1-Alkyl-benzotriazole-5-carboxylic Acids Are Highly Selective Agonists of the Human Orphan G-Protein-Coupled Receptor GPR109b
Semple, Graeme, Skinner, Philip J, Cherrier, Martin C, Webb, Peter J, Sage, Carleton R, Tamura, Susan Y, Chen, Ruoping, Richman, Jeremy G, Connolly, Daniel T
Published in Journal of medicinal chemistry (23.02.2006)
Published in Journal of medicinal chemistry (23.02.2006)
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Fluorinated pyrazole acids are agonists of the high affinity niacin receptor GPR109a
Skinner, Philip J., Cherrier, Martin C., Webb, Peter J., Shin, Young-Jun, Gharbaoui, Tawfik, Lindstrom, Andrew, Hong, Vu, Tamura, Susan Y., Dang, Huong T., Pride, Cameron C., Chen, Ruoping, Richman, Jeremy G., Connolly, Daniel T., Semple, Graeme
Published in Bioorganic & medicinal chemistry letters (15.10.2007)
Published in Bioorganic & medicinal chemistry letters (15.10.2007)
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3-(1H-Tetrazol-5-yl)-1,4,5,6-tetrahydro-cyclopentapyrazole (MK-0354): A Partial Agonist of the Nicotinic Acid Receptor, G-Protein Coupled Receptor 109a, with Antilipolytic but No Vasodilatory Activity in Mice
Semple, Graeme, Skinner, Philip J, Gharbaoui, Tawfik, Shin, Young-Jun, Jung, Jae-Kyu, Cherrier, Martin C, Webb, Peter J, Tamura, Susan Y, Boatman, P. Douglas, Sage, Carleton R, Schrader, Thomas O, Chen, Ruoping, Colletti, Steven L, Tata, James R, Waters, M. Gerard, Cheng, Kang, Taggart, Andrew K, Cai, Tian-Quan, Carballo-Jane, Ester, Behan, Dominic P, Connolly, Daniel T, Richman, Jeremy G
Published in Journal of medicinal chemistry (28.08.2008)
Published in Journal of medicinal chemistry (28.08.2008)
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5-N,N-Disubstituted 5-aminopyrazole-3-carboxylic acids are highly potent agonists of GPR109b
Skinner, Philip J., Webb, Peter J., Sage, Carleton R, Dang, Huong T., Pride, Cameron C., Chen, Ruoping, Tamura, Susan Y., Richman, Jeremy G., Connolly, Daniel T., Semple, Graeme
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
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Journal Article
Automated synthesis of peptide C-terminal aldehydes
Murphy, Aileen M, Dagnino, Raymond, Vallar, Pureza L, Trippe, Anthony J, Sherman, Shannon L, Lumpkin, Richard H, Tamura, Susan Y, Webb, Thomas R
Published in Journal of the American Chemical Society (01.04.1992)
Published in Journal of the American Chemical Society (01.04.1992)
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Discovery of SCH446211 (SCH6): A New Ketoamide Inhibitor of the HCV NS3 Serine Protease and HCV Subgenomic RNA Replication
Bogen, Stéphane L, Arasappan, Ashok, Bennett, Frank, Chen, Kevin, Jao, Edwin, Liu, Yi-Tsung, Lovey, Raymond G, Venkatraman, Srikanth, Pan, Weidong, Parekh, Tajel, Pike, Russel E, Ruan, Sumei, Liu, Rong, Baroudy, Bahige, Agrawal, Sony, Chase, Robert, Ingravallo, Paul, Pichardo, John, Prongay, Andrew, Brisson, Jean-Marc, Hsieh, Tony Y, Cheng, Kuo-Chi, Kemp, Scott J, Levy, Odile E, Lim-Wilby, Marguerita, Tamura, Susan Y, Saksena, Anil K, Girijavallabhan, Viyyoor, Njoroge, F. George
Published in Journal of medicinal chemistry (04.05.2006)
Published in Journal of medicinal chemistry (04.05.2006)
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3-Nitro-4-amino benzoic acids and 6-amino nicotinic acids are highly selective agonists of GPR109b
Skinner, Philip J., Cherrier, Martin C., Webb, Peter J., Sage, Carleton R., Dang, Huong T., Pride, Cameron C., Chen, Ruoping, Tamura, Susan Y., Richman, Jeremy G., Connolly, Daniel T., Semple, Graeme
Published in Bioorganic & medicinal chemistry (01.12.2007)
Published in Bioorganic & medicinal chemistry (01.12.2007)
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Andrimid, a new peptide antibiotic produced by an intracellular bacterial symbiont isolated from a brown planthopper
Fredenhagen, Andreas, Tamura, Susan Y, Kenny, Peter T. M, Komura, Hajime, Naya, Yoko, Nakanishi, Koji, Nishiyama, Koushi, Sugiura, Miyoji, Kita, Hiroshi
Published in Journal of the American Chemical Society (01.07.1987)
Published in Journal of the American Chemical Society (01.07.1987)
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Agonist lead identification for the high affinity niacin receptor GPR109a
Gharbaoui, Tawfik, Skinner, Philip J., Shin, Young-Jun, Averbuj, Claudia, Jung, Jae-Kyu, Johnson, Benjamin R., Duong, Tracy, Decaire, Marc, Uy, Jane, Cherrier, Martin C., Webb, Peter J., Tamura, Susan Y., Zou, Ning, Rodriguez, Nathalie, Boatman, P. Douglas, Sage, Carleton R., Lindstrom, Andrew, Xu, Jerry, Schrader, Thomas O., Smith, Brian M., Chen, Ruoping, Richman, Jeremy G., Connolly, Daniel T., Colletti, Steven L., Tata, James R., Semple, Graeme
Published in Bioorganic & medicinal chemistry letters (01.09.2007)
Published in Bioorganic & medicinal chemistry letters (01.09.2007)
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Synthesis and biological activity of peptidyl aldehyde urokinase inhibitors
Tamura, S Y, Weinhouse, M I, Roberts, C A, Goldman, E A, Masukawa, K, Anderson, S M, Cohen, C R, Bradbury, A E, Bernardino, V T, Dixon, S A, Ma, M G, Nolan, T G, Brunck, T K
Published in Bioorganic & medicinal chemistry letters (01.05.2000)
Published in Bioorganic & medicinal chemistry letters (01.05.2000)
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Design, Synthesis, and Evolution of a Novel, Selective, and Orally Bioavailable Class of Thrombin Inhibitors: P1-Argininal Derivatives Incorporating P3-P4 Lactam Sulfonamide Moieties
Semple, J. Edward, Rowley, David C, Brunck, Terence K, Ha-Uong, Theresa, Minami, Nathaniel K, Owens, Timothy D, Tamura, Susan Y, Goldman, Erick A, Siev, Daniel V, Ardecky, Robert J, Carpenter, Stephen H, Ge, Yu, Richard, Brigitte M, Nolan, Thomas G, Håkanson, Kjell, Tulinsky, Al, Nutt, Ruth F, Ripka, William C
Published in Journal of medicinal chemistry (08.11.1996)
Published in Journal of medicinal chemistry (08.11.1996)
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Novel benzo-fused lactam scaffolds as factor Xa inhibitors
Tamura, Susan Y., Goldman, Erick A., Bergum, Peter W., Semple, J. Edward
Published in Bioorganic & medicinal chemistry letters (06.09.1999)
Published in Bioorganic & medicinal chemistry letters (06.09.1999)
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Rational design, synthesis, and serine protease inhibitory activity of a novel P1-argininal derivative featuring a conformationally constrained P2-P3 bicyclic lactam moiety
TAMURA, S. Y, GOLDMAN, E. A, BRUNCK, T. K, RIPKA, W. C, SEMPLE, J. E
Published in Bioorganic & medicinal chemistry letters (04.02.1997)
Published in Bioorganic & medicinal chemistry letters (04.02.1997)
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Journal Article
Rational design and synthesis of a novel, selective class of thrombin inhibitors: P1-argininal derivatives incorporating P3P4 quaternary lactam dipeptide surrogates
Semple, J.Edward, Minami, Nathaniel K., Tamura, Susan Y., Brunck, Terence K., Nutt, Ruth F., Ripka, William C.
Published in Bioorganic & medicinal chemistry letters (23.09.1997)
Published in Bioorganic & medicinal chemistry letters (23.09.1997)
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Journal Article
Rational design, synthesis, and serine protease inhibitory activity of a novel P 1-argininal derivative featuring a conformationally constrained P 2–P 3 bicyclic lactam moiety
Tamura, Susan Y., Goldman, Erick A., Brunck, Terence K., Ripka, William C., Edward Semple, J.
Published in Bioorganic & medicinal chemistry letters (04.02.1997)
Published in Bioorganic & medicinal chemistry letters (04.02.1997)
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