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Kariolis, Mihalis S, Wells, Robert C, Getz, Jennifer A, Kwan, Wanda, Mahon, Cathal S, Tong, Raymond, Kim, Do Jin, Srivastava, Ankita, Bedard, Catherine, Henne, Kirk R, Giese, Tina, Assimon, Victoria A, Chen, Xiaocheng, Zhang, Yin, Solanoy, Hilda, Jenkins, Katherine, Sanchez, Pascal E, Kane, Lesley, Miyamoto, Takashi, Chew, Kylie S, Pizzo, Michelle E, Liang, Nicholas, Calvert, Meredith E K, DeVos, Sarah L, Baskaran, Sulochanadevi, Hall, Sejal, Sweeney, Zachary K, Thorne, Robert G, Watts, Ryan J, Dennis, Mark S, Silverman, Adam P, Zuchero, Y Joy Yu
Published in Science translational medicine (27.05.2020)
Published in Science translational medicine (27.05.2020)
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Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson's disease
Jennings, Danna, Huntwork-Rodriguez, Sarah, Henry, Anastasia G, Sasaki, Jennifer C, Meisner, René, Diaz, Dolores, Solanoy, Hilda, Wang, Xiang, Negrou, Elvira, Bondar, Vitaliy V, Ghosh, Rajarshi, Maloney, Michael T, Propson, Nicholas E, Zhu, Yuda, Maciuca, Romeo D, Harris, Laura, Kay, Angela, LeWitt, Peter, King, T Alex, Kern, Drew, Ellenbogen, Aaron, Goodman, Ira, Siderowf, Andrew, Aldred, Jason, Omidvar, Omid, Masoud, Shababa T, Davis, Sonnet S, Arguello, Annie, Estrada, Anthony A, de Vicente, Javier, Sweeney, Zachary K, Astarita, Giuseppe, Borin, Marie T, Wong, Bradley K, Wong, Harvey, Nguyen, Hoang, Scearce-Levie, Kimberly, Ho, Carole, Troyer, Matthew D
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Published in Science translational medicine (08.06.2022)
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Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation
Liao, Fan, Li, Aimin, Xiong, Monica, Bien-Ly, Nga, Jiang, Hong, Zhang, Yin, Finn, Mary Beth, Hoyle, Rosa, Keyser, Jennifer, Lefton, Katheryn B, Robinson, Grace O, Serrano, Javier Remolina, Silverman, Adam P, Guo, Jing L, Getz, Jennifer, Henne, Kirk, Leyns, Cheryl Eg, Gallardo, Gilbert, Ulrich, Jason D, Sullivan, Patrick M, Lerner, Eli Paul, Hudry, Eloise, Sweeney, Zachary K, Dennis, Mark S, Hyman, Bradley T, Watts, Ryan J, Holtzman, David M
Published in The Journal of clinical investigation (01.05.2018)
Published in The Journal of clinical investigation (01.05.2018)
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Structure-Based Drug Design of RN486, a Potent and Selective Bruton’s Tyrosine Kinase (BTK) Inhibitor, for the Treatment of Rheumatoid Arthritis
Lou, Yan, Han, Xiaochun, Kuglstatter, Andreas, Kondru, Rama K., Sweeney, Zachary K., Soth, Michael, McIntosh, Joel, Litman, Renee, Suh, Judy, Kocer, Buelent, Davis, Dana, Park, Jaehyeon, Frauchiger, Sandra, Dewdney, Nolan, Zecic, Hasim, Taygerly, Joshua P., Sarma, Keshab, Hong, Junbae, Hill, Ronald J., Gabriel, Tobias, Goldstein, David M., Owens, Timothy D.
Published in Journal of medicinal chemistry (08.01.2015)
Published in Journal of medicinal chemistry (08.01.2015)
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Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations
Sheng, Zejuan, Zhang, Shuo, Bustos, Daisy, Kleinheinz, Tracy, Le Pichon, Claire E, Dominguez, Sara L, Solanoy, Hilda O, Drummond, Jason, Zhang, Xiaolin, Ding, Xiao, Cai, Fang, Song, Qinghua, Li, Xianting, Yue, Zhenyu, van der Brug, Marcel P, Burdick, Daniel J, Gunzner-Toste, Janet, Chen, Huifen, Liu, Xingrong, Estrada, Anthony A, Sweeney, Zachary K, Scearce-Levie, Kimberly, Moffat, John G, Kirkpatrick, Donald S, Zhu, Haitao
Published in Science translational medicine (12.12.2012)
Published in Science translational medicine (12.12.2012)
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Effect of selective LRRK2 kinase inhibition on nonhuman primate lung
Fuji, Reina N, Flagella, Michael, Baca, Miriam, Baptista, Marco A S, Brodbeck, Jens, Chan, Bryan K, Fiske, Brian K, Honigberg, Lee, Jubb, Adrian M, Katavolos, Paula, Lee, Donna W, Lewin-Koh, Sock-Cheng, Lin, Tori, Liu, Xingrong, Liu, Shannon, Lyssikatos, Joseph P, O'Mahony, Jennifer, Reichelt, Mike, Roose-Girma, Merone, Sheng, Zejuan, Sherer, Todd, Smith, Ashley, Solon, Margaret, Sweeney, Zachary K, Tarrant, Jacqueline, Urkowitz, Alison, Warming, Søren, Yaylaoglu, Murat, Zhang, Shuo, Zhu, Haitao, Estrada, Anthony A, Watts, Ryan J
Published in Science translational medicine (04.02.2015)
Published in Science translational medicine (04.02.2015)
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Estrada, Anthony A, Liu, Xingrong, Baker-Glenn, Charles, Beresford, Alan, Burdick, Daniel J, Chambers, Mark, Chan, Bryan K, Chen, Huifen, Ding, Xiao, DiPasquale, Antonio G, Dominguez, Sara L, Dotson, Jennafer, Drummond, Jason, Flagella, Michael, Flynn, Sean, Fuji, Reina, Gill, Andrew, Gunzner-Toste, Janet, Harris, Seth F, Heffron, Timothy P, Kleinheinz, Tracy, Lee, Donna W, Le Pichon, Claire E, Lyssikatos, Joseph P, Medhurst, Andrew D, Moffat, John G, Mukund, Susmith, Nash, Kevin, Scearce-Levie, Kimberly, Sheng, Zejuan, Shore, Daniel G, Tran, Thuy, Trivedi, Naimisha, Wang, Shumei, Zhang, Shuo, Zhang, Xiaolin, Zhao, Guiling, Zhu, Haitao, Sweeney, Zachary K
Published in Journal of medicinal chemistry (26.11.2012)
Published in Journal of medicinal chemistry (26.11.2012)
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Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes
Wang, Xiang, Bondar, Vitaliy V, Davis, Oliver B, Maloney, Michael T, Agam, Maayan, Chin, Marcus Y, Cheuk-Nga Ho, Audrey, Ghosh, Rajarshi, Leto, Dara E, Joy, David, Calvert, Meredith E K, Lewcock, Joseph W, Di Paolo, Gilbert, Thorne, Robert G, Sweeney, Zachary K, Henry, Anastasia G
Published in eLife (24.10.2023)
Published in eLife (24.10.2023)
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Discovery of Highly Potent, Selective, and Brain-Penetrant Aminopyrazole Leucine-Rich Repeat Kinase 2 (LRRK2) Small Molecule Inhibitors
Estrada, Anthony A, Chan, Bryan K, Baker-Glenn, Charles, Beresford, Alan, Burdick, Daniel J, Chambers, Mark, Chen, Huifen, Dominguez, Sara L, Dotson, Jennafer, Drummond, Jason, Flagella, Michael, Fuji, Reina, Gill, Andrew, Halladay, Jason, Harris, Seth F, Heffron, Timothy P, Kleinheinz, Tracy, Lee, Donna W, Pichon, Claire E. Le, Liu, Xingrong, Lyssikatos, Joseph P, Medhurst, Andrew D, Moffat, John G, Nash, Kevin, Scearce-Levie, Kimberly, Sheng, Zejuan, Shore, Daniel G, Wong, Susan, Zhang, Shuo, Zhang, Xiaolin, Zhu, Haitao, Sweeney, Zachary K
Published in Journal of medicinal chemistry (13.02.2014)
Published in Journal of medicinal chemistry (13.02.2014)
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Discovery of Potent and Selective Dual Leucine Zipper Kinase/Leucine Zipper-Bearing Kinase Inhibitors with Neuroprotective Properties in In Vitro and In Vivo Models of Amyotrophic Lateral Sclerosis
Craig, Robert A., Fox, Brian M., Hu, Cheng, Lexa, Katrina W., Osipov, Maksim, Thottumkara, Arun P., Larhammar, Martin, Miyamoto, Takashi, Rana, Anil, Kane, Lesley A., Yulyaningsih, Ernie, Solanoy, Hilda, Nguyen, Hoang, Chau, Roni, Earr, Timothy, Kajiwara, Yuji, Fleck, Daniel, Lucas, Anthony, Haddick, Patrick C. G., Takahashi, Ryan H., Tong, Vincent, Wang, Jing, Canet, Mark J., Poda, Suresh B., Scearce-Levie, Kimberly, Srivastava, Ankita, Sweeney, Zachary K., Xu, Musheng, Zhang, Rui, He, Jianrong, Lei, Yanan, Zhuo, Zheng, de Vicente, Javier
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Published in Journal of medicinal chemistry (22.12.2022)
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Application of Virtual Screening to the Identification of New LpxC Inhibitor Chemotypes, Oxazolidinone and Isoxazoline
Lee, Patrick S, Lapointe, Guillaume, Madera, Ann Marie, Simmons, Robert L, Xu, Wenjian, Yifru, Aregahegn, Tjandra, Meiliana, Karur, Subramanian, Rico, Alice, Thompson, Katherine, Bojkovic, Jade, Xie, Lili, Uehara, Kyoko, Liu, Amy, Shu, Wei, Bellamacina, Cornelia, McKenney, David, Morris, Laura, Tonn, George R, Osborne, Colin, Benton, Bret M, McDowell, Laura, Fu, Jiping, Sweeney, Zachary K
Published in Journal of medicinal chemistry (25.10.2018)
Published in Journal of medicinal chemistry (25.10.2018)
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Discovery of Selective LRRK2 Inhibitors Guided by Computational Analysis and Molecular Modeling
Chen, Huifen, Chan, Bryan K, Drummond, Jason, Estrada, Anthony A, Gunzner-Toste, Janet, Liu, Xingrong, Liu, Yichin, Moffat, John, Shore, Daniel, Sweeney, Zachary K, Tran, Thuy, Wang, Shumei, Zhao, Guiling, Zhu, Haitao, Burdick, Daniel J
Published in Journal of medicinal chemistry (14.06.2012)
Published in Journal of medicinal chemistry (14.06.2012)
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High-Throughput Liquid Chromatography-Tandem Mass Spectrometry Quantification of Glycosaminoglycans as Biomarkers of Mucopolysaccharidosis II
Wang, Junhua, Bhalla, Akhil, Ullman, Julie C, Fang, Meng, Ravi, Ritesh, Arguello, Annie, Thomsen, Elliot, Tsogtbaatar, Buyankhishig, Guo, Jing L, Skuja, Lukas L, Dugas, Jason C, Davis, Sonnet S, Poda, Suresh B, Gunasekaran, Kannan, Costanzo, Simona, Sweeney, Zachary K, Henry, Anastasia G, Harris, Jeffrey M, Henne, Kirk R, Astarita, Giuseppe
Published in International journal of molecular sciences (30.07.2020)
Published in International journal of molecular sciences (30.07.2020)
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Discovery of potent azaindazole leucine-rich repeat kinase 2 (LRRK2) inhibitors possessing a key intramolecular hydrogen bond – Part 2
Shore, Daniel G.M., Sweeney, Zachary K., Beresford, Alan, Chan, Bryan K., Chen, Huifen, Drummond, Jason, Gill, Andrew, Kleinheinz, Tracy, Liu, Xingrong, Medhurst, Andrew D., McIver, Edward G., Moffat, John G., Zhu, Haitao, Estrada, Anthony A.
Published in Bioorganic & medicinal chemistry letters (15.02.2019)
Published in Bioorganic & medicinal chemistry letters (15.02.2019)
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Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice
Ullman, Julie C, Arguello, Annie, Getz, Jennifer A, Bhalla, Akhil, Mahon, Cathal S, Wang, Junhua, Giese, Tina, Bedard, Catherine, Kim, Do Jin, Blumenfeld, Jessica R, Liang, Nicholas, Ravi, Ritesh, Nugent, Alicia A, Davis, Sonnet S, Ha, Connie, Duque, Joseph, Tran, Hai L, Wells, Robert C, Lianoglou, Steve, Daryani, Vinay M, Kwan, Wanda, Solanoy, Hilda, Nguyen, Hoang, Earr, Timothy, Dugas, Jason C, Tuck, Michael D, Harvey, Jennifer L, Reyzer, Michelle L, Caprioli, Richard M, Hall, Sejal, Poda, Suresh, Sanchez, Pascal E, Dennis, Mark S, Gunasekaran, Kannan, Srivastava, Ankita, Sandmann, Thomas, Henne, Kirk R, Thorne, Robert G, Di Paolo, Gilbert, Astarita, Giuseppe, Diaz, Dolores, Silverman, Adam P, Watts, Ryan J, Sweeney, Zachary K, Kariolis, Mihalis S, Henry, Anastasia G
Published in Science translational medicine (27.05.2020)
Published in Science translational medicine (27.05.2020)
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Potent and Highly Selective Benzimidazole Inhibitors of PI3-Kinase Delta
Murray, Jeremy M, Sweeney, Zachary K, Chan, Bryan K, Balazs, Mercedesz, Bradley, Erin, Castanedo, Georgette, Chabot, Christine, Chantry, David, Flagella, Michael, Goldstein, David M, Kondru, Rama, Lesnick, John, Li, Jun, Lucas, Matthew C, Nonomiya, Jim, Pang, Jodie, Price, Stephen, Salphati, Laurent, Safina, Brian, Savy, Pascal P. A, Seward, Eileen M, Ultsch, Mark, Sutherlin, Daniel P
Published in Journal of medicinal chemistry (13.09.2012)
Published in Journal of medicinal chemistry (13.09.2012)
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Finding the perfect spot for fluorine: Improving potency up to 40-fold during a rational fluorine scan of a Bruton's Tyrosine Kinase (BTK) inhibitor scaffold
Lou, Yan, Sweeney, Zachary K., Kuglstatter, Andreas, Davis, Dana, Goldstein, David M., Han, Xiaochun, Hong, Junbae, Kocer, Buelent, Kondru, Rama K., Litman, Renee, McIntosh, Joel, Sarma, Keshab, Suh, Judy, Taygerly, Joshua, Owens, Timothy D.
Published in Bioorganic & medicinal chemistry letters (15.01.2015)
Published in Bioorganic & medicinal chemistry letters (15.01.2015)
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Potent Nonimmunosuppressive Cyclophilin Inhibitors With Improved Pharmaceutical Properties and Decreased Transporter Inhibition
Fu, Jiping, Tjandra, Meiliana, Becker, Christopher, Bednarczyk, Dallas, Capparelli, Michael, Elling, Robert, Hanna, Imad, Fujimoto, Roger, Furegati, Markus, Karur, Subramanian, Kasprzyk, Theresa, Knapp, Mark, Leung, Kwan, Li, Xiaolin, Lu, Peichao, Mergo, Wosenu, Miault, Charlotte, Ng, Simon, Parker, David, Peng, Yunshan, Roggo, Silvio, Rivkin, Alexey, Simmons, Robert L, Wang, Michael, Wiedmann, Brigitte, Weiss, Andrew H, Xiao, Linda, Xie, Lili, Xu, Wenjian, Yifru, Aregahegn, Yang, Shengtian, Zhou, Bo, Sweeney, Zachary K
Published in Journal of medicinal chemistry (23.10.2014)
Published in Journal of medicinal chemistry (23.10.2014)
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