Optimization of Pharmacokinetic and In Vitro Safety Profile of a Series of Pyridine Diamide Indirect AMPK Activators
Shaw, Simon J., Goff, Dane A., Boralsky, Luke A., Singh, Rajinder, Sweeny, David J., Park, Gary, Sun, Tian-Qiang, Jenkins, Yonchu, Markovtsov, Vadim, Issakani, Sarkiz D., Payan, Donald G., Hitoshi, Yasumichi
Published in Journal of medicinal chemistry (28.12.2023)
Published in Journal of medicinal chemistry (28.12.2023)
Get full text
Journal Article
Structure activity relationships leading to the identification of the indirect activator of AMPK, R419
Shaw, Simon J., Goff, Dane A., Carroll, David C., Singh, Rajinder, Sweeny, David J., Park, Gary, Jenkins, Yonchu, Markovtsov, Vadim, Sun, Tian-Qiang, Issakani, Sarkiz D., Hitoshi, Yasumichi, Payan, Donald G.
Published in Bioorganic & medicinal chemistry (01.10.2022)
Published in Bioorganic & medicinal chemistry (01.10.2022)
Get full text
Journal Article
AMPK activation through mitochondrial regulation results in increased substrate oxidation and improved metabolic parameters in models of diabetes
Jenkins, Yonchu, Sun, Tian-Qiang, Markovtsov, Vadim, Foretz, Marc, Li, Wei, Nguyen, Henry, Li, Yingwu, Pan, Alison, Uy, Gerald, Gross, Lisa, Baltgalvis, Kristen, Yung, Stephanie L, Gururaja, Tarikere, Kinoshita, Taisei, Owyang, Alexander, Smith, Ira J, McCaughey, Kelly, White, Kathy, Godinez, Guillermo, Alcantara, Raniel, Choy, Carmen, Ren, Hong, Basile, Rachel, Sweeny, David J, Xu, Xiang, Issakani, Sarkiz D, Carroll, David C, Goff, Dane A, Shaw, Simon J, Singh, Rajinder, Boros, Laszlo G, Laplante, Marc-André, Marcotte, Bruno, Kohen, Rita, Viollet, Benoit, Marette, André, Payan, Donald G, Kinsella, Todd M, Hitoshi, Yasumichi
Published in PloS one (05.12.2013)
Published in PloS one (05.12.2013)
Get full text
Journal Article
Metabolism of Fostamatinib, the Oral Methylene Phosphate Prodrug of the Spleen Tyrosine Kinase Inhibitor R406 in Humans: Contribution of Hepatic and Gut Bacterial Processes to the Overall Biotransformation
SWEENY, David J, WEIQUN LI, CLOUGH, Jeffrey, BHAMIDIPATI, Somasekhar, SINGH, Rajinder, PARK, Gary, BALUOM, Muhammad, GROSSBARD, Elliott, LAU, David T.-W
Published in Drug metabolism and disposition (01.07.2010)
Published in Drug metabolism and disposition (01.07.2010)
Get full text
Journal Article
Single- and multiple-dose disposition kinetics of sunitinib malate, a multitargeted receptor tyrosine kinase inhibitor: comparative plasma kinetics in non-clinical species
Haznedar, Joshua Ö., Patyna, Shem, Bello, Carlo L., Peng, Geoffrey W., Speed, William, Yu, Xiaoming, Zhang, Qingling, Sukbuntherng, Juthamas, Sweeny, David J., Antonian, Lida, Wu, Ellen Y.
Published in Cancer chemotherapy and pharmacology (01.09.2009)
Published in Cancer chemotherapy and pharmacology (01.09.2009)
Get full text
Journal Article
Effects of CYP3A4 Inhibitors Ketoconazole and Verapamil and the CYP3A4 Inducer Rifampicin on the Pharmacokinetic Parameters of Fostamatinib: Results from In Vitro and Phase I Clinical Studies
Martin, Paul, Gillen, Michael, Millson, David, Oliver, Stuart, Brealey, Clive, Grossbard, Elliott B., Baluom, Muhammad, Lau, David, Sweeny, David, Mant, Tim, Craven, Kelli
Published in Drugs in R&D (01.03.2016)
Published in Drugs in R&D (01.03.2016)
Get full text
Journal Article
Effects of Fostamatinib on the Pharmacokinetics of the CYP2C8 Substrate Pioglitazone: Results From In Vitro and Phase 1 Clinical Studies
Martin, Paul, Gillen, Michael, Millson, David, Oliver, Stuart, Brealey, Clive, Surry, Dominic, Sweeny, David, Lau, David, Leese, Philip
Published in Clinical pharmacology in drug development (01.05.2016)
Published in Clinical pharmacology in drug development (01.05.2016)
Get full text
Journal Article
Distribution, metabolism, and excretion of the anti-angiogenic compound SU5416
Ye, Christine, Sweeny, David, Sukbuntherng, Juthamas, Zhang, Qingling, Tan, Weiwei, Wong, Simon, Madan, Ajay, Ogilvie, Brian, Parkinson, Andrew, Antonian, Lida
Published in Toxicology in vitro (01.03.2006)
Published in Toxicology in vitro (01.03.2006)
Get full text
Journal Article
Metabolism of the Influenza Neuraminidase Inhibitor Prodrug Oseltamivir in the Rat
SWEENY, D. J, LYNCH, G, BIDGOOD, A. M, LEW, W, WANG, K.-Y, CUNDY, K. C
Published in Drug metabolism and disposition (01.07.2000)
Get full text
Published in Drug metabolism and disposition (01.07.2000)
Journal Article
Preclinical characterization of Aurora kinase inhibitor R763/AS703569 identified through an image-based phenotypic screen
McLaughlin, John, Markovtsov, Vadim, Li, Hui, Wong, Steve, Gelman, Marina, Zhu, Yanhong, Franci, Christian, Lang, D. Wayne, Pali, Erlina, Lasaga, Joe, Low, Caroline, Zhao, Feifei, Chang, Betty, Gururaja, Tarikere L, Xu, Weiduan, Baluom, Muhammad, Sweeny, David, Carroll, David, Sran, Arvinder, Thota, Sambaiah, Parmer, Manjeet, Romane, Angela, Clemens, George, Grossbard, Elliott, Qu, Kunbin, Jenkins, Yonchu, Kinoshita, Taisei, Taylor, Vanessa, Holland, Sacha J, Argade, Ankush, Singh, Rajinder, Pine, Polly, Payan, Donald G, Hitoshi, Yasumichi
Published in Journal of cancer research and clinical oncology (2010)
Published in Journal of cancer research and clinical oncology (2010)
Get full text
Journal Article
Stereospecific synthesis of a GS 4104 metabolite: Determination of absolute sterochemistry and influenza neuraminidase inhibitory activity
Lew, Willard, Escarpe, Paul A., Mendel, Dirk B., Sweeny, David J., Kim, Choung U.
Published in Bioorganic & medicinal chemistry letters (01.10.1999)
Published in Bioorganic & medicinal chemistry letters (01.10.1999)
Get full text
Journal Article
Synthesis of active metabolites of indole pyrrolothiazole paf antagonists
Davidsen, Steven K., Summers, James B., Sweeny, David J., Holms, James H., Albert, Daniel H., Carrera, George M., Tapang, Paul, Magoc, Terrance J., Conway, Richard G., Rhein, David A.
Published in Bioorganic & medicinal chemistry letters (07.12.1995)
Published in Bioorganic & medicinal chemistry letters (07.12.1995)
Get full text
Journal Article