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The 14-3-3 Protein Translates the NA+,K+-ATPase α1-Subunit Phosphorylation Signal into Binding and Activation of Phosphoinositide 3-Kinase during Endocytosis
Efendiev, Riad, Chen, Zongpei, Krmar, Rafael T., Uhles, Sabine, Katz, Adrian I., Pedemonte, Carlos H., Bertorello, Alejandro M.
Published in The Journal of biological chemistry (22.04.2005)
Published in The Journal of biological chemistry (22.04.2005)
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Journal Article
Interferon alpha-induced apoptosis in tumor cells is mediated through the phosphoinositide 3-kinase/mammalian target of rapamycin signaling pathway
Thyrell, Lena, Hjortsberg, Linn, Arulampalam, Velmurugesan, Panaretakis, Theocharis, Uhles, Sabine, Dagnell, Markus, Zhivotovsky, Boris, Leibiger, Ingo, Grandér, Dan, Pokrovskaja, Katja
Published in The Journal of biological chemistry (04.06.2004)
Published in The Journal of biological chemistry (04.06.2004)
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Journal Article
Isoform-Specific Insulin Receptor Signaling Involves Different Plasma Membrane Domains
Uhles, Sabine, Moede, Tilo, Leibiger, Barbara, Berggren, Per-Olof, Leibiger, Ingo B.
Published in The Journal of cell biology (22.12.2003)
Published in The Journal of cell biology (22.12.2003)
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Journal Article
Selective gene activation by spatial segregation of insulin receptor B signaling
Uhles, Sabine, Moede, Tilo, Leibiger, Barbara, Berggren, Per-Olof, Leibiger, Ingo B
Published in The FASEB journal (01.05.2007)
Published in The FASEB journal (01.05.2007)
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Journal Article
Insulin-feedback via PI3K-C2alpha activated PKBalpha/Akt1 is required for glucose-stimulated insulin secretion
Leibiger, Barbara, Moede, Tilo, Uhles, Sabine, Barker, Christopher J, Creveaux, Marion, Domin, Jan, Berggren, Per-Olof, Leibiger, Ingo B
Published in The FASEB journal (01.06.2010)
Published in The FASEB journal (01.06.2010)
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