Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms
Shen, Kuang, Sabatini, David M.
Published in Proceedings of the National Academy of Sciences - PNAS (18.09.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (18.09.2018)
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Journal Article
Genetic Screens in Human Cells Using the CRISPR-Cas9 System
Wang, Tim, Wei, Jenny J., Sabatini, David M., Lander, Eric S.
Published in Science (American Association for the Advancement of Science) (03.01.2014)
Published in Science (American Association for the Advancement of Science) (03.01.2014)
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Journal Article
Amino acids and mTORC1: from lysosomes to disease
Efeyan, Alejo, Zoncu, Roberto, Sabatini, David M
Published in Trends in molecular medicine (01.09.2012)
Published in Trends in molecular medicine (01.09.2012)
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Journal Article
Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1
Bar-Peled, Liron, Schweitzer, Lawrence D., Zoncu, Roberto, Sabatini, David M.
Published in Cell (14.09.2012)
Published in Cell (14.09.2012)
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Journal Article
Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism
Chen, Walter W., Freinkman, Elizaveta, Wang, Tim, Birsoy, Kıvanç, Sabatini, David M.
Published in Cell (25.08.2016)
Published in Cell (25.08.2016)
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Journal Article
Identification and characterization of essential genes in the human genome
Wang, Tim, Birsoy, Kivanç, Hughes, Nicholas W., Krupczak, Kevin M., Post, Yorick, Wei, Jenny J., Lander, Eric S., Sabatini, David M.
Published in Science (American Association for the Advancement of Science) (27.11.2015)
Published in Science (American Association for the Advancement of Science) (27.11.2015)
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Journal Article
Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes
Abu-Remaileh, Monther, Wyant, Gregory A., Kim, Choah, Laqtom, Nouf N., Abbasi, Maria, Chan, Sze Ham, Freinkman, Elizaveta, Sabatini, David M.
Published in Science (American Association for the Advancement of Science) (10.11.2017)
Published in Science (American Association for the Advancement of Science) (10.11.2017)
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Journal Article
Mechanism of arginine sensing by CASTOR1 upstream of mTORC1
Saxton, Robert A, Chantranupong, Lynne, Knockenhauer, Kevin E, Schwartz, Thomas U, Sabatini, David M
Published in Nature (London) (11.08.2016)
Published in Nature (London) (11.08.2016)
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Journal Article
The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1
Tsun, Zhi-Yang, Bar-Peled, Liron, Chantranupong, Lynne, Zoncu, Roberto, Wang, Tim, Kim, Choah, Spooner, Eric, Sabatini, David M
Published in Molecular cell (21.11.2013)
Published in Molecular cell (21.11.2013)
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Journal Article
Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase
Cantor, Jason R., Abu-Remaileh, Monther, Kanarek, Naama, Freinkman, Elizaveta, Gao, Xin, Louissaint, Abner, Lewis, Caroline A., Sabatini, David M.
Published in Cell (06.04.2017)
Published in Cell (06.04.2017)
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