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Anti-Inflammatory Properties of a Novel N-Phenyl Pyridinone Inhibitor of p38 Mitogen-Activated Protein Kinase: Preclinical-to-Clinical Translation
Hope, Heidi R, Anderson, Gary D, Burnette, Barry L, Compton, Robert P, Devraj, Rajesh V, Hirsch, Jeffrey L, Keith, Robert H, Li, Xiong, Mbalaviele, Gabriel, Messing, Dean M, Saabye, Matthew J, Schindler, John F, Selness, Shaun R, Stillwell, Loreen I, Webb, Elizabeth G, Zhang, Jian, Monahan, Joseph B
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Published in The Journal of pharmacology and experimental therapeutics (01.12.2009)
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Selective inhibition of the p38α MAPK-MK2 axis inhibits inflammatory cues including inflammasome priming signals
Wang, Chun, Hockerman, Susan, Jacobsen, E Jon, Alippe, Yael, Selness, Shaun R, Hope, Heidi R, Hirsch, Jeffrey L, Mnich, Stephen J, Saabye, Matthew J, Hood, William F, Bonar, Sheri L, Abu-Amer, Yousef, Haimovich, Ariela, Hoffman, Hal M, Monahan, Joseph B, Mbalaviele, Gabriel
Published in The Journal of experimental medicine (07.05.2018)
Published in The Journal of experimental medicine (07.05.2018)
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High-Throughput Kinetic Characterization of Irreversible Covalent Inhibitors of KRAS G12C by Intact Protein MS and Targeted MRM
Li, Ke Sherry, Quinn, John G, Saabye, Matthew J, Guerrero, Jesus F Salcido, Nonomiya, Jim, Lian, Qihui, Phung, Wilson, Izrayelit, Yevgeniy, Walters, Benjamin T, Gustafson, Amy, Endres, Nicholas F, Beresini, Maureen H, Mulvihill, Melinda M
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Published in Analytical chemistry (Washington) (18.01.2022)
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A benzothiophene inhibitor of mitogen-activated protein kinase-activated protein kinase 2 inhibits tumor necrosis factor alpha production and has oral anti-inflammatory efficacy in acute and chronic models of inflammation
Mourey, Robert J, Burnette, Barry L, Brustkern, Sarah J, Daniels, J Scott, Hirsch, Jeffrey L, Hood, William F, Meyers, Marvin J, Mnich, Stephen J, Pierce, Betsy S, Saabye, Matthew J, Schindler, John F, South, Sarah A, Webb, Elizabeth G, Zhang, Jian, Anderson, David R
Published in The Journal of pharmacology and experimental therapeutics (01.06.2010)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2010)
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Expression, purification, characterization and crystallization of non- and phosphorylated states of JAK2 and JAK3 kinase domain
Hall, Troii, Emmons, Thomas L., Chrencik, Jill E., Gormley, Jennifer A., Weinberg, Robin A., Leone, Joseph W., Hirsch, Jeffrey L., Saabye, Matthew J., Schindler, John F., Day, Jacqueline E., Williams, Jennifer M., Kiefer, James R., Lightle, Sandra A., Harris, Melissa S., Guru, Siradanahalli, Fischer, H. David, Tomasselli, Alfredo G.
Published in Protein expression and purification (01.01.2010)
Published in Protein expression and purification (01.01.2010)
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High-Throughput Kinetic Characterization of Irreversible Covalent Inhibitors of KRASG12C by Intact Protein MS and Targeted MRM
Li, Ke Sherry, Quinn, John G, Saabye, Matthew J, Guerrero, Jesus F. Salcido, Nonomiya, Jim, Lian, Qihui, Phung, Wilson, Izrayelit, Yevgeniy, Walters, Benjamin T, Gustafson, Amy, Endres, Nicholas F, Beresini, Maureen H, Mulvihill, Melinda M
Published in Analytical chemistry (Washington) (18.01.2022)
Published in Analytical chemistry (Washington) (18.01.2022)
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Examination of the kinetic mechanism of mitogen-activated protein kinase activated protein kinase-2
Schindler, John F, Godbey, Andrew, Hood, William F, Bolten, Suzanne L, Broadus, Richard M, Kasten, Thomas P, Cassely, Aaron J, Hirsch, Jeffery L, Merwood, Michelle A, Nagy, Mark A, Fok, Kam F, Saabye, Matthew J, Morgan, Heidi M, Compton, Robert P, Mourey, Robert J, Wittwer, Arthur J, Monahan, Joseph B
Published in Biochimica et biophysica acta (29.07.2002)
Published in Biochimica et biophysica acta (29.07.2002)
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