Rebalancing TGFβ1/BMP signals in exhausted T cells unlocks responsiveness to immune checkpoint blockade therapy
Saadey, Abbey A, Yousif, Amir, Osborne, Nicole, Shahinfar, Roya, Chen, Yu-Lin, Laster, Brooke, Rajeev, Meera, Bauman, Parker, Webb, Amy, Ghoneim, Hazem E
Published in Nature immunology (01.02.2023)
Published in Nature immunology (01.02.2023)
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Aiolos represses CD4+ T cell cytotoxic programming via reciprocal regulation of TFH transcription factors and IL-2 sensitivity
Read, Kaitlin A., Jones, Devin M., Pokhrel, Srijana, Hales, Emily D. S., Varkey, Aditi, Tuazon, Jasmine A., Eisele, Caprice D., Abdouni, Omar, Saadey, Abbey, Leonard, Melissa R., Warren, Robert T., Powell, Michael D., Boss, Jeremy M., Hemann, Emily A., Yount, Jacob S., Xin, Gang, Ghoneim, Hazem E., Lio, Chan-Wang J., Freud, Aharon G., Collins, Patrick L., Oestreich, Kenneth J.
Published in Nature communications (24.03.2023)
Published in Nature communications (24.03.2023)
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DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates inflammation and amyloid-β deposition in Alzheimer's disease
Daily, Kylene P, Badr, Asmaa, Eltobgy, Mostafa, Estfanous, Shady, Whitham, Owen, Tan, Michelle H, Carafice, Cierra, Krause, Kathrin, McNamara, Andrew, Hamilton, Kaitlin, Houle, Samuel, Gupta, Spandan, Gupta, Gauruv A, Madhu, Shruthi, Fitzgerald, Julie, Saadey, Abbey A, Laster, Brooke, Yan, Pearlly, Webb, Amy, Zhang, Xiaoli, Pietrzak, Maciej, Kokiko-Cochran, Olga N, Ghoneim, Hazem E, Amer, Amal O
Published in Alzheimer's research & therapy (08.02.2024)
Published in Alzheimer's research & therapy (08.02.2024)
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Targeting epigenetic crosstalk that restrains the responses of exhausted T cells to immune checkpoint blockade therapy
Yousif, Amir, Saadey, Abbey, Castillo, Chelsea, Saini, Ankita, Webb, Amy, Oltz, Eugene M, Ghoneim, Hazem
Published in The Journal of immunology (1950) (01.05.2023)
Published in The Journal of immunology (1950) (01.05.2023)
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TGFβ1 and BMP signals modulate CD8+ T cell functionality and responsiveness to immune checkpoint blockade therapy
Saadey, Abbey, Yousif, Amir, Osborne, Nicole, Shahinfar, Roya, Castillo, Chelsea, Laster, Brooke, Rajeev, Meera, Kumar, Shrea, Webb, Amy, Ghoneim, Hazem
Published in The Journal of immunology (1950) (01.05.2023)
Published in The Journal of immunology (1950) (01.05.2023)
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Journal Article
Rebalancing TGFβ1/BMP Signaling Epigenetically Reprograms Fully Exhausted Human CD8 T Cells into a Functional State
Ghoneim, Hazem E., Saadey, Abbey A, Yousif, Amir, Osborne, Nicole, Chen, Yu-Lin, Laster, Brooke, Zayed, Ahmed, Bauman, Parker
Published in The Journal of immunology (1950) (01.05.2022)
Published in The Journal of immunology (1950) (01.05.2022)
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Journal Article
Aiolos supports TFH cell differentiation by antagonizing the IL-2/STAT5 signaling pathway
Read, Kaitlin, Pokhrel, Srijana, Jones, Devin M, Saadey, Abbey, Eisele, Caprice, Warren, Robert T, Collins, Patrick, Ghoneim, Hazem E., Freud, Aharon, Oestreich, Kenneth J
Published in The Journal of immunology (1950) (01.05.2022)
Published in The Journal of immunology (1950) (01.05.2022)
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Eos differentially regulates Th1 versus Tfh differentiation through feed-forward propagation of the IL-2/STAT5 signaling pathway
Read, Kaitlin, Sreekumar, Bharath, Powell, Michael Duane, Jones, Devin M, Pokhrel, Srijana, Saadey, Abbey, Collins, Patrick, Ghoneim, Hazem, Oestreich, Kenneth J
Published in The Journal of immunology (1950) (01.05.2021)
Published in The Journal of immunology (1950) (01.05.2021)
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Journal Article
DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates inflammation and amyloid-[beta] deposition in Alzheimer's disease
Daily, Kylene P, Badr, Asmaa, Eltobgy, Mostafa, Estfanous, Shady, Whitham, Owen, Tan, Michelle H, Carafice, Cierra, Krause, Kathrin, McNamara, Andrew, Hamilton, Kaitlin, Houle, Samuel, Gupta, Spandan, Gupta, Gauruv A, Madhu, Shruthi, Fitzgerald, Julie, Saadey, Abbey A, Laster, Brooke, Yan, Pearlly, Webb, Amy, Zhang, Xiaoli, Pietrzak, Maciej, Kokiko-Cochran, Olga N, Ghoneim, Hazem E, Amer, Amal O
Published in Alzheimer's research & therapy (08.02.2024)
Published in Alzheimer's research & therapy (08.02.2024)
Get full text
Journal Article
Aiolos represses CD4 + T cell cytotoxic programming via reciprocal regulation of T FH transcription factors and IL-2 sensitivity
Read, Kaitlin A, Jones, Devin M, Pokhrel, Srijana, Hales, Emily D S, Varkey, Aditi, Tuazon, Jasmine A, Eisele, Caprice D, Abdouni, Omar, Saadey, Abbey, Leonard, Melissa R, Warren, Robert T, Powell, Michael D, Boss, Jeremy M, Hemann, Emily A, Yount, Jacob S, Xin, Gang, Ghoneim, Hazem E, Lio, Chan-Wang J, Freud, Aharon G, Collins, Patrick L, Oestreich, Kenneth J
Published in Nature communications (24.03.2023)
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Published in Nature communications (24.03.2023)
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DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates neuroinflammation and amyloid-β deposition in Alzheimer's disease The Ohio State University College of Medicine
Daily, Kylene P, Badr, Asmaa, Eltobgy, Mostafa, Estfanous, Shady, Whitham, Owen, Tan, Michelle H, Carafice, Cierra, Krause, Kathrin, McNamara, Andrew, Hamilton, Kaitlin, Houle, Samuel, Gupta, Spandan, Gupta, Gauruv A, Madhu, Shruthi, Fitzgerald, Julie, Saadey, Abbey A, Laster, Brooke, Yan, Pearlly, Webb, Amy, Zhang, Xiaoli, Pietrzak, Maciej, Kokiko-Cochran, Olga N, Ghoneim, Hazem E, Amer, Amal O
Published in bioRxiv : the preprint server for biology (01.09.2023)
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Published in bioRxiv : the preprint server for biology (01.09.2023)
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