GSDMD is critical for autoinflammatory pathology in a mouse model of Familial Mediterranean Fever
Kanneganti, Apurva, Malireddi, R K Subbarao, Saavedra, Pedro H V, Vande Walle, Lieselotte, Van Gorp, Hanne, Kambara, Hiroto, Tillman, Heather, Vogel, Peter, Luo, Hongbo R, Xavier, Ramnik J, Chi, Hongbo, Lamkanfi, Mohamed
Published in The Journal of experimental medicine (04.06.2018)
Published in The Journal of experimental medicine (04.06.2018)
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Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4
Van Opdenbosch, Nina, Van Gorp, Hanne, Verdonckt, Maarten, Saavedra, Pedro H.V., de Vasconcelos, Nathalia M., Gonçalves, Amanda, Vande Walle, Lieselotte, Demon, Dieter, Matusiak, Magdalena, Van Hauwermeiren, Filip, D’Hont, Jinke, Hochepied, Tino, Krautwald, Stefan, Kanneganti, Thirumala-Devi, Lamkanfi, Mohamed
Published in Cell reports (Cambridge) (19.12.2017)
Published in Cell reports (Cambridge) (19.12.2017)
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MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition
Vande Walle, Lieselotte, Stowe, Irma B, Šácha, Pavel, Lee, Bettina L, Demon, Dieter, Fossoul, Amelie, Van Hauwermeiren, Filip, Saavedra, Pedro H V, Šimon, Petr, Šubrt, Vladimír, Kostka, Libor, Stivala, Craig E, Pham, Victoria C, Staben, Steven T, Yamazoe, Sayumi, Konvalinka, Jan, Kayagaki, Nobuhiko, Lamkanfi, Mohamed
Published in PLoS biology (16.09.2019)
Published in PLoS biology (16.09.2019)
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Journal Article
Miconazole loaded chitosan-based nanoparticles for local treatment of vulvovaginal candidiasis fungal infections
Amaral, Andre Correa, Saavedra, Pedro H.V., Oliveira Souza, Ana Camila, de Melo, Maryanne Trafani, Tedesco, Antonio Claudio, Morais, Paulo Cesar, Soares Felipe, Maria Sueli, Bocca, Anamelia Lorenzetti
Published in Colloids and surfaces, B, Biointerfaces (01.02.2019)
Published in Colloids and surfaces, B, Biointerfaces (01.02.2019)
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Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis
Saavedra, Pedro H. V., Huang, Linyan, Ghazavi, Farzaneh, Kourula, Stephanie, Vanden Berghe, Tom, Takahashi, Nozomi, Vandenabeele, Peter, Lamkanfi, Mohamed
Published in Nature communications (19.11.2018)
Published in Nature communications (19.11.2018)
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Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation
Van Gorp, Hanne, Saavedra, Pedro H. V., de Vasconcelos, Nathalia M., Van Opdenbosch, Nina, Vande Walle, Lieselotte, Matusiak, Magdalena, Prencipe, Giusi, Insalaco, Antonella, Van Hauwermeiren, Filip, Demon, Dieter, Bogaert, Delfien J., Dullaers, Melissa, De Baere, Elfride, Hochepied, Tino, Dehoorne, Joke, Vermaelen, Karim Y., Haerynck, Filomeen, De Benedetti, Fabrizio, Lamkanfi, Mohamed
Published in Proceedings of the National Academy of Sciences - PNAS (13.12.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (13.12.2016)
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Journal Article
IL1β Promotes Immune Suppression in the Tumor Microenvironment Independent of the Inflammasome and Gasdermin D
Kiss, Máté, Vande Walle, Lieselotte, Saavedra, Pedro H V, Lebegge, Els, Van Damme, Helena, Murgaski, Aleksandar, Qian, Junbin, Ehling, Manuel, Pretto, Samantha, Bolli, Evangelia, Keirsse, Jiri, Bardet, Pauline M R, Arnouk, Sana M, Elkrim, Yvon, Schmoetten, Maryse, Brughmans, Jan, Debraekeleer, Ayla, Fossoul, Amelie, Boon, Louis, Raes, Geert, van Loo, Geert, Lambrechts, Diether, Mazzone, Massimiliano, Beschin, Alain, Wullaert, Andy, Lamkanfi, Mohamed, Van Ginderachter, Jo A, Laoui, Damya
Published in Cancer immunology research (01.03.2021)
Published in Cancer immunology research (01.03.2021)
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Escherichia coli Rho GTPase-activating toxin CNF1 mediates NLRP3 inflammasome activation via p21-activated kinases-1/2 during bacteraemia in mice
Dufies, Océane, Doye, Anne, Courjon, Johan, Torre, Cédric, Michel, Gregory, Loubatier, Celine, Jacquel, Arnaud, Chaintreuil, Paul, Majoor, Alissa, Guinamard, Rodolphe R., Gallerand, Alexandre, Saavedra, Pedro H. V., Verhoeyen, Els, Rey, Amaury, Marchetti, Sandrine, Ruimy, Raymond, Czerucka, Dorota, Lamkanfi, Mohamed, Py, Bénédicte F., Munro, Patrick, Visvikis, Orane, Boyer, Laurent
Published in Nature microbiology (01.03.2021)
Published in Nature microbiology (01.03.2021)
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Protective and detrimental roles of inflammasomes in disease
Saavedra, Pedro H. V., Demon, Dieter, Van Gorp, Hanne, Lamkanfi, Mohamed
Published in Seminars in immunopathology (01.07.2015)
Published in Seminars in immunopathology (01.07.2015)
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Journal Article
Cryptococcus neoformans secretes small molecules that inhibit IL-1β inflammasome-dependent secretion
Bürgel, Pedro Henrique, Clara Luna Marina, Saavedra, Pedro H V, Albuquerque, Patrícia, Holanda, Paulo Henrique, Raffael De Araújo Castro, Heyman, Heino, Coelho, Carolina, Cordero, Radames J B, Casadevall, Arturo, Nosanchuk, Joshua, Nakayasu, Ernesto, May, Robin C, Tavares, Aldo Henrique, Bocca, Anamelia
Published in bioRxiv (19.02.2019)
Published in bioRxiv (19.02.2019)
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