The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex
He, Yupeng, Selvaraju, Sujatha, Curtin, Michael L, Jakob, Clarissa G, Zhu, Haizhong, Comess, Kenneth M, Shaw, Bailin, The, Juliana, Lima-Fernandes, Evelyne, Szewczyk, Magdalena M, Cheng, Dong, Klinge, Kelly L, Li, Huan-Qiu, Pliushchev, Marina, Algire, Mikkel A, Maag, David, Guo, Jun, Dietrich, Justin, Panchal, Sanjay C, Petros, Andrew M, Sweis, Ramzi F, Torrent, Maricel, Bigelow, Lance J, Senisterra, Guillermo, Li, Fengling, Kennedy, Steven, Wu, Qin, Osterling, Donald J, Lindley, David J, Gao, Wenqing, Galasinski, Scott, Barsyte-Lovejoy, Dalia, Vedadi, Masoud, Buchanan, Fritz G, Arrowsmith, Cheryl H, Chiang, Gary G, Sun, Chaohong, Pappano, William N
Published in Nature chemical biology (01.04.2017)
Published in Nature chemical biology (01.04.2017)
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The Histone Methyltransferase Inhibitor A-366 Uncovers a Role for G9a/GLP in the Epigenetics of Leukemia
Pappano, William N, Guo, Jun, He, Yupeng, Ferguson, Debra, Jagadeeswaran, Sujatha, Osterling, Donald J, Gao, Wenqing, Spence, Julie K, Pliushchev, Marina, Sweis, Ramzi F, Buchanan, Fritz G, Michaelides, Michael R, Shoemaker, Alexander R, Tse, Chris, Chiang, Gary G
Published in PloS one (06.07.2015)
Published in PloS one (06.07.2015)
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The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity
Bromberg, Kenneth D, Mitchell, Taylor R H, Upadhyay, Anup K, Jakob, Clarissa G, Jhala, Manisha A, Comess, Kenneth M, Lasko, Loren M, Li, Conglei, Tuzon, Creighton T, Dai, Yujia, Li, Fengling, Eram, Mohammad S, Nuber, Alexander, Soni, Niru B, Manaves, Vlasios, Algire, Mikkel A, Sweis, Ramzi F, Torrent, Maricel, Schotta, Gunnar, Sun, Chaohong, Michaelides, Michael R, Shoemaker, Alex R, Arrowsmith, Cheryl H, Brown, Peter J, Santhakumar, Vijayaratnam, Martin, Alberto, Rice, Judd C, Chiang, Gary G, Vedadi, Masoud, Barsyte-Lovejoy, Dalia, Pappano, William N
Published in Nature chemical biology (01.03.2017)
Published in Nature chemical biology (01.03.2017)
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Discovery and Development of Potent and Selective Inhibitors of Histone Methyltransferase G9a
Sweis, Ramzi F, Pliushchev, Marina, Brown, Peter J, Guo, Jun, Li, Fengling, Maag, David, Petros, Andrew M, Soni, Nirupama B, Tse, Chris, Vedadi, Masoud, Michaelides, Michael R, Chiang, Gary G, Pappano, William N
Published in ACS medicinal chemistry letters (13.02.2014)
Published in ACS medicinal chemistry letters (13.02.2014)
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SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding
Curtin, Michael L., Pliushchev, Marina A., Li, Huan-Qiu, Torrent, Maricel, Dietrich, Justin D., Jakob, Clarissa G., Zhu, Haizhong, Zhao, Hongyu, Wang, Ying, Ji, Zhiqin, Clark, Richard F., Sarris, Kathy A., Selvaraju, Sujatha, Shaw, Bailin, Algire, Mikkel A., He, Yupeng, Richardson, Paul L., Sweis, Ramzi F., Sun, Chaohong, Chiang, Gary G., Michaelides, Michael R.
Published in Bioorganic & medicinal chemistry letters (01.04.2017)
Published in Bioorganic & medicinal chemistry letters (01.04.2017)
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Discovery of A‑893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2
Sweis, Ramzi F., Wang, Zhi, Algire, Mikkel, Arrowsmith, Cheryl H., Brown, Peter J., Chiang, Gary G., Guo, Jun, Jakob, Clarissa G., Kennedy, Steven, Li, Fengling, Maag, David, Shaw, Bailin, Soni, Nirupama B., Vedadi, Masoud, Pappano, William N.
Published in ACS medicinal chemistry letters (11.06.2015)
Published in ACS medicinal chemistry letters (11.06.2015)
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Superoxide produced by mitochondrial site IQ inactivates cardiac succinate dehydrogenase and induces hepatic steatosis in Sod2 knockout mice
Wong, Hoi-Shan, Mezera, Vojtech, Dighe, Pratiksha, Melov, Simon, Gerencser, Akos A., Sweis, Ramzi F., Pliushchev, Marina, Wang, Zhi, Esbenshade, Tim, McKibben, Bryan, Riedmaier, Stephan, Brand, Martin D.
Published in Free radical biology & medicine (20.02.2021)
Published in Free radical biology & medicine (20.02.2021)
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2-(4-Carbonylphenyl)benzoxazole inhibitors of CETP: Scaffold design and advancement in HDLc-raising efficacy
Sweis, Ramzi F., Hunt, Julianne A., Kallashi, Florida, Hammond, Milton L., Chen, Ying, Eveland, Suzanne S., Guo, Qiu, Hyland, Sheryl A., Milot, Denise P., Cumiskey, Anne-Marie, Latham, Melanie, Rosa, Raymond, Peterson, Larry, Sparrow, Carl P., Wright, Samuel D., Anderson, Matt S., Sinclair, Peter J.
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
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Superoxide produced by mitochondrial site I Q inactivates cardiac succinate dehydrogenase and induces hepatic steatosis in Sod2 knockout mice
Wong, Hoi-Shan, Mezera, Vojtech, Dighe, Pratiksha, Melov, Simon, Gerencser, Akos A, Sweis, Ramzi F, Pliushchev, Marina, Wang, Zhi, Esbenshade, Tim, McKibben, Bryan, Riedmaier, Stephan, Brand, Martin D
Published in Free radical biology & medicine (20.02.2021)
Published in Free radical biology & medicine (20.02.2021)
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SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT)
Curtin, Michael L., Heyman, H. Robin, Clark, Richard F., Sorensen, Bryan K., Doherty, George A., Hansen, T. Matthew, Frey, Robin R., Sarris, Kathy A., Aguirre, Ana L., Shrestha, Anurupa, Tu, Noah, Woller, Kevin, Pliushchev, Marina A., Sweis, Ramzi F., Cheng, Min, Wilsbacher, Julie L., Kovar, Peter J., Guo, Jun, Cheng, Dong, Longenecker, Kenton L., Raich, Diana, Korepanova, Alla V., Soni, Nirupama B., Algire, Mikkel A., Richardson, Paul L., Marin, Violeta L., Badagnani, Ilaria, Vasudevan, Anil, Buchanan, F. Greg, Maag, David, Chiang, Gary G., Tse, Chris, Michaelides, Michael R.
Published in Bioorganic & medicinal chemistry letters (01.08.2017)
Published in Bioorganic & medicinal chemistry letters (01.08.2017)
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Optimization of Preclinical Metabolism for Somatostatin Receptor Subtype 5‑Selective Antagonists
Liu, Weiguo, Hussain, Zahid, Zang, Yi, Sweis, Ramzi F, Romero, F. Anthony, Finke, Paul E, Moningka, Remond, Bao, Jianming, Plotkin, Michael A, Shang, Jin, Dingley, Karen H, Salituro, Gino, Murphy, Beth Ann, Howard, Andrew D, Ujjainwalla, Feroze, Wood, Harold B, Duffy, Joseph L
Published in ACS medicinal chemistry letters (08.11.2018)
Published in ACS medicinal chemistry letters (08.11.2018)
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Discovery and Optimization of a Novel Triazole Series of GPR142 Agonists for the Treatment of Type 2 Diabetes
Guo, Liangqin, Parker, Dann L, Zang, Yi, Sweis, Ramzi F, Liu, Weiguo, Sherer, Edward C, Buist, Nicole, Terebetski, Jenna, Kelly, Terri, Bugianesi, Randal, Priest, Birgit T, Dingley, Karen H, Li, Xiaofang, Mitelman, Stan, Salituro, Gino, Trujillo, Maria E, Pachanski, Michele, Kirkland, Melissa, Powles, Mary Ann, Eiermann, George J, Feng, Yue, Shang, Jin, Howard, Andrew D, Ujjainwalla, Feroze, Sinz, Christopher J, Debenham, John S, Edmondson, Scott D, Nargund, Ravi P, Hagmann, William K, Li, Derun
Published in ACS medicinal chemistry letters (08.12.2016)
Published in ACS medicinal chemistry letters (08.12.2016)
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2-(4-Carbonylphenyl)benzoxazole inhibitors of CETP: Attenuation of hERG binding and improved HDLc-raising efficacy
Sweis, Ramzi F., Hunt, Julianne A., Sinclair, Peter J., Chen, Ying, Eveland, Suzanne S., Guo, Qiu, Hyland, Sheryl A., Milot, Denise P., Cumiskey, Anne-Marie, Latham, Melanie, Rosa, Raymond, Peterson, Larry, Sparrow, Carl P., Anderson, Matt S.
Published in Bioorganic & medicinal chemistry letters (01.05.2011)
Published in Bioorganic & medicinal chemistry letters (01.05.2011)
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Journal Article
NAMPT INHIBITORS
HEYMAN HOWARD R, HANSEN TODD M, MICHAELIDES MICHAEL R, DOHERTY GEORGE, SWEIS RAMZI F, SORENSEN BRYAN, LONGENECKER KENTON, FREY ROBIN, CURTIN MICHAEL L, JUDD ANDY, OSUMA AUGUSTINE T, PLIUSHCHEV MARINA A, CLARK RICHARD F
Year of Publication 20.01.2015
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Year of Publication 20.01.2015
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